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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HIF1A

Z-value: 0.85

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Transcription factors associated with HIF1A

Gene Symbol Gene ID Gene Info
ENSG00000100644.12 hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HIF1Ahg19_v2_chr14_+_62162258_62162269-0.491.2e-02Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_89182178 4.82 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 4.75 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr8_+_17354617 4.63 ENST00000470360.1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr8_+_17354587 4.52 ENST00000494857.1
ENST00000522656.1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr15_+_89181974 4.09 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr10_-_49732281 3.59 ENST00000374170.1
Rho GTPase activating protein 22
chr21_+_26934165 3.43 ENST00000456917.1
MIR155 host gene (non-protein coding)
chr3_-_127541679 2.63 ENST00000265052.5
monoglyceride lipase
chr1_+_65613852 2.51 ENST00000327299.7
adenylate kinase 4
chr3_-_145878954 2.16 ENST00000282903.5
ENST00000360060.3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr3_+_133292851 2.16 ENST00000503932.1
CDV3 homolog (mouse)
chr3_+_133292759 2.05 ENST00000431519.2
CDV3 homolog (mouse)
chr20_+_53092123 2.03 ENST00000262593.5
docking protein 5
chr7_+_128095900 1.90 ENST00000435296.2
hypoxia inducible lipid droplet-associated
chr20_+_53092232 1.86 ENST00000395939.1
docking protein 5
chr12_-_121734489 1.60 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr5_-_131563501 1.52 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
prolyl 4-hydroxylase, alpha polypeptide II
chr7_+_128095945 1.51 ENST00000257696.4
hypoxia inducible lipid droplet-associated
chr7_-_22396533 1.51 ENST00000344041.6
Rap guanine nucleotide exchange factor (GEF) 5
chr5_+_70883178 1.48 ENST00000323375.8
methylcrotonoyl-CoA carboxylase 2 (beta)
chr5_+_49962495 1.40 ENST00000515175.1
poly (ADP-ribose) polymerase family, member 8
chr13_+_25875785 1.39 ENST00000381747.3
nucleoporin like 1
chr2_-_208031542 1.35 ENST00000423015.1
Kruppel-like factor 7 (ubiquitous)
chr1_-_8939265 1.26 ENST00000489867.1
enolase 1, (alpha)
chr5_+_70883117 1.06 ENST00000340941.6
methylcrotonoyl-CoA carboxylase 2 (beta)
chr7_-_27170352 1.03 ENST00000428284.2
ENST00000360046.5
homeobox A4
chr12_-_51422017 0.96 ENST00000394904.3
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr9_-_136857403 0.96 ENST00000406606.3
ENST00000371850.3
vav 2 guanine nucleotide exchange factor
chr21_+_45719921 0.94 ENST00000349048.4
phosphofructokinase, liver
chr18_+_77439775 0.93 ENST00000299543.7
ENST00000075430.7
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr7_-_98741642 0.93 ENST00000361368.2
SMAD specific E3 ubiquitin protein ligase 1
chr11_-_73471655 0.92 ENST00000400470.2
RAB6A, member RAS oncogene family
chr5_+_49962772 0.90 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
poly (ADP-ribose) polymerase family, member 8
chr3_-_50374869 0.90 ENST00000327761.3
Ras association (RalGDS/AF-6) domain family member 1
chr17_-_36831156 0.85 ENST00000325814.5
chromosome 17 open reading frame 96
chr6_+_108487245 0.83 ENST00000368986.4
nuclear receptor subfamily 2, group E, member 1
chr12_+_72148614 0.81 ENST00000261263.3
RAB21, member RAS oncogene family
chr2_+_173420697 0.78 ENST00000282077.3
ENST00000392571.2
ENST00000410055.1
pyruvate dehydrogenase kinase, isozyme 1
chr20_-_44540686 0.78 ENST00000477313.1
ENST00000542937.1
ENST00000372431.3
ENST00000354050.4
ENST00000420868.2
phospholipid transfer protein
chr6_+_30539153 0.76 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ATP-binding cassette, sub-family F (GCN20), member 1
chr17_-_42908155 0.75 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
gap junction protein, gamma 1, 45kDa
chr3_-_195808952 0.74 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
transferrin receptor
chr17_-_42907564 0.72 ENST00000592524.1
gap junction protein, gamma 1, 45kDa
chr14_-_53162361 0.72 ENST00000395686.3
ERO1-like (S. cerevisiae)
chr3_-_156272924 0.72 ENST00000467789.1
ENST00000265044.2
signal sequence receptor, gamma (translocon-associated protein gamma)
chr6_+_108882069 0.72 ENST00000406360.1
forkhead box O3
chr20_+_48552908 0.72 ENST00000244061.2
ring finger protein 114
chr9_-_94186131 0.69 ENST00000297689.3
nuclear factor, interleukin 3 regulated
chr12_-_123849374 0.68 ENST00000602398.1
ENST00000602750.1
strawberry notch homolog 1 (Drosophila)
chr3_-_195808980 0.68 ENST00000360110.4
transferrin receptor
chr1_-_159894319 0.67 ENST00000320307.4
transgelin 2
chr15_+_52311398 0.65 ENST00000261845.5
mitogen-activated protein kinase 6
chr5_-_146889619 0.65 ENST00000343218.5
dihydropyrimidinase-like 3
chr1_-_167522982 0.64 ENST00000370509.4
cellular repressor of E1A-stimulated genes 1
chr4_-_4291761 0.63 ENST00000513174.1
Ly1 antibody reactive
chr10_+_101419187 0.62 ENST00000370489.4
ectonucleoside triphosphate diphosphohydrolase 7
chr11_+_6624970 0.62 ENST00000420936.2
ENST00000528995.1
integrin-linked kinase
chr7_-_139876812 0.61 ENST00000397560.2
lysine (K)-specific demethylase 7A
chr1_-_8938736 0.61 ENST00000234590.4
enolase 1, (alpha)
chr17_+_17942684 0.60 ENST00000376345.3
GID complex subunit 4
chr3_-_71632894 0.59 ENST00000493089.1
forkhead box P1
chr10_+_122216316 0.58 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
phosphatidic acid phosphatase type 2 domain containing 1A
chr12_+_6977258 0.58 ENST00000488464.2
ENST00000535434.1
ENST00000493987.1
triosephosphate isomerase 1
chr6_-_159240415 0.57 ENST00000367075.3
ezrin
chr12_+_131356582 0.57 ENST00000448750.3
ENST00000541630.1
ENST00000392369.2
ENST00000254675.3
ENST00000535090.1
ENST00000392367.3
RAN, member RAS oncogene family
chr16_-_54963026 0.56 ENST00000560208.1
ENST00000557792.1
colorectal neoplasia differentially expressed (non-protein coding)
chr4_-_39529049 0.55 ENST00000501493.2
ENST00000509391.1
ENST00000507089.1
UDP-glucose 6-dehydrogenase
chr22_+_29279552 0.55 ENST00000544604.2
zinc and ring finger 3
chr2_+_111878483 0.55 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2-like 11 (apoptosis facilitator)
chr17_-_67323232 0.55 ENST00000592568.1
ENST00000392676.3
ATP-binding cassette, sub-family A (ABC1), member 5
chr16_-_69788816 0.54 ENST00000268802.5
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr17_-_67323305 0.53 ENST00000392677.2
ENST00000593153.1
ATP-binding cassette, sub-family A (ABC1), member 5
chr6_+_64282447 0.52 ENST00000370650.2
ENST00000578299.1
protein tyrosine phosphatase type IVA, member 1
chr11_+_6625046 0.50 ENST00000396751.2
integrin-linked kinase
chr3_+_113666748 0.50 ENST00000330212.3
ENST00000498275.1
zinc finger, DHHC-type containing 23
chr8_+_67341239 0.50 ENST00000320270.2
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr4_-_4291748 0.50 ENST00000452476.1
Ly1 antibody reactive
chr11_+_6624955 0.50 ENST00000299421.4
ENST00000537806.1
integrin-linked kinase
chr4_-_4291861 0.49 ENST00000343470.4
Ly1 antibody reactive
chr2_+_68384976 0.49 ENST00000263657.2
partner of NOB1 homolog (S. cerevisiae)
chr19_-_663277 0.48 ENST00000292363.5
ring finger protein 126
chr4_-_39529180 0.48 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UDP-glucose 6-dehydrogenase
chr11_+_57435219 0.47 ENST00000527985.1
ENST00000287169.3
zinc finger, DHHC-type containing 5
chr9_-_115983641 0.46 ENST00000238256.3
FK506 binding protein 15, 133kDa
chr6_+_64281906 0.46 ENST00000370651.3
protein tyrosine phosphatase type IVA, member 1
chr10_-_96122682 0.45 ENST00000371361.3
nucleolar complex associated 3 homolog (S. cerevisiae)
chr2_+_192543153 0.45 ENST00000425611.2
nucleic acid binding protein 1
chr8_+_75896731 0.45 ENST00000262207.4
cysteine-rich secretory protein LCCL domain containing 1
chr10_+_98592009 0.45 ENST00000540664.1
ENST00000371103.3
ligand dependent nuclear receptor corepressor
chr7_+_43152191 0.44 ENST00000395891.2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr1_-_111991850 0.44 ENST00000411751.2
WD repeat domain 77
chr19_-_5719860 0.44 ENST00000590729.1
lon peptidase 1, mitochondrial
chr17_+_45000483 0.43 ENST00000576910.2
ENST00000439730.2
ENST00000393456.2
ENST00000415811.2
ENST00000575949.1
ENST00000225567.4
ENST00000572403.1
ENST00000570879.1
golgi SNAP receptor complex member 2
chr12_-_113909877 0.42 ENST00000261731.3
LIM homeobox 5
chr1_-_241520525 0.42 ENST00000366565.1
regulator of G-protein signaling 7
chr3_-_50329835 0.42 ENST00000429673.2
interferon-related developmental regulator 2
chr12_+_7023491 0.42 ENST00000541477.1
ENST00000229277.1
enolase 2 (gamma, neuronal)
chr2_+_118846008 0.42 ENST00000245787.4
insulin induced gene 2
chr13_-_44361025 0.42 ENST00000261488.6
ecto-NOX disulfide-thiol exchanger 1
chr17_+_57642886 0.42 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr19_-_5720248 0.41 ENST00000360614.3
lon peptidase 1, mitochondrial
chr12_+_7023735 0.41 ENST00000538763.1
ENST00000544774.1
ENST00000545045.2
enolase 2 (gamma, neuronal)
chr7_+_44084262 0.41 ENST00000456905.1
ENST00000440166.1
ENST00000452943.1
ENST00000468694.1
ENST00000494774.1
ENST00000490734.2
drebrin-like
chr9_+_133569108 0.40 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
exosome component 2
chrX_+_16804544 0.40 ENST00000380122.5
ENST00000398155.4
taxilin gamma
chr18_+_43913919 0.40 ENST00000587853.1
ring finger protein 165
chr17_-_74449252 0.40 ENST00000319380.7
ubiquitin-conjugating enzyme E2O
chr12_-_125473600 0.40 ENST00000308736.2
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr3_+_19988885 0.40 ENST00000422242.1
RAB5A, member RAS oncogene family
chr1_+_117452669 0.39 ENST00000393203.2
prostaglandin F2 receptor inhibitor
chr19_-_38397285 0.39 ENST00000303868.5
WD repeat domain 87
chr19_-_5720123 0.39 ENST00000587365.1
ENST00000585374.1
ENST00000593119.1
lon peptidase 1, mitochondrial
chr15_+_101420028 0.38 ENST00000557963.1
ENST00000346623.6
aldehyde dehydrogenase 1 family, member A3
chr11_+_576494 0.38 ENST00000533464.1
ENST00000413872.2
ENST00000416188.2
PHD and ring finger domains 1
chr2_+_26915584 0.37 ENST00000302909.3
potassium channel, subfamily K, member 3
chr16_-_4466622 0.37 ENST00000570645.1
ENST00000574025.1
ENST00000572898.1
ENST00000537233.2
ENST00000571059.1
ENST00000251166.4
coronin 7
chr2_+_55459808 0.37 ENST00000404735.1
ribosomal protein S27a
chr7_-_92465868 0.37 ENST00000424848.2
cyclin-dependent kinase 6
chr2_+_178077477 0.36 ENST00000411529.2
ENST00000435711.1
heterogeneous nuclear ribonucleoprotein A3
chr21_+_45138941 0.36 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
pyridoxal (pyridoxine, vitamin B6) kinase
chrX_-_137793826 0.36 ENST00000315930.6
fibroblast growth factor 13
chr11_-_14665163 0.36 ENST00000418988.2
proteasome (prosome, macropain) subunit, alpha type, 1
chr11_-_64014379 0.36 ENST00000309318.3
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr20_-_62258394 0.36 ENST00000370077.1
glucocorticoid modulatory element binding protein 2
chr4_-_54930790 0.35 ENST00000263921.3
cysteine-rich hydrophobic domain 2
chr16_-_4466565 0.35 ENST00000572467.1
ENST00000423908.2
ENST00000572044.1
ENST00000571052.1
CORO7-PAM16 readthrough
coronin 7
chr22_-_36424458 0.35 ENST00000438146.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr8_-_97273807 0.34 ENST00000517720.1
ENST00000287025.3
ENST00000523821.1
MTERF domain containing 1
chr15_+_98503922 0.34 ENST00000268042.6
arrestin domain containing 4
chr12_+_54348618 0.33 ENST00000243103.3
homeobox C12
chr20_+_30946106 0.33 ENST00000375687.4
ENST00000542461.1
additional sex combs like 1 (Drosophila)
chr4_-_104119528 0.32 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
centromere protein E, 312kDa
chr2_-_214016314 0.32 ENST00000434687.1
ENST00000374319.4
IKAROS family zinc finger 2 (Helios)
chrX_+_69509927 0.32 ENST00000374403.3
kinesin family member 4A
chr19_-_1568057 0.32 ENST00000402693.4
ENST00000388824.6
mex-3 RNA binding family member D
chr9_+_132388566 0.32 ENST00000372480.1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chrX_+_105969893 0.31 ENST00000255499.2
ring finger protein 128, E3 ubiquitin protein ligase
chr1_+_193091080 0.30 ENST00000367435.3
cell division cycle 73
chr11_+_60609537 0.30 ENST00000227520.5
coiled-coil domain containing 86
chr3_+_52719936 0.30 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr20_-_17662705 0.30 ENST00000455029.2
ribosome binding protein 1
chr7_+_65540853 0.30 ENST00000380839.4
ENST00000395332.3
ENST00000362000.5
ENST00000395331.3
argininosuccinate lyase
chr22_-_30987849 0.30 ENST00000402284.3
ENST00000354694.7
pescadillo ribosomal biogenesis factor 1
chr8_+_109455845 0.28 ENST00000220853.3
ER membrane protein complex subunit 2
chr1_-_246729544 0.28 ENST00000544618.1
ENST00000366514.4
transcription factor B2, mitochondrial
chr12_-_58146048 0.28 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
cyclin-dependent kinase 4
chr11_+_126225789 0.28 ENST00000530591.1
ENST00000534083.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr17_+_6918354 0.28 ENST00000552775.1
chromosome 17 open reading frame 49
chr3_-_52719810 0.28 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
polybromo 1
chr4_-_24586140 0.27 ENST00000336812.4
DEAH (Asp-Glu-Ala-His) box helicase 15
chr2_+_27665232 0.27 ENST00000543753.1
ENST00000288873.3
keratinocyte associated protein 3
chr3_+_19988566 0.27 ENST00000273047.4
RAB5A, member RAS oncogene family
chr7_+_65540780 0.27 ENST00000304874.9
argininosuccinate lyase
chr13_-_38443860 0.26 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
transient receptor potential cation channel, subfamily C, member 4
chr10_-_44070016 0.26 ENST00000374446.2
ENST00000426961.1
ENST00000535642.1
zinc finger protein 239
chr3_-_50329990 0.26 ENST00000417626.2
interferon-related developmental regulator 2
chr16_+_69166418 0.26 ENST00000314423.7
ENST00000562237.1
ENST00000567460.1
ENST00000566227.1
ENST00000352319.4
ENST00000563094.1
cirrhosis, autosomal recessive 1A (cirhin)
chr15_-_43622736 0.26 ENST00000544735.1
ENST00000567039.1
ENST00000305641.5
leucine carboxyl methyltransferase 2
chr12_-_58146128 0.26 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
cyclin-dependent kinase 4
chrX_+_47078069 0.25 ENST00000357227.4
ENST00000519758.1
ENST00000520893.1
ENST00000517426.1
cyclin-dependent kinase 16
chr6_+_151187615 0.25 ENST00000441122.1
ENST00000423867.1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chrX_+_47077632 0.24 ENST00000457458.2
cyclin-dependent kinase 16
chr17_-_2614927 0.24 ENST00000435359.1
clustered mitochondria (cluA/CLU1) homolog
chr11_-_17498348 0.24 ENST00000389817.3
ENST00000302539.4
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr14_-_81687575 0.24 ENST00000434192.2
general transcription factor IIA, 1, 19/37kDa
chr1_-_111991908 0.24 ENST00000235090.5
WD repeat domain 77
chr16_-_30022735 0.24 ENST00000564944.1
double C2-like domains, alpha
chr11_+_33279850 0.24 ENST00000531504.1
ENST00000456517.1
homeodomain interacting protein kinase 3
chr11_+_576457 0.24 ENST00000264555.5
PHD and ring finger domains 1
chr19_-_38397228 0.23 ENST00000447313.2
WD repeat domain 87
chr22_-_30987837 0.23 ENST00000335214.6
pescadillo ribosomal biogenesis factor 1
chr8_-_30515693 0.23 ENST00000355904.4
general transcription factor IIE, polypeptide 2, beta 34kDa
chr1_+_22333943 0.23 ENST00000400271.2
chymotrypsin-like elastase family, member 3A
chr9_-_115983568 0.23 ENST00000446284.1
ENST00000414250.1
FK506 binding protein 15, 133kDa
chr22_+_35653445 0.22 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr21_-_38639601 0.22 ENST00000539844.1
ENST00000476950.1
ENST00000399001.1
Down syndrome critical region gene 3
chr16_+_16043406 0.22 ENST00000399410.3
ENST00000399408.2
ENST00000346370.5
ENST00000351154.5
ENST00000345148.5
ENST00000349029.5
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr20_-_17662878 0.22 ENST00000377813.1
ENST00000377807.2
ENST00000360807.4
ENST00000398782.2
ribosome binding protein 1
chr1_+_45805342 0.22 ENST00000372090.5
target of EGR1, member 1 (nuclear)
chr16_-_30022293 0.22 ENST00000565273.1
ENST00000567332.2
ENST00000350119.4
double C2-like domains, alpha
chr11_+_75479850 0.21 ENST00000376262.3
ENST00000604733.1
diacylglycerol O-acyltransferase 2
chr9_-_139137648 0.21 ENST00000358701.5
quiescin Q6 sulfhydryl oxidase 2
chr6_+_74072375 0.21 ENST00000370367.3
KH domain containing 3-like, subcortical maternal complex member
chr12_+_54332535 0.21 ENST00000243056.3
homeobox C13
chr14_+_96968802 0.21 ENST00000556619.1
ENST00000392990.2
poly(A) polymerase alpha
chr2_-_232329186 0.21 ENST00000322723.4
nucleolin
chr9_+_133884469 0.21 ENST00000361069.4
laminin, gamma 3
chr9_+_115983808 0.20 ENST00000374210.6
ENST00000374212.4
solute carrier family 31 (copper transporter), member 1
chr11_+_73882144 0.20 ENST00000328257.8
protein phosphatase methylesterase 1
chr10_+_76969909 0.20 ENST00000298468.5
ENST00000543351.1
voltage-dependent anion channel 2
chr2_+_27665289 0.20 ENST00000407293.1
keratinocyte associated protein 3
chr1_-_1709845 0.20 ENST00000341426.5
ENST00000344463.4
NAD kinase
chr18_-_45457478 0.20 ENST00000402690.2
ENST00000356825.4
SMAD family member 2
chr18_+_33877654 0.20 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
formin homology 2 domain containing 3
chr16_+_66878814 0.20 ENST00000394069.3
carbonic anhydrase VII
chr11_+_73882311 0.19 ENST00000398427.4
ENST00000544401.1
protein phosphatase methylesterase 1
chr7_+_44084233 0.19 ENST00000448521.1
drebrin-like
chr5_+_55033845 0.19 ENST00000353507.5
ENST00000514278.2
ENST00000505374.1
ENST00000506511.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr17_+_35306175 0.19 ENST00000225402.5
apoptosis antagonizing transcription factor
chr19_+_50180507 0.19 ENST00000454376.2
ENST00000524771.1
protein arginine methyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0061461 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
2.7 13.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.9 3.4 GO:0035425 autocrine signaling(GO:0035425)
0.7 2.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.4 1.2 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.4 2.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 1.5 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021)
0.3 1.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.3 0.9 GO:1902534 single-organism membrane invagination(GO:1902534)
0.3 2.5 GO:0006552 leucine catabolic process(GO:0006552)
0.3 0.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.3 1.9 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.3 2.5 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.2 0.7 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.2 4.0 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 0.8 GO:0042360 vitamin E metabolic process(GO:0042360)
0.2 0.6 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 1.0 GO:0015692 lead ion transport(GO:0015692)
0.2 0.4 GO:0060166 olfactory pit development(GO:0060166)
0.2 0.6 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.2 0.6 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.2 0.9 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 0.5 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.2 1.0 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.2 0.5 GO:0018016 N-terminal protein amino acid methylation(GO:0006480) N-terminal peptidyl-alanine methylation(GO:0018011) N-terminal peptidyl-alanine trimethylation(GO:0018012) N-terminal peptidyl-glycine methylation(GO:0018013) N-terminal peptidyl-proline dimethylation(GO:0018016) peptidyl-alanine modification(GO:0018194) N-terminal peptidyl-proline methylation(GO:0035568) N-terminal peptidyl-serine methylation(GO:0035570) N-terminal peptidyl-serine dimethylation(GO:0035572) N-terminal peptidyl-serine trimethylation(GO:0035573)
0.1 0.9 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 0.4 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.1 0.4 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.8 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1 0.6 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.4 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.1 0.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.7 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.6 GO:2000051 Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.3 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.9 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.7 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 0.4 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.4 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.3 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 1.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.1 GO:0012502 induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501)
0.1 0.9 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 1.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 0.3 GO:0061198 fungiform papilla formation(GO:0061198)
0.1 0.3 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
0.1 0.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.2 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.1 0.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 1.6 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.1 0.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.2 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 1.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.2 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.1 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.0 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.6 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.3 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.6 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.2 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.0 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 1.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.5 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0001711 endodermal cell fate commitment(GO:0001711) positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.4 GO:0051481 stabilization of membrane potential(GO:0030322) negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.0 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.2 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.7 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.5 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0006244 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.5 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.5 GO:0097503 sialylation(GO:0097503)
0.0 0.6 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.0 GO:0038001 paracrine signaling(GO:0038001)
0.0 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.4 2.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.8 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 1.0 GO:0070826 paraferritin complex(GO:0070826)
0.2 0.6 GO:0042565 RNA nuclear export complex(GO:0042565)
0.2 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 1.5 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.2 13.9 GO:0015030 Cajal body(GO:0015030)
0.2 0.9 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.6 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.5 GO:0070876 SOSS complex(GO:0070876)
0.1 0.5 GO:0070545 PeBoW complex(GO:0070545)
0.1 2.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 1.5 GO:0005922 connexon complex(GO:0005922)
0.1 1.0 GO:0034709 methylosome(GO:0034709)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.9 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0071547 piP-body(GO:0071547)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0008859 exoribonuclease II activity(GO:0008859)
2.3 9.2 GO:0005287 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.7 2.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.5 2.5 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.5 2.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.5 1.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.4 1.2 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.4 2.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.5 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.2 1.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 0.8 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.0 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.6 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.2 0.9 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 0.5 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 2.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.4 GO:0031403 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.1 0.4 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.5 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.1 0.2 GO:0015235 cobalamin transporter activity(GO:0015235)
0.1 0.6 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 3.9 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.4 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 1.0 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.9 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.4 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.4 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.4 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.1 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.8 GO:0051287 NAD binding(GO:0051287)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 3.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 4.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 13.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 4.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.0 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 3.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol