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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXA2_HOXB1

Z-value: 0.70

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
HOXA2
ENSG00000105996.5 homeobox A2
HOXB1
ENSG00000120094.6 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA2hg19_v2_chr7_-_27142290_271424300.271.9e-01Click!
HOXB1hg19_v2_chr17_-_46608272_46608385-0.048.6e-01Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_12857015 3.70 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr2_+_12857043 3.64 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr4_-_90756769 2.53 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_90757364 2.53 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_102267953 2.52 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_-_92351769 1.84 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr16_-_49890016 1.71 ENST00000563137.2
ZNF423
zinc finger protein 423
chr17_+_7758374 1.61 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr20_+_42574317 1.29 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr17_-_42277203 1.26 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr9_+_40028620 1.18 ENST00000426179.1
AL353791.1
AL353791.1
chr17_-_42276574 1.18 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr11_-_2162162 1.12 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr20_+_34802295 1.11 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chrX_-_10645773 1.03 ENST00000453318.2
MID1
midline 1 (Opitz/BBB syndrome)
chr13_-_110438914 0.96 ENST00000375856.3
IRS2
insulin receptor substrate 2
chr12_-_15038779 0.95 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr7_+_79765071 0.95 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr7_-_86595190 0.94 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
KIAA1324L
KIAA1324-like
chr7_-_120497178 0.91 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr18_-_53070913 0.90 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr12_+_101988627 0.88 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
MYBPC1
myosin binding protein C, slow type
chr20_+_34742650 0.80 ENST00000373945.1
ENST00000338074.2
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_-_46623441 0.78 ENST00000330070.4
HOXB2
homeobox B2
chr2_-_44588679 0.73 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr2_-_44588694 0.72 ENST00000409957.1
PREPL
prolyl endopeptidase-like
chr12_+_101988774 0.70 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
MYBPC1
myosin binding protein C, slow type
chr18_+_56887381 0.69 ENST00000256857.2
ENST00000529320.2
ENST00000420468.2
GRP
gastrin-releasing peptide
chr6_-_112575687 0.60 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr1_+_52082751 0.60 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
OSBPL9
oxysterol binding protein-like 9
chr15_-_74501310 0.59 ENST00000423167.2
ENST00000432245.2
STRA6
stimulated by retinoic acid 6
chr16_+_15596123 0.54 ENST00000452191.2
C16orf45
chromosome 16 open reading frame 45
chr6_+_151561085 0.53 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr15_-_93616892 0.51 ENST00000556658.1
ENST00000538818.1
ENST00000425933.2
RGMA
repulsive guidance molecule family member a
chr6_-_112575838 0.50 ENST00000455073.1
LAMA4
laminin, alpha 4
chr10_-_65028938 0.50 ENST00000402544.1
JMJD1C
jumonji domain containing 1C
chr2_-_242089677 0.47 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr12_+_57482877 0.46 ENST00000342556.6
ENST00000357680.4
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chrX_-_30993201 0.46 ENST00000288422.2
ENST00000378932.2
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr10_-_65028817 0.46 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr17_+_58755184 0.45 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr19_+_13051206 0.45 ENST00000586760.1
CALR
calreticulin
chr14_+_22985251 0.44 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27
chr3_-_51813009 0.42 ENST00000398780.3
IQCF6
IQ motif containing F6
chr10_+_89264625 0.40 ENST00000371996.4
ENST00000371994.4
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr6_-_112575912 0.39 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr6_-_112575758 0.39 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr13_+_97928395 0.38 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr15_-_74501360 0.38 ENST00000323940.5
STRA6
stimulated by retinoic acid 6
chr5_-_125930929 0.38 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr13_+_36050881 0.35 ENST00000537702.1
NBEA
neurobeachin
chr14_+_68189190 0.35 ENST00000539142.1
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr17_+_36584662 0.34 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr19_+_47421933 0.34 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr15_+_48009541 0.32 ENST00000536845.2
ENST00000558816.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_242089833 0.30 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr6_+_32006042 0.27 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr17_-_57229155 0.24 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr16_+_85645007 0.23 ENST00000405402.2
GSE1
Gse1 coiled-coil protein
chr2_+_135011731 0.23 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr4_+_129732467 0.23 ENST00000413543.2
PHF17
jade family PHD finger 1
chr10_+_124320156 0.21 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr10_+_124320195 0.19 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr17_+_37824700 0.19 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr17_+_39975544 0.18 ENST00000544340.1
FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_39975455 0.18 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr6_+_32006159 0.18 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr1_+_243419306 0.17 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8
serologically defined colon cancer antigen 8
chr15_-_93616340 0.17 ENST00000557420.1
ENST00000542321.2
RGMA
repulsive guidance molecule family member a
chr13_+_52586517 0.16 ENST00000523764.1
ENST00000521508.1
ALG11
ALG11, alpha-1,2-mannosyltransferase
chr11_+_57365150 0.16 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_189507460 0.15 ENST00000434928.1
TP63
tumor protein p63
chr5_+_133861790 0.15 ENST00000395003.1
PHF15
jade family PHD finger 2
chr15_+_75335604 0.14 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr12_+_7282795 0.14 ENST00000266546.6
CLSTN3
calsyntenin 3
chr6_+_151561506 0.14 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr2_-_200322723 0.13 ENST00000417098.1
SATB2
SATB homeobox 2
chr5_+_147582348 0.12 ENST00000514389.1
SPINK6
serine peptidase inhibitor, Kazal type 6
chr7_-_100881041 0.12 ENST00000412417.1
ENST00000414035.1
CLDN15
claudin 15
chr12_-_28124903 0.12 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr2_-_200323414 0.11 ENST00000443023.1
SATB2
SATB homeobox 2
chr1_-_182641367 0.11 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr7_+_26591441 0.11 ENST00000420912.1
ENST00000457000.1
ENST00000430426.1
AC004947.2
AC004947.2
chr1_-_182642017 0.11 ENST00000367557.4
ENST00000258302.4
RGS8
regulator of G-protein signaling 8
chrY_+_26997726 0.11 ENST00000382296.2
DAZ4
deleted in azoospermia 4
chr7_-_144107320 0.11 ENST00000483238.1
ENST00000467773.1
NOBOX
NOBOX oogenesis homeobox
chr17_+_21729593 0.11 ENST00000581769.1
ENST00000584755.1
UBBP4
ubiquitin B pseudogene 4
chr9_-_101471479 0.11 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr17_-_27418537 0.11 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr17_+_79495397 0.09 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr17_+_43239231 0.09 ENST00000591576.1
ENST00000591070.1
ENST00000592695.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr3_+_191046810 0.09 ENST00000392455.3
ENST00000392456.3
CCDC50
coiled-coil domain containing 50
chr3_-_156877997 0.08 ENST00000295926.3
CCNL1
cyclin L1
chrX_+_99899180 0.08 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr7_-_14029283 0.08 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr10_+_102505468 0.07 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
PAX2
paired box 2
chr4_+_77356248 0.07 ENST00000296043.6
SHROOM3
shroom family member 3
chr1_-_109584768 0.07 ENST00000357672.3
WDR47
WD repeat domain 47
chr1_+_12524965 0.07 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr3_+_148545586 0.06 ENST00000282957.4
ENST00000468341.1
CPB1
carboxypeptidase B1 (tissue)
chr1_-_109584716 0.06 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WDR47
WD repeat domain 47
chr1_-_108507631 0.05 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr7_-_14029515 0.05 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr14_-_21516590 0.05 ENST00000555026.1
NDRG2
NDRG family member 2
chr1_+_178062855 0.05 ENST00000448150.3
RASAL2
RAS protein activator like 2
chr5_+_167181917 0.05 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr9_+_132099158 0.05 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr1_-_109584608 0.05 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WDR47
WD repeat domain 47
chr7_-_100881109 0.03 ENST00000308344.5
CLDN15
claudin 15
chr6_+_29426230 0.03 ENST00000442615.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr21_-_43430440 0.02 ENST00000398505.3
ENST00000310826.5
ENST00000449949.1
ENST00000398499.1
ENST00000398497.2
ENST00000398511.3
ZBTB21
zinc finger and BTB domain containing 21
chrX_+_125953746 0.02 ENST00000371125.3
CXorf64
chromosome X open reading frame 64
chr7_+_20370746 0.02 ENST00000222573.4
ITGB8
integrin, beta 8
chr10_+_95848824 0.02 ENST00000371385.3
ENST00000371375.1
PLCE1
phospholipase C, epsilon 1
chr13_-_36050819 0.02 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr1_-_43833628 0.02 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr3_+_189507523 0.01 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr10_-_46342921 0.01 ENST00000448048.2
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr1_-_67390474 0.01 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
WDR78
WD repeat domain 78
chr8_+_143530791 0.01 ENST00000517894.1
BAI1
brain-specific angiogenesis inhibitor 1
chr2_+_26624775 0.01 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr11_-_122930121 0.01 ENST00000524552.1
HSPA8
heat shock 70kDa protein 8
chr20_+_21283941 0.01 ENST00000377191.3
ENST00000430571.2
XRN2
5'-3' exoribonuclease 2
chr8_-_38008783 0.01 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr20_+_21284416 0.01 ENST00000539513.1
XRN2
5'-3' exoribonuclease 2
chr17_-_1588101 0.00 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
PRPF8
pre-mRNA processing factor 8

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.3 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.0 5.1 GO:0051945 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.8 2.5 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.5 1.8 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.3 0.8 GO:0021569 rhombomere 3 development(GO:0021569)
0.2 1.0 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 1.0 GO:0010748 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1 0.7 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 0.4 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.4 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.1 0.5 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.1 1.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 2.4 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.5 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.4 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 1.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.9 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 0.5 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 1.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.7 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 1.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.0 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 1.5 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 1.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.9 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.1 GO:0072179 vestibulocochlear nerve formation(GO:0021650) pronephric field specification(GO:0039003) pattern specification involved in pronephros development(GO:0039017) kidney field specification(GO:0072004) nephric duct formation(GO:0072179) positive regulation of metanephric glomerulus development(GO:0072300) regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072304) negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072305) mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309) mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) apoptotic process involved in metanephric collecting duct development(GO:1900204) apoptotic process involved in metanephric nephron tubule development(GO:1900205) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212) regulation of apoptotic process involved in metanephric collecting duct development(GO:1900214) negative regulation of apoptotic process involved in metanephric collecting duct development(GO:1900215) regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900217) negative regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900218) mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:1901147) regulation of metanephric DCT cell differentiation(GO:2000592) positive regulation of metanephric DCT cell differentiation(GO:2000594)
0.0 0.1 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.3 2.5 GO:0005955 calcineurin complex(GO:0005955)
0.2 2.4 GO:0000124 SAGA complex(GO:0000124)
0.1 5.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.6 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 1.9 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.4 7.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.3 2.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.8 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.2 0.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.4 GO:0008969 phosphohistidine phosphatase activity(GO:0008969)
0.1 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.6 GO:0031432 titin binding(GO:0031432)
0.1 0.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.5 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 1.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.7 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 2.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 2.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.0 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 0.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 2.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.8 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 1.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.9 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions