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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HIVEP1
Z-value: 1.78
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Transcription factors associated with HIVEP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIVEP1 | hg19_v2_chr6_+_12012536_12012571 | 0.53 | 6.0e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76944621 Show fit | 12.02 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr4_+_74702214 Show fit | 11.17 |
ENST00000226317.5
ENST00000515050.1 |
chemokine (C-X-C motif) ligand 6 |
|
| chr19_+_4229495 Show fit | 8.77 |
ENST00000221847.5
|
Epstein-Barr virus induced 3 |
|
| chr5_-_150460914 Show fit | 8.55 |
ENST00000389378.2
|
TNFAIP3 interacting protein 1 |
|
| chr1_-_8000872 Show fit | 8.15 |
ENST00000377507.3
|
tumor necrosis factor receptor superfamily, member 9 |
|
| chr17_+_40440481 Show fit | 8.05 |
ENST00000590726.2
ENST00000452307.2 ENST00000444283.1 ENST00000588868.1 |
signal transducer and activator of transcription 5A |
|
| chr9_-_123691047 Show fit | 7.53 |
ENST00000373887.3
|
TNF receptor-associated factor 1 |
|
| chr19_+_45504688 Show fit | 7.39 |
ENST00000221452.8
ENST00000540120.1 ENST00000505236.1 |
v-rel avian reticuloendotheliosis viral oncogene homolog B |
|
| chr1_-_209824643 Show fit | 6.70 |
ENST00000391911.1
ENST00000415782.1 |
laminin, beta 3 |
|
| chr17_-_53499310 Show fit | 6.37 |
ENST00000262065.3
|
monocyte to macrophage differentiation-associated |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIVEP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.6 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.2 | 17.3 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 1.2 | 14.6 | GO:0010819 | regulation of T cell chemotaxis(GO:0010819) |
| 3.5 | 14.1 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 1.3 | 13.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 1.3 | 11.8 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) |
| 2.2 | 11.0 | GO:0060611 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.8 | 9.7 | GO:0032782 | bile acid secretion(GO:0032782) |
| 2.3 | 9.0 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.8 | 8.8 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.2 | 13.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 13.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.5 | 11.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 1.8 | 11.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.9 | 9.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 8.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.8 | 6.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 6.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 2.1 | 6.2 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 23.1 | GO:0004386 | helicase activity(GO:0004386) |
| 1.5 | 17.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.4 | 14.0 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 2.4 | 12.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 1.4 | 11.0 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.8 | 10.9 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 9.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.2 | 9.5 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.6 | 8.8 | GO:0031996 | thioesterase binding(GO:0031996) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 19.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 17.8 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.3 | 11.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 8.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 8.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 7.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 6.3 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.2 | 5.9 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.2 | 5.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 34.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.3 | 13.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 10.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.5 | 10.3 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.2 | 8.3 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.4 | 8.1 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 7.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 5.7 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.2 | 4.9 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 4.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |