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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HESX1
Z-value: 0.67
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Transcription factors associated with HESX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HESX1 | hg19_v2_chr3_-_57260377_57260549 | -0.07 | 7.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156588350 Show fit | 2.47 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr21_+_46020497 Show fit | 1.93 |
ENST00000380102.2
|
keratin associated protein 10-7 |
|
| chr3_+_39851094 Show fit | 1.79 |
ENST00000302541.6
|
myosin VIIA and Rab interacting protein |
|
| chr7_+_12727250 Show fit | 1.45 |
ENST00000404894.1
|
ADP-ribosylation factor-like 4A |
|
| chr8_-_93029865 Show fit | 1.42 |
ENST00000422361.2
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
|
| chr6_-_41888843 Show fit | 1.29 |
ENST00000434077.1
ENST00000409312.1 |
mediator complex subunit 20 |
|
| chr4_+_144303093 Show fit | 1.14 |
ENST00000505913.1
|
GRB2-associated binding protein 1 |
|
| chr1_+_15256230 Show fit | 1.14 |
ENST00000376028.4
ENST00000400798.2 |
kazrin, periplakin interacting protein |
|
| chr5_+_52285144 Show fit | 1.14 |
ENST00000296585.5
|
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
|
| chr2_-_160654745 Show fit | 1.12 |
ENST00000259053.4
ENST00000429078.2 |
CD302 molecule |
Network of associatons between targets according to the STRING database.
First level regulatory network of HESX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0031424 | keratinization(GO:0031424) |
| 0.4 | 2.5 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.6 | 1.9 | GO:0032888 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.1 | 1.8 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 1.6 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.0 | 1.5 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 1.4 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 1.2 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.4 | 1.1 | GO:0033341 | regulation of collagen binding(GO:0033341) |
| 0.1 | 1.1 | GO:0055091 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) phospholipid homeostasis(GO:0055091) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.0 | GO:0016592 | mediator complex(GO:0016592) |
| 0.6 | 1.9 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.1 | 1.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 1.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.2 | 1.1 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 1.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.0 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 2.1 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 2.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 1.9 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.3 | 1.3 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 0.1 | 1.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.4 | 1.1 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.2 | 1.1 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.0 | 1.1 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.2 | 1.0 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.1 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.1 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 1.1 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 0.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.4 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 2.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.9 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 1.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 1.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 1.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.1 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.9 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |