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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HIC2
Z-value: 1.33
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Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg19_v2_chr22_+_21771656_21771693 | -0.34 | 9.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.4 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.1 | 2.5 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.6 | 2.3 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 0.4 | 2.3 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.1 | 1.9 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 1.9 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.4 | 1.8 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.1 | 1.8 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 1.7 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.1 | 1.6 | GO:0051601 | exocyst localization(GO:0051601) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.7 | 2.1 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.0 | 1.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 1.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 1.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 1.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 1.1 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.1 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 2.7 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.4 | 2.5 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.1 | 2.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 2.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 2.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 2.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 1.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 1.8 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 1.7 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 2.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 1.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 2.7 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 2.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 2.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.1 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 2.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 1.9 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 1.9 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |