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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for GMEB1
Z-value: 1.26
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Transcription factors associated with GMEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB1 | hg19_v2_chr1_+_28995231_28995250 | 0.68 | 2.0e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_123691047 Show fit | 4.47 |
ENST00000373887.3
|
TNF receptor-associated factor 1 |
|
| chr9_-_123691439 Show fit | 4.34 |
ENST00000540010.1
|
TNF receptor-associated factor 1 |
|
| chr6_+_32821924 Show fit | 3.62 |
ENST00000374859.2
ENST00000453265.2 |
proteasome (prosome, macropain) subunit, beta type, 9 |
|
| chr11_+_69455855 Show fit | 3.60 |
ENST00000227507.2
ENST00000536559.1 |
cyclin D1 |
|
| chr1_+_65613340 Show fit | 3.56 |
ENST00000546702.1
|
adenylate kinase 4 |
|
| chr16_-_75590114 Show fit | 3.36 |
ENST00000568377.1
ENST00000565067.1 ENST00000258173.6 |
transmembrane protein 231 |
|
| chr16_-_67969888 Show fit | 3.21 |
ENST00000574576.2
|
proteasome (prosome, macropain) subunit, beta type, 10 |
|
| chr1_+_65613217 Show fit | 3.13 |
ENST00000545314.1
|
adenylate kinase 4 |
|
| chr7_-_25019760 Show fit | 3.11 |
ENST00000352860.1
ENST00000353930.1 ENST00000431825.2 ENST00000313367.2 |
oxysterol binding protein-like 3 |
|
| chr8_+_54793454 Show fit | 3.07 |
ENST00000276500.4
|
regulator of G-protein signaling 20 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.9 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.1 | 7.6 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.2 | 7.0 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.8 | 6.9 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.7 | 5.5 | GO:0021564 | vagus nerve development(GO:0021564) |
| 1.2 | 4.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.4 | 4.3 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.1 | 3.9 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 1.3 | 3.8 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.4 | 3.7 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.7 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.8 | 6.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 5.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 5.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.7 | 4.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 4.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 3.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 3.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 3.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.5 | 3.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 9.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 9.0 | GO:0004386 | helicase activity(GO:0004386) |
| 0.9 | 8.4 | GO:0046977 | TAP binding(GO:0046977) TAP1 binding(GO:0046978) |
| 0.3 | 8.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.3 | 6.7 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.2 | 5.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 4.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.3 | 3.8 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.3 | 3.6 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 6.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 4.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 4.7 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 4.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 3.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 8.0 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 4.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 4.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 3.8 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.4 | 3.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 3.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 3.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.3 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |