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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HESX1

Z-value: 0.67

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Transcription factors associated with HESX1

Gene Symbol Gene ID Gene Info
HESX1
ENSG00000163666.4 HESX homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HESX1hg19_v2_chr3_-_57260377_57260549-0.077.5e-01Click!

Activity profile of HESX1 motif

Sorted Z-values of HESX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_156588350 2.47 ENST00000296518.7
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr21_+_46020497 1.93 ENST00000380102.2
KRTAP10-7
keratin associated protein 10-7
chr3_+_39851094 1.79 ENST00000302541.6
MYRIP
myosin VIIA and Rab interacting protein
chr7_+_12727250 1.45 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr8_-_93029865 1.42 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_41888843 1.29 ENST00000434077.1
ENST00000409312.1
MED20
mediator complex subunit 20
chr4_+_144303093 1.14 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr1_+_15256230 1.14 ENST00000376028.4
ENST00000400798.2
KAZN
kazrin, periplakin interacting protein
chr5_+_52285144 1.14 ENST00000296585.5
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr2_-_160654745 1.12 ENST00000259053.4
ENST00000429078.2
CD302
CD302 molecule
chr14_+_61654271 1.00 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
PRKCH
protein kinase C, eta
chr11_-_71791435 0.98 ENST00000351960.6
ENST00000541719.1
ENST00000535111.1
NUMA1
nuclear mitotic apparatus protein 1
chr11_-_71791518 0.96 ENST00000537217.1
ENST00000366394.3
ENST00000358965.6
ENST00000546131.1
ENST00000543937.1
ENST00000368959.5
ENST00000541641.1
NUMA1
nuclear mitotic apparatus protein 1
chr13_+_100741269 0.93 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chr17_-_57184260 0.90 ENST00000376149.3
ENST00000393066.3
TRIM37
tripartite motif containing 37
chr2_-_89247338 0.90 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr9_-_34376851 0.84 ENST00000297625.7
KIAA1161
KIAA1161
chr16_-_67217844 0.80 ENST00000563902.1
ENST00000561621.1
ENST00000290881.7
KIAA0895L
KIAA0895-like
chr3_+_14860469 0.79 ENST00000285046.5
FGD5
FYVE, RhoGEF and PH domain containing 5
chr19_+_41698927 0.78 ENST00000310054.4
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr2_-_183387064 0.76 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr6_-_41888814 0.69 ENST00000409060.1
ENST00000265350.4
MED20
mediator complex subunit 20
chr16_+_56995762 0.69 ENST00000200676.3
ENST00000379780.2
CETP
cholesteryl ester transfer protein, plasma
chr4_-_48782259 0.68 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr12_+_13197218 0.66 ENST00000197268.8
KIAA1467
KIAA1467
chr7_+_130126165 0.64 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr12_-_121019165 0.63 ENST00000341039.2
ENST00000357500.4
POP5
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr2_-_85829811 0.62 ENST00000306353.3
TMEM150A
transmembrane protein 150A
chr11_+_126139005 0.59 ENST00000263578.5
ENST00000442061.2
ENST00000532125.1
FOXRED1
FAD-dependent oxidoreductase domain containing 1
chr11_-_1629693 0.57 ENST00000399685.1
KRTAP5-3
keratin associated protein 5-3
chr19_+_45312347 0.57 ENST00000270233.6
ENST00000591520.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr6_+_116421976 0.56 ENST00000319550.4
ENST00000419791.1
NT5DC1
5'-nucleotidase domain containing 1
chr21_-_38445443 0.55 ENST00000360525.4
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr6_-_83775489 0.53 ENST00000369747.3
UBE3D
ubiquitin protein ligase E3D
chr17_+_73089382 0.52 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr19_+_41699135 0.50 ENST00000542619.1
ENST00000600561.1
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr7_+_115850547 0.49 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr16_-_14724057 0.49 ENST00000539279.1
ENST00000420015.2
ENST00000437198.2
PARN
poly(A)-specific ribonuclease
chr2_+_90198535 0.47 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr2_-_197036289 0.47 ENST00000263955.4
STK17B
serine/threonine kinase 17b
chr5_+_78532003 0.45 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr14_-_25103472 0.45 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr16_-_57219721 0.45 ENST00000562406.1
ENST00000568671.1
ENST00000567044.1
FAM192A
family with sequence similarity 192, member A
chr2_-_43823093 0.44 ENST00000405006.4
THADA
thyroid adenoma associated
chr19_+_2249308 0.43 ENST00000592877.1
ENST00000221496.4
AMH
anti-Mullerian hormone
chr14_-_25103388 0.43 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr16_+_56995854 0.42 ENST00000566128.1
CETP
cholesteryl ester transfer protein, plasma
chr14_-_106066376 0.42 ENST00000412518.1
ENST00000428654.1
ENST00000427543.1
ENST00000420153.1
ENST00000577108.1
ENST00000576077.1
AL928742.12
IGHE
AL928742.12
immunoglobulin heavy constant epsilon
chr1_+_45265897 0.41 ENST00000372201.4
PLK3
polo-like kinase 3
chr11_+_73019282 0.41 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr5_+_40679584 0.40 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr5_-_122758994 0.39 ENST00000306467.5
ENST00000515110.1
CEP120
centrosomal protein 120kDa
chr2_-_89292422 0.39 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr11_+_47587129 0.38 ENST00000326656.8
ENST00000326674.9
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr22_+_50354104 0.37 ENST00000360612.4
PIM3
pim-3 oncogene
chr20_-_34117447 0.36 ENST00000246199.2
ENST00000424444.1
ENST00000374345.4
ENST00000444723.1
C20orf173
chromosome 20 open reading frame 173
chr11_+_47586982 0.35 ENST00000426530.2
ENST00000534775.1
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr21_-_38445470 0.35 ENST00000399098.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr10_-_75634326 0.35 ENST00000322635.3
ENST00000444854.2
ENST00000423381.1
ENST00000322680.3
ENST00000394762.2
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr13_-_52378231 0.35 ENST00000280056.2
ENST00000444610.2
DHRS12
dehydrogenase/reductase (SDR family) member 12
chr19_-_14201507 0.35 ENST00000533683.2
SAMD1
sterile alpha motif domain containing 1
chr14_-_70883708 0.34 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr20_-_40247133 0.34 ENST00000373233.3
ENST00000309279.7
CHD6
chromodomain helicase DNA binding protein 6
chr2_-_89340242 0.34 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr15_+_80364901 0.34 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr1_-_54637997 0.33 ENST00000536061.1
AL357673.1
CDNA: FLJ21031 fis, clone CAE07336; HCG1780521; Uncharacterized protein
chr2_-_128399706 0.33 ENST00000426981.1
LIMS2
LIM and senescent cell antigen-like domains 2
chr2_-_89310012 0.31 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr21_-_38445011 0.31 ENST00000464265.1
ENST00000399102.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr12_-_55367361 0.31 ENST00000532804.1
ENST00000531122.1
ENST00000533446.1
TESPA1
thymocyte expressed, positive selection associated 1
chr7_-_2595337 0.31 ENST00000340611.4
BRAT1
BRCA1-associated ATM activator 1
chr22_+_44351301 0.30 ENST00000350028.4
SAMM50
SAMM50 sorting and assembly machinery component
chr5_-_122759032 0.29 ENST00000510582.3
ENST00000328236.5
ENST00000306481.6
ENST00000508442.2
ENST00000395431.2
CEP120
centrosomal protein 120kDa
chr3_+_158519654 0.29 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr2_-_43823119 0.29 ENST00000403856.1
ENST00000404790.1
ENST00000405975.2
ENST00000415080.2
THADA
thyroid adenoma associated
chr21_-_34852304 0.29 ENST00000542230.2
TMEM50B
transmembrane protein 50B
chr19_+_34919257 0.29 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr5_-_159797627 0.28 ENST00000393975.3
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr8_-_110656995 0.28 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr6_-_31138439 0.28 ENST00000259915.8
POU5F1
POU class 5 homeobox 1
chr4_+_83956237 0.28 ENST00000264389.2
COPS4
COP9 signalosome subunit 4
chr4_+_83956312 0.28 ENST00000509317.1
ENST00000503682.1
ENST00000511653.1
COPS4
COP9 signalosome subunit 4
chr22_+_44351419 0.27 ENST00000396202.3
SAMM50
SAMM50 sorting and assembly machinery component
chr7_-_37024665 0.27 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr8_-_16035454 0.27 ENST00000355282.2
MSR1
macrophage scavenger receptor 1
chr14_-_22938665 0.27 ENST00000535880.2
TRDV3
T cell receptor delta variable 3
chr15_-_83316711 0.27 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr1_+_151372010 0.26 ENST00000290541.6
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr21_+_33784670 0.25 ENST00000300255.2
EVA1C
eva-1 homolog C (C. elegans)
chr21_+_38445539 0.24 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
TTC3
tetratricopeptide repeat domain 3
chr17_+_46018872 0.24 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
PNPO
pyridoxamine 5'-phosphate oxidase
chr7_-_112758589 0.24 ENST00000413744.1
ENST00000439551.1
ENST00000441359.1
LINC00998
long intergenic non-protein coding RNA 998
chr1_-_17216143 0.24 ENST00000457075.1
RP11-108M9.4
RP11-108M9.4
chr3_-_196695692 0.24 ENST00000412723.1
PIGZ
phosphatidylinositol glycan anchor biosynthesis, class Z
chr8_+_124084899 0.23 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1D31
TBC1 domain family, member 31
chr3_+_46921732 0.23 ENST00000418619.1
PTH1R
parathyroid hormone 1 receptor
chr8_+_71581565 0.22 ENST00000408926.3
ENST00000520030.1
XKR9
XK, Kell blood group complex subunit-related family, member 9
chr4_+_175204818 0.22 ENST00000503780.1
CEP44
centrosomal protein 44kDa
chr3_-_9885626 0.22 ENST00000424438.1
ENST00000433555.1
ENST00000427174.1
ENST00000418713.1
ENST00000433535.2
ENST00000383820.5
ENST00000433972.1
RPUSD3
RNA pseudouridylate synthase domain containing 3
chr16_-_1661988 0.22 ENST00000426508.2
IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chrX_+_135730373 0.22 ENST00000370628.2
CD40LG
CD40 ligand
chr16_-_57219926 0.22 ENST00000566584.1
ENST00000566481.1
ENST00000566077.1
ENST00000564108.1
ENST00000565458.1
ENST00000566681.1
ENST00000567439.1
FAM192A
family with sequence similarity 192, member A
chrX_+_135730297 0.21 ENST00000370629.2
CD40LG
CD40 ligand
chr1_-_204165610 0.21 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr12_-_54070098 0.21 ENST00000394349.3
ENST00000549164.1
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr18_+_56892724 0.21 ENST00000456142.3
ENST00000530323.1
GRP
gastrin-releasing peptide
chr12_-_11091862 0.20 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr7_-_99679324 0.20 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
ZNF3
zinc finger protein 3
chr20_-_35807970 0.20 ENST00000400440.2
ENST00000421643.1
MROH8
maestro heat-like repeat family member 8
chr8_+_79428539 0.20 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr14_-_69263043 0.20 ENST00000408913.2
ZFP36L1
ZFP36 ring finger protein-like 1
chr20_-_62587735 0.18 ENST00000354216.6
ENST00000369892.3
ENST00000358711.3
UCKL1
uridine-cytidine kinase 1-like 1
chr9_+_21440440 0.18 ENST00000276927.1
IFNA1
interferon, alpha 1
chr7_+_1022811 0.18 ENST00000308919.7
CYP2W1
cytochrome P450, family 2, subfamily W, polypeptide 1
chr19_-_39694894 0.17 ENST00000318438.6
SYCN
syncollin
chrX_+_118602363 0.17 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr2_+_90248739 0.17 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr16_-_57219966 0.17 ENST00000565760.1
ENST00000309137.8
ENST00000570184.1
ENST00000562324.1
FAM192A
family with sequence similarity 192, member A
chr14_-_91884150 0.16 ENST00000553403.1
CCDC88C
coiled-coil domain containing 88C
chr14_-_72458326 0.16 ENST00000542853.1
AC005477.1
AC005477.1
chr18_+_54318566 0.16 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr19_+_42388437 0.15 ENST00000378152.4
ENST00000337665.4
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr3_-_52860850 0.15 ENST00000441637.2
ITIH4
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr13_+_108870714 0.14 ENST00000375898.3
ABHD13
abhydrolase domain containing 13
chr1_-_169337176 0.14 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr4_-_89619386 0.14 ENST00000323061.5
NAP1L5
nucleosome assembly protein 1-like 5
chr4_+_15683369 0.14 ENST00000503617.1
FAM200B
family with sequence similarity 200, member B
chr4_+_6784401 0.14 ENST00000425103.1
ENST00000307659.5
KIAA0232
KIAA0232
chr17_-_57184064 0.14 ENST00000262294.7
TRIM37
tripartite motif containing 37
chr4_-_144826682 0.14 ENST00000358615.4
ENST00000437468.2
GYPE
glycophorin E (MNS blood group)
chr16_+_215965 0.14 ENST00000356815.3
HBM
hemoglobin, mu
chr7_-_112758665 0.13 ENST00000397764.3
LINC00998
long intergenic non-protein coding RNA 998
chr7_+_99746514 0.13 ENST00000341942.5
ENST00000441173.1
LAMTOR4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr19_+_11457232 0.13 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr17_+_45286387 0.13 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr17_+_27573875 0.13 ENST00000225387.3
CRYBA1
crystallin, beta A1
chr17_+_45286706 0.12 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr7_+_1022973 0.12 ENST00000340150.6
CYP2W1
cytochrome P450, family 2, subfamily W, polypeptide 1
chrX_-_7895479 0.12 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr19_+_42082506 0.11 ENST00000187608.9
ENST00000401445.2
CEACAM21
carcinoembryonic antigen-related cell adhesion molecule 21
chr2_+_128175997 0.11 ENST00000234071.3
ENST00000429925.1
ENST00000442644.1
ENST00000453608.2
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr16_+_1662326 0.11 ENST00000397412.3
CRAMP1L
Crm, cramped-like (Drosophila)
chr12_-_123717643 0.11 ENST00000541437.1
ENST00000606320.1
MPHOSPH9
M-phase phosphoprotein 9
chr6_+_52285046 0.10 ENST00000371068.5
EFHC1
EF-hand domain (C-terminal) containing 1
chr17_+_55163075 0.10 ENST00000571629.1
ENST00000570423.1
ENST00000575186.1
ENST00000573085.1
ENST00000572814.1
AKAP1
A kinase (PRKA) anchor protein 1
chr2_+_90259593 0.10 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr1_-_165738085 0.10 ENST00000464650.1
ENST00000392129.6
TMCO1
transmembrane and coiled-coil domains 1
chr15_-_31453157 0.10 ENST00000559177.1
ENST00000558445.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr6_-_74063979 0.10 ENST00000370370.3
DPPA5
developmental pluripotency associated 5
chr7_+_23637118 0.10 ENST00000448353.1
CCDC126
coiled-coil domain containing 126
chr9_-_123239632 0.09 ENST00000416449.1
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr4_-_2264015 0.08 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr4_-_175204765 0.08 ENST00000513696.1
ENST00000503293.1
FBXO8
F-box protein 8
chr1_-_26372602 0.08 ENST00000374278.3
ENST00000374276.3
SLC30A2
solute carrier family 30 (zinc transporter), member 2
chr8_+_27182862 0.08 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr1_+_46016703 0.07 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr22_+_31892373 0.07 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr7_+_99425633 0.07 ENST00000354829.2
ENST00000421837.2
ENST00000417625.1
ENST00000342499.4
ENST00000444905.1
ENST00000415413.1
ENST00000312017.5
ENST00000222382.5
CYP3A43
cytochrome P450, family 3, subfamily A, polypeptide 43
chr20_-_35807741 0.07 ENST00000434295.1
ENST00000441008.2
ENST00000400441.3
ENST00000343811.4
MROH8
maestro heat-like repeat family member 8
chr15_+_80351910 0.06 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr20_-_32274179 0.06 ENST00000343380.5
E2F1
E2F transcription factor 1
chr1_-_26394114 0.06 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr12_+_131438443 0.06 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr7_-_72742085 0.06 ENST00000333149.2
TRIM50
tripartite motif containing 50
chr19_+_37407212 0.05 ENST00000427117.1
ENST00000587130.1
ENST00000333987.7
ENST00000415168.1
ENST00000444991.1
ZNF568
zinc finger protein 568
chr10_+_103348031 0.05 ENST00000370151.4
ENST00000370147.1
ENST00000370148.2
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr2_+_220071490 0.05 ENST00000409206.1
ENST00000409594.1
ENST00000289528.5
ENST00000422255.1
ENST00000409412.1
ENST00000409097.1
ENST00000409336.1
ENST00000409217.1
ENST00000409319.1
ENST00000444522.2
ZFAND2B
zinc finger, AN1-type domain 2B
chr8_+_97274119 0.05 ENST00000455950.2
PTDSS1
phosphatidylserine synthase 1
chr16_-_70719925 0.04 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr1_-_165738072 0.04 ENST00000481278.1
TMCO1
transmembrane and coiled-coil domains 1
chr14_+_69726656 0.04 ENST00000337827.4
GALNT16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr12_-_752786 0.03 ENST00000433832.2
ENST00000542920.1
NINJ2
ninjurin 2
chr12_+_6644443 0.03 ENST00000396858.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr15_-_82824843 0.03 ENST00000560826.1
ENST00000559187.1
ENST00000330339.7
RPS17
ribosomal protein S17
chr8_-_93029520 0.03 ENST00000521553.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_56820018 0.03 ENST00000370746.3
BEND6
BEN domain containing 6
chr6_-_29600832 0.03 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr14_-_90798273 0.03 ENST00000357904.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr20_+_35807449 0.02 ENST00000237530.6
RPN2
ribophorin II
chr2_+_233562015 0.02 ENST00000427233.1
ENST00000373566.3
ENST00000373563.4
ENST00000428883.1
ENST00000456491.1
ENST00000409480.1
ENST00000421433.1
ENST00000425040.1
ENST00000430720.1
ENST00000409547.1
ENST00000423659.1
ENST00000409196.3
ENST00000409451.3
ENST00000429187.1
ENST00000440945.1
GIGYF2
GRB10 interacting GYF protein 2
chr18_+_54318616 0.02 ENST00000254442.3
WDR7
WD repeat domain 7
chr20_+_18269121 0.02 ENST00000377671.3
ENST00000360010.5
ENST00000396026.3
ENST00000402618.2
ENST00000401790.1
ENST00000434018.1
ENST00000538547.1
ENST00000535822.1
ZNF133
zinc finger protein 133
chr20_-_61002584 0.02 ENST00000252998.1
RBBP8NL
RBBP8 N-terminal like
chr16_+_84733575 0.02 ENST00000219473.7
ENST00000563892.1
ENST00000562283.1
ENST00000570191.1
ENST00000569038.1
ENST00000570053.1
USP10
ubiquitin specific peptidase 10
chr4_+_129349188 0.02 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr22_+_19419425 0.01 ENST00000333130.3
MRPL40
mitochondrial ribosomal protein L40
chr9_-_131486367 0.01 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr7_+_74508372 0.01 ENST00000356115.5
ENST00000430511.2
ENST00000312575.7
GTF2IRD2B
GTF2I repeat domain containing 2B
chr18_-_54318353 0.01 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr5_-_41071392 0.01 ENST00000399564.4
MROH2B
maestro heat-like repeat family member 2B
chr11_-_57148619 0.01 ENST00000287143.2
PRG3
proteoglycan 3
chr17_+_18128896 0.01 ENST00000316843.4
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr2_+_176957619 0.01 ENST00000392539.3
HOXD13
homeobox D13
chr6_+_56819773 0.01 ENST00000370750.2
BEND6
BEN domain containing 6
chr1_+_92545862 0.01 ENST00000370382.3
ENST00000342818.3
BTBD8
BTB (POZ) domain containing 8

Network of associatons between targets according to the STRING database.

First level regulatory network of HESX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.4 2.5 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.4 1.1 GO:0033341 regulation of collagen binding(GO:0033341)
0.3 1.0 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 0.7 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.2 0.9 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 0.4 GO:2000777 endomitotic cell cycle(GO:0007113) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.4 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.1 0.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1 1.8 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 1.0 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.5 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 1.1 GO:0055091 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) phospholipid homeostasis(GO:0055091)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.1 0.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.7 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 0.2 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.1 0.6 GO:0009249 protein lipoylation(GO:0009249)
0.1 1.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.2 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.1 0.6 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 1.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.3 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0 0.8 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.0 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.6 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.5 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 1.1 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0015853 adenine transport(GO:0015853)
0.0 0.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.0 1.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.5 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.1 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.4 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.3 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.4 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 2.7 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.0 GO:0052042 induction of programmed cell death(GO:0012502) peptidyl-cysteine S-trans-nitrosylation(GO:0035606) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501)
0.0 0.4 GO:0097503 sialylation(GO:0097503)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0055028 cortical microtubule(GO:0055028)
0.2 1.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 1.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.8 GO:0031045 dense core granule(GO:0031045)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 2.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 1.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0017129 triglyceride binding(GO:0017129)
0.3 1.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.0 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 1.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 1.9 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.9 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 2.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.4 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 0.6 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.7 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.2 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.3 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 2.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 2.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.1 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID EPO PATHWAY EPO signaling pathway
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 3.0 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 1.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis