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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXB7

Z-value: 0.55

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Transcription factors associated with HOXB7

Gene Symbol Gene ID Gene Info
ENSG00000260027.3 homeobox B7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB7hg19_v2_chr17_-_46688334_46688385-0.404.8e-02Click!

Activity profile of HOXB7 motif

Sorted Z-values of HOXB7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_67418047 1.81 ENST00000540846.2
SMAD family member 3
chr5_+_131409476 1.77 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr21_+_43619796 1.27 ENST00000398457.2
ATP-binding cassette, sub-family G (WHITE), member 1
chr12_+_21168630 1.20 ENST00000421593.2
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr2_+_161993465 1.16 ENST00000457476.1
TRAF family member-associated NFKB activator
chr12_+_20968608 1.11 ENST00000381541.3
ENST00000540229.1
ENST00000553473.1
ENST00000554957.1
Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein
solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr18_+_61554932 1.06 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr11_-_102668879 1.02 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr6_+_29068386 1.01 ENST00000377171.3
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr3_+_141105705 0.84 ENST00000513258.1
zinc finger and BTB domain containing 38
chr13_+_97928395 0.82 ENST00000445661.2
muscleblind-like splicing regulator 2
chr8_+_31497271 0.77 ENST00000520407.1
neuregulin 1
chr2_+_161993412 0.76 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr16_+_66442411 0.71 ENST00000499966.1
long intergenic non-protein coding RNA 920
chr14_+_55034599 0.68 ENST00000392067.3
ENST00000357634.3
sterile alpha motif domain containing 4A
chr3_+_111393659 0.65 ENST00000477665.1
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr14_-_101295407 0.65 ENST00000596284.1
AL117190.2
chr3_-_185270342 0.63 ENST00000424591.2
lipase, member H
chr5_+_125695805 0.58 ENST00000513040.1
GRAM domain containing 3
chr10_-_21786179 0.56 ENST00000377113.5
cancer susceptibility candidate 10
chr14_+_51955831 0.56 ENST00000356218.4
FERM domain containing 6
chr6_-_137539651 0.54 ENST00000543628.1
interferon gamma receptor 1
chr7_-_45151272 0.52 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
transforming growth factor beta regulator 4
chr2_-_197226875 0.51 ENST00000409111.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr10_+_13142225 0.50 ENST00000378747.3
optineurin
chr11_-_57194948 0.50 ENST00000533235.1
ENST00000526621.1
ENST00000352187.1
solute carrier family 43, member 3
chr5_+_125758865 0.49 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr10_+_13142075 0.49 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
optineurin
chr5_+_125758813 0.49 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr2_+_27719697 0.48 ENST00000264717.2
ENST00000424318.2
glucokinase (hexokinase 4) regulator
chr11_-_67981046 0.48 ENST00000402789.1
ENST00000402185.2
ENST00000458496.1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr10_+_13141441 0.47 ENST00000263036.5
optineurin
chrX_+_9431324 0.46 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr3_+_111393501 0.46 ENST00000393934.3
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr17_-_39296739 0.44 ENST00000345847.4
keratin associated protein 4-6
chr3_+_173116225 0.43 ENST00000457714.1
neuroligin 1
chr15_-_75748115 0.43 ENST00000360439.4
SIN3 transcription regulator family member A
chr5_-_58295712 0.42 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr20_-_1309809 0.42 ENST00000360779.3
syndecan binding protein (syntenin) 2
chr7_-_47579188 0.42 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
tensin 3
chr9_-_73029540 0.41 ENST00000377126.2
Kruppel-like factor 9
chr3_-_58613323 0.41 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr3_-_108836977 0.41 ENST00000232603.5
MORC family CW-type zinc finger 1
chr5_-_179047881 0.40 ENST00000521173.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chrX_-_39923656 0.40 ENST00000413905.1
BCL6 corepressor
chr18_-_10748498 0.40 ENST00000579949.1
piezo-type mechanosensitive ion channel component 2
chr1_+_101702417 0.38 ENST00000305352.6
sphingosine-1-phosphate receptor 1
chr10_+_118305435 0.36 ENST00000369221.2
pancreatic lipase
chr5_-_179045199 0.36 ENST00000523921.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr15_-_74374891 0.35 ENST00000290438.3
golgin A6 family, member A
chr4_-_70080449 0.35 ENST00000446444.1
UDP glucuronosyltransferase 2 family, polypeptide B11
chr11_-_126870655 0.34 ENST00000525144.2
kin of IRRE like 3 (Drosophila)
chr6_+_34204642 0.34 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr10_+_13141585 0.34 ENST00000378764.2
optineurin
chr10_+_71561630 0.33 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr20_+_52105495 0.32 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr10_+_118083919 0.31 ENST00000333254.3
coiled-coil domain containing 172
chr2_+_168043793 0.31 ENST00000409273.1
ENST00000409605.1
xin actin-binding repeat containing 2
chr2_-_161350305 0.31 ENST00000348849.3
RNA binding motif, single stranded interacting protein 1
chr2_+_63277927 0.31 ENST00000282549.2
orthodenticle homeobox 1
chr11_-_102496063 0.31 ENST00000260228.2
matrix metallopeptidase 20
chr19_+_41698927 0.29 ENST00000310054.4
cytochrome P450, family 2, subfamily S, polypeptide 1
chr9_+_125132803 0.29 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_+_20370746 0.28 ENST00000222573.4
integrin, beta 8
chr7_-_3214287 0.28 ENST00000404626.3
LOC392621; Uncharacterized protein
chr1_+_205473720 0.28 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
cyclin-dependent kinase 18
chr3_+_141106458 0.27 ENST00000509883.1
zinc finger and BTB domain containing 38
chr4_+_169013666 0.27 ENST00000359299.3
annexin A10
chr1_+_44584522 0.27 ENST00000372299.3
Kruppel-like factor 17
chr12_-_50290839 0.27 ENST00000552863.1
Fas apoptotic inhibitory molecule 2
chr12_+_43086018 0.27 ENST00000550177.1
RP11-25I15.3
chr3_+_159943362 0.27 ENST00000326474.3
chromosome 3 open reading frame 80
chr10_+_71561649 0.27 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
collagen, type XIII, alpha 1
chr2_+_103035102 0.27 ENST00000264260.2
interleukin 18 receptor accessory protein
chr3_-_4927447 0.27 ENST00000449914.1
Uncharacterized protein
chr9_-_32526299 0.26 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr5_-_59481406 0.26 ENST00000546160.1
phosphodiesterase 4D, cAMP-specific
chr2_+_89986318 0.25 ENST00000491977.1
immunoglobulin kappa variable 2D-29
chr5_+_162887556 0.25 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
hyaluronan-mediated motility receptor (RHAMM)
chr12_+_12764773 0.25 ENST00000228865.2
cAMP responsive element binding protein-like 2
chr9_-_128246769 0.25 ENST00000444226.1
mitogen-activated protein kinase associated protein 1
chr11_-_70507901 0.25 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SH3 and multiple ankyrin repeat domains 2
chr3_+_189349162 0.25 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
tumor protein p63
chr6_+_114178512 0.25 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr17_-_41738931 0.25 ENST00000329168.3
ENST00000549132.1
mesenchyme homeobox 1
chr3_-_189840223 0.25 ENST00000427335.2
leprecan-like 1
chr17_-_41739283 0.24 ENST00000393661.2
ENST00000318579.4
mesenchyme homeobox 1
chr6_-_2634820 0.24 ENST00000296847.3
chromosome 6 open reading frame 195
chr3_+_68055366 0.24 ENST00000496687.1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr17_+_21030260 0.24 ENST00000579303.1
dehydrogenase/reductase (SDR family) member 7B
chr12_+_113229543 0.24 ENST00000447659.2
rabphilin 3A homolog (mouse)
chr11_+_128563652 0.24 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr3_-_145878954 0.24 ENST00000282903.5
ENST00000360060.3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr2_+_20646824 0.23 ENST00000272233.4
ras homolog family member B
chr19_+_13135386 0.23 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_151102529 0.23 ENST00000302632.3
purinergic receptor P2Y, G-protein coupled, 12
chr12_+_113229452 0.23 ENST00000389385.4
rabphilin 3A homolog (mouse)
chr5_+_98109322 0.22 ENST00000513185.1
repulsive guidance molecule family member b
chr1_+_168148273 0.22 ENST00000367830.3
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr6_+_45390222 0.22 ENST00000359524.5
runt-related transcription factor 2
chr4_-_69536346 0.22 ENST00000338206.5
UDP glucuronosyltransferase 2 family, polypeptide B15
chr2_-_145278475 0.22 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr12_-_86650045 0.22 ENST00000604798.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_+_244515930 0.22 ENST00000366537.1
ENST00000308105.4
chromosome 1 open reading frame 100
chr15_+_75575176 0.21 ENST00000434739.3
golgin A6 family, member D
chr22_-_30642782 0.21 ENST00000249075.3
leukemia inhibitory factor
chr12_+_113229737 0.21 ENST00000551052.1
ENST00000415485.3
rabphilin 3A homolog (mouse)
chr3_+_101818088 0.21 ENST00000491959.1
zona pellucida-like domain containing 1
chrX_+_1387693 0.21 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr11_+_113779704 0.21 ENST00000537778.1
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr12_-_91573132 0.21 ENST00000550563.1
ENST00000546370.1
decorin
chrX_-_110655391 0.21 ENST00000356915.2
ENST00000356220.3
doublecortin
chrX_+_36053908 0.21 ENST00000378660.2
calponin homology domain containing 2
chr15_-_32695396 0.21 ENST00000512626.2
ENST00000435655.2
golgin A8 family, member K
Uncharacterized protein; cDNA FLJ52611
chrX_+_99839799 0.21 ENST00000373031.4
tenomodulin
chr7_+_119913688 0.21 ENST00000331113.4
potassium voltage-gated channel, Shal-related subfamily, member 2
chr6_-_66417107 0.21 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
eyes shut homolog (Drosophila)
chr11_+_57365150 0.21 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_-_142166904 0.20 ENST00000264951.4
5'-3' exoribonuclease 1
chr15_+_30375158 0.20 ENST00000341650.6
ENST00000567927.1
golgin A8 family, member J
chr5_-_76788024 0.20 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WD repeat domain 41
chr8_-_67874805 0.20 ENST00000563496.1
transcription factor 24
chr8_+_12803176 0.20 ENST00000524591.2
KIAA1456
chr11_-_123525289 0.20 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
sodium channel, voltage-gated, type III, beta subunit
chr3_+_148415571 0.20 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
angiotensin II receptor, type 1
chr3_+_141105235 0.19 ENST00000503809.1
zinc finger and BTB domain containing 38
chr19_-_49955050 0.19 ENST00000262265.5
PIH1 domain containing 1
chr20_+_238357 0.19 ENST00000382376.3
defensin, beta 132
chr18_+_45778672 0.19 ENST00000600091.1
HCG1818186; Uncharacterized protein
chr9_-_93405352 0.19 ENST00000375765.3
DIRAS family, GTP-binding RAS-like 2
chr11_-_107729887 0.19 ENST00000525815.1
solute carrier family 35, member F2
chr16_+_84801852 0.19 ENST00000569925.1
ENST00000567526.1
ubiquitin specific peptidase 10
chrX_+_113818545 0.19 ENST00000371951.1
ENST00000276198.1
ENST00000371950.3
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
chr5_-_54281407 0.19 ENST00000381403.4
endothelial cell-specific molecule 1
chr18_+_29171689 0.19 ENST00000237014.3
transthyretin
chr12_+_6603253 0.19 ENST00000382457.4
ENST00000545962.1
non-SMC condensin I complex, subunit D2
chr5_-_138718973 0.18 ENST00000353963.3
ENST00000348729.3
solute carrier family 23 (ascorbic acid transporter), member 1
chr7_+_30185406 0.18 ENST00000324489.5
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr1_+_75600567 0.18 ENST00000356261.3
LIM homeobox 8
chr12_+_9980069 0.18 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
killer cell lectin-like receptor subfamily F, member 1
chr12_-_22063787 0.17 ENST00000544039.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr8_-_67090825 0.17 ENST00000276571.3
corticotropin releasing hormone
chr18_+_580367 0.17 ENST00000327228.3
centrin, EF-hand protein, 1
chr10_+_24755416 0.17 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr1_-_85100703 0.17 ENST00000370624.1
chromosome 1 open reading frame 180
chr2_+_105050794 0.17 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
long intergenic non-protein coding RNA 1102
chr1_-_147610081 0.17 ENST00000369226.3
neuroblastoma breakpoint family, member 24
chr1_+_32379174 0.17 ENST00000391369.1
HCG2032337; PRO1848; Uncharacterized protein
chr3_-_190167571 0.17 ENST00000354905.2
transmembrane protein 207
chr8_+_107738343 0.16 ENST00000521592.1
oxidation resistance 1
chr9_-_73736511 0.16 ENST00000377110.3
ENST00000377111.2
transient receptor potential cation channel, subfamily M, member 3
chr15_+_64680003 0.16 ENST00000261884.3
thyroid hormone receptor interactor 4
chr2_+_169659121 0.16 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
nitric oxide synthase trafficking
chr6_-_90025011 0.16 ENST00000402938.3
gamma-aminobutyric acid (GABA) A receptor, rho 2
chr10_+_102891048 0.16 ENST00000467928.2
T-cell leukemia homeobox 1
chr3_+_181429704 0.16 ENST00000431565.2
ENST00000325404.1
SRY (sex determining region Y)-box 2
chr12_+_21679220 0.16 ENST00000256969.2
chromosome 12 open reading frame 39
chr4_-_155511887 0.16 ENST00000302053.3
ENST00000403106.3
fibrinogen alpha chain
chrX_+_95939711 0.16 ENST00000373049.4
ENST00000324765.8
diaphanous-related formin 2
chr17_-_49021974 0.15 ENST00000501718.2
RP11-700H6.1
chrX_-_77225135 0.15 ENST00000458128.1
phosphoglycerate mutase family member 4
chr14_+_35747825 0.15 ENST00000540871.1
proteasome (prosome, macropain) subunit, alpha type, 6
chr6_-_90024967 0.15 ENST00000602399.1
gamma-aminobutyric acid (GABA) A receptor, rho 2
chr7_-_27142290 0.15 ENST00000222718.5
homeobox A2
chr1_-_241520525 0.15 ENST00000366565.1
regulator of G-protein signaling 7
chr4_-_48014931 0.15 ENST00000420489.2
ENST00000504722.1
cyclic nucleotide gated channel alpha 1
chrX_+_1387721 0.15 ENST00000419094.1
ENST00000381509.3
ENST00000494969.2
ENST00000355805.2
ENST00000355432.3
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr17_+_45973516 0.14 ENST00000376741.4
Sp2 transcription factor
chr5_-_75919217 0.14 ENST00000504899.1
coagulation factor II (thrombin) receptor-like 2
chr17_-_38821373 0.14 ENST00000394052.3
keratin 222
chr12_-_109025849 0.14 ENST00000228463.6
selectin P ligand
chr11_-_5345582 0.14 ENST00000328813.2
olfactory receptor, family 51, subfamily B, member 2
chr16_+_86612112 0.14 ENST00000320241.3
forkhead box L1
chr1_-_146068184 0.14 ENST00000604894.1
ENST00000369323.3
ENST00000479926.2
neuroblastoma breakpoint family, member 11
chr3_+_191046810 0.14 ENST00000392455.3
ENST00000392456.3
coiled-coil domain containing 50
chr7_+_141695671 0.14 ENST00000497673.1
ENST00000475668.2
maltase-glucoamylase (alpha-glucosidase)
chr17_-_8770956 0.14 ENST00000311434.9
phosphoinositide-3-kinase, regulatory subunit 6
chr15_-_38519066 0.14 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
chr3_-_46608010 0.14 ENST00000395905.3
leucine rich repeat containing 2
chr9_-_127269661 0.14 ENST00000373588.4
nuclear receptor subfamily 5, group A, member 1
chr15_-_55489097 0.14 ENST00000260443.4
ribosomal L24 domain containing 1
chr19_-_33360647 0.14 ENST00000590341.1
ENST00000587772.1
ENST00000023064.4
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr2_+_102413726 0.14 ENST00000350878.4
mitogen-activated protein kinase kinase kinase kinase 4
chr3_-_112564797 0.14 ENST00000398214.1
ENST00000448932.1
CD200 receptor 1-like
chr7_+_93535866 0.13 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr5_-_54281491 0.13 ENST00000381405.4
endothelial cell-specific molecule 1
chr3_+_156009623 0.13 ENST00000389634.5
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr14_-_31926623 0.13 ENST00000356180.4
D-tyrosyl-tRNA deacylase 2 (putative)
chrX_+_57618269 0.13 ENST00000374888.1
zinc finger, X-linked, duplicated B
chr9_+_97136833 0.13 ENST00000375344.3
hippocampus abundant transcript-like 1
chr17_-_64225508 0.13 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr15_+_49715293 0.13 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr3_-_21792838 0.13 ENST00000281523.2
zinc finger protein 385D
chr3_+_35682913 0.13 ENST00000449196.1
cAMP-regulated phosphoprotein, 21kDa
chr19_+_52693259 0.12 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
protein phosphatase 2, regulatory subunit A, alpha
chrX_-_110655306 0.12 ENST00000371993.2
doublecortin
chr4_+_86748898 0.12 ENST00000509300.1
Rho GTPase activating protein 24
chr16_+_10837643 0.12 ENST00000574334.1
ENST00000283027.5
ENST00000433392.2
nucleotide binding protein 1
chr9_-_27529726 0.12 ENST00000262244.5
MOB kinase activator 3B
chr2_-_190044480 0.12 ENST00000374866.3
collagen, type V, alpha 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.4 1.8 GO:0032747 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.3 1.9 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 1.3 GO:0055099 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.2 1.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.4 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.4 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.8 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.6 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 0.3 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.4 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 0.5 GO:0061056 sclerotome development(GO:0061056)
0.1 0.4 GO:0044026 DNA hypermethylation(GO:0044026)
0.1 0.5 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.6 GO:0003383 apical constriction(GO:0003383)
0.1 0.2 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.3 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.2 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.1 0.2 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.1 0.2 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 0.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.1 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0051414 response to cortisol(GO:0051414)
0.1 0.2 GO:2000854 negative regulation of glucagon secretion(GO:0070093) cellular response to cocaine(GO:0071314) positive regulation of corticosterone secretion(GO:2000854)
0.1 0.2 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 0.3 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 0.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.0 0.1 GO:0035283 rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 2.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.3 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.3 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.0 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0007538 primary sex determination(GO:0007538)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.1 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.2 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.2 GO:1904139 negative regulation of norepinephrine secretion(GO:0010700) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 1.0 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 1.0 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 0.1 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.1 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.4 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.1 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0 0.3 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:0060578 subthalamic nucleus development(GO:0021763) deltoid tuberosity development(GO:0035993) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.5 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.1 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.0 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.0 GO:2000412 positive regulation of thymocyte migration(GO:2000412) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.0 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.4 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 0.6 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 0.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.4 1.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 1.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.5 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 0.3 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 2.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.3 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.2 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.7 GO:0008430 selenium binding(GO:0008430)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 1.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.0 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 2.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.4 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein