Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for HIF1A

Z-value: 0.85

Motif logo

logo of

Transcription factors associated with HIF1A

Gene Symbol Gene ID Gene Info
HIF1A
ENSG00000100644.12 hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HIF1Ahg19_v2_chr14_+_62162258_62162269-0.491.2e-02Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_89182178 4.82 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 4.75 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_+_17354617 4.63 ENST00000470360.1
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr8_+_17354587 4.52 ENST00000494857.1
ENST00000522656.1
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr15_+_89181974 4.09 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr10_-_49732281 3.59 ENST00000374170.1
ARHGAP22
Rho GTPase activating protein 22
chr21_+_26934165 3.43 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr3_-_127541679 2.63 ENST00000265052.5
MGLL
monoglyceride lipase
chr1_+_65613852 2.51 ENST00000327299.7
AK4
adenylate kinase 4
chr3_-_145878954 2.16 ENST00000282903.5
ENST00000360060.3
PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr3_+_133292851 2.16 ENST00000503932.1
CDV3
CDV3 homolog (mouse)
chr3_+_133292759 2.05 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr20_+_53092123 2.03 ENST00000262593.5
DOK5
docking protein 5
chr7_+_128095900 1.90 ENST00000435296.2
HILPDA
hypoxia inducible lipid droplet-associated
chr20_+_53092232 1.86 ENST00000395939.1
DOK5
docking protein 5
chr12_-_121734489 1.60 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr5_-_131563501 1.52 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr7_+_128095945 1.51 ENST00000257696.4
HILPDA
hypoxia inducible lipid droplet-associated
chr7_-_22396533 1.51 ENST00000344041.6
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr5_+_70883178 1.48 ENST00000323375.8
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr5_+_49962495 1.40 ENST00000515175.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr13_+_25875785 1.39 ENST00000381747.3
NUPL1
nucleoporin like 1
chr2_-_208031542 1.35 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_8939265 1.26 ENST00000489867.1
ENO1
enolase 1, (alpha)
chr5_+_70883117 1.06 ENST00000340941.6
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr7_-_27170352 1.03 ENST00000428284.2
ENST00000360046.5
HOXA4
homeobox A4
chr12_-_51422017 0.96 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr9_-_136857403 0.96 ENST00000406606.3
ENST00000371850.3
VAV2
vav 2 guanine nucleotide exchange factor
chr21_+_45719921 0.94 ENST00000349048.4
PFKL
phosphofructokinase, liver
chr18_+_77439775 0.93 ENST00000299543.7
ENST00000075430.7
CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr7_-_98741642 0.93 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr11_-_73471655 0.92 ENST00000400470.2
RAB6A
RAB6A, member RAS oncogene family
chr5_+_49962772 0.90 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr3_-_50374869 0.90 ENST00000327761.3
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr17_-_36831156 0.85 ENST00000325814.5
C17orf96
chromosome 17 open reading frame 96
chr6_+_108487245 0.83 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr12_+_72148614 0.81 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr2_+_173420697 0.78 ENST00000282077.3
ENST00000392571.2
ENST00000410055.1
PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr20_-_44540686 0.78 ENST00000477313.1
ENST00000542937.1
ENST00000372431.3
ENST00000354050.4
ENST00000420868.2
PLTP
phospholipid transfer protein
chr6_+_30539153 0.76 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
chr17_-_42908155 0.75 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
GJC1
gap junction protein, gamma 1, 45kDa
chr3_-_195808952 0.74 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC
transferrin receptor
chr17_-_42907564 0.72 ENST00000592524.1
GJC1
gap junction protein, gamma 1, 45kDa
chr14_-_53162361 0.72 ENST00000395686.3
ERO1L
ERO1-like (S. cerevisiae)
chr3_-_156272924 0.72 ENST00000467789.1
ENST00000265044.2
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr6_+_108882069 0.72 ENST00000406360.1
FOXO3
forkhead box O3
chr20_+_48552908 0.72 ENST00000244061.2
RNF114
ring finger protein 114
chr9_-_94186131 0.69 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr12_-_123849374 0.68 ENST00000602398.1
ENST00000602750.1
SBNO1
strawberry notch homolog 1 (Drosophila)
chr3_-_195808980 0.68 ENST00000360110.4
TFRC
transferrin receptor
chr1_-_159894319 0.67 ENST00000320307.4
TAGLN2
transgelin 2
chr15_+_52311398 0.65 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr5_-_146889619 0.65 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr1_-_167522982 0.64 ENST00000370509.4
CREG1
cellular repressor of E1A-stimulated genes 1
chr4_-_4291761 0.63 ENST00000513174.1
LYAR
Ly1 antibody reactive
chr10_+_101419187 0.62 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr11_+_6624970 0.62 ENST00000420936.2
ENST00000528995.1
ILK
integrin-linked kinase
chr7_-_139876812 0.61 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr1_-_8938736 0.61 ENST00000234590.4
ENO1
enolase 1, (alpha)
chr17_+_17942684 0.60 ENST00000376345.3
GID4
GID complex subunit 4
chr3_-_71632894 0.59 ENST00000493089.1
FOXP1
forkhead box P1
chr10_+_122216316 0.58 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr12_+_6977258 0.58 ENST00000488464.2
ENST00000535434.1
ENST00000493987.1
TPI1
triosephosphate isomerase 1
chr6_-_159240415 0.57 ENST00000367075.3
EZR
ezrin
chr12_+_131356582 0.57 ENST00000448750.3
ENST00000541630.1
ENST00000392369.2
ENST00000254675.3
ENST00000535090.1
ENST00000392367.3
RAN
RAN, member RAS oncogene family
chr16_-_54963026 0.56 ENST00000560208.1
ENST00000557792.1
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr4_-_39529049 0.55 ENST00000501493.2
ENST00000509391.1
ENST00000507089.1
UGDH
UDP-glucose 6-dehydrogenase
chr22_+_29279552 0.55 ENST00000544604.2
ZNRF3
zinc and ring finger 3
chr2_+_111878483 0.55 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr17_-_67323232 0.55 ENST00000592568.1
ENST00000392676.3
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr16_-_69788816 0.54 ENST00000268802.5
NOB1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr17_-_67323305 0.53 ENST00000392677.2
ENST00000593153.1
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr6_+_64282447 0.52 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_+_6625046 0.50 ENST00000396751.2
ILK
integrin-linked kinase
chr3_+_113666748 0.50 ENST00000330212.3
ENST00000498275.1
ZDHHC23
zinc finger, DHHC-type containing 23
chr8_+_67341239 0.50 ENST00000320270.2
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr4_-_4291748 0.50 ENST00000452476.1
LYAR
Ly1 antibody reactive
chr11_+_6624955 0.50 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr4_-_4291861 0.49 ENST00000343470.4
LYAR
Ly1 antibody reactive
chr2_+_68384976 0.49 ENST00000263657.2
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr19_-_663277 0.48 ENST00000292363.5
RNF126
ring finger protein 126
chr4_-_39529180 0.48 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH
UDP-glucose 6-dehydrogenase
chr11_+_57435219 0.47 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chr9_-_115983641 0.46 ENST00000238256.3
FKBP15
FK506 binding protein 15, 133kDa
chr6_+_64281906 0.46 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_-_96122682 0.45 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr2_+_192543153 0.45 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chr8_+_75896731 0.45 ENST00000262207.4
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr10_+_98592009 0.45 ENST00000540664.1
ENST00000371103.3
LCOR
ligand dependent nuclear receptor corepressor
chr7_+_43152191 0.44 ENST00000395891.2
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr1_-_111991850 0.44 ENST00000411751.2
WDR77
WD repeat domain 77
chr19_-_5719860 0.44 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr17_+_45000483 0.43 ENST00000576910.2
ENST00000439730.2
ENST00000393456.2
ENST00000415811.2
ENST00000575949.1
ENST00000225567.4
ENST00000572403.1
ENST00000570879.1
GOSR2
golgi SNAP receptor complex member 2
chr12_-_113909877 0.42 ENST00000261731.3
LHX5
LIM homeobox 5
chr1_-_241520525 0.42 ENST00000366565.1
RGS7
regulator of G-protein signaling 7
chr3_-_50329835 0.42 ENST00000429673.2
IFRD2
interferon-related developmental regulator 2
chr12_+_7023491 0.42 ENST00000541477.1
ENST00000229277.1
ENO2
enolase 2 (gamma, neuronal)
chr2_+_118846008 0.42 ENST00000245787.4
INSIG2
insulin induced gene 2
chr13_-_44361025 0.42 ENST00000261488.6
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr17_+_57642886 0.42 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr19_-_5720248 0.41 ENST00000360614.3
LONP1
lon peptidase 1, mitochondrial
chr12_+_7023735 0.41 ENST00000538763.1
ENST00000544774.1
ENST00000545045.2
ENO2
enolase 2 (gamma, neuronal)
chr7_+_44084262 0.41 ENST00000456905.1
ENST00000440166.1
ENST00000452943.1
ENST00000468694.1
ENST00000494774.1
ENST00000490734.2
DBNL
drebrin-like
chr9_+_133569108 0.40 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
EXOSC2
exosome component 2
chrX_+_16804544 0.40 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr18_+_43913919 0.40 ENST00000587853.1
RNF165
ring finger protein 165
chr17_-_74449252 0.40 ENST00000319380.7
UBE2O
ubiquitin-conjugating enzyme E2O
chr12_-_125473600 0.40 ENST00000308736.2
DHX37
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr3_+_19988885 0.40 ENST00000422242.1
RAB5A
RAB5A, member RAS oncogene family
chr1_+_117452669 0.39 ENST00000393203.2
PTGFRN
prostaglandin F2 receptor inhibitor
chr19_-_38397285 0.39 ENST00000303868.5
WDR87
WD repeat domain 87
chr19_-_5720123 0.39 ENST00000587365.1
ENST00000585374.1
ENST00000593119.1
LONP1
lon peptidase 1, mitochondrial
chr15_+_101420028 0.38 ENST00000557963.1
ENST00000346623.6
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr11_+_576494 0.38 ENST00000533464.1
ENST00000413872.2
ENST00000416188.2
PHRF1
PHD and ring finger domains 1
chr2_+_26915584 0.37 ENST00000302909.3
KCNK3
potassium channel, subfamily K, member 3
chr16_-_4466622 0.37 ENST00000570645.1
ENST00000574025.1
ENST00000572898.1
ENST00000537233.2
ENST00000571059.1
ENST00000251166.4
CORO7
coronin 7
chr2_+_55459808 0.37 ENST00000404735.1
RPS27A
ribosomal protein S27a
chr7_-_92465868 0.37 ENST00000424848.2
CDK6
cyclin-dependent kinase 6
chr2_+_178077477 0.36 ENST00000411529.2
ENST00000435711.1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr21_+_45138941 0.36 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chrX_-_137793826 0.36 ENST00000315930.6
FGF13
fibroblast growth factor 13
chr11_-_14665163 0.36 ENST00000418988.2
PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr11_-_64014379 0.36 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr20_-_62258394 0.36 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr4_-_54930790 0.35 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr16_-_4466565 0.35 ENST00000572467.1
ENST00000423908.2
ENST00000572044.1
ENST00000571052.1
CORO7-PAM16
CORO7
CORO7-PAM16 readthrough
coronin 7
chr22_-_36424458 0.35 ENST00000438146.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr8_-_97273807 0.34 ENST00000517720.1
ENST00000287025.3
ENST00000523821.1
MTERFD1
MTERF domain containing 1
chr15_+_98503922 0.34 ENST00000268042.6
ARRDC4
arrestin domain containing 4
chr12_+_54348618 0.33 ENST00000243103.3
HOXC12
homeobox C12
chr20_+_30946106 0.33 ENST00000375687.4
ENST00000542461.1
ASXL1
additional sex combs like 1 (Drosophila)
chr4_-_104119528 0.32 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr2_-_214016314 0.32 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chrX_+_69509927 0.32 ENST00000374403.3
KIF4A
kinesin family member 4A
chr19_-_1568057 0.32 ENST00000402693.4
ENST00000388824.6
MEX3D
mex-3 RNA binding family member D
chr9_+_132388566 0.32 ENST00000372480.1
NTMT1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chrX_+_105969893 0.31 ENST00000255499.2
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr1_+_193091080 0.30 ENST00000367435.3
CDC73
cell division cycle 73
chr11_+_60609537 0.30 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr3_+_52719936 0.30 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr20_-_17662705 0.30 ENST00000455029.2
RRBP1
ribosome binding protein 1
chr7_+_65540853 0.30 ENST00000380839.4
ENST00000395332.3
ENST00000362000.5
ENST00000395331.3
ASL
argininosuccinate lyase
chr22_-_30987849 0.30 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr8_+_109455845 0.28 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr1_-_246729544 0.28 ENST00000544618.1
ENST00000366514.4
TFB2M
transcription factor B2, mitochondrial
chr12_-_58146048 0.28 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
CDK4
cyclin-dependent kinase 4
chr11_+_126225789 0.28 ENST00000530591.1
ENST00000534083.1
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr17_+_6918354 0.28 ENST00000552775.1
C17orf49
chromosome 17 open reading frame 49
chr3_-_52719810 0.28 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
PBRM1
polybromo 1
chr4_-_24586140 0.27 ENST00000336812.4
DHX15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr2_+_27665232 0.27 ENST00000543753.1
ENST00000288873.3
KRTCAP3
keratinocyte associated protein 3
chr3_+_19988566 0.27 ENST00000273047.4
RAB5A
RAB5A, member RAS oncogene family
chr7_+_65540780 0.27 ENST00000304874.9
ASL
argininosuccinate lyase
chr13_-_38443860 0.26 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4
transient receptor potential cation channel, subfamily C, member 4
chr10_-_44070016 0.26 ENST00000374446.2
ENST00000426961.1
ENST00000535642.1
ZNF239
zinc finger protein 239
chr3_-_50329990 0.26 ENST00000417626.2
IFRD2
interferon-related developmental regulator 2
chr16_+_69166418 0.26 ENST00000314423.7
ENST00000562237.1
ENST00000567460.1
ENST00000566227.1
ENST00000352319.4
ENST00000563094.1
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr15_-_43622736 0.26 ENST00000544735.1
ENST00000567039.1
ENST00000305641.5
LCMT2
leucine carboxyl methyltransferase 2
chr12_-_58146128 0.26 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
CDK4
cyclin-dependent kinase 4
chrX_+_47078069 0.25 ENST00000357227.4
ENST00000519758.1
ENST00000520893.1
ENST00000517426.1
CDK16
cyclin-dependent kinase 16
chr6_+_151187615 0.25 ENST00000441122.1
ENST00000423867.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chrX_+_47077632 0.24 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr17_-_2614927 0.24 ENST00000435359.1
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr11_-_17498348 0.24 ENST00000389817.3
ENST00000302539.4
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr14_-_81687575 0.24 ENST00000434192.2
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr1_-_111991908 0.24 ENST00000235090.5
WDR77
WD repeat domain 77
chr16_-_30022735 0.24 ENST00000564944.1
DOC2A
double C2-like domains, alpha
chr11_+_33279850 0.24 ENST00000531504.1
ENST00000456517.1
HIPK3
homeodomain interacting protein kinase 3
chr11_+_576457 0.24 ENST00000264555.5
PHRF1
PHD and ring finger domains 1
chr19_-_38397228 0.23 ENST00000447313.2
WDR87
WD repeat domain 87
chr22_-_30987837 0.23 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr8_-_30515693 0.23 ENST00000355904.4
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr1_+_22333943 0.23 ENST00000400271.2
CELA3A
chymotrypsin-like elastase family, member 3A
chr9_-_115983568 0.23 ENST00000446284.1
ENST00000414250.1
FKBP15
FK506 binding protein 15, 133kDa
chr22_+_35653445 0.22 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr21_-_38639601 0.22 ENST00000539844.1
ENST00000476950.1
ENST00000399001.1
DSCR3
Down syndrome critical region gene 3
chr16_+_16043406 0.22 ENST00000399410.3
ENST00000399408.2
ENST00000346370.5
ENST00000351154.5
ENST00000345148.5
ENST00000349029.5
ABCC1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr20_-_17662878 0.22 ENST00000377813.1
ENST00000377807.2
ENST00000360807.4
ENST00000398782.2
RRBP1
ribosome binding protein 1
chr1_+_45805342 0.22 ENST00000372090.5
TOE1
target of EGR1, member 1 (nuclear)
chr16_-_30022293 0.22 ENST00000565273.1
ENST00000567332.2
ENST00000350119.4
DOC2A
double C2-like domains, alpha
chr11_+_75479850 0.21 ENST00000376262.3
ENST00000604733.1
DGAT2
diacylglycerol O-acyltransferase 2
chr9_-_139137648 0.21 ENST00000358701.5
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr6_+_74072375 0.21 ENST00000370367.3
KHDC3L
KH domain containing 3-like, subcortical maternal complex member
chr12_+_54332535 0.21 ENST00000243056.3
HOXC13
homeobox C13
chr14_+_96968802 0.21 ENST00000556619.1
ENST00000392990.2
PAPOLA
poly(A) polymerase alpha
chr2_-_232329186 0.21 ENST00000322723.4
NCL
nucleolin
chr9_+_133884469 0.21 ENST00000361069.4
LAMC3
laminin, gamma 3
chr9_+_115983808 0.20 ENST00000374210.6
ENST00000374212.4
SLC31A1
solute carrier family 31 (copper transporter), member 1
chr11_+_73882144 0.20 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr10_+_76969909 0.20 ENST00000298468.5
ENST00000543351.1
VDAC2
voltage-dependent anion channel 2
chr2_+_27665289 0.20 ENST00000407293.1
KRTCAP3
keratinocyte associated protein 3
chr1_-_1709845 0.20 ENST00000341426.5
ENST00000344463.4
NADK
NAD kinase
chr18_-_45457478 0.20 ENST00000402690.2
ENST00000356825.4
SMAD2
SMAD family member 2
chr18_+_33877654 0.20 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr16_+_66878814 0.20 ENST00000394069.3
CA7
carbonic anhydrase VII
chr11_+_73882311 0.19 ENST00000398427.4
ENST00000544401.1
PPME1
protein phosphatase methylesterase 1
chr7_+_44084233 0.19 ENST00000448521.1
DBNL
drebrin-like
chr5_+_55033845 0.19 ENST00000353507.5
ENST00000514278.2
ENST00000505374.1
ENST00000506511.1
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr17_+_35306175 0.19 ENST00000225402.5
AATF
apoptosis antagonizing transcription factor
chr19_+_50180507 0.19 ENST00000454376.2
ENST00000524771.1
PRMT1
protein arginine methyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0061461 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
2.7 13.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.9 3.4 GO:0035425 autocrine signaling(GO:0035425)
0.7 2.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.4 1.2 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.4 2.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 1.5 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021)
0.3 1.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.3 0.9 GO:1902534 single-organism membrane invagination(GO:1902534)
0.3 2.5 GO:0006552 leucine catabolic process(GO:0006552)
0.3 0.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.3 1.9 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.3 2.5 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.2 0.7 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.2 4.0 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 0.8 GO:0042360 vitamin E metabolic process(GO:0042360)
0.2 0.6 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 1.0 GO:0015692 lead ion transport(GO:0015692)
0.2 0.4 GO:0060166 olfactory pit development(GO:0060166)
0.2 0.6 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.2 0.6 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.2 0.9 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 0.5 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.2 1.0 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.2 0.5 GO:0018016 N-terminal protein amino acid methylation(GO:0006480) N-terminal peptidyl-alanine methylation(GO:0018011) N-terminal peptidyl-alanine trimethylation(GO:0018012) N-terminal peptidyl-glycine methylation(GO:0018013) N-terminal peptidyl-proline dimethylation(GO:0018016) peptidyl-alanine modification(GO:0018194) N-terminal peptidyl-proline methylation(GO:0035568) N-terminal peptidyl-serine methylation(GO:0035570) N-terminal peptidyl-serine dimethylation(GO:0035572) N-terminal peptidyl-serine trimethylation(GO:0035573)
0.1 0.9 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 0.4 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.1 0.4 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.8 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1 0.6 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.4 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.1 0.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.7 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.6 GO:2000051 Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.3 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.9 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.7 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 0.4 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.4 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.3 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 1.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.1 GO:0012502 induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501)
0.1 0.9 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 1.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 0.3 GO:0061198 fungiform papilla formation(GO:0061198)
0.1 0.3 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
0.1 0.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.2 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.1 0.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 1.6 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.1 0.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.2 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 1.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.2 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.1 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.0 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.6 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.3 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.6 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.2 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.0 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 1.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.5 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0001711 endodermal cell fate commitment(GO:0001711) positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.4 GO:0051481 stabilization of membrane potential(GO:0030322) negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.0 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.2 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.7 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.5 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0006244 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.5 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.5 GO:0097503 sialylation(GO:0097503)
0.0 0.6 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.0 GO:0038001 paracrine signaling(GO:0038001)
0.0 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.4 2.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.8 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 1.0 GO:0070826 paraferritin complex(GO:0070826)
0.2 0.6 GO:0042565 RNA nuclear export complex(GO:0042565)
0.2 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 1.5 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.2 13.9 GO:0015030 Cajal body(GO:0015030)
0.2 0.9 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.6 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.5 GO:0070876 SOSS complex(GO:0070876)
0.1 0.5 GO:0070545 PeBoW complex(GO:0070545)
0.1 2.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 1.5 GO:0005922 connexon complex(GO:0005922)
0.1 1.0 GO:0034709 methylosome(GO:0034709)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.9 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0071547 piP-body(GO:0071547)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0008859 exoribonuclease II activity(GO:0008859)
2.3 9.2 GO:0005287 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.7 2.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.5 2.5 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.5 2.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.5 1.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.4 1.2 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.4 2.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.5 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.2 1.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 0.8 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.0 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.6 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.2 0.9 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 0.5 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 2.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.4 GO:0031403 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.1 0.4 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.5 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.1 0.2 GO:0015235 cobalamin transporter activity(GO:0015235)
0.1 0.6 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 3.9 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.4 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 1.0 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.9 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.4 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.4 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.4 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.1 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.8 GO:0051287 NAD binding(GO:0051287)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 3.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 4.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 13.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 4.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.0 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 3.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol