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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HNF4A

Z-value: 0.60

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Transcription factors associated with HNF4A

Gene Symbol Gene ID Gene Info
HNF4A
ENSG00000101076.12 hepatocyte nuclear factor 4 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF4Ahg19_v2_chr20_+_42984330_42984445-0.213.1e-01Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_95009837 1.92 ENST00000551457.1
TMCC3
transmembrane and coiled-coil domain family 3
chr1_+_78511586 1.50 ENST00000370759.3
GIPC2
GIPC PDZ domain containing family, member 2
chrX_+_118108601 1.03 ENST00000371628.3
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr14_+_38677123 0.99 ENST00000267377.2
SSTR1
somatostatin receptor 1
chrX_+_66764375 0.98 ENST00000374690.3
AR
androgen receptor
chrX_+_118108571 0.92 ENST00000304778.7
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr2_-_222436988 0.91 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
EPHA4
EPH receptor A4
chr11_-_62997124 0.90 ENST00000306494.6
SLC22A25
solute carrier family 22, member 25
chr18_+_29769978 0.85 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr10_-_17171817 0.85 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr17_-_7082861 0.78 ENST00000269299.3
ASGR1
asialoglycoprotein receptor 1
chr19_-_48867291 0.78 ENST00000435956.3
TMEM143
transmembrane protein 143
chr2_+_191792376 0.76 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr6_+_30881982 0.70 ENST00000321897.5
ENST00000416670.2
ENST00000542001.1
ENST00000428017.1
VARS2
valyl-tRNA synthetase 2, mitochondrial
chr19_+_18496957 0.68 ENST00000252809.3
GDF15
growth differentiation factor 15
chr19_-_48867171 0.68 ENST00000377431.2
ENST00000436660.2
ENST00000541566.1
TMEM143
transmembrane protein 143
chr10_-_116444371 0.65 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr13_+_50656307 0.64 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr6_+_30882108 0.63 ENST00000541562.1
ENST00000421263.1
VARS2
valyl-tRNA synthetase 2, mitochondrial
chr1_-_11863171 0.58 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_-_42812143 0.55 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr12_+_121416437 0.51 ENST00000402929.1
ENST00000535955.1
ENST00000538626.1
ENST00000543427.1
HNF1A
HNF1 homeobox A
chr6_+_143999072 0.46 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
PHACTR2
phosphatase and actin regulator 2
chr2_-_219433014 0.45 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr20_-_36156125 0.44 ENST00000397135.1
ENST00000397137.1
BLCAP
bladder cancer associated protein
chr13_+_113777105 0.44 ENST00000409306.1
ENST00000375551.3
ENST00000375559.3
F10
coagulation factor X
chr12_-_6665200 0.43 ENST00000336604.4
ENST00000396840.2
ENST00000356896.4
IFFO1
intermediate filament family orphan 1
chr20_-_36156293 0.43 ENST00000373537.2
ENST00000414542.2
BLCAP
bladder cancer associated protein
chr9_-_116065551 0.43 ENST00000297894.5
RNF183
ring finger protein 183
chr2_+_159313452 0.43 ENST00000389757.3
ENST00000389759.3
PKP4
plakophilin 4
chr6_-_30080863 0.42 ENST00000540829.1
TRIM31
tripartite motif containing 31
chr10_+_70320413 0.42 ENST00000373644.4
TET1
tet methylcytosine dioxygenase 1
chr16_+_8768422 0.41 ENST00000268251.8
ENST00000564714.1
ABAT
4-aminobutyrate aminotransferase
chr3_-_158390282 0.39 ENST00000264265.3
LXN
latexin
chr14_+_64680854 0.39 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr3_-_125775629 0.39 ENST00000383598.2
SLC41A3
solute carrier family 41, member 3
chr16_+_81272287 0.38 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr11_+_118868830 0.36 ENST00000334418.1
CCDC84
coiled-coil domain containing 84
chr1_+_94883991 0.36 ENST00000370214.4
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
chr1_-_167059830 0.35 ENST00000367868.3
GPA33
glycoprotein A33 (transmembrane)
chr12_-_118810688 0.35 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr6_+_147527103 0.35 ENST00000179882.6
STXBP5
syntaxin binding protein 5 (tomosyn)
chr7_+_100663353 0.35 ENST00000306151.4
MUC17
mucin 17, cell surface associated
chr8_-_16859690 0.34 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr12_-_109219937 0.34 ENST00000546697.1
SSH1
slingshot protein phosphatase 1
chr7_-_15601595 0.34 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr8_+_70404996 0.32 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr2_-_28113217 0.32 ENST00000444339.2
RBKS
ribokinase
chr8_+_96037205 0.32 ENST00000396124.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr1_+_94883931 0.32 ENST00000394233.2
ENST00000454898.2
ENST00000536817.1
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
chr20_-_36661826 0.32 ENST00000373448.2
ENST00000373447.3
TTI1
TELO2 interacting protein 1
chr1_-_50489547 0.31 ENST00000371836.1
ENST00000371839.1
ENST00000371838.1
AGBL4
ATP/GTP binding protein-like 4
chr3_+_9745510 0.31 ENST00000383831.3
CPNE9
copine family member IX
chr3_-_53878644 0.31 ENST00000481668.1
ENST00000467802.1
CHDH
choline dehydrogenase
chr8_+_96037255 0.30 ENST00000286687.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr10_+_52152766 0.30 ENST00000596442.1
AC069547.2
Uncharacterized protein
chr6_-_31864977 0.30 ENST00000395728.3
ENST00000375528.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr22_+_19950060 0.29 ENST00000449653.1
COMT
catechol-O-methyltransferase
chr6_+_43028182 0.28 ENST00000394058.1
KLC4
kinesin light chain 4
chr1_+_94884023 0.28 ENST00000315713.5
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
chr5_-_42811986 0.28 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr17_+_27369918 0.27 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr1_-_60392452 0.27 ENST00000371204.3
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr4_+_113152978 0.26 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr10_+_102106829 0.26 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr8_+_22436635 0.26 ENST00000452226.1
ENST00000397760.4
ENST00000339162.7
ENST00000397761.2
PDLIM2
PDZ and LIM domain 2 (mystique)
chr2_-_62733476 0.26 ENST00000335390.5
TMEM17
transmembrane protein 17
chr6_+_31691121 0.26 ENST00000480039.1
ENST00000375810.4
ENST00000375805.2
ENST00000375809.3
ENST00000375804.2
ENST00000375814.3
ENST00000375806.2
C6orf25
chromosome 6 open reading frame 25
chr2_-_180871780 0.26 ENST00000410053.3
ENST00000295749.6
ENST00000404136.2
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr1_+_199996733 0.25 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr16_+_66600294 0.25 ENST00000535705.1
ENST00000332695.7
ENST00000336328.6
ENST00000528324.1
ENST00000531885.1
ENST00000529506.1
ENST00000457188.2
ENST00000533666.1
ENST00000533953.1
ENST00000379500.2
ENST00000328020.6
CMTM1
CKLF-like MARVEL transmembrane domain containing 1
chr12_-_54121261 0.24 ENST00000549784.1
ENST00000262059.4
CALCOCO1
calcium binding and coiled-coil domain 1
chr3_-_49851313 0.23 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr3_-_141868357 0.22 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_+_79950463 0.22 ENST00000265081.6
MSH3
mutS homolog 3
chr8_+_104831554 0.21 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr12_-_54121212 0.21 ENST00000548263.1
ENST00000430117.2
ENST00000550804.1
ENST00000549173.1
ENST00000551900.1
ENST00000546619.1
ENST00000548177.1
ENST00000549349.1
CALCOCO1
calcium binding and coiled-coil domain 1
chr6_-_30080876 0.21 ENST00000376734.3
TRIM31
tripartite motif containing 31
chr22_-_31063782 0.21 ENST00000404885.1
ENST00000403268.1
ENST00000407308.1
ENST00000342474.4
ENST00000334679.3
DUSP18
dual specificity phosphatase 18
chr10_+_104404218 0.20 ENST00000302424.7
TRIM8
tripartite motif containing 8
chr19_-_14201776 0.20 ENST00000269724.5
SAMD1
sterile alpha motif domain containing 1
chr17_+_1646130 0.20 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr2_+_219135115 0.20 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr22_+_30163340 0.20 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr13_+_76334498 0.19 ENST00000534657.1
LMO7
LIM domain 7
chr3_+_46919235 0.19 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr9_-_71155783 0.19 ENST00000377311.3
TMEM252
transmembrane protein 252
chr4_-_10023095 0.19 ENST00000264784.3
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chrX_-_77041685 0.19 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr5_-_102455801 0.19 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr4_+_113152881 0.18 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr9_+_27109133 0.18 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr1_+_241695424 0.18 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_+_63898275 0.18 ENST00000538065.1
ATXN7
ataxin 7
chr17_-_7082668 0.18 ENST00000573083.1
ENST00000574388.1
ASGR1
asialoglycoprotein receptor 1
chr1_+_199996702 0.17 ENST00000367362.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr9_+_139839711 0.17 ENST00000224181.3
C8G
complement component 8, gamma polypeptide
chr11_-_10315741 0.16 ENST00000256190.8
SBF2
SET binding factor 2
chr11_-_116694009 0.16 ENST00000357780.3
APOA4
apolipoprotein A-IV
chr1_-_26197744 0.16 ENST00000374296.3
PAQR7
progestin and adipoQ receptor family member VII
chr2_+_28113583 0.16 ENST00000344773.2
ENST00000379624.1
ENST00000342045.2
ENST00000379632.2
ENST00000361704.2
BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr11_+_119056178 0.16 ENST00000525131.1
ENST00000531114.1
ENST00000355547.5
ENST00000322712.4
PDZD3
PDZ domain containing 3
chr11_-_63536113 0.16 ENST00000433688.1
ENST00000546282.2
C11orf95
RP11-466C23.4
chromosome 11 open reading frame 95
RP11-466C23.4
chr1_+_241695670 0.16 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_+_109541772 0.15 ENST00000506397.1
ENST00000394668.2
RPL34
ribosomal protein L34
chr2_+_48796120 0.15 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr7_+_192969 0.15 ENST00000313766.5
FAM20C
family with sequence similarity 20, member C
chr2_-_31637560 0.15 ENST00000379416.3
XDH
xanthine dehydrogenase
chr3_-_141868293 0.15 ENST00000317104.7
ENST00000494358.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_23694794 0.15 ENST00000374608.3
ZNF436
zinc finger protein 436
chr1_-_177939041 0.15 ENST00000308284.6
SEC16B
SEC16 homolog B (S. cerevisiae)
chr3_+_123813543 0.15 ENST00000360013.3
KALRN
kalirin, RhoGEF kinase
chr4_+_109541740 0.14 ENST00000394665.1
RPL34
ribosomal protein L34
chr15_-_101142362 0.14 ENST00000559577.1
ENST00000561308.1
ENST00000560133.1
ENST00000560941.1
ENST00000559736.1
ENST00000560272.1
LINS
lines homolog (Drosophila)
chr16_-_88752889 0.14 ENST00000332281.5
SNAI3
snail family zinc finger 3
chr17_-_38256973 0.14 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr19_-_35625765 0.14 ENST00000591633.1
LGI4
leucine-rich repeat LGI family, member 4
chr1_-_248903150 0.14 ENST00000590317.1
LYPD8
LY6/PLAUR domain containing 8
chr11_+_1856034 0.14 ENST00000341958.3
SYT8
synaptotagmin VIII
chr2_-_43019698 0.14 ENST00000431905.1
ENST00000294973.6
HAAO
3-hydroxyanthranilate 3,4-dioxygenase
chr3_+_124303539 0.14 ENST00000428018.2
KALRN
kalirin, RhoGEF kinase
chr19_+_7660716 0.13 ENST00000160298.4
ENST00000446248.2
CAMSAP3
calmodulin regulated spectrin-associated protein family, member 3
chr11_-_124253258 0.13 ENST00000375013.2
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr15_+_50716576 0.13 ENST00000560297.1
ENST00000307179.4
ENST00000396444.3
ENST00000433963.1
ENST00000425032.3
USP8
ubiquitin specific peptidase 8
chr6_+_31949801 0.13 ENST00000428956.2
ENST00000498271.1
C4A
complement component 4A (Rodgers blood group)
chr2_+_44502597 0.13 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr6_+_32146131 0.13 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr20_+_57875457 0.13 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr17_+_61554413 0.13 ENST00000538928.1
ENST00000290866.4
ENST00000428043.1
ACE
angiotensin I converting enzyme
chr20_+_62694461 0.13 ENST00000343484.5
ENST00000395053.3
TCEA2
transcription elongation factor A (SII), 2
chr4_+_109541722 0.13 ENST00000394667.3
ENST00000502534.1
RPL34
ribosomal protein L34
chr15_-_63448973 0.13 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr19_-_15235906 0.12 ENST00000600984.1
ILVBL
ilvB (bacterial acetolactate synthase)-like
chr11_+_63137251 0.12 ENST00000310969.4
ENST00000279178.3
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr20_-_3644046 0.12 ENST00000290417.2
ENST00000319242.3
GFRA4
GDNF family receptor alpha 4
chr11_+_1855645 0.12 ENST00000381968.3
ENST00000381978.3
SYT8
synaptotagmin VIII
chr17_-_44896047 0.12 ENST00000225512.5
WNT3
wingless-type MMTV integration site family, member 3
chr16_-_3350614 0.12 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr1_-_41131106 0.11 ENST00000372683.1
RIMS3
regulating synaptic membrane exocytosis 3
chr4_-_109541539 0.11 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr12_-_53594227 0.11 ENST00000550743.2
ITGB7
integrin, beta 7
chr19_-_41256207 0.11 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
C19orf54
chromosome 19 open reading frame 54
chr12_+_121416340 0.10 ENST00000257555.6
ENST00000400024.2
HNF1A
HNF1 homeobox A
chr5_+_79615790 0.10 ENST00000296739.4
SPZ1
spermatogenic leucine zipper 1
chr12_+_53497263 0.10 ENST00000551896.1
ENST00000301466.3
SOAT2
sterol O-acyltransferase 2
chr6_-_29343068 0.10 ENST00000396806.3
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr13_+_76334567 0.10 ENST00000321797.8
LMO7
LIM domain 7
chr22_+_25003626 0.10 ENST00000451366.1
ENST00000406383.2
ENST00000428855.1
GGT1
gamma-glutamyltransferase 1
chr2_-_39348137 0.10 ENST00000426016.1
SOS1
son of sevenless homolog 1 (Drosophila)
chr19_-_36304201 0.09 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr13_+_76334795 0.09 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr3_+_46538981 0.09 ENST00000296142.3
RTP3
receptor (chemosensory) transporter protein 3
chr12_+_109273806 0.09 ENST00000228476.3
ENST00000547768.1
DAO
D-amino-acid oxidase
chr14_+_100485712 0.09 ENST00000544450.2
EVL
Enah/Vasp-like
chr16_-_16317321 0.09 ENST00000205557.7
ENST00000575728.1
ABCC6
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr19_-_35626104 0.08 ENST00000310123.3
ENST00000392225.3
LGI4
leucine-rich repeat LGI family, member 4
chr1_+_110163709 0.08 ENST00000369840.2
ENST00000527846.1
AMPD2
adenosine monophosphate deaminase 2
chr20_-_44485835 0.08 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr6_-_149806105 0.08 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D
zinc finger CCCH-type containing 12D
chr17_+_4692230 0.08 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr1_-_29508321 0.08 ENST00000546138.1
SRSF4
serine/arginine-rich splicing factor 4
chr11_+_64073699 0.08 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr3_+_123813509 0.08 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr10_-_61513146 0.08 ENST00000430431.1
LINC00948
long intergenic non-protein coding RNA 948
chr2_-_208994548 0.08 ENST00000282141.3
CRYGC
crystallin, gamma C
chr10_-_61513201 0.07 ENST00000414264.1
ENST00000594536.1
LINC00948
long intergenic non-protein coding RNA 948
chr14_+_77648167 0.07 ENST00000554346.1
ENST00000298351.4
TMEM63C
transmembrane protein 63C
chr11_-_69590101 0.07 ENST00000168712.1
FGF4
fibroblast growth factor 4
chr6_+_31982539 0.07 ENST00000435363.2
ENST00000425700.2
C4B
complement component 4B (Chido blood group)
chr11_-_73720276 0.07 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr15_+_81489213 0.07 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr17_+_48423453 0.07 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2
xylosyltransferase II
chr4_+_159593271 0.06 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr19_-_12886327 0.06 ENST00000397668.3
ENST00000587178.1
ENST00000264827.5
HOOK2
hook microtubule-tethering protein 2
chr3_-_125313934 0.06 ENST00000296220.5
OSBPL11
oxysterol binding protein-like 11
chr18_-_54318353 0.06 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr10_-_103815874 0.06 ENST00000370033.4
ENST00000311122.5
C10orf76
chromosome 10 open reading frame 76
chr14_+_39735411 0.06 ENST00000603904.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr14_-_76447336 0.06 ENST00000556285.1
TGFB3
transforming growth factor, beta 3
chr17_+_77704681 0.06 ENST00000328313.5
ENPP7
ectonucleotide pyrophosphatase/phosphodiesterase 7
chr15_-_73925651 0.06 ENST00000545878.1
ENST00000287226.8
ENST00000345330.4
NPTN
neuroplastin
chr1_+_180601139 0.06 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr2_+_14772810 0.06 ENST00000295092.2
ENST00000331243.4
FAM84A
family with sequence similarity 84, member A
chr3_-_194072019 0.06 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chr11_-_64660916 0.06 ENST00000413053.1
MIR194-2
microRNA 194-2
chr11_-_118550346 0.05 ENST00000530256.1
TREH
trehalase (brush-border membrane glycoprotein)
chr14_-_51561784 0.05 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr11_-_123756334 0.05 ENST00000528595.1
ENST00000375026.2
TMEM225
transmembrane protein 225
chr6_+_31926857 0.05 ENST00000375394.2
ENST00000544581.1
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr22_+_25003568 0.05 ENST00000447416.1
GGT1
gamma-glutamyltransferase 1
chr17_+_41857793 0.05 ENST00000449302.3
C17orf105
chromosome 17 open reading frame 105
chr1_-_151138323 0.05 ENST00000368908.5
LYSMD1
LysM, putative peptidoglycan-binding, domain containing 1
chr17_-_27503770 0.05 ENST00000533112.1
MYO18A
myosin XVIIIA
chr6_+_30594619 0.04 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr20_+_57875758 0.04 ENST00000395654.3
EDN3
endothelin 3
chr6_+_43266063 0.04 ENST00000372574.3
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr2_-_150444116 0.04 ENST00000428879.1
ENST00000422782.2
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr19_+_39881951 0.04 ENST00000315588.5
ENST00000594368.1
ENST00000599213.2
ENST00000596297.1
MED29
mediator complex subunit 29
chr12_-_14849470 0.04 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr1_-_41131326 0.04 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
0.3 0.9 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.3 1.3 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.2 1.0 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 0.6 GO:0035565 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.2 1.0 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.2 0.8 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.4 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.6 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.3 GO:0098976 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 0.4 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 0.3 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.0 GO:0015747 urate transport(GO:0015747)
0.1 0.5 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.2 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.3 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.3 GO:0050668 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.1 0.2 GO:0097187 dentinogenesis(GO:0097187)
0.1 0.4 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.3 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.4 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:1904253 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.2 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.8 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.9 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.5 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.0 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.4 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.3 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.9 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 2.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.0 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.4 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.1 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.2 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 0.8 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.4 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.8 GO:0004882 androgen receptor activity(GO:0004882)
0.1 1.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.4 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 0.9 GO:0042731 transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731)
0.1 1.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.8 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.2 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.3 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 2.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.1 GO:0044390 ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.0 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism