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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXB4_LHX9

Z-value: 0.56

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Transcription factors associated with HOXB4_LHX9

Gene Symbol Gene ID Gene Info
HOXB4
ENSG00000182742.5 homeobox B4
LHX9
ENSG00000143355.11 LIM homeobox 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB4hg19_v2_chr17_-_46657473_46657473-0.404.5e-02Click!
LHX9hg19_v2_chr1_+_197881592_1978816350.174.1e-01Click!

Activity profile of HOXB4_LHX9 motif

Sorted Z-values of HOXB4_LHX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_29527702 2.23 ENST00000377050.4
UBD
ubiquitin D
chr2_+_152214098 1.74 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr2_-_225811747 1.43 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr6_+_26402465 1.37 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_+_26440700 1.25 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr1_-_8000872 1.21 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr15_+_67418047 1.08 ENST00000540846.2
SMAD3
SMAD family member 3
chr7_+_134528635 1.05 ENST00000445569.2
CALD1
caldesmon 1
chr8_-_90996459 1.05 ENST00000517337.1
ENST00000409330.1
NBN
nibrin
chr2_+_102953608 0.98 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr15_+_64680003 0.96 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr8_-_90996837 0.96 ENST00000519426.1
ENST00000265433.3
NBN
nibrin
chr6_+_114178512 0.88 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr4_+_86525299 0.86 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr5_-_35938674 0.84 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr6_-_32806506 0.81 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr11_+_5710919 0.79 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr6_+_26402517 0.77 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr10_+_24755416 0.74 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr14_+_31046959 0.73 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr15_+_89631647 0.72 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr11_+_33061543 0.70 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr4_+_169418195 0.70 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr12_+_26348582 0.69 ENST00000535504.1
SSPN
sarcospan
chr4_+_169418255 0.67 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr17_+_1674982 0.64 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr18_-_74839891 0.63 ENST00000581878.1
MBP
myelin basic protein
chr14_-_51027838 0.63 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr19_+_54466179 0.55 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr6_+_26365443 0.54 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr15_+_89631381 0.53 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr9_-_26947453 0.52 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr4_-_103749205 0.51 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr3_-_157221380 0.51 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr22_+_46476192 0.51 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr5_-_16916624 0.50 ENST00000513882.1
MYO10
myosin X
chr11_-_107729887 0.50 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr1_-_57045228 0.49 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_191000172 0.47 ENST00000427544.2
UTS2B
urotensin 2B
chr6_+_29079668 0.45 ENST00000377169.1
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr11_-_55703876 0.43 ENST00000301532.3
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr20_+_31805131 0.43 ENST00000375454.3
ENST00000375452.3
BPIFA3
BPI fold containing family A, member 3
chr17_+_66511540 0.43 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr8_+_50824233 0.43 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr4_+_108745711 0.42 ENST00000394684.4
SGMS2
sphingomyelin synthase 2
chr5_-_150473127 0.41 ENST00000521001.1
TNIP1
TNFAIP3 interacting protein 1
chr10_-_27529486 0.41 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr4_+_169552748 0.41 ENST00000504519.1
ENST00000512127.1
PALLD
palladin, cytoskeletal associated protein
chr11_-_104827425 0.41 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr18_+_56806701 0.40 ENST00000587834.1
SEC11C
SEC11 homolog C (S. cerevisiae)
chr21_-_37914898 0.39 ENST00000399136.1
CLDN14
claudin 14
chr8_+_104310661 0.39 ENST00000522566.1
FZD6
frizzled family receptor 6
chr4_-_39979576 0.38 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr10_-_13043697 0.37 ENST00000378825.3
CCDC3
coiled-coil domain containing 3
chr15_-_72523924 0.37 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
PKM
pyruvate kinase, muscle
chr8_-_116504448 0.36 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr1_+_225600404 0.36 ENST00000366845.2
AC092811.1
AC092811.1
chr4_-_103998439 0.36 ENST00000503230.1
ENST00000503818.1
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr13_+_97928395 0.36 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr19_-_3557570 0.36 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr3_-_157221357 0.34 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chrX_+_1710484 0.34 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr4_-_103749179 0.33 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_69536346 0.32 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr20_+_18488137 0.32 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chrX_+_30261847 0.32 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr4_+_119810134 0.31 ENST00000434046.2
SYNPO2
synaptopodin 2
chr10_+_18549645 0.31 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr2_+_102456277 0.31 ENST00000421882.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_-_231005310 0.31 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr12_+_26348246 0.30 ENST00000422622.2
SSPN
sarcospan
chr7_+_134430212 0.30 ENST00000436461.2
CALD1
caldesmon 1
chr15_+_66679155 0.29 ENST00000307102.5
MAP2K1
mitogen-activated protein kinase kinase 1
chr6_+_31553978 0.29 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr14_-_25078864 0.29 ENST00000216338.4
ENST00000557220.2
ENST00000382548.4
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr13_+_77522632 0.28 ENST00000377462.1
IRG1
immunoresponsive 1 homolog (mouse)
chrX_-_100662881 0.28 ENST00000218516.3
GLA
galactosidase, alpha
chr11_+_35201826 0.28 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr11_-_128894053 0.28 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr8_-_125577940 0.27 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr2_+_187454749 0.27 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr12_+_112279782 0.27 ENST00000550735.2
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
chr8_-_30670384 0.27 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr12_+_26348429 0.27 ENST00000242729.2
SSPN
sarcospan
chr4_-_120243545 0.26 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chrX_+_108779004 0.26 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr14_-_45252031 0.26 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr10_-_75415825 0.25 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr7_-_140482926 0.25 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr14_+_103851712 0.25 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr19_-_14945933 0.24 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr11_-_119991589 0.24 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr4_-_119759795 0.24 ENST00000419654.2
SEC24D
SEC24 family member D
chr7_-_87856303 0.23 ENST00000394641.3
SRI
sorcin
chr6_-_89927151 0.23 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chrX_-_15332665 0.23 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr2_-_169887827 0.23 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr7_-_87856280 0.22 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr4_-_103998060 0.22 ENST00000339611.4
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr7_-_25702669 0.22 ENST00000446840.1
AC003090.1
AC003090.1
chr2_-_136678123 0.21 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr14_+_22465771 0.21 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr20_-_1447467 0.21 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr16_-_29934558 0.21 ENST00000568995.1
ENST00000566413.1
KCTD13
potassium channel tetramerization domain containing 13
chr1_+_160370344 0.20 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr20_-_1447547 0.20 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr18_-_51750948 0.20 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr22_-_32651326 0.20 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr3_-_122233723 0.20 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr21_+_33671160 0.20 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr3_-_141747950 0.20 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_87804815 0.19 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr3_+_111718173 0.19 ENST00000494932.1
TAGLN3
transgelin 3
chrX_+_44703249 0.19 ENST00000339042.4
DUSP21
dual specificity phosphatase 21
chrX_-_77225135 0.19 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr11_-_121986923 0.19 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr4_-_103997862 0.19 ENST00000394785.3
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr6_+_42584847 0.18 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr2_-_128284020 0.18 ENST00000295321.4
ENST00000455721.2
IWS1
IWS1 homolog (S. cerevisiae)
chr3_+_138340049 0.18 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr4_-_103749105 0.18 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_+_35415851 0.18 ENST00000374726.3
CREM
cAMP responsive element modulator
chr10_+_90424196 0.18 ENST00000394375.3
ENST00000608620.1
ENST00000238983.4
ENST00000355843.2
LIPF
lipase, gastric
chr2_+_90248739 0.17 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr20_-_56265680 0.17 ENST00000414037.1
PMEPA1
prostate transmembrane protein, androgen induced 1
chr14_+_95027772 0.17 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr14_-_53258314 0.17 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr14_-_72458326 0.17 ENST00000542853.1
AC005477.1
AC005477.1
chr4_-_39033963 0.17 ENST00000381938.3
TMEM156
transmembrane protein 156
chr4_-_10686373 0.17 ENST00000442825.2
CLNK
cytokine-dependent hematopoietic cell linker
chrX_+_83116142 0.17 ENST00000329312.4
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr18_-_3219847 0.16 ENST00000261606.7
MYOM1
myomesin 1
chr20_+_30697298 0.16 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr12_-_22063787 0.16 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr12_-_23737534 0.16 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr5_-_172036436 0.15 ENST00000601856.1
AC027309.1
AC027309.1
chr15_+_89922345 0.15 ENST00000558982.1
LINC00925
long intergenic non-protein coding RNA 925
chr1_+_157963063 0.15 ENST00000360089.4
ENST00000368173.3
ENST00000392272.2
KIRREL
kin of IRRE like (Drosophila)
chr11_+_60383204 0.15 ENST00000412599.1
ENST00000320202.4
LINC00301
long intergenic non-protein coding RNA 301
chr13_+_32313658 0.15 ENST00000380314.1
ENST00000298386.2
RXFP2
relaxin/insulin-like family peptide receptor 2
chr1_+_28261492 0.14 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr4_+_100432161 0.14 ENST00000326581.4
ENST00000514652.1
C4orf17
chromosome 4 open reading frame 17
chr1_+_196743912 0.14 ENST00000367425.4
CFHR3
complement factor H-related 3
chr5_+_66300446 0.14 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_-_72772462 0.14 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chrX_-_21676442 0.14 ENST00000379499.2
KLHL34
kelch-like family member 34
chr11_-_101000445 0.14 ENST00000534013.1
PGR
progesterone receptor
chrX_+_36254051 0.13 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr2_-_161056802 0.13 ENST00000283249.2
ENST00000409872.1
ITGB6
integrin, beta 6
chr4_-_185275104 0.13 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr17_-_39324424 0.13 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr4_-_103748880 0.13 ENST00000453744.2
ENST00000349311.8
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_103749313 0.13 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr7_-_108168580 0.13 ENST00000453085.1
PNPLA8
patatin-like phospholipase domain containing 8
chr6_-_91296737 0.13 ENST00000369332.3
ENST00000369329.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr6_-_91296602 0.13 ENST00000369325.3
ENST00000369327.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr20_-_21494654 0.13 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr6_+_36562132 0.13 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr3_+_38537960 0.13 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr9_-_28670283 0.13 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr17_-_4938712 0.13 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr7_-_111032971 0.12 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr21_-_31538971 0.12 ENST00000286808.3
CLDN17
claudin 17
chr16_+_31271274 0.12 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr14_-_80697396 0.12 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr7_+_120628731 0.12 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr1_-_153518270 0.12 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr19_-_41870026 0.12 ENST00000243578.3
B9D2
B9 protein domain 2
chr17_-_45266542 0.12 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr3_-_58613323 0.12 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr1_-_152131703 0.12 ENST00000316073.3
RPTN
repetin
chrX_+_19362011 0.12 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr1_-_47184745 0.12 ENST00000544071.1
EFCAB14
EF-hand calcium binding domain 14
chr21_-_42219065 0.12 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr3_+_139063372 0.12 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr18_+_21033239 0.12 ENST00000581585.1
ENST00000577501.1
RIOK3
RIO kinase 3
chr11_-_75917569 0.12 ENST00000322563.3
WNT11
wingless-type MMTV integration site family, member 11
chr8_+_105235572 0.12 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr7_-_86849883 0.11 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr14_+_56584414 0.11 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr8_+_9953214 0.11 ENST00000382490.5
MSRA
methionine sulfoxide reductase A
chr3_+_111717511 0.11 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr11_+_55594695 0.11 ENST00000378397.1
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr3_+_138340067 0.11 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr8_+_9953061 0.11 ENST00000522907.1
ENST00000528246.1
MSRA
methionine sulfoxide reductase A
chr5_-_159546396 0.11 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr1_-_89357179 0.11 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr8_-_90769422 0.11 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr4_+_119809984 0.11 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr3_+_111717600 0.11 ENST00000273368.4
TAGLN3
transgelin 3
chr4_-_159956333 0.11 ENST00000434826.2
C4orf45
chromosome 4 open reading frame 45
chr6_+_47624172 0.11 ENST00000507065.1
ENST00000296862.1
GPR111
G protein-coupled receptor 111
chr2_+_27255806 0.11 ENST00000238788.9
ENST00000404032.3
TMEM214
transmembrane protein 214
chr14_-_107049312 0.10 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr1_+_12851545 0.10 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr1_-_205091115 0.10 ENST00000264515.6
ENST00000367164.1
RBBP5
retinoblastoma binding protein 5
chr14_+_22670455 0.10 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr12_-_52604607 0.10 ENST00000551894.1
ENST00000553017.1
C12orf80
chromosome 12 open reading frame 80
chr15_+_69857515 0.10 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr4_+_72897521 0.10 ENST00000308744.6
ENST00000344413.5
NPFFR2
neuropeptide FF receptor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB4_LHX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.4 2.2 GO:0070842 aggresome assembly(GO:0070842)
0.3 0.8 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.2 1.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 1.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.2 1.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 2.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.1 GO:0060031 mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775)
0.1 0.6 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.4 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 1.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.4 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.8 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.6 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 1.8 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.2 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.2 GO:0061346 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.3 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 2.0 GO:0030728 ovulation(GO:0030728)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.3 GO:0030035 microspike assembly(GO:0030035)
0.1 0.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.3 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 1.3 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.5 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.3 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.2 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.4 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.1 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.0 0.1 GO:0006203 dGTP catabolic process(GO:0006203)
0.0 0.1 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 1.0 GO:1901998 toxin transport(GO:1901998)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.0 GO:2000053 negative regulation of B cell differentiation(GO:0045578) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.3 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.1 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.0 GO:0070173 regulation of enamel mineralization(GO:0070173)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0042585 germinal vesicle(GO:0042585)
0.2 2.0 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.4 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 1.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.8 GO:0042825 TAP complex(GO:0042825)
0.1 0.4 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 1.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.3 GO:0030478 actin cap(GO:0030478)
0.1 0.5 GO:0044326 dendritic spine neck(GO:0044326)
0.1 0.6 GO:0033269 internode region of axon(GO:0033269)
0.1 0.2 GO:0036030 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 0.2 GO:0033150 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.1 0.6 GO:0043203 axon hillock(GO:0043203)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 1.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 2.3 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 1.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 0.8 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.2 0.8 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 2.3 GO:0070628 proteasome binding(GO:0070628)
0.1 0.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.4 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 2.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0016936 galactoside binding(GO:0016936)
0.1 1.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 2.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 1.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0035539 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.5 GO:0005549 odorant binding(GO:0005549)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.2 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 2.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol