Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for GTF2I
Z-value: 1.25
Motif logo
Transcription factors associated with GTF2I
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2I | hg19_v2_chr7_+_74072011_74072119 | 0.79 | 2.7e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_16900242 Show fit | 10.56 |
ENST00000502640.1
ENST00000506732.1 |
LIM domain binding 2 |
|
| chr4_-_16900217 Show fit | 10.01 |
ENST00000441778.2
|
LIM domain binding 2 |
|
| chr4_-_16900410 Show fit | 9.25 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr4_-_16900184 Show fit | 8.52 |
ENST00000515064.1
|
LIM domain binding 2 |
|
| chr5_-_81046841 Show fit | 5.16 |
ENST00000509013.2
ENST00000505980.1 ENST00000509053.1 |
single-stranded DNA binding protein 2 |
|
| chr14_-_54423529 Show fit | 5.11 |
ENST00000245451.4
ENST00000559087.1 |
bone morphogenetic protein 4 |
|
| chr11_+_125034586 Show fit | 4.86 |
ENST00000298282.9
|
PBX/knotted 1 homeobox 2 |
|
| chr7_+_30951461 Show fit | 4.09 |
ENST00000311813.4
|
aquaporin 1 (Colton blood group) |
|
| chr5_-_81046904 Show fit | 4.08 |
ENST00000515395.1
|
single-stranded DNA binding protein 2 |
|
| chr1_+_164528866 Show fit | 3.77 |
ENST00000420696.2
|
pre-B-cell leukemia homeobox 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GTF2I
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 39.0 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.1 | 8.7 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 1.2 | 8.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 7.7 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 1.1 | 5.3 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 1.7 | 5.1 | GO:2000006 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 1.0 | 4.2 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 1.4 | 4.1 | GO:0072229 | carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 0.1 | 4.0 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.9 | 3.7 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 48.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 9.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 7.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.4 | 6.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.4 | 5.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 5.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.4 | 4.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 4.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.4 | 4.1 | GO:0020003 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.4 | 3.7 | GO:0000125 | PCAF complex(GO:0000125) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 37.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 7.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 6.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.4 | 4.9 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 4.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 4.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 4.3 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.1 | 4.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.4 | 4.1 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.5 | 3.7 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 7.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 5.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 5.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 4.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 4.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 3.7 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 3.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 7.2 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.1 | 5.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.3 | 4.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 3.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.2 | 3.3 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.2 | 3.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 2.4 | REACTOME ADP SIGNALLING THROUGH P2RY1 | Genes involved in ADP signalling through P2Y purinoceptor 1 |
| 0.1 | 2.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.2 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |