ISMARA results: HES1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HES1

Z-value: 0.93

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Transcription factors associated with HES1

Gene Symbol	Gene ID	Gene Info
HES1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000114315.3	hes family bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HES1	hg19_v2_chr3_+_193853927_193853944	-0.68	2.0e-04	Click!

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_89182178 Show fit	3.65	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 Show fit	3.60	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 Show fit	3.16	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr2_-_225907150 Show fit	2.63	ENST00000258390.7	DOCK10 Ensembl NCBI GeneCards UniProt NextProt Show fit	dedicator of cytokinesis 10
chr3_-_127541679 Show fit	2.48	ENST00000265052.5	MGLL Ensembl NCBI GeneCards UniProt NextProt Show fit	monoglyceride lipase
chr11_-_60719213 Show fit	2.18	ENST00000227880.3	SLC15A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 15 (oligopeptide transporter), member 3
chr1_-_9189229 Show fit	2.01	ENST00000377411.4	GPR157 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 157
chr7_+_73703728 Show fit	2.01	ENST00000361545.5 ENST00000223398.6	CLIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CAP-GLY domain containing linker protein 2
chr16_+_2039946 Show fit	1.85	ENST00000248121.2 ENST00000568896.1	SYNGR3 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptogyrin 3
chr1_+_23037323 Show fit	1.80	ENST00000544305.1 ENST00000374630.3 ENST00000400191.3 ENST00000374632.3	EPHB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	EPH receptor B2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	10.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.8	5.8	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
0.2	4.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	3.8	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2	2.6	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.0	2.3	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	2.1	GO:0015992	proton transport(GO:0015992)
0.1	2.0	GO:0060019	radial glial cell differentiation(GO:0060019)
0.1	2.0	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.2	1.8	GO:1904783	positive regulation of NMDA glutamate receptor activity(GO:1904783)

Showing 1 to 10 of 261 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.1	GO:0015030	Cajal body(GO:0015030)
0.0	5.4	GO:0019898	extrinsic component of membrane(GO:0019898)
0.0	5.0	GO:0030016	myofibril(GO:0030016)
0.0	3.0	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	3.0	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.1	2.3	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1	2.1	GO:0035371	microtubule plus-end(GO:0035371)
0.0	2.0	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	1.9	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	1.8	GO:0030673	axolemma(GO:0030673)

Showing 1 to 10 of 107 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	10.4	GO:0008859	exoribonuclease II activity(GO:0008859)
0.3	5.8	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.4	4.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	3.3	GO:0044325	ion channel binding(GO:0044325)
0.0	2.3	GO:0008565	protein transporter activity(GO:0008565)
0.5	2.2	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1	2.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	2.2	GO:0042169	SH2 domain binding(GO:0042169)
0.1	1.9	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	1.8	GO:0005109	frizzled binding(GO:0005109)

Showing 1 to 10 of 181 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	2.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	2.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	1.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	1.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.6	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	1.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	1.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	5.8	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	3.4	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	2.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	1.9	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	1.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.6	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	1.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	1.4	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.1	1.3	REACTOME POL SWITCHING	Genes involved in Polymerase switching

Showing 1 to 10 of 67 entries

Results for HES1

Z-value: 0.93

Motif logo

Transcription factors associated with HES1

Activity-expression correlation:

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: