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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HIC1
Z-value: 1.07
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Transcription factors associated with HIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC1 | hg19_v2_chr17_+_1958388_1958404, hg19_v2_chr17_+_1959369_1959604 | 0.44 | 2.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_7057523 Show fit | 3.45 |
ENST00000320892.6
|
ring finger protein 144A |
|
| chr20_-_62680984 Show fit | 2.48 |
ENST00000340356.7
|
SRY (sex determining region Y)-box 18 |
|
| chr3_+_52280220 Show fit | 2.27 |
ENST00000409502.3
ENST00000323588.4 |
protein phosphatase, Mg2+/Mn2+ dependent, 1M |
|
| chr12_-_42983478 Show fit | 2.26 |
ENST00000345127.3
ENST00000547113.1 |
prickle homolog 1 (Drosophila) |
|
| chr12_+_53440753 Show fit | 2.18 |
ENST00000379902.3
|
tensin like C1 domain containing phosphatase (tensin 2) |
|
| chr3_+_32147997 Show fit | 2.16 |
ENST00000282541.5
|
glycerol-3-phosphate dehydrogenase 1-like |
|
| chr3_+_52280173 Show fit | 2.15 |
ENST00000296487.4
|
protein phosphatase, Mg2+/Mn2+ dependent, 1M |
|
| chr3_+_37903432 Show fit | 2.10 |
ENST00000443503.2
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
|
| chr6_-_13487784 Show fit | 2.07 |
ENST00000379287.3
|
glucose-fructose oxidoreductase domain containing 1 |
|
| chr12_-_95044309 Show fit | 1.92 |
ENST00000261226.4
|
transmembrane and coiled-coil domain family 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.1 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 4.4 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 1.1 | 4.3 | GO:0061289 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.3 | 3.9 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.0 | 3.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 2.9 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.9 | 2.7 | GO:0021793 | chemorepulsion of branchiomotor axon(GO:0021793) |
| 0.0 | 2.7 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.5 | 2.6 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.4 | 2.5 | GO:0060214 | stem cell fate commitment(GO:0048865) endocardium formation(GO:0060214) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.3 | 3.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 3.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 2.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.4 | 2.2 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 2.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 2.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 2.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 2.1 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 2.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.4 | 4.0 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.2 | 3.8 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 3.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.4 | 3.5 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 3.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 2.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.6 | 2.4 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 0.1 | 2.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 2.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.2 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 2.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 2.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 2.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 1.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 2.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 2.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 2.3 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 2.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 2.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 1.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |