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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HNF1A_HNF1B

Z-value: 0.93

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1 homeobox A
HNF1B
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416489_1214165520.262.1e-01Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_76944621 3.00 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_-_154751629 2.98 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr5_+_176514413 2.08 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr22_-_30968813 1.72 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr2_+_27719697 1.49 ENST00000264717.2
ENST00000424318.2
GCKR
glucokinase (hexokinase 4) regulator
chr16_-_69385681 1.37 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr4_+_74347400 1.19 ENST00000226355.3
AFM
afamin
chr10_+_99344071 1.12 ENST00000370647.4
ENST00000370646.4
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr15_+_67418047 1.11 ENST00000540846.2
SMAD3
SMAD family member 3
chr5_-_61031495 1.09 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr16_-_57831914 1.06 ENST00000421376.2
KIFC3
kinesin family member C3
chr4_+_100495864 1.02 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr1_+_17906970 1.02 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr3_-_157221357 0.98 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr4_+_155484155 0.98 ENST00000509493.1
FGB
fibrinogen beta chain
chr3_-_157221380 0.94 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr12_+_93096759 0.87 ENST00000544406.2
C12orf74
chromosome 12 open reading frame 74
chr15_-_99057551 0.87 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr22_-_30970560 0.87 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr12_+_93096619 0.81 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chr12_-_39837192 0.81 ENST00000361961.3
ENST00000395670.3
KIF21A
kinesin family member 21A
chr7_-_47579188 0.79 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr6_-_161085291 0.77 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr10_+_74451883 0.75 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr11_+_64323098 0.72 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr4_+_8201091 0.69 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr2_-_47572105 0.68 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr16_-_55909211 0.68 ENST00000520435.1
CES5A
carboxylesterase 5A
chr16_-_55909255 0.66 ENST00000290567.9
CES5A
carboxylesterase 5A
chr16_-_55909272 0.66 ENST00000319165.9
CES5A
carboxylesterase 5A
chr14_+_65171315 0.66 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_-_64225508 0.63 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_-_94759595 0.62 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_-_69536346 0.61 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr14_-_94759408 0.60 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_+_73642315 0.59 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr1_+_205197304 0.58 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr14_-_94759361 0.57 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_42984330 0.57 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_107729887 0.56 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr4_-_69817481 0.54 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr17_+_73642486 0.52 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr20_-_7921090 0.50 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr14_-_57960545 0.50 ENST00000526336.1
ENST00000216445.3
C14orf105
chromosome 14 open reading frame 105
chr19_+_39138271 0.50 ENST00000252699.2
ACTN4
actinin, alpha 4
chr14_+_65171099 0.49 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr16_-_66952742 0.49 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chr6_+_54173227 0.49 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr11_+_64323156 0.48 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr16_-_66952779 0.47 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr12_+_100750846 0.46 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chrX_-_105282712 0.46 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr4_+_155484103 0.45 ENST00000302068.4
FGB
fibrinogen beta chain
chrX_-_15683147 0.43 ENST00000380342.3
TMEM27
transmembrane protein 27
chr16_-_87970122 0.42 ENST00000309893.2
CA5A
carbonic anhydrase VA, mitochondrial
chr6_+_50061315 0.42 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr19_+_39138320 0.42 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
ACTN4
actinin, alpha 4
chr16_-_57831676 0.40 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3
kinesin family member C3
chr17_+_41363854 0.39 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr3_+_75955817 0.39 ENST00000487694.3
ENST00000602589.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr6_-_29013017 0.38 ENST00000377175.1
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr1_+_48688357 0.37 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr2_-_68052694 0.37 ENST00000457448.1
AC010987.6
AC010987.6
chr14_+_95027772 0.37 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr9_-_215744 0.36 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr2_-_228244013 0.36 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr21_-_19775973 0.35 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr1_-_168464875 0.33 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr6_+_54172653 0.33 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr1_-_197036364 0.33 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr4_+_169013666 0.32 ENST00000359299.3
ANXA10
annexin A10
chr4_-_155511887 0.32 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr12_+_70132632 0.31 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3IP
RAB3A interacting protein
chr12_-_91574142 0.30 ENST00000547937.1
DCN
decorin
chr12_+_40787194 0.30 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr2_+_182850743 0.29 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr10_+_111765562 0.29 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr11_-_117695449 0.29 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr7_+_45927956 0.29 ENST00000275525.3
ENST00000457280.1
IGFBP1
insulin-like growth factor binding protein 1
chr10_-_61495760 0.28 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr9_-_123812542 0.28 ENST00000223642.1
C5
complement component 5
chr17_+_4692230 0.28 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr4_+_3443614 0.27 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr2_-_99917639 0.27 ENST00000308528.4
LYG1
lysozyme G-like 1
chr13_-_103719196 0.27 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr3_-_137834436 0.27 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr7_-_115608304 0.27 ENST00000457268.1
TFEC
transcription factor EC
chr7_+_141695633 0.27 ENST00000549489.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr1_-_159684371 0.27 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr20_+_35973080 0.27 ENST00000445403.1
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr1_+_119911425 0.26 ENST00000361035.4
ENST00000325945.3
HAO2
hydroxyacid oxidase 2 (long chain)
chr7_+_141695671 0.26 ENST00000497673.1
ENST00000475668.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr5_+_6714718 0.26 ENST00000230859.6
ENST00000515721.1
PAPD7
PAP associated domain containing 7
chr6_+_7541845 0.25 ENST00000418664.2
DSP
desmoplakin
chrX_-_124097620 0.25 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr8_-_70745575 0.25 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr7_+_23749767 0.25 ENST00000355870.3
STK31
serine/threonine kinase 31
chr22_+_32439019 0.25 ENST00000266088.4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr2_-_88427568 0.25 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr6_-_127840453 0.24 ENST00000556132.1
SOGA3
SOGA family member 3
chr6_+_167704798 0.24 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr6_+_167704838 0.24 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chrX_+_1710484 0.24 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr3_-_192445289 0.23 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr22_-_38506619 0.23 ENST00000332536.5
ENST00000381669.3
BAIAP2L2
BAI1-associated protein 2-like 2
chr6_+_12717892 0.23 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr22_-_32651326 0.23 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr11_+_560956 0.22 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr17_+_41052808 0.22 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr3_+_183948161 0.21 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr15_+_58430368 0.21 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr7_-_87856303 0.21 ENST00000394641.3
SRI
sorcin
chr7_-_87856280 0.21 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr8_+_104892639 0.21 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr6_+_126070726 0.21 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr7_+_45928079 0.20 ENST00000468955.1
IGFBP1
insulin-like growth factor binding protein 1
chr15_+_58430567 0.20 ENST00000536493.1
AQP9
aquaporin 9
chr1_+_104293028 0.20 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr4_+_71494461 0.20 ENST00000396073.3
ENAM
enamelin
chr17_+_79953310 0.20 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr8_-_87755878 0.19 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr4_-_72649763 0.19 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chr4_+_39408470 0.18 ENST00000257408.4
KLB
klotho beta
chr22_+_45098067 0.18 ENST00000336985.6
ENST00000403696.1
ENST00000457960.1
ENST00000361473.5
PRR5
PRR5-ARHGAP8
proline rich 5 (renal)
PRR5-ARHGAP8 readthrough
chr10_-_128359074 0.17 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr4_-_70518941 0.17 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr8_+_20054878 0.17 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr16_+_21244986 0.17 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_-_26743546 0.16 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr5_+_140772381 0.16 ENST00000398604.2
PCDHGA8
protocadherin gamma subfamily A, 8
chr3_+_63428752 0.16 ENST00000295894.5
SYNPR
synaptoporin
chr6_-_127840336 0.16 ENST00000525778.1
SOGA3
SOGA family member 3
chr7_-_44580861 0.16 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr11_-_128894053 0.16 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr3_+_185431080 0.16 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr9_+_140125385 0.16 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr11_+_46740730 0.15 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr8_-_95220775 0.15 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr9_-_94712434 0.15 ENST00000375708.3
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr11_+_1860200 0.15 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr18_+_5748793 0.15 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
RP11-945C19.1
chr5_-_138718973 0.14 ENST00000353963.3
ENST00000348729.3
SLC23A1
solute carrier family 23 (ascorbic acid transporter), member 1
chr11_+_2405833 0.14 ENST00000527343.1
ENST00000464784.2
CD81
CD81 molecule
chr6_-_127840021 0.14 ENST00000465909.2
SOGA3
SOGA family member 3
chr10_-_75193308 0.14 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chrX_-_15619076 0.14 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr2_-_158300556 0.13 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr9_+_82186872 0.13 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_104159999 0.13 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr6_+_131571535 0.13 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr12_-_18243119 0.13 ENST00000538724.1
ENST00000229002.2
RERGL
RERG/RAS-like
chr10_+_135340859 0.13 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr4_+_187187337 0.13 ENST00000492972.2
F11
coagulation factor XI
chr6_-_133084580 0.12 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr9_-_98079965 0.12 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr10_-_52645416 0.12 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr12_-_102874416 0.12 ENST00000392904.1
ENST00000337514.6
IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_117747015 0.12 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr6_-_25874440 0.12 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr4_+_14113592 0.12 ENST00000502759.1
ENST00000511200.1
ENST00000512754.1
ENST00000506739.1
LINC01085
long intergenic non-protein coding RNA 1085
chrX_+_36254051 0.12 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr17_+_26800648 0.11 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr19_+_54466179 0.11 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr17_+_26800296 0.11 ENST00000444914.3
ENST00000314669.5
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr4_+_74269956 0.11 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr6_+_47624172 0.11 ENST00000507065.1
ENST00000296862.1
GPR111
G protein-coupled receptor 111
chr2_+_182850551 0.11 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr17_+_26800756 0.10 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr9_+_140125209 0.10 ENST00000538474.1
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr12_+_122242597 0.10 ENST00000267197.5
SETD1B
SET domain containing 1B
chr1_-_110284384 0.10 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr6_+_29141311 0.10 ENST00000377167.2
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr4_-_1166954 0.10 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
SPON2
spondin 2, extracellular matrix protein
chr12_-_54653313 0.09 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr22_-_22337154 0.09 ENST00000413067.2
ENST00000437929.1
ENST00000456075.1
ENST00000434517.1
ENST00000424393.1
ENST00000449704.1
ENST00000437103.1
TOP3B
topoisomerase (DNA) III beta
chr12_-_102874378 0.09 ENST00000456098.1
IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_-_164796269 0.09 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr17_-_26733179 0.09 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr7_+_152456829 0.09 ENST00000377776.3
ENST00000256001.8
ENST00000397282.2
ACTR3B
ARP3 actin-related protein 3 homolog B (yeast)
chr12_-_24102576 0.09 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
SOX5
SRY (sex determining region Y)-box 5
chr11_-_83393457 0.08 ENST00000404783.3
DLG2
discs, large homolog 2 (Drosophila)
chr19_+_6464243 0.08 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chr19_-_42133420 0.08 ENST00000221954.2
ENST00000600925.1
CEACAM4
carcinoembryonic antigen-related cell adhesion molecule 4
chr22_-_32767017 0.08 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr5_-_10761206 0.08 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr10_+_115312766 0.08 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr1_-_20141763 0.08 ENST00000375121.2
RNF186
ring finger protein 186
chr16_+_20462783 0.07 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr14_+_62585332 0.07 ENST00000554895.1
LINC00643
long intergenic non-protein coding RNA 643
chr16_+_81272287 0.07 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr16_+_89696692 0.07 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr14_+_39703084 0.07 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr4_+_159443024 0.07 ENST00000448688.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr19_+_6464502 0.07 ENST00000308243.7
CRB3
crumbs homolog 3 (Drosophila)
chr10_+_101542462 0.07 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_153585539 0.06 ENST00000368706.4
S100A16
S100 calcium binding protein A16
chr17_-_49021974 0.06 ENST00000501718.2
RP11-700H6.1
RP11-700H6.1
chr6_+_106534192 0.06 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr16_-_420338 0.06 ENST00000450882.1
ENST00000441883.1
ENST00000447696.1
ENST00000389675.2
MRPL28
mitochondrial ribosomal protein L28
chr22_-_32766972 0.06 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.3 1.9 GO:1903412 response to bile acid(GO:1903412)
0.3 0.9 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.3 3.0 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509)
0.3 2.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 1.8 GO:0008218 bioluminescence(GO:0008218)
0.2 1.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 1.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 1.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.7 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.1 0.7 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 3.0 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 1.5 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.4 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.2 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.1 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.3 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.5 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.2 GO:1904106 protein localization to microvillus(GO:1904106)
0.1 0.3 GO:0051801 cytolysis in other organism involved in symbiotic interaction(GO:0051801)
0.1 0.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.2 GO:0033625 germinal center B cell differentiation(GO:0002314) positive regulation of integrin activation(GO:0033625)
0.0 0.1 GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.2 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.5 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.3 GO:0071896 protein localization to adherens junction(GO:0071896) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.3 GO:0051180 vitamin transport(GO:0051180)
0.0 0.2 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) sodium-dependent phosphate transport(GO:0044341) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.2 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 0.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.6 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.8 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.3 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.0 0.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.1 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.2 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.7 GO:1990246 uniplex complex(GO:1990246)
0.1 1.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.4 GO:0097182 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 1.5 GO:0005915 zonula adherens(GO:0005915)
0.1 0.8 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.9 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 1.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.3 1.2 GO:0008431 vitamin E binding(GO:0008431)
0.3 2.6 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.3 0.8 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 1.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 0.7 GO:0016160 amylase activity(GO:0016160)
0.2 1.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 1.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 0.4 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.8 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 1.0 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.3 GO:0033265 choline binding(GO:0033265)
0.1 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.4 GO:0032190 acrosin binding(GO:0032190)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.8 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.1 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.9 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.1 PID FGF PATHWAY FGF signaling pathway
0.0 1.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 3.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.7 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.5 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.0 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation