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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HMBOX1
Z-value: 0.56
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Transcription factors associated with HMBOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMBOX1 | hg19_v2_chr8_+_28747884_28747938 | -0.19 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_22234381 Show fit | 1.01 |
ENST00000458533.1
|
Rap guanine nucleotide exchange factor (GEF) 5 |
|
| chr12_-_56236734 Show fit | 0.79 |
ENST00000548629.1
|
matrix metallopeptidase 19 |
|
| chr2_+_162087577 Show fit | 0.76 |
ENST00000439442.1
|
TRAF family member-associated NFKB activator |
|
| chr14_+_22615942 Show fit | 0.63 |
ENST00000390457.2
|
T cell receptor alpha variable 27 |
|
| chr1_-_173176452 Show fit | 0.61 |
ENST00000281834.3
|
tumor necrosis factor (ligand) superfamily, member 4 |
|
| chr7_+_128095900 Show fit | 0.56 |
ENST00000435296.2
|
hypoxia inducible lipid droplet-associated |
|
| chr8_-_63951730 Show fit | 0.55 |
ENST00000260118.6
|
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
|
| chr9_-_73029540 Show fit | 0.55 |
ENST00000377126.2
|
Kruppel-like factor 9 |
|
| chr7_+_128095945 Show fit | 0.48 |
ENST00000257696.4
|
hypoxia inducible lipid droplet-associated |
|
| chr11_+_19798964 Show fit | 0.47 |
ENST00000527559.2
|
neuron navigator 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMBOX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0035425 | autocrine signaling(GO:0035425) |
| 0.1 | 0.8 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.8 | GO:0001554 | luteolysis(GO:0001554) |
| 0.2 | 0.6 | GO:2000525 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.2 | 0.6 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.2 | 0.5 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.1 | 0.5 | GO:0035936 | testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
| 0.1 | 0.5 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.1 | 0.5 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.0 | 0.5 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.5 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.3 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.0 | 0.3 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.2 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 0.2 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.8 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 0.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.6 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 0.5 | GO:0036435 | K48-linked polyubiquitin binding(GO:0036435) |
| 0.1 | 0.5 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363) |
| 0.0 | 0.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 0.4 | GO:0005174 | CD40 receptor binding(GO:0005174) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.2 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |