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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for GFI1
Z-value: 1.50
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Transcription factors associated with GFI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1 | hg19_v2_chr1_-_92951607_92951661, hg19_v2_chr1_-_92949505_92949543, hg19_v2_chr1_-_92952433_92952489 | 0.02 | 9.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.9 | GO:0007286 | spermatid development(GO:0007286) |
| 0.5 | 11.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 8.2 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 1.8 | 7.3 | GO:2000691 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 1.5 | 5.9 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.3 | 5.7 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.2 | 5.5 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 5.3 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 5.0 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 5.0 | GO:0031424 | keratinization(GO:0031424) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 18.9 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.2 | 7.0 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 3.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 3.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 3.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 1.0 | 3.0 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.4 | 2.8 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 2.7 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 2.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.1 | GO:0003779 | actin binding(GO:0003779) |
| 0.2 | 16.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.3 | 5.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 5.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 5.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 5.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 4.6 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 4.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 4.1 | GO:0017022 | myosin binding(GO:0017022) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 11.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 4.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 4.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 5.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.2 | 5.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 5.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 4.9 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 4.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 4.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 3.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 3.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |