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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for GUGCAAA
Z-value: 1.24
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miRNA associated with seed GUGCAAA
Network of associatons between targets according to the STRING database.
First level regulatory network of GUGCAAA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.3 | 4.8 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.2 | 4.7 | GO:0072189 | ureter development(GO:0072189) |
| 0.6 | 4.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 4.3 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 1.0 | 4.1 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.4 | 4.1 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 1.2 | 3.7 | GO:0060435 | bronchiole development(GO:0060435) |
| 1.2 | 3.7 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.0 | 3.7 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 5.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 4.4 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.3 | 4.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 4.1 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 4.0 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.6 | 3.9 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.7 | 3.7 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 3.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 2.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 5.5 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 5.0 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.3 | 4.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 4.3 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 4.0 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.6 | 3.7 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 3.3 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 3.3 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 3.1 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 6.2 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 4.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 3.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 2.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 5.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 4.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 4.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 4.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 4.1 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 3.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 2.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 2.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |