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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HDX

Z-value: 0.21

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_83757487-0.629.7e-04Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_84630053 0.79 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_47489240 0.41 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr5_-_35230434 0.27 ENST00000504500.1
PRLR
prolactin receptor
chr5_-_135290705 0.26 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr1_+_84630367 0.22 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_54157480 0.22 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_-_58485895 0.21 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr3_-_165555200 0.19 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr2_+_87754887 0.18 ENST00000409054.1
ENST00000331944.6
ENST00000409139.1
LINC00152
long intergenic non-protein coding RNA 152
chr3_+_107241882 0.18 ENST00000416476.2
BBX
bobby sox homolog (Drosophila)
chr19_+_36602104 0.15 ENST00000585332.1
ENST00000262637.4
OVOL3
ovo-like zinc finger 3
chr11_+_9685604 0.15 ENST00000447399.2
ENST00000318950.6
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr5_+_140165876 0.15 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1
protocadherin alpha 1
chr7_+_99954224 0.14 ENST00000608825.1
PILRB
paired immunoglobin-like type 2 receptor beta
chr4_+_48807155 0.14 ENST00000504654.1
OCIAD1
OCIA domain containing 1
chr22_+_40440804 0.14 ENST00000441751.1
ENST00000301923.9
TNRC6B
trinucleotide repeat containing 6B
chr5_+_140625147 0.11 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr12_-_31743901 0.11 ENST00000354285.4
DENND5B
DENN/MADD domain containing 5B
chr2_+_128403720 0.07 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr13_+_24144796 0.07 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr2_+_169926047 0.07 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr12_+_101869096 0.06 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr10_+_45406627 0.06 ENST00000389583.4
TMEM72
transmembrane protein 72
chr2_+_128403439 0.06 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr2_+_113735575 0.06 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr1_-_48866517 0.05 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr11_-_66675371 0.05 ENST00000393955.2
PC
pyruvate carboxylase
chr8_+_110098850 0.04 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr12_-_118797475 0.03 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr1_+_117602925 0.03 ENST00000369466.4
TTF2
transcription termination factor, RNA polymerase II
chr1_-_169680745 0.03 ENST00000236147.4
SELL
selectin L
chrX_+_55649833 0.02 ENST00000339140.3
FOXR2
forkhead box R2
chr1_+_21880560 0.02 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr19_-_41934635 0.01 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr12_+_10460417 0.01 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr1_-_159684371 0.01 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0097338 response to clozapine(GO:0097338)
0.1 0.2 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.0 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis