Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for GRHL1

Z-value: 0.30

Motif logo

logo of

Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091815_10091864,
hg19_v2_chr2_+_10091783_10091811		0.232.8e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_156588249 0.88 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr9_-_77703115 0.48 ENST00000361092.4
ENST00000376808.4
NMRK1
nicotinamide riboside kinase 1
chr2_-_209118974 0.43 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr9_+_5450503 0.42 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr20_-_61002584 0.34 ENST00000252998.1
RBBP8NL
RBBP8 N-terminal like
chr12_-_10959892 0.30 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr11_-_69590101 0.29 ENST00000168712.1
FGF4
fibroblast growth factor 4
chr7_-_102184083 0.28 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr7_-_102283238 0.26 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr5_-_132299313 0.26 ENST00000265343.5
AFF4
AF4/FMR2 family, member 4
chr19_-_11849697 0.23 ENST00000586121.1
ENST00000431998.1
ENST00000341191.6
ENST00000545749.1
ENST00000440527.1
ZNF823
zinc finger protein 823
chr1_+_210406121 0.23 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr3_-_172241250 0.20 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr7_+_76139833 0.19 ENST00000257632.5
UPK3B
uroplakin 3B
chr7_+_76139925 0.19 ENST00000394849.1
UPK3B
uroplakin 3B
chr19_+_45312347 0.18 ENST00000270233.6
ENST00000591520.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr19_-_291133 0.17 ENST00000327790.3
PPAP2C
phosphatidic acid phosphatase type 2C
chr12_+_18414446 0.17 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr20_-_25320367 0.16 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr8_-_130799134 0.16 ENST00000276708.4
GSDMC
gasdermin C
chr19_+_10736183 0.16 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr3_-_49142504 0.15 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr3_-_49142178 0.14 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
QARS
glutaminyl-tRNA synthetase
chr6_+_32121218 0.14 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr6_-_46889694 0.13 ENST00000283296.7
ENST00000362015.4
ENST00000456426.2
GPR116
G protein-coupled receptor 116
chr11_+_706595 0.13 ENST00000531348.1
ENST00000530636.1
EPS8L2
EPS8-like 2
chr9_+_77703414 0.13 ENST00000346234.6
OSTF1
osteoclast stimulating factor 1
chr14_-_80677815 0.11 ENST00000557125.1
ENST00000555750.1
DIO2
deiodinase, iodothyronine, type II
chr13_+_48807334 0.10 ENST00000378549.5
ITM2B
integral membrane protein 2B
chr3_+_101568349 0.10 ENST00000326151.5
ENST00000326172.5
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr18_-_55470320 0.10 ENST00000536015.1
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr19_-_17356697 0.09 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr15_+_49170083 0.09 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr6_+_168227611 0.09 ENST00000344191.4
ENST00000351017.4
ENST00000392108.3
ENST00000366806.2
ENST00000392112.1
ENST00000400824.4
ENST00000447894.2
ENST00000400822.3
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr6_-_31107127 0.08 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr12_+_123874589 0.08 ENST00000437502.1
SETD8
SET domain containing (lysine methyltransferase) 8
chr5_-_132299290 0.08 ENST00000378595.3
AFF4
AF4/FMR2 family, member 4
chr7_+_76139741 0.07 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
UPK3B
uroplakin 3B
chr12_+_118814185 0.07 ENST00000543473.1
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr11_+_119039414 0.07 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
NLRX1
NLR family member X1
chr1_-_51425772 0.06 ENST00000371778.4
FAF1
Fas (TNFRSF6) associated factor 1
chr1_+_35247859 0.06 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr11_-_67442196 0.05 ENST00000525827.1
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr22_+_18560675 0.04 ENST00000329627.7
PEX26
peroxisomal biogenesis factor 26
chr2_+_95940186 0.04 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr1_+_52521797 0.04 ENST00000313334.8
BTF3L4
basic transcription factor 3-like 4
chr1_+_40723779 0.04 ENST00000372759.3
ZMPSTE24
zinc metallopeptidase STE24
chr1_-_234667504 0.03 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr13_+_48807288 0.03 ENST00000378565.5
ITM2B
integral membrane protein 2B
chr4_-_99850243 0.03 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr10_+_81838411 0.02 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
TMEM254
transmembrane protein 254
chr19_+_12035913 0.02 ENST00000591944.1
ZNF763
Uncharacterized protein; Zinc finger protein 763
chr5_+_134303591 0.02 ENST00000282611.6
CATSPER3
cation channel, sperm associated 3
chr1_-_153113927 0.02 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr10_+_81838792 0.02 ENST00000372273.3
TMEM254
transmembrane protein 254
chr1_-_36863481 0.02 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr20_-_18038521 0.02 ENST00000278780.6
OVOL2
ovo-like zinc finger 2
chr5_+_125758813 0.01 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr9_+_104161123 0.01 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
ZNF189
zinc finger protein 189
chr12_+_49687425 0.01 ENST00000257860.4
PRPH
peripherin
chr13_-_20806440 0.01 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6
gap junction protein, beta 6, 30kDa
chr1_+_44440575 0.01 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr11_-_67442079 0.01 ENST00000349015.3
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr14_+_23938891 0.01 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
NGDN
neuroguidin, EIF4E binding protein
chr1_-_24469602 0.01 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr3_+_186383741 0.01 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr5_+_125758865 0.00 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr1_-_51425902 0.00 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr14_-_80677613 0.00 ENST00000556811.1
DIO2
deiodinase, iodothyronine, type II
chr17_+_9728828 0.00 ENST00000262441.5
GLP2R
glucagon-like peptide 2 receptor
chr11_-_14992712 0.00 ENST00000486207.1
CALCA
calcitonin-related polypeptide alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.3 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.1 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.2 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.3 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.1 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.0 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.5 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.1 0.5 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 0.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.9 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism