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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GZF1

Z-value: 0.38

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Transcription factors associated with GZF1

Gene Symbol Gene ID Gene Info
ENSG00000125812.11 GDNF inducible zinc finger protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GZF1hg19_v2_chr20_+_23342783_233429570.442.8e-02Click!

Activity profile of GZF1 motif

Sorted Z-values of GZF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_79816965 1.31 ENST00000464233.1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_+_79115503 1.10 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr7_-_27183263 0.59 ENST00000222726.3
homeobox A5
chr12_+_107168418 0.39 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8 guanine nucleotide exchange factor B
chr6_+_7108210 0.34 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
ras responsive element binding protein 1
chr1_-_144995002 0.34 ENST00000369356.4
phosphodiesterase 4D interacting protein
chr16_+_67876180 0.33 ENST00000303596.1
THAP domain containing 11
chr1_-_201438282 0.30 ENST00000367311.3
ENST00000367309.1
pleckstrin homology-like domain, family A, member 3
chr12_+_115800817 0.27 ENST00000547948.1
HCG2038717; Uncharacterized protein
chr4_-_89619386 0.25 ENST00000323061.5
nucleosome assembly protein 1-like 5
chr19_-_44384291 0.25 ENST00000324394.6
zinc finger protein 404
chr14_-_52535712 0.25 ENST00000216286.5
ENST00000541773.1
nidogen 2 (osteonidogen)
chr4_-_147443043 0.22 ENST00000394059.4
ENST00000502607.1
ENST00000335472.7
ENST00000432059.2
ENST00000394062.3
solute carrier family 10, member 7
chr1_-_144994909 0.20 ENST00000369347.4
ENST00000369354.3
phosphodiesterase 4D interacting protein
chr10_+_97759848 0.19 ENST00000424464.1
ENST00000410012.2
ENST00000344386.3
coiled-coil and C2 domain containing 2B
chr19_-_3786253 0.19 ENST00000585778.1
megakaryocyte-associated tyrosine kinase
chr9_-_124976154 0.19 ENST00000482062.1
LIM homeobox 6
chr1_-_144994840 0.18 ENST00000369351.3
ENST00000369349.3
phosphodiesterase 4D interacting protein
chr9_-_124976185 0.18 ENST00000464484.2
LIM homeobox 6
chr19_+_36157715 0.16 ENST00000379013.2
ENST00000222275.2
uroplakin 1A
chr1_+_9711781 0.16 ENST00000536656.1
ENST00000377346.4
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr10_+_60028818 0.15 ENST00000333926.5
CDGSH iron sulfur domain 1
chr3_-_87040233 0.15 ENST00000398399.2
vestigial like 3 (Drosophila)
chr19_-_36545128 0.15 ENST00000538849.1
THAP domain containing 8
chr6_-_42418999 0.14 ENST00000340840.2
ENST00000354325.2
transcriptional regulating factor 1
chr17_-_70588936 0.14 ENST00000453722.2
long intergenic non-protein coding RNA 511
chr17_-_29648761 0.14 ENST00000247270.3
ENST00000462804.2
ecotropic viral integration site 2A
chr19_-_3786354 0.13 ENST00000395040.2
ENST00000310132.6
megakaryocyte-associated tyrosine kinase
chr11_-_17498348 0.13 ENST00000389817.3
ENST00000302539.4
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr8_+_144373550 0.13 ENST00000330143.3
ENST00000521537.1
ENST00000518432.1
ENST00000520333.1
zinc finger protein 696
chr1_-_2461684 0.12 ENST00000378453.3
hes family bHLH transcription factor 5
chr1_-_144995074 0.11 ENST00000534536.1
phosphodiesterase 4D interacting protein
chr3_-_170588163 0.11 ENST00000295830.8
ribosomal protein L22-like 1
chr6_+_30525051 0.11 ENST00000376557.3
proline rich 3
chr6_+_30524663 0.11 ENST00000376560.3
proline rich 3
chr2_-_150444116 0.09 ENST00000428879.1
ENST00000422782.2
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr16_+_86612112 0.09 ENST00000320241.3
forkhead box L1
chr2_-_150444300 0.09 ENST00000303319.5
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr5_+_92919043 0.09 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr12_+_104458235 0.09 ENST00000229330.4
host cell factor C2
chr16_+_87636474 0.09 ENST00000284262.2
junctophilin 3
chr11_+_101918153 0.08 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
chromosome 11 open reading frame 70
chr12_-_76478446 0.08 ENST00000393263.3
ENST00000548044.1
ENST00000547704.1
ENST00000431879.3
ENST00000549596.1
ENST00000550934.1
ENST00000551600.1
ENST00000547479.1
ENST00000547773.1
ENST00000544816.1
ENST00000542344.1
ENST00000548273.1
nucleosome assembly protein 1-like 1
chr8_-_57026541 0.07 ENST00000311923.1
v-mos Moloney murine sarcoma viral oncogene homolog
chr14_-_59950724 0.07 ENST00000481608.1
L-3-hydroxyproline dehydratase (trans-)
chr7_-_105029812 0.07 ENST00000482897.1
SRSF protein kinase 2
chr1_-_42384343 0.07 ENST00000372584.1
human immunodeficiency virus type I enhancer binding protein 3
chr5_+_170814803 0.07 ENST00000521672.1
ENST00000351986.6
ENST00000393820.2
ENST00000523622.1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr19_-_59084647 0.06 ENST00000594234.1
ENST00000596039.1
myeloid zinc finger 1
chr12_-_76478417 0.06 ENST00000552342.1
nucleosome assembly protein 1-like 1
chr19_-_59084922 0.05 ENST00000215057.2
ENST00000599369.1
myeloid zinc finger 1
chr3_-_114035026 0.05 ENST00000570269.1
RP11-553L6.5
chr7_-_105029329 0.05 ENST00000393651.3
ENST00000460391.1
SRSF protein kinase 2
chr1_+_41174988 0.05 ENST00000372652.1
nuclear transcription factor Y, gamma
chr2_-_27603582 0.05 ENST00000323703.6
ENST00000436006.1
zinc finger protein 513
chr12_-_76478386 0.05 ENST00000535020.2
nucleosome assembly protein 1-like 1
chr1_+_26606608 0.05 ENST00000319041.6
SH3 domain binding glutamic acid-rich protein like 3
chr20_+_42086525 0.04 ENST00000244020.3
serine/arginine-rich splicing factor 6
chr13_+_98086445 0.04 ENST00000245304.4
RAP2A, member of RAS oncogene family
chr12_-_102513843 0.04 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa
chr14_+_101292445 0.04 ENST00000429159.2
ENST00000520714.1
ENST00000522771.2
ENST00000424076.3
ENST00000423456.1
ENST00000521404.1
ENST00000556736.1
ENST00000451743.2
ENST00000398518.2
ENST00000554639.1
ENST00000452120.2
ENST00000519709.1
ENST00000412736.2
maternally expressed 3 (non-protein coding)
chr1_-_11107280 0.04 ENST00000400897.3
ENST00000400898.3
mannan-binding lectin serine peptidase 2
chr12_+_102513950 0.03 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARP1 binding protein
chr16_-_46797149 0.03 ENST00000536476.1
myosin light chain kinase 3
chr20_-_31331212 0.03 ENST00000474815.2
ENST00000446419.2
COMM domain containing 7
chr22_+_50639408 0.03 ENST00000380903.2
Selenoprotein O
chr7_-_26904317 0.02 ENST00000345317.2
src kinase associated phosphoprotein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.2 0.6 GO:0060435 bronchiole development(GO:0060435)
0.1 0.3 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.0 0.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031) mast cell differentiation(GO:0060374)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0047661 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac