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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GLIS3

Z-value: 0.26

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.17 GLIS family zinc finger 3

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_74904398 0.50 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr1_-_92371839 0.25 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr20_-_30310693 0.16 ENST00000307677.4
ENST00000420653.1
BCL2L1
BCL2-like 1
chr11_+_5646213 0.15 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr1_+_107599267 0.14 ENST00000361318.5
ENST00000370078.1
PRMT6
protein arginine methyltransferase 6
chr20_-_30310656 0.14 ENST00000376055.4
BCL2L1
BCL2-like 1
chr7_+_65958693 0.13 ENST00000445681.1
ENST00000452565.1
GS1-124K5.4
GS1-124K5.4
chr8_-_29120580 0.13 ENST00000524189.1
KIF13B
kinesin family member 13B
chr6_+_24495185 0.13 ENST00000348925.2
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr9_-_139658965 0.10 ENST00000316144.5
LCN15
lipocalin 15
chr15_+_84116106 0.10 ENST00000535412.1
ENST00000324537.5
SH3GL3
SH3-domain GRB2-like 3
chr3_-_160167508 0.10 ENST00000479460.1
TRIM59
tripartite motif containing 59
chr4_-_84255935 0.10 ENST00000513463.1
HPSE
heparanase
chr19_+_46850251 0.10 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr19_+_46850320 0.10 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr22_-_21482046 0.09 ENST00000419447.1
POM121L7
POM121 transmembrane nucleoporin-like 7
chr20_-_6103666 0.09 ENST00000536936.1
FERMT1
fermitin family member 1
chr6_+_159084188 0.09 ENST00000367081.3
SYTL3
synaptotagmin-like 3
chr2_-_208030647 0.09 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_-_160167301 0.08 ENST00000494486.1
TRIM59
tripartite motif containing 59
chr9_-_116061476 0.08 ENST00000441031.3
RNF183
ring finger protein 183
chr19_-_41859814 0.08 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr1_-_42800860 0.08 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
FOXJ3
forkhead box J3
chr19_+_11909329 0.08 ENST00000323169.5
ENST00000450087.1
ZNF491
zinc finger protein 491
chr20_-_23969416 0.08 ENST00000335694.4
GGTLC1
gamma-glutamyltransferase light chain 1
chr20_+_61867235 0.08 ENST00000342412.6
ENST00000217169.3
BIRC7
baculoviral IAP repeat containing 7
chr9_-_98279241 0.07 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
PTCH1
patched 1
chr1_-_42801540 0.07 ENST00000372573.1
FOXJ3
forkhead box J3
chr6_+_24495067 0.07 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr2_-_241759622 0.06 ENST00000320389.7
ENST00000498729.2
KIF1A
kinesin family member 1A
chr20_-_44718538 0.06 ENST00000290231.6
ENST00000372291.3
NCOA5
nuclear receptor coactivator 5
chr5_+_41925325 0.06 ENST00000296812.2
ENST00000281623.3
ENST00000509134.1
FBXO4
F-box protein 4
chr1_-_157108266 0.06 ENST00000326786.4
ETV3
ets variant 3
chr6_+_89791507 0.06 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr1_-_45987526 0.06 ENST00000372079.1
ENST00000262746.1
ENST00000447184.1
ENST00000319248.8
PRDX1
peroxiredoxin 1
chr11_-_18813110 0.06 ENST00000396168.1
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr19_+_40697514 0.05 ENST00000253055.3
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr11_+_57308979 0.05 ENST00000457912.1
SMTNL1
smoothelin-like 1
chr6_+_44191290 0.05 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr18_+_3451584 0.05 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr17_-_73178599 0.05 ENST00000578238.1
SUMO2
small ubiquitin-like modifier 2
chr6_+_44191507 0.05 ENST00000371724.1
ENST00000371713.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr1_+_31886653 0.05 ENST00000536384.1
SERINC2
serine incorporator 2
chr21_+_38071430 0.05 ENST00000290399.6
SIM2
single-minded family bHLH transcription factor 2
chr1_-_53018654 0.05 ENST00000257177.4
ENST00000355809.4
ENST00000528642.1
ENST00000470626.1
ENST00000371544.3
ZCCHC11
zinc finger, CCHC domain containing 11
chr5_-_137090028 0.05 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr12_-_57400227 0.04 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr1_-_160254913 0.04 ENST00000440949.3
ENST00000368072.5
ENST00000608310.1
ENST00000556710.1
PEX19
DCAF8
DCAF8
peroxisomal biogenesis factor 19
DDB1 and CUL4 associated factor 8
DDB1- and CUL4-associated factor 8
chr19_-_38397228 0.04 ENST00000447313.2
WDR87
WD repeat domain 87
chr1_+_16062820 0.04 ENST00000294454.5
SLC25A34
solute carrier family 25, member 34
chr21_-_46330545 0.04 ENST00000320216.6
ENST00000397852.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_-_241737128 0.04 ENST00000404283.3
KIF1A
kinesin family member 1A
chrX_+_118370211 0.04 ENST00000217971.7
PGRMC1
progesterone receptor membrane component 1
chr13_+_25670268 0.04 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr22_+_31489344 0.03 ENST00000404574.1
SMTN
smoothelin
chr6_+_33172407 0.03 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_45988542 0.03 ENST00000424390.1
PRDX1
peroxiredoxin 1
chr22_-_21482352 0.03 ENST00000329949.3
POM121L7
POM121 transmembrane nucleoporin-like 7
chr8_-_12051576 0.03 ENST00000524571.2
ENST00000533852.2
ENST00000533513.1
ENST00000448228.2
ENST00000534520.1
ENST00000321602.8
FAM86B1
family with sequence similarity 86, member B1
chr19_-_49828438 0.03 ENST00000454748.3
ENST00000598828.1
ENST00000335875.4
SLC6A16
solute carrier family 6, member 16
chr17_+_4675175 0.03 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr5_-_180671172 0.03 ENST00000512805.1
GNB2L1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr17_-_56605341 0.03 ENST00000583114.1
SEPT4
septin 4
chr10_+_71389983 0.02 ENST00000373279.4
C10orf35
chromosome 10 open reading frame 35
chrX_+_118370288 0.02 ENST00000535419.1
PGRMC1
progesterone receptor membrane component 1
chr3_-_160167540 0.02 ENST00000496222.1
ENST00000471396.1
ENST00000471155.1
ENST00000309784.4
TRIM59
tripartite motif containing 59
chr2_+_220379052 0.02 ENST00000347842.3
ENST00000358078.4
ASIC4
acid-sensing (proton-gated) ion channel family member 4
chr14_+_105190514 0.02 ENST00000330877.2
ADSSL1
adenylosuccinate synthase like 1
chr3_+_127348005 0.02 ENST00000342480.6
PODXL2
podocalyxin-like 2
chr7_+_23636992 0.02 ENST00000307471.3
ENST00000409765.1
CCDC126
coiled-coil domain containing 126
chr1_-_157108130 0.02 ENST00000368192.4
ETV3
ets variant 3
chr11_+_68451943 0.02 ENST00000265643.3
GAL
galanin/GMAP prepropeptide
chr20_-_62103862 0.02 ENST00000344462.4
ENST00000357249.2
ENST00000359125.2
ENST00000360480.3
ENST00000370224.1
ENST00000344425.5
ENST00000354587.3
ENST00000359689.1
KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2
chr17_+_46018872 0.01 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
PNPO
pyridoxamine 5'-phosphate oxidase
chr18_+_3451646 0.01 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1
TGFB-induced factor homeobox 1
chr15_+_91478493 0.01 ENST00000418476.2
UNC45A
unc-45 homolog A (C. elegans)
chr12_+_132312931 0.01 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr17_-_77925806 0.01 ENST00000574241.2
TBC1D16
TBC1 domain family, member 16
chr19_-_14224969 0.01 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr18_+_11752040 0.01 ENST00000423027.3
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr19_+_13875316 0.01 ENST00000319545.8
ENST00000593245.1
ENST00000040663.6
MRI1
methylthioribose-1-phosphate isomerase 1
chr19_-_10613421 0.00 ENST00000393623.2
KEAP1
kelch-like ECH-associated protein 1
chr17_-_73179046 0.00 ENST00000314523.7
ENST00000420826.2
SUMO2
small ubiquitin-like modifier 2
chr5_+_172386419 0.00 ENST00000265100.2
ENST00000519239.1
RPL26L1
ribosomal protein L26-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.2 GO:0006083 acetate metabolic process(GO:0006083) gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:0044416 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0048817 negative regulation of hair follicle maturation(GO:0048817)
0.0 0.5 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.