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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HINFP
Z-value: 0.64
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Transcription factors associated with HINFP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HINFP | hg19_v2_chr11_+_118992269_118992334 | 0.32 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_149363662 Show fit | 2.15 |
ENST00000355292.3
ENST00000358102.3 |
nuclear receptor subfamily 3, group C, member 2 |
|
| chr10_-_131762105 Show fit | 1.89 |
ENST00000368648.3
ENST00000355311.5 |
early B-cell factor 3 |
|
| chr1_+_109102652 Show fit | 1.44 |
ENST00000370035.3
ENST00000405454.1 |
family with sequence similarity 102, member B |
|
| chr22_-_28197486 Show fit | 1.34 |
ENST00000302326.4
|
meningioma (disrupted in balanced translocation) 1 |
|
| chr10_+_94608218 Show fit | 1.33 |
ENST00000371543.1
|
exocyst complex component 6 |
|
| chr1_+_61547405 Show fit | 1.23 |
ENST00000371189.4
|
nuclear factor I/A |
|
| chr4_-_186733363 Show fit | 1.23 |
ENST00000393523.2
ENST00000393528.3 ENST00000449407.2 |
sorbin and SH3 domain containing 2 |
|
| chr3_+_110790590 Show fit | 1.14 |
ENST00000485303.1
|
poliovirus receptor-related 3 |
|
| chr1_+_61547894 Show fit | 1.14 |
ENST00000403491.3
|
nuclear factor I/A |
|
| chr6_+_24495185 Show fit | 1.02 |
ENST00000348925.2
|
aldehyde dehydrogenase 5 family, member A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HINFP
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 2.0 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 1.5 | GO:2000288 | positive regulation of myoblast proliferation(GO:2000288) |
| 0.2 | 1.4 | GO:0009450 | acetate metabolic process(GO:0006083) gamma-aminobutyric acid catabolic process(GO:0009450) |
| 0.2 | 1.3 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.2 | 1.2 | GO:1904849 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.0 | 1.2 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 1.0 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.2 | 0.9 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.1 | 0.9 | GO:0090219 | negative regulation of lipid kinase activity(GO:0090219) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.0 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.2 | 0.9 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 0.7 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.6 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 0.6 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.6 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 1.5 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.0 | 1.4 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 1.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 1.2 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 0.9 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 0.8 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 0.6 | GO:0005119 | smoothened binding(GO:0005119) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.2 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 1.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |