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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HMX3
Z-value: 0.87
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Transcription factors associated with HMX3
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_101439242 Show fit | 2.96 |
ENST00000296420.4
|
endomucin |
|
| chr4_+_156588249 Show fit | 2.79 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_-_90756769 Show fit | 2.48 |
ENST00000345009.4
ENST00000505199.1 ENST00000502987.1 |
synuclein, alpha (non A4 component of amyloid precursor) |
|
| chr4_-_101439148 Show fit | 2.32 |
ENST00000511970.1
ENST00000502569.1 ENST00000305864.3 |
endomucin |
|
| chr12_-_10022735 Show fit | 2.17 |
ENST00000228438.2
|
C-type lectin domain family 2, member B |
|
| chr17_+_39394250 Show fit | 2.07 |
ENST00000254072.6
|
keratin associated protein 9-8 |
|
| chr4_-_90759440 Show fit | 2.00 |
ENST00000336904.3
|
synuclein, alpha (non A4 component of amyloid precursor) |
|
| chr2_+_173686303 Show fit | 1.81 |
ENST00000397087.3
|
Rap guanine nucleotide exchange factor (GEF) 4 |
|
| chr9_+_71986182 Show fit | 1.77 |
ENST00000303068.7
|
family with sequence similarity 189, member A2 |
|
| chr8_-_93029865 Show fit | 1.73 |
ENST00000422361.2
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.1 | GO:1903285 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 3.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 2.8 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.1 | 2.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 2.3 | GO:0031424 | keratinization(GO:0031424) |
| 0.3 | 2.1 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.1 | 2.1 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.1 | 2.0 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 1.8 | GO:0090022 | regulation of neutrophil chemotaxis(GO:0090022) |
| 0.0 | 1.7 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 2.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 2.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.9 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 1.6 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 1.4 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 1.3 | GO:0070652 | HAUS complex(GO:0070652) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 2.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 2.2 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 2.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 2.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.2 | 1.9 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 1.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.3 | 1.4 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 1.4 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 1.4 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.1 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 1.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.8 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.8 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.6 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 2.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.7 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.1 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 1.1 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |