ISMARA results: GGCAGUG

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GGCAGUG

Z-value: 0.51

Motif logo

miRNA associated with seed GGCAGUG

Name	miRBASE accession
hsa-miR-34a-5p miRBase	MIMAT0000255
hsa-miR-34c-5p miRBase	MIMAT0000686
hsa-miR-449a miRBase	MIMAT0001541
hsa-miR-449b-5p miRBase	MIMAT0003327

Activity profile of GGCAGUG motif

Sorted Z-values of GGCAGUG motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_136172820 Show fit	0.74	ENST00000308191.6	PDE7B Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphodiesterase 7B
chr14_-_74253948 Show fit	0.61	ENST00000394071.2	ELMSAN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELM2 and Myb/SANT-like domain containing 1
chr5_+_176560742 Show fit	0.51	ENST00000439151.2	NSD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear receptor binding SET domain protein 1
chr8_-_57123815 Show fit	0.47	ENST00000316981.3 ENST00000423799.2 ENST00000429357.2	PLAG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleiomorphic adenoma gene 1
chr12_+_8185288 Show fit	0.43	ENST00000162391.3	FOXJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box J2
chr17_+_1646130 Show fit	0.40	ENST00000453066.1 ENST00000324015.3 ENST00000450523.2 ENST00000453723.1 ENST00000382061.4	SERPINF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr12_-_95044309 Show fit	0.39	ENST00000261226.4	TMCC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane and coiled-coil domain family 3
chr19_+_41725088 Show fit	0.35	ENST00000301178.4	AXL Ensembl NCBI GeneCards UniProt NextProt Show fit	AXL receptor tyrosine kinase
chr12_+_107168342 Show fit	0.34	ENST00000392837.4	RIC8B Ensembl NCBI GeneCards UniProt NextProt Show fit	RIC8 guanine nucleotide exchange factor B
chr6_-_30585009 Show fit	0.34	ENST00000376511.2	PPP1R10 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 10

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GGCAGUG

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:2000969	NMDA glutamate receptor clustering(GO:0097114) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.1	0.5	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.5	GO:0060252	positive regulation of glial cell proliferation(GO:0060252)
0.1	0.4	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.1	0.4	GO:0003072	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.1	0.3	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0	0.3	GO:2000669	positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.0	0.3	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1	0.2	GO:0018008	N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.1	0.2	GO:1903762	positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033)

Showing 1 to 10 of 85 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0043194	axon initial segment(GO:0043194)
0.0	0.4	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.3	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.3	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.1	0.2	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.2	GO:0031251	PAN complex(GO:0031251)
0.0	0.2	GO:1902937	inward rectifier potassium channel complex(GO:1902937)
0.0	0.2	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.4	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.4	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.3	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.3	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.3	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.3	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.3	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.3	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.3	GO:0001965	G-protein alpha-subunit binding(GO:0001965)

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Showing 1 to 6 of 6 entries

Results for GGCAGUG

Z-value: 0.51

Motif logo

miRNA associated with seed GGCAGUG

Activity profile of GGCAGUG motif

Sorted Z-values of GGCAGUG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GGCAGUG

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: