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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HOMEZ
Z-value: 1.53
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Transcription factors associated with HOMEZ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOMEZ | hg19_v2_chr14_-_23755297_23755350 | -0.48 | 1.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156588249 Show fit | 7.85 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588350 Show fit | 7.80 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588115 Show fit | 7.71 |
ENST00000455639.2
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156587979 Show fit | 7.01 |
ENST00000511507.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_-_70626314 Show fit | 6.89 |
ENST00000510821.1
|
sulfotransferase family, cytosolic, 1B, member 1 |
|
| chr16_-_30032610 Show fit | 6.77 |
ENST00000574405.1
|
double C2-like domains, alpha |
|
| chrX_-_119709637 Show fit | 5.51 |
ENST00000404115.3
|
cullin 4B |
|
| chr7_+_89783689 Show fit | 4.88 |
ENST00000297205.2
|
six transmembrane epithelial antigen of the prostate 1 |
|
| chr4_+_126237554 Show fit | 4.07 |
ENST00000394329.3
|
FAT atypical cadherin 4 |
|
| chr11_+_62104897 Show fit | 3.82 |
ENST00000415229.2
ENST00000535727.1 ENST00000301776.5 |
asparaginase like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOMEZ
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 30.4 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.3 | 8.2 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.1 | 6.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.3 | 5.5 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 1.0 | 4.1 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.5 | 4.1 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.4 | 3.8 | GO:0006528 | asparagine metabolic process(GO:0006528) |
| 0.1 | 3.3 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 3.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 2.5 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 29.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 6.7 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.8 | 6.6 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 6.6 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.3 | 6.2 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 4.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 4.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 4.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 3.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 3.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 29.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 7.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 7.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 6.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 5.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 4.9 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.6 | 4.1 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.0 | 4.0 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.2 | 3.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 1.3 | 3.8 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 2.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.6 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 1.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 29.3 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.2 | 6.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 3.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.5 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 2.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 2.3 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 2.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 2.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |