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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HMGA2

Z-value: 0.47

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218212_66218244-0.414.1e-02Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_193853927 1.42 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr1_-_76398077 1.09 ENST00000284142.6
ASB17
ankyrin repeat and SOCS box containing 17
chr13_+_50656307 0.84 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chrY_+_22918021 0.83 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr15_-_70994612 0.60 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_-_183387430 0.59 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_+_1417228 0.58 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr15_+_84904525 0.57 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr9_+_2157655 0.55 ENST00000452193.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr12_-_10541575 0.51 ENST00000540818.1
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr1_+_196621002 0.51 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr2_+_177134201 0.42 ENST00000452865.1
MTX2
metaxin 2
chr9_+_42704004 0.41 ENST00000457288.1
CBWD7
COBW domain containing 7
chr11_+_73661364 0.41 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr2_+_177134134 0.39 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr6_-_29324054 0.39 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr10_+_35456444 0.38 ENST00000361599.4
CREM
cAMP responsive element modulator
chr9_+_104296122 0.38 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr19_+_41882466 0.37 ENST00000436170.2
TMEM91
transmembrane protein 91
chr15_+_83098710 0.36 ENST00000561062.1
ENST00000358583.3
GOLGA6L9
golgin A6 family-like 20
chr6_+_123110302 0.36 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr1_+_196621156 0.36 ENST00000359637.2
CFH
complement factor H
chr5_-_135290705 0.35 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr10_-_5046042 0.35 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr15_+_82722225 0.35 ENST00000300515.8
GOLGA6L9
golgin A6 family-like 9
chr2_+_235887329 0.34 ENST00000409212.1
ENST00000344528.4
ENST00000444916.1
SH3BP4
SH3-domain binding protein 4
chr14_+_88852059 0.34 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr2_+_170683979 0.33 ENST00000418381.1
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr2_+_170683942 0.32 ENST00000272793.5
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr2_-_183387064 0.30 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr17_-_295730 0.27 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr2_-_183387283 0.25 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr15_+_58702742 0.24 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr3_-_123680246 0.23 ENST00000488653.2
CCDC14
coiled-coil domain containing 14
chr19_-_38146289 0.22 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
ZFP30
ZFP30 zinc finger protein
chr6_-_52705641 0.21 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr4_+_25378912 0.20 ENST00000510092.1
ENST00000505991.1
ANAPC4
anaphase promoting complex subunit 4
chr3_-_157221128 0.20 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr9_-_34729457 0.20 ENST00000378788.3
FAM205A
family with sequence similarity 205, member A
chr7_+_80275953 0.18 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr17_-_26220366 0.18 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr7_+_80267973 0.17 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr13_+_51483814 0.16 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr12_-_8765446 0.15 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr12_-_122750957 0.15 ENST00000451053.2
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr12_-_10324716 0.15 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chrX_-_7895479 0.15 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr12_+_113587558 0.14 ENST00000335621.6
CCDC42B
coiled-coil domain containing 42B
chrX_-_7895755 0.14 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4
patatin-like phospholipase domain containing 4
chrX_-_153523462 0.13 ENST00000361930.3
ENST00000369926.1
TEX28
testis expressed 28
chr6_-_127664736 0.13 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
ECHDC1
enoyl CoA hydratase domain containing 1
chr21_+_38792602 0.13 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr1_+_227751231 0.12 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
ZNF678
zinc finger protein 678
chr6_+_116892641 0.12 ENST00000487832.2
ENST00000518117.1
RWDD1
RWD domain containing 1
chrX_-_135962876 0.11 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chrX_-_77150911 0.11 ENST00000373336.3
MAGT1
magnesium transporter 1
chr11_+_67250490 0.09 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr2_-_216257849 0.09 ENST00000456923.1
FN1
fibronectin 1
chr11_-_130786400 0.09 ENST00000265909.4
SNX19
sorting nexin 19
chr3_-_106959424 0.08 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
LINC00882
long intergenic non-protein coding RNA 882
chr9_-_115480303 0.08 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INIP
INTS3 and NABP interacting protein
chr20_-_31989307 0.08 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr18_-_14132422 0.08 ENST00000589498.1
ENST00000590202.1
ZNF519
zinc finger protein 519
chr21_-_31852663 0.07 ENST00000390689.2
KRTAP19-1
keratin associated protein 19-1
chr17_-_76220740 0.07 ENST00000600484.1
AC087645.1
Uncharacterized protein
chr5_-_102455801 0.07 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr6_-_132967142 0.07 ENST00000275216.1
TAAR1
trace amine associated receptor 1
chr11_+_65122216 0.07 ENST00000309880.5
TIGD3
tigger transposable element derived 3
chr6_-_127664683 0.07 ENST00000528402.1
ENST00000454591.2
ECHDC1
enoyl CoA hydratase domain containing 1
chr19_-_11456722 0.06 ENST00000354882.5
TMEM205
transmembrane protein 205
chr19_-_11457082 0.05 ENST00000587948.1
TMEM205
transmembrane protein 205
chr15_-_82939157 0.05 ENST00000559949.1
RP13-996F3.5
golgin A6 family-like 18
chr15_-_83018198 0.05 ENST00000557886.1
RP13-996F3.4
golgin A6 family-like 19
chr11_+_60163775 0.05 ENST00000300187.6
ENST00000395005.2
MS4A14
membrane-spanning 4-domains, subfamily A, member 14
chr3_+_186501336 0.05 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr2_+_120436733 0.05 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
TMEM177
transmembrane protein 177
chr7_-_102985035 0.05 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr19_-_11457162 0.04 ENST00000590482.1
TMEM205
transmembrane protein 205
chr19_+_11457175 0.04 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr19_-_11456905 0.04 ENST00000588560.1
ENST00000592952.1
TMEM205
transmembrane protein 205
chr17_-_4607335 0.04 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
PELP1
proline, glutamate and leucine rich protein 1
chr3_+_106959530 0.04 ENST00000466734.1
ENST00000463143.1
ENST00000490441.1
LINC00883
long intergenic non-protein coding RNA 883
chr3_+_137728842 0.04 ENST00000183605.5
CLDN18
claudin 18
chrX_-_134186144 0.03 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr17_+_73230799 0.03 ENST00000579838.1
NUP85
nucleoporin 85kDa
chr18_-_29340827 0.02 ENST00000269205.5
SLC25A52
solute carrier family 25, member 52
chr18_-_21017817 0.02 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241
transmembrane protein 241
chr5_+_36608422 0.02 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_71792477 0.02 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr19_-_43099070 0.02 ENST00000244336.5
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr19_-_11456872 0.02 ENST00000586218.1
TMEM205
transmembrane protein 205
chr15_+_30427352 0.02 ENST00000569052.1
GOLGA8T
golgin A8 family, member T
chr19_-_11456935 0.01 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
TMEM205
RAB3D
transmembrane protein 205
RAB3D, member RAS oncogene family
chr6_+_29426230 0.01 ENST00000442615.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr11_+_60260248 0.01 ENST00000526784.1
ENST00000016913.4
ENST00000537076.1
ENST00000530007.1
MS4A12
membrane-spanning 4-domains, subfamily A, member 12
chr2_-_130031335 0.01 ENST00000375987.3
AC079586.1
AC079586.1
chr15_+_28623784 0.01 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
GOLGA8F
golgin A8 family, member F
chr1_-_43638168 0.01 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chrX_+_135614293 0.00 ENST00000370634.3
VGLL1
vestigial like 1 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0045608 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.2 0.5 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.4 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 1.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.2 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.3 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.6 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.6 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.3 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.4 GO:0051087 chaperone binding(GO:0051087)
0.0 0.8 GO:0019843 rRNA binding(GO:0019843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import