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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for HOXB6_PRRX2
Z-value: 2.19
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB6 | hg19_v2_chr17_-_46682321_46682362 | -0.42 | 3.9e-02 | Click! |
| PRRX2 | hg19_v2_chr9_+_132427883_132427951 | -0.40 | 4.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_2159850 Show fit | 19.90 |
ENST00000416751.1
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
|
| chr1_+_61869748 Show fit | 18.55 |
ENST00000357977.5
|
nuclear factor I/A |
|
| chr13_-_72441315 Show fit | 13.79 |
ENST00000305425.4
ENST00000313174.7 ENST00000354591.4 |
dachshund homolog 1 (Drosophila) |
|
| chr7_-_27183263 Show fit | 13.76 |
ENST00000222726.3
|
homeobox A5 |
|
| chr4_+_41614909 Show fit | 13.36 |
ENST00000509454.1
ENST00000396595.3 ENST00000381753.4 |
LIM and calponin homology domains 1 |
|
| chr1_+_84630053 Show fit | 13.31 |
ENST00000394838.2
ENST00000370682.3 ENST00000432111.1 |
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr5_-_88179302 Show fit | 13.28 |
ENST00000504921.2
|
myocyte enhancer factor 2C |
|
| chr9_-_14308004 Show fit | 13.15 |
ENST00000493697.1
|
nuclear factor I/B |
|
| chr9_+_2158485 Show fit | 12.98 |
ENST00000417599.1
ENST00000382185.1 ENST00000382183.1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
|
| chr9_+_2158443 Show fit | 12.42 |
ENST00000302401.3
ENST00000324954.5 ENST00000423555.1 ENST00000382186.1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 57.2 | GO:0007286 | spermatid development(GO:0007286) |
| 1.7 | 41.3 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 28.3 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 3.9 | 27.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 3.7 | 25.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 6.3 | 25.3 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.7 | 23.6 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.4 | 22.0 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 1.3 | 17.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.2 | 15.8 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 58.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 2.3 | 55.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 30.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 28.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 1.2 | 27.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 1.5 | 25.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 2.5 | 24.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 17.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 13.5 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.2 | 12.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 72.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.8 | 50.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 1.2 | 29.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 2.2 | 29.1 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.5 | 27.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.9 | 25.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 21.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 20.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.8 | 14.0 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 14.0 | GO:0003682 | chromatin binding(GO:0003682) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 70.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 55.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.3 | 33.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.5 | 24.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.5 | 24.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 15.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 14.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 11.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 9.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 8.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 53.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.7 | 27.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.8 | 25.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 14.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.7 | 11.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 11.4 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 9.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 8.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 6.6 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 5.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |