Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for GLI2
Z-value: 0.69
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Transcription factors associated with GLI2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_205782304 Show fit | 1.47 |
ENST00000367137.3
|
solute carrier family 41 (magnesium transporter), member 1 |
|
| chr12_+_113354341 Show fit | 1.06 |
ENST00000553152.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr17_+_41158742 Show fit | 0.95 |
ENST00000415816.2
ENST00000438323.2 |
interferon-induced protein 35 |
|
| chr1_-_47407097 Show fit | 0.77 |
ENST00000457840.2
|
cytochrome P450, family 4, subfamily A, polypeptide 11 |
|
| chr5_+_131409476 Show fit | 0.74 |
ENST00000296871.2
|
colony stimulating factor 2 (granulocyte-macrophage) |
|
| chr7_-_47579188 Show fit | 0.67 |
ENST00000398879.1
ENST00000355730.3 ENST00000442536.2 ENST00000458317.2 |
tensin 3 |
|
| chr19_+_44084696 Show fit | 0.66 |
ENST00000562255.1
ENST00000569031.2 |
phospholipase A2 inhibitor and LY6/PLAUR domain containing |
|
| chr19_-_7939319 Show fit | 0.66 |
ENST00000539422.1
|
Protein FLJ22184 |
|
| chr15_-_78526855 Show fit | 0.63 |
ENST00000541759.1
ENST00000558130.1 |
acyl-CoA synthetase bubblegum family member 1 |
|
| chr11_+_13690249 Show fit | 0.57 |
ENST00000532701.1
|
fatty acyl CoA reductase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.2 | 1.5 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.0 | 1.3 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.2 | 0.9 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.1 | 0.8 | GO:0014028 | notochord formation(GO:0014028) |
| 0.1 | 0.7 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.0 | 0.7 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.7 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.7 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.2 | 0.6 | GO:1903697 | negative regulation of microvillus assembly(GO:1903697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.9 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 0.8 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 0.7 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 0.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.5 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.5 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.1 | 0.4 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 1.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 0.9 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.1 | 0.8 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.1 | 0.8 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.6 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 0.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 0.6 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 0.6 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 0.6 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.4 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.2 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 0.0 | 0.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.7 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.6 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |