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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HLF_TEF

Z-value: 0.62

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Transcription factors associated with HLF_TEF

Gene Symbol Gene ID Gene Info
HLF
ENSG00000108924.9 HLF transcription factor, PAR bZIP family member
TEF
ENSG00000167074.10 TEF transcription factor, PAR bZIP family member

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HLFhg19_v2_chr17_+_53343577_533435880.321.2e-01Click!
TEFhg19_v2_chr22_+_41777927_41777971,
hg19_v2_chr22_+_41763274_41763337		-0.242.6e-01Click!

Activity profile of HLF_TEF motif

Sorted Z-values of HLF_TEF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_27011584 2.38 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
JAM2
junctional adhesion molecule 2
chr1_+_169079823 2.03 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr16_+_70680439 1.18 ENST00000288098.2
IL34
interleukin 34
chr1_-_156721389 1.12 ENST00000537739.1
HDGF
hepatoma-derived growth factor
chr17_-_41623716 1.11 ENST00000319349.5
ETV4
ets variant 4
chr17_-_41623009 1.11 ENST00000393664.2
ETV4
ets variant 4
chr17_-_41623691 1.07 ENST00000545954.1
ETV4
ets variant 4
chr17_-_41623259 1.06 ENST00000538265.1
ENST00000591713.1
ETV4
ets variant 4
chr17_-_41623075 1.05 ENST00000545089.1
ETV4
ets variant 4
chr7_-_83824169 0.90 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_+_65613513 0.87 ENST00000395334.2
AK4
adenylate kinase 4
chr3_-_190580404 0.85 ENST00000442080.1
GMNC
geminin coiled-coil domain containing
chr1_-_244013384 0.84 ENST00000366539.1
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr7_-_22259845 0.80 ENST00000420196.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_-_76928641 0.78 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr6_-_46459099 0.68 ENST00000371374.1
RCAN2
regulator of calcineurin 2
chr1_+_144339738 0.67 ENST00000538264.1
AL592284.1
Protein LOC642441
chr7_-_141401951 0.67 ENST00000536163.1
KIAA1147
KIAA1147
chr6_+_4706368 0.67 ENST00000328908.5
CDYL
chromodomain protein, Y-like
chr1_+_7844312 0.66 ENST00000377541.1
PER3
period circadian clock 3
chr21_+_45138941 0.64 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr14_+_78227105 0.61 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chr19_+_41594377 0.59 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr11_+_35201826 0.58 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr1_+_212738676 0.58 ENST00000366981.4
ENST00000366987.2
ATF3
activating transcription factor 3
chr19_-_41388657 0.58 ENST00000301146.4
ENST00000291764.3
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
chr1_-_156721502 0.49 ENST00000357325.5
HDGF
hepatoma-derived growth factor
chr4_-_153274078 0.49 ENST00000263981.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr5_-_54830871 0.48 ENST00000307259.8
PPAP2A
phosphatidic acid phosphatase type 2A
chr10_-_14372870 0.47 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chrX_+_9431324 0.45 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr3_-_99594948 0.42 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr1_+_174933899 0.42 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr2_+_186603355 0.41 ENST00000343098.5
FSIP2
fibrous sheath interacting protein 2
chr15_-_83621435 0.41 ENST00000450735.2
ENST00000426485.1
ENST00000399166.2
ENST00000304231.8
HOMER2
homer homolog 2 (Drosophila)
chr3_+_154797877 0.40 ENST00000462745.1
ENST00000493237.1
MME
membrane metallo-endopeptidase
chr7_+_90032667 0.38 ENST00000496677.1
ENST00000287916.4
ENST00000535571.1
ENST00000394604.1
ENST00000394605.2
CLDN12
claudin 12
chr1_+_144989309 0.37 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr18_-_5396271 0.36 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr3_+_63953415 0.35 ENST00000484332.1
ATXN7
ataxin 7
chr7_+_23146271 0.34 ENST00000545771.1
KLHL7
kelch-like family member 7
chr17_-_41984835 0.34 ENST00000520406.1
ENST00000518478.1
ENST00000522172.1
ENST00000461854.1
ENST00000521178.1
ENST00000520305.1
ENST00000523501.1
ENST00000520241.1
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr3_-_99595037 0.33 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr5_+_34757309 0.32 ENST00000397449.1
RAI14
retinoic acid induced 14
chr17_-_39306054 0.32 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr5_-_58882219 0.31 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_31380502 0.31 ENST00000297142.3
NEUROD6
neuronal differentiation 6
chr16_-_54962704 0.30 ENST00000502066.2
ENST00000560912.1
ENST00000558952.1
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr21_+_35736302 0.30 ENST00000290310.3
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr7_+_23145884 0.30 ENST00000409689.1
ENST00000410047.1
KLHL7
kelch-like family member 7
chr11_-_85397167 0.29 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr9_+_136399929 0.28 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr3_-_48130314 0.28 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr16_-_54962415 0.28 ENST00000501177.3
ENST00000559598.2
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr22_-_50221160 0.27 ENST00000404760.1
BRD1
bromodomain containing 1
chr16_+_56965960 0.27 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr16_-_54962625 0.26 ENST00000559432.1
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr18_+_21032781 0.26 ENST00000339486.3
RIOK3
RIO kinase 3
chr15_-_49255632 0.26 ENST00000332408.4
SHC4
SHC (Src homology 2 domain containing) family, member 4
chr14_+_96722539 0.25 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr12_-_88423164 0.25 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr19_-_41356347 0.24 ENST00000301141.5
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr9_+_71819927 0.24 ENST00000535702.1
TJP2
tight junction protein 2
chr9_+_71820057 0.24 ENST00000539225.1
TJP2
tight junction protein 2
chr12_-_101801505 0.24 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr3_-_48130707 0.23 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr4_+_96012614 0.22 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr16_-_755726 0.22 ENST00000324361.5
FBXL16
F-box and leucine-rich repeat protein 16
chr5_+_95998070 0.22 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chr12_-_53074182 0.22 ENST00000252244.3
KRT1
keratin 1
chr17_-_32690239 0.22 ENST00000225842.3
CCL1
chemokine (C-C motif) ligand 1
chr16_-_755819 0.22 ENST00000397621.1
FBXL16
F-box and leucine-rich repeat protein 16
chr1_+_25757376 0.22 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
TMEM57
transmembrane protein 57
chr11_+_69061594 0.22 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
MYEOV
myeloma overexpressed
chr17_+_685513 0.21 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr5_-_147162263 0.21 ENST00000333010.6
ENST00000265272.5
JAKMIP2
janus kinase and microtubule interacting protein 2
chr14_+_60716159 0.20 ENST00000325658.3
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr3_-_196910721 0.20 ENST00000443183.1
DLG1
discs, large homolog 1 (Drosophila)
chr5_+_95997769 0.20 ENST00000338252.3
ENST00000508830.1
CAST
calpastatin
chr13_+_23755099 0.19 ENST00000537476.1
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr12_-_113574028 0.19 ENST00000546530.1
ENST00000261729.5
RASAL1
RAS protein activator like 1 (GAP1 like)
chr13_-_29292956 0.19 ENST00000266943.6
SLC46A3
solute carrier family 46, member 3
chr5_+_172332220 0.18 ENST00000518247.1
ENST00000326654.2
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr9_-_128246769 0.18 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr18_+_32621324 0.18 ENST00000300249.5
ENST00000538170.2
ENST00000588910.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr10_+_94050913 0.17 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr14_+_96722152 0.17 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr1_-_247094628 0.17 ENST00000366508.1
ENST00000326225.3
ENST00000391829.2
AHCTF1
AT hook containing transcription factor 1
chr14_-_72458326 0.17 ENST00000542853.1
AC005477.1
AC005477.1
chr3_+_88188254 0.17 ENST00000309495.5
ZNF654
zinc finger protein 654
chr14_+_102276192 0.17 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr2_+_198318147 0.17 ENST00000263960.2
COQ10B
coenzyme Q10 homolog B (S. cerevisiae)
chr2_+_113885138 0.16 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr7_+_20687017 0.16 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr6_+_53948328 0.16 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr17_-_61850894 0.15 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr3_+_182983090 0.15 ENST00000465010.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr9_+_110045537 0.14 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_-_114505624 0.14 ENST00000513154.1
TRIM36
tripartite motif containing 36
chr3_+_148447887 0.14 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr6_-_64029879 0.14 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr2_+_192543153 0.14 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chr8_+_50824233 0.14 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr11_-_62313090 0.14 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr4_-_21950356 0.14 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr2_+_183989157 0.13 ENST00000541912.1
NUP35
nucleoporin 35kDa
chr8_+_24151553 0.13 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr3_-_45883558 0.13 ENST00000445698.1
ENST00000296135.6
LZTFL1
leucine zipper transcription factor-like 1
chr1_-_178840157 0.13 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr14_+_93260569 0.13 ENST00000163416.2
GOLGA5
golgin A5
chr1_-_167883327 0.13 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr17_+_61851504 0.13 ENST00000359353.5
ENST00000389924.2
DDX42
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr11_-_18270182 0.13 ENST00000528349.1
ENST00000526900.1
ENST00000529528.1
ENST00000414546.2
ENST00000256733.4
SAA2
serum amyloid A2
chr2_-_98280383 0.12 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr9_-_114246635 0.12 ENST00000338205.5
KIAA0368
KIAA0368
chr1_+_75594119 0.12 ENST00000294638.5
LHX8
LIM homeobox 8
chr12_-_54758251 0.12 ENST00000267015.3
ENST00000551809.1
GPR84
G protein-coupled receptor 84
chr15_+_49913201 0.12 ENST00000329873.5
ENST00000558653.1
ENST00000559164.1
ENST00000560632.1
ENST00000559405.1
ENST00000251250.6
DTWD1
DTW domain containing 1
chr19_+_33865218 0.12 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr7_-_45026419 0.12 ENST00000578968.1
ENST00000580528.1
SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chrX_+_36246735 0.12 ENST00000378653.3
CXorf30
chromosome X open reading frame 30
chr1_-_167883353 0.12 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr1_+_204839959 0.12 ENST00000404076.1
NFASC
neurofascin
chr2_-_31637560 0.11 ENST00000379416.3
XDH
xanthine dehydrogenase
chr21_+_19617140 0.11 ENST00000299295.2
ENST00000338326.3
CHODL
chondrolectin
chr11_-_72145426 0.11 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr19_+_49259325 0.11 ENST00000222157.3
FGF21
fibroblast growth factor 21
chr2_+_183989083 0.11 ENST00000295119.4
NUP35
nucleoporin 35kDa
chr17_-_42144949 0.11 ENST00000591247.1
LSM12
LSM12 homolog (S. cerevisiae)
chr15_+_58430368 0.11 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr7_-_45026200 0.11 ENST00000577700.1
ENST00000580458.1
ENST00000579383.1
ENST00000584686.1
ENST00000585030.1
ENST00000582727.1
SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr11_-_77185094 0.11 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_-_72566613 0.11 ENST00000306821.3
NEGR1
neuronal growth regulator 1
chr5_-_146435694 0.11 ENST00000356826.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr7_-_45026159 0.11 ENST00000584327.1
ENST00000438705.3
SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr13_-_33780133 0.11 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr9_+_101705893 0.11 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr22_-_29457832 0.11 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr2_+_46769798 0.11 ENST00000238738.4
RHOQ
ras homolog family member Q
chr11_-_14993819 0.11 ENST00000396372.2
ENST00000361010.3
ENST00000359642.3
ENST00000331587.4
CALCA
calcitonin-related polypeptide alpha
chr4_+_41937131 0.11 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr3_-_10547192 0.10 ENST00000360273.2
ENST00000343816.4
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr17_-_19651654 0.10 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr4_-_65275162 0.10 ENST00000381210.3
ENST00000507440.1
TECRL
trans-2,3-enoyl-CoA reductase-like
chr8_+_24151620 0.10 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr17_-_39324424 0.10 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr16_-_20367584 0.10 ENST00000570689.1
UMOD
uromodulin
chr15_+_58430567 0.10 ENST00000536493.1
AQP9
aquaporin 9
chr10_-_104211294 0.10 ENST00000239125.1
C10orf95
chromosome 10 open reading frame 95
chr19_-_4065730 0.10 ENST00000601588.1
ZBTB7A
zinc finger and BTB domain containing 7A
chr1_+_45212074 0.10 ENST00000372217.1
KIF2C
kinesin family member 2C
chr5_+_150404904 0.09 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr8_+_24298597 0.09 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr5_+_95997918 0.09 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
CAST
calpastatin
chr14_-_67826486 0.09 ENST00000555431.1
ENST00000554236.1
ENST00000555474.1
ATP6V1D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr14_+_93260642 0.09 ENST00000355976.2
GOLGA5
golgin A5
chr17_-_39538550 0.09 ENST00000394001.1
KRT34
keratin 34
chr11_+_62495997 0.09 ENST00000316461.4
TTC9C
tetratricopeptide repeat domain 9C
chr16_+_3507985 0.08 ENST00000421765.3
ENST00000360862.5
ENST00000414063.2
ENST00000610180.1
ENST00000608993.1
NAA60
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60
chr1_+_45212051 0.08 ENST00000372222.3
KIF2C
kinesin family member 2C
chr19_+_52076425 0.08 ENST00000436511.2
ZNF175
zinc finger protein 175
chr13_-_38172863 0.08 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr19_-_35992780 0.08 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN
dermokine
chr8_+_24298531 0.08 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr3_+_62304648 0.08 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr8_-_102216925 0.08 ENST00000517844.1
ZNF706
zinc finger protein 706
chr8_+_77318769 0.08 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr21_-_30365136 0.08 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1
listerin E3 ubiquitin protein ligase 1
chr2_+_103378472 0.08 ENST00000412401.2
TMEM182
transmembrane protein 182
chr19_-_3985455 0.07 ENST00000309311.6
EEF2
eukaryotic translation elongation factor 2
chr8_+_90914073 0.07 ENST00000297438.2
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr17_-_19651668 0.07 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr6_-_133055896 0.07 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr19_+_49258775 0.07 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr10_-_82049424 0.07 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr9_-_123639304 0.07 ENST00000436309.1
PHF19
PHD finger protein 19
chr17_-_26941179 0.07 ENST00000301037.5
ENST00000530121.1
ENST00000525510.1
ENST00000577790.1
ENST00000531839.1
ENST00000534850.1
SGK494
RP11-192H23.4
uncharacterized serine/threonine-protein kinase SgK494
Uncharacterized protein
chr1_-_161207875 0.07 ENST00000512372.1
ENST00000437437.2
ENST00000442691.2
ENST00000412844.2
ENST00000428574.2
ENST00000505005.1
ENST00000508740.1
ENST00000508387.1
ENST00000504010.1
ENST00000511676.1
ENST00000502985.1
ENST00000367981.3
ENST00000515621.1
ENST00000511944.1
ENST00000511748.1
ENST00000367984.4
ENST00000367985.3
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr14_+_21423611 0.07 ENST00000304625.2
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr1_-_161087802 0.07 ENST00000368010.3
PFDN2
prefoldin subunit 2
chr1_-_161207953 0.07 ENST00000367982.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr2_-_113594279 0.07 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr16_-_30102547 0.06 ENST00000279386.2
TBX6
T-box 6
chr2_-_239197201 0.06 ENST00000254658.3
PER2
period circadian clock 2
chr19_-_42947121 0.06 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr10_+_18629628 0.06 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr17_-_685493 0.06 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
GLOD4
glyoxalase domain containing 4
chr1_-_161208013 0.06 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr1_-_161207986 0.06 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr12_+_57624119 0.06 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr9_-_130712995 0.06 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr1_-_114429997 0.06 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2-like 15
chr14_+_65453432 0.05 ENST00000246166.2
FNTB
farnesyltransferase, CAAX box, beta
chr16_+_3508063 0.05 ENST00000576787.1
ENST00000572942.1
ENST00000576916.1
ENST00000575076.1
ENST00000572131.1
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr8_-_102217515 0.05 ENST00000520347.1
ENST00000523922.1
ENST00000520984.1
ZNF706
zinc finger protein 706
chr1_+_11249398 0.05 ENST00000376819.3
ANGPTL7
angiopoietin-like 7
chr5_+_126988732 0.05 ENST00000395322.3
CTXN3
cortexin 3
chr2_-_225362533 0.04 ENST00000451538.1
CUL3
cullin 3
chr2_+_102608306 0.04 ENST00000332549.3
IL1R2
interleukin 1 receptor, type II
chr8_+_7801144 0.04 ENST00000443676.1
ZNF705B
zinc finger protein 705B

Network of associatons between targets according to the STRING database.

First level regulatory network of HLF_TEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0044861 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
0.2 0.6 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.2 0.6 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 0.9 GO:0048880 sensory system development(GO:0048880)
0.1 0.8 GO:0009804 coumarin metabolic process(GO:0009804)
0.1 0.5 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.9 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.4 GO:0046449 creatinine metabolic process(GO:0046449) cellular response to UV-A(GO:0071492)
0.1 0.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.3 GO:1902159 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.1 0.6 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 1.2 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.1 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.5 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.2 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.4 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 0.2 GO:1904640 response to methionine(GO:1904640)
0.0 0.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.1 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.3 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:1903286 regulation of potassium ion import(GO:1903286)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0070487 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) monocyte aggregation(GO:0070487)
0.0 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.1 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.7 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:0030952 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.1 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.2 GO:0006983 ER overload response(GO:0006983)
0.0 0.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.4 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.9 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.4 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.3 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 2.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 3.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0098651 basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0008478 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.2 0.9 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 2.0 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.4 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.1 0.2 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.3 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.1 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.1 GO:0031716 calcitonin receptor binding(GO:0031716)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.2 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 5.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.6 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.9 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.5 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis