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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for GLI3
Z-value: 1.39
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Transcription factors associated with GLI3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI3 | hg19_v2_chr7_-_42276612_42276782 | -0.29 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_67430339 Show fit | 5.97 |
ENST00000439724.3
|
SMAD family member 3 |
|
| chr9_-_123676827 Show fit | 5.50 |
ENST00000546084.1
|
TNF receptor-associated factor 1 |
|
| chr1_+_183155373 Show fit | 5.22 |
ENST00000493293.1
ENST00000264144.4 |
laminin, gamma 2 |
|
| chr3_-_127542051 Show fit | 4.50 |
ENST00000398104.1
|
monoglyceride lipase |
|
| chr10_-_49701686 Show fit | 4.38 |
ENST00000417247.2
|
Rho GTPase activating protein 22 |
|
| chr7_-_47579188 Show fit | 4.33 |
ENST00000398879.1
ENST00000355730.3 ENST00000442536.2 ENST00000458317.2 |
tensin 3 |
|
| chr3_-_127542021 Show fit | 4.31 |
ENST00000434178.2
|
monoglyceride lipase |
|
| chr1_-_205782304 Show fit | 4.30 |
ENST00000367137.3
|
solute carrier family 41 (magnesium transporter), member 1 |
|
| chr5_+_113769205 Show fit | 3.95 |
ENST00000503706.1
|
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
|
| chr19_+_18284477 Show fit | 3.93 |
ENST00000407280.3
|
interferon, gamma-inducible protein 30 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 1.3 | 8.8 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 7.5 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 1.7 | 6.8 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.2 | 6.4 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.1 | 6.4 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.3 | 6.2 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 1.2 | 6.0 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.5 | 6.0 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 1.3 | 5.3 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.6 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 7.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.8 | 6.5 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.7 | 6.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.2 | 5.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 1.7 | 5.2 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.0 | 4.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 4.1 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 3.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.4 | 3.3 | GO:0030870 | Mre11 complex(GO:0030870) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 7.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.3 | 6.2 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 1.2 | 6.0 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 5.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.4 | 5.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 5.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.8 | 4.2 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 0.2 | 4.1 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 3.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 6.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 5.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 5.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 4.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.4 | 4.2 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 3.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 8.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 6.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 6.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 5.3 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 5.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 3.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 3.4 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |