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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXB5

Z-value: 0.43

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_46671323-0.471.9e-02Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_127541194 2.54 ENST00000453507.2
MGLL
monoglyceride lipase
chr6_-_32820529 1.67 ENST00000425148.2
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_-_164914640 0.71 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr16_-_84651647 0.70 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr15_-_72523454 0.66 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
PKM
pyruvate kinase, muscle
chr1_+_146373546 0.65 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr5_-_35048047 0.55 ENST00000231420.6
AGXT2
alanine--glyoxylate aminotransferase 2
chr4_-_114900831 0.55 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr1_+_155579979 0.49 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr11_-_57089671 0.48 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr1_+_22307592 0.47 ENST00000400277.2
CELA3B
chymotrypsin-like elastase family, member 3B
chr10_+_114135952 0.43 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_+_133842243 0.37 ENST00000515627.2
AC005355.2
AC005355.2
chr14_-_24020858 0.36 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr1_+_4714792 0.33 ENST00000378190.3
AJAP1
adherens junctions associated protein 1
chr16_-_1821496 0.32 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr1_+_154975110 0.31 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chrM_+_12331 0.29 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr5_+_67511524 0.28 ENST00000521381.1
ENST00000521657.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_101801505 0.27 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr1_-_155658260 0.27 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
YY1AP1
YY1 associated protein 1
chr14_-_102704783 0.26 ENST00000522534.1
MOK
MOK protein kinase
chrX_+_47077632 0.26 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr16_-_1821721 0.25 ENST00000219302.3
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr19_-_12267524 0.25 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr17_+_46970127 0.25 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr6_-_31869769 0.25 ENST00000375527.2
ZBTB12
zinc finger and BTB domain containing 12
chr1_+_154229547 0.24 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr17_+_46970178 0.23 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr8_+_118147498 0.23 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr11_-_35440579 0.23 ENST00000606205.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_+_66217911 0.23 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr9_+_4662282 0.23 ENST00000381883.2
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr12_-_53614155 0.22 ENST00000543726.1
RARG
retinoic acid receptor, gamma
chr17_-_42143963 0.22 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr12_-_53614043 0.21 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr3_+_130613226 0.20 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr10_-_103603568 0.20 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr16_-_58004992 0.19 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr17_+_46970134 0.17 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr1_-_155658518 0.17 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
YY1AP1
YY1 associated protein 1
chr3_+_51422478 0.17 ENST00000528157.1
MANF
mesencephalic astrocyte-derived neurotrophic factor
chrX_-_139587225 0.16 ENST00000370536.2
SOX3
SRY (sex determining region Y)-box 3
chr3_-_195538728 0.16 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr12_+_54955235 0.16 ENST00000550620.1
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr18_-_33077556 0.16 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr2_-_220173685 0.15 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chr1_-_235491462 0.15 ENST00000418304.1
ENST00000264183.3
ENST00000349213.3
ARID4B
AT rich interactive domain 4B (RBP1-like)
chr7_-_102252038 0.15 ENST00000461209.1
RASA4
RAS p21 protein activator 4
chr13_-_54706954 0.15 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
LINC00458
long intergenic non-protein coding RNA 458
chr15_-_75017711 0.15 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr1_-_155658766 0.15 ENST00000295566.4
ENST00000368330.2
YY1AP1
YY1 associated protein 1
chr1_+_155658849 0.15 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr9_-_112970436 0.14 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr2_+_219283815 0.14 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr6_-_31509714 0.14 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_-_155658085 0.13 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr12_-_6798410 0.13 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chrX_+_103411189 0.13 ENST00000493442.1
FAM199X
family with sequence similarity 199, X-linked
chr18_+_32558208 0.13 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_+_145575980 0.13 ENST00000393045.2
PIAS3
protein inhibitor of activated STAT, 3
chr7_+_130020932 0.13 ENST00000484324.1
CPA1
carboxypeptidase A1 (pancreatic)
chr1_+_145576007 0.13 ENST00000369298.1
PIAS3
protein inhibitor of activated STAT, 3
chr12_-_6798523 0.13 ENST00000319770.3
ZNF384
zinc finger protein 384
chr17_+_2496971 0.12 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr12_-_6798616 0.11 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr12_-_52715179 0.10 ENST00000293670.3
KRT83
keratin 83
chr2_-_47168850 0.07 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr17_+_6679528 0.07 ENST00000321535.4
FBXO39
F-box protein 39
chr7_+_5322561 0.07 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
SLC29A4
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chr11_-_125648690 0.07 ENST00000436890.2
ENST00000358524.3
PATE2
prostate and testis expressed 2
chr6_-_31510181 0.06 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr16_+_71560023 0.06 ENST00000572450.1
CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr3_-_195538760 0.05 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr20_-_6034672 0.04 ENST00000378858.4
LRRN4
leucine rich repeat neuronal 4
chr15_-_49103235 0.04 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr14_+_21498666 0.03 ENST00000481535.1
TPPP2
tubulin polymerization-promoting protein family member 2
chr15_+_41913690 0.03 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chrX_-_107225600 0.02 ENST00000302917.1
TEX13B
testis expressed 13B
chr19_-_42724261 0.02 ENST00000595337.1
DEDD2
death effector domain containing 2
chr5_+_149569520 0.02 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr16_-_30381580 0.02 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr1_+_235491714 0.01 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
GGPS1
geranylgeranyl diphosphate synthase 1
chr14_+_21498360 0.01 ENST00000321760.6
ENST00000460647.2
ENST00000530140.2
ENST00000472458.1
TPPP2
tubulin polymerization-promoting protein family member 2
chr19_-_7764281 0.00 ENST00000360067.4
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr1_+_206317450 0.00 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr1_-_161193349 0.00 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr2_+_17721920 0.00 ENST00000295156.4
VSNL1
visinin-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 2.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.6 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.1 0.7 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.3 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.4 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.3 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.2 GO:0031049 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.0 0.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.2 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.5 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.7 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.3 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0042825 TAP complex(GO:0042825)
0.1 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0046979 TAP2 binding(GO:0046979)
0.2 0.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 2.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.6 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.1 0.2 GO:0035501 MH1 domain binding(GO:0035501)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.3 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0046923 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.3 GO:0019789 SUMO transferase activity(GO:0019789)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA