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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HNF1A_HNF1B
Z-value: 0.93
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Transcription factors associated with HNF1A_HNF1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF1A | hg19_v2_chr12_+_121416489_121416552 | 0.26 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76944621 Show fit | 3.00 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr6_-_154751629 Show fit | 2.98 |
ENST00000424998.1
|
CNKSR family member 3 |
|
| chr5_+_176514413 Show fit | 2.08 |
ENST00000513166.1
|
fibroblast growth factor receptor 4 |
|
| chr22_-_30968813 Show fit | 1.72 |
ENST00000443111.2
ENST00000443136.1 ENST00000426220.1 |
galactose-3-O-sulfotransferase 1 |
|
| chr2_+_27719697 Show fit | 1.49 |
ENST00000264717.2
ENST00000424318.2 |
glucokinase (hexokinase 4) regulator |
|
| chr16_-_69385681 Show fit | 1.37 |
ENST00000288025.3
|
transmembrane emp24 protein transport domain containing 6 |
|
| chr4_+_74347400 Show fit | 1.19 |
ENST00000226355.3
|
afamin |
|
| chr10_+_99344071 Show fit | 1.12 |
ENST00000370647.4
ENST00000370646.4 |
4-hydroxy-2-oxoglutarate aldolase 1 |
|
| chr15_+_67418047 Show fit | 1.11 |
ENST00000540846.2
|
SMAD family member 3 |
|
| chr5_-_61031495 Show fit | 1.09 |
ENST00000506550.1
ENST00000512882.2 |
CTD-2170G1.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF1A_HNF1B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.0 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.1 | 3.0 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.3 | 2.6 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.3 | 1.9 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.3 | 1.8 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.2 | 1.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 1.7 | GO:0034197 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.2 | 1.5 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.2 | 1.5 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 1.5 | GO:0046415 | urate metabolic process(GO:0046415) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 1.1 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.7 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 0.5 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.1 | 0.4 | GO:0097182 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.1 | 0.4 | GO:0044326 | dendritic spine neck(GO:0044326) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.3 | 2.6 | GO:0050694 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 2.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 1.9 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 1.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 1.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 1.5 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.3 | 1.2 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.2 | 1.1 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.2 | 1.1 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 2.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.1 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 1.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.6 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 2.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.9 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 1.7 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.0 | 1.5 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.5 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.0 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 1.0 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |