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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for GCUACAU
Z-value: 0.46
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miRNA associated with seed GCUACAU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_20522179 Show fit | 1.63 |
ENST00000359062.3
|
phosphodiesterase 3A, cGMP-inhibited |
|
| chr4_+_55524085 Show fit | 1.45 |
ENST00000412167.2
ENST00000288135.5 |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
|
| chr6_-_16761678 Show fit | 1.24 |
ENST00000244769.4
ENST00000436367.1 |
ataxin 1 |
|
| chr13_+_32605437 Show fit | 1.22 |
ENST00000380250.3
|
furry homolog (Drosophila) |
|
| chr15_-_52970820 Show fit | 1.08 |
ENST00000261844.7
ENST00000399202.4 ENST00000562135.1 |
family with sequence similarity 214, member A |
|
| chr12_+_12870055 Show fit | 1.07 |
ENST00000228872.4
|
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
|
| chr8_-_93115445 Show fit | 0.89 |
ENST00000523629.1
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
|
| chr2_-_43453734 Show fit | 0.82 |
ENST00000282388.3
|
ZFP36 ring finger protein-like 2 |
|
| chrX_+_28605516 Show fit | 0.82 |
ENST00000378993.1
|
interleukin 1 receptor accessory protein-like 1 |
|
| chr6_+_16129308 Show fit | 0.71 |
ENST00000356840.3
ENST00000349606.4 |
myosin regulatory light chain interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCUACAU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.5 | 1.5 | GO:0038109 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162) |
| 0.2 | 1.2 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 1.1 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 0.8 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.1 | 0.8 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.1 | 0.7 | GO:0032803 | regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) |
| 0.1 | 0.7 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.0 | 0.7 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.7 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 1.2 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 1.1 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.3 | GO:0031213 | RSF complex(GO:0031213) |
| 0.0 | 0.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.3 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.3 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.2 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.2 | 1.1 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 1.1 | GO:0005072 | transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072) |
| 0.1 | 0.9 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 0.8 | GO:0019966 | interleukin-1 binding(GO:0019966) |
| 0.0 | 0.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.7 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 0.5 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.5 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 1.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.1 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.7 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.2 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |