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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXC10_HOXD13

Z-value: 0.77

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Transcription factors associated with HOXC10_HOXD13

Gene Symbol Gene ID Gene Info
ENSG00000180818.4 homeobox C10
ENSG00000128714.5 homeobox D13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD13hg19_v2_chr2_+_176957619_176957619-0.174.2e-01Click!
HOXC10hg19_v2_chr12_+_54378923_543789700.154.6e-01Click!

Activity profile of HOXC10_HOXD13 motif

Sorted Z-values of HOXC10_HOXD13 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_132891461 1.39 ENST00000275198.1
trace amine associated receptor 6
chr14_-_72458326 1.15 ENST00000542853.1
AC005477.1
chr17_-_39646116 1.12 ENST00000328119.6
keratin 36
chr1_-_9129895 1.04 ENST00000473209.1
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_+_84630645 0.81 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_42873548 0.73 ENST00000533338.1
ENST00000534420.1
hook microtubule-tethering protein 3
Uncharacterized protein
chr9_+_82188077 0.72 ENST00000425506.1
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_+_109204743 0.72 ENST00000332345.6
LIM and senescent cell antigen-like domains 1
chr17_-_46690839 0.72 ENST00000498634.2
homeobox B8
chr8_+_76452097 0.69 ENST00000396423.2
hepatocyte nuclear factor 4, gamma
chr20_+_58179582 0.67 ENST00000371015.1
ENST00000395639.4
phosphatase and actin regulator 3
chr8_+_38831683 0.60 ENST00000302495.4
HtrA serine peptidase 4
chr3_-_112127981 0.55 ENST00000486726.2
RP11-231E6.1
chr2_-_209010874 0.55 ENST00000260988.4
crystallin, gamma B
chr5_+_147582387 0.55 ENST00000325630.2
serine peptidase inhibitor, Kazal type 6
chr12_-_91576429 0.52 ENST00000552145.1
ENST00000546745.1
decorin
chr12_-_91573132 0.51 ENST00000550563.1
ENST00000546370.1
decorin
chr19_+_46367518 0.51 ENST00000302177.2
forkhead box A3
chrX_-_19688475 0.50 ENST00000541422.1
SH3-domain kinase binding protein 1
chr9_+_82187630 0.49 ENST00000265284.6
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_9129631 0.49 ENST00000377414.3
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr9_+_82187487 0.48 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_18243119 0.48 ENST00000538724.1
ENST00000229002.2
RERG/RAS-like
chr2_+_106679690 0.47 ENST00000409944.1
chromosome 2 open reading frame 40
chr7_+_134551583 0.46 ENST00000435928.1
caldesmon 1
chr17_+_58018269 0.42 ENST00000591035.1
Uncharacterized protein
chr12_-_95510743 0.42 ENST00000551521.1
FYVE, RhoGEF and PH domain containing 6
chr1_+_116654376 0.41 ENST00000369500.3
mab-21-like 3 (C. elegans)
chr4_-_164534657 0.40 ENST00000339875.5
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr1_+_26485511 0.39 ENST00000374268.3
family with sequence similarity 110, member D
chrX_+_135388147 0.38 ENST00000394141.1
G protein-coupled receptor 112
chr3_-_185270342 0.38 ENST00000424591.2
lipase, member H
chr6_+_12007897 0.38 ENST00000437559.1
RP11-456H18.2
chr11_-_7961141 0.37 ENST00000360759.3
olfactory receptor, family 10, subfamily A, member 3
chr12_+_130646999 0.37 ENST00000539839.1
ENST00000229030.4
frizzled family receptor 10
chr1_+_84630053 0.37 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_152635854 0.37 ENST00000368784.1
late cornified envelope 2D
chr12_-_58220078 0.36 ENST00000549039.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chrX_+_65382433 0.36 ENST00000374727.3
hephaestin
chr1_-_76398077 0.36 ENST00000284142.6
ankyrin repeat and SOCS box containing 17
chr1_-_9129598 0.36 ENST00000535586.1
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_+_12976450 0.35 ENST00000361079.2
PRAME family member 7
chr5_-_111093759 0.35 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
neuronal regeneration related protein
chr9_+_21967137 0.35 ENST00000441769.2
chromosome 9 open reading frame 53
chrX_+_65382381 0.35 ENST00000519389.1
hephaestin
chr12_-_81992111 0.35 ENST00000443686.3
ENST00000407050.4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr3_+_68053359 0.34 ENST00000478136.1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr12_+_20963647 0.34 ENST00000381545.3
solute carrier organic anion transporter family, member 1B3
chr12_+_20963632 0.32 ENST00000540853.1
ENST00000261196.2
solute carrier organic anion transporter family, member 1B3
chr22_+_41956767 0.32 ENST00000306149.7
cold shock domain containing C2, RNA binding
chr18_-_12656715 0.30 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
spire-type actin nucleation factor 1
chr10_+_115614370 0.29 ENST00000369301.3
NHL repeat containing 2
chr14_+_31046959 0.29 ENST00000547532.1
ENST00000555429.1
G2/M-phase specific E3 ubiquitin protein ligase
chr10_+_60759378 0.29 ENST00000432535.1
long intergenic non-protein coding RNA 844
chr1_+_209859510 0.28 ENST00000367028.2
ENST00000261465.1
hydroxysteroid (11-beta) dehydrogenase 1
chr18_-_52989217 0.27 ENST00000570287.2
transcription factor 4
chr7_+_80275752 0.27 ENST00000419819.2
CD36 molecule (thrombospondin receptor)
chr2_-_216300784 0.27 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
fibronectin 1
chr2_+_109237717 0.27 ENST00000409441.1
LIM and senescent cell antigen-like domains 1
chr11_-_19082216 0.27 ENST00000329773.2
MAS-related GPR, member X2
chr14_-_51027838 0.27 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr6_-_27775694 0.26 ENST00000377401.2
histone cluster 1, H2bl
chr9_+_79074068 0.26 ENST00000444201.2
ENST00000376730.4
glucosaminyl (N-acetyl) transferase 1, core 2
chr18_+_61223393 0.26 ENST00000269491.1
ENST00000382768.1
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr17_-_53809473 0.26 ENST00000575734.1
transmembrane protein 100
chr12_-_49418407 0.26 ENST00000526209.1
lysine (K)-specific methyltransferase 2D
chr7_+_80275621 0.26 ENST00000426978.1
ENST00000432207.1
CD36 molecule (thrombospondin receptor)
chrX_-_117119243 0.25 ENST00000539496.1
ENST00000469946.1
kelch-like family member 13
chr3_+_15045419 0.25 ENST00000406272.2
nuclear receptor subfamily 2, group C, member 2
chr17_+_35851570 0.25 ENST00000394386.1
dual specificity phosphatase 14
chr12_+_59989918 0.25 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr3_+_57875711 0.25 ENST00000442599.2
sarcolemma associated protein
chrX_-_30327495 0.25 ENST00000453287.1
nuclear receptor subfamily 0, group B, member 1
chr20_+_42984330 0.25 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
hepatocyte nuclear factor 4, alpha
chr7_+_80275953 0.24 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36 molecule (thrombospondin receptor)
chr9_-_114521783 0.24 ENST00000394779.3
ENST00000394777.4
chromosome 9 open reading frame 84
chr11_-_47447970 0.24 ENST00000298852.3
ENST00000530912.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr12_-_15038779 0.24 ENST00000228938.5
ENST00000539261.1
matrix Gla protein
chr11_-_47447767 0.24 ENST00000530651.1
ENST00000524447.2
ENST00000531051.2
ENST00000526993.1
ENST00000602866.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr7_-_142139783 0.23 ENST00000390374.3
T cell receptor beta variable 7-6
chr20_+_52105495 0.23 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr3_-_141747950 0.23 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_111093167 0.23 ENST00000446294.2
ENST00000419114.2
neuronal regeneration related protein
chr2_+_242289502 0.23 ENST00000451310.1
septin 2
chr10_-_50970322 0.23 ENST00000374103.4
oxoglutarate dehydrogenase-like
chr11_-_5537920 0.23 ENST00000380184.1
ubiquilin-like
chr18_-_53069419 0.23 ENST00000570177.2
transcription factor 4
chr11_+_101785727 0.22 ENST00000263468.8
KIAA1377
chr12_-_58027138 0.22 ENST00000341156.4
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr20_+_37554955 0.22 ENST00000217429.4
family with sequence similarity 83, member D
chr1_-_167059830 0.22 ENST00000367868.3
glycoprotein A33 (transmembrane)
chr6_-_137815524 0.22 ENST00000367734.2
oligodendrocyte transcription factor 3
chr10_-_116444371 0.22 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr7_-_11871815 0.22 ENST00000423059.4
thrombospondin, type I, domain containing 7A
chr3_+_57881966 0.22 ENST00000495364.1
sarcolemma associated protein
chr16_+_333152 0.22 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
protein disulfide isomerase family A, member 2
chr6_+_155470243 0.22 ENST00000456877.2
ENST00000528391.2
T-cell lymphoma invasion and metastasis 2
chr2_+_90198535 0.21 ENST00000390276.2
immunoglobulin kappa variable 1D-12
chr22_+_35462129 0.21 ENST00000404699.2
ENST00000308700.6
intestine-specific homeobox
chr9_-_21202204 0.21 ENST00000239347.3
interferon, alpha 7
chr7_+_108210012 0.21 ENST00000249356.3
DnaJ (Hsp40) homolog, subfamily B, member 9
chr2_-_165424973 0.21 ENST00000543549.1
growth factor receptor-bound protein 14
chr16_+_25228242 0.21 ENST00000219660.5
aquaporin 8
chr6_+_108487245 0.20 ENST00000368986.4
nuclear receptor subfamily 2, group E, member 1
chr12_-_81763127 0.20 ENST00000541017.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_81763184 0.20 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr1_-_161207875 0.20 ENST00000512372.1
ENST00000437437.2
ENST00000442691.2
ENST00000412844.2
ENST00000428574.2
ENST00000505005.1
ENST00000508740.1
ENST00000508387.1
ENST00000504010.1
ENST00000511676.1
ENST00000502985.1
ENST00000367981.3
ENST00000515621.1
ENST00000511944.1
ENST00000511748.1
ENST00000367984.4
ENST00000367985.3
nuclear receptor subfamily 1, group I, member 3
chr19_+_36706024 0.20 ENST00000443387.2
zinc finger protein 146
chr5_-_111312622 0.20 ENST00000395634.3
neuronal regeneration related protein
chr1_+_75600567 0.20 ENST00000356261.3
LIM homeobox 8
chr10_+_21823079 0.20 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_-_227505289 0.20 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chr12_+_52695617 0.19 ENST00000293525.5
keratin 86
chr2_+_179149636 0.19 ENST00000409631.1
oxysterol binding protein-like 6
chr3_-_151034734 0.19 ENST00000260843.4
G protein-coupled receptor 87
chrX_+_16668278 0.19 ENST00000380200.3
S100 calcium binding protein G
chr21_-_39493433 0.19 ENST00000398948.1
ENST00000328264.3
Down syndrome critical region gene 4
chr1_-_161207953 0.19 ENST00000367982.4
nuclear receptor subfamily 1, group I, member 3
chr6_-_116833500 0.19 ENST00000356128.4
trafficking protein particle complex 3-like
chr21_-_31859755 0.19 ENST00000334055.3
keratin associated protein 19-2
chr5_-_43412418 0.19 ENST00000537013.1
ENST00000361115.4
chemokine (C-C motif) ligand 28
chr1_+_211432775 0.18 ENST00000419091.2
REST corepressor 3
chr19_-_19626838 0.18 ENST00000360913.3
testis-specific serine kinase 6
chr21_+_35736302 0.18 ENST00000290310.3
potassium voltage-gated channel, Isk-related family, member 2
chr11_-_76155700 0.18 ENST00000572035.1
RP11-111M22.3
chr6_-_26247259 0.18 ENST00000244537.4
histone cluster 1, H4g
chr9_-_124990680 0.18 ENST00000541397.2
ENST00000560485.1
LIM homeobox 6
chr7_+_77428066 0.18 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
putative homeodomain transcription factor 2
chr17_-_34417479 0.17 ENST00000225245.5
chemokine (C-C motif) ligand 3
chr22_+_39916558 0.17 ENST00000337304.2
ENST00000396680.1
activating transcription factor 4
chr7_+_1727755 0.17 ENST00000424383.2
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr3_-_123710199 0.17 ENST00000184183.4
rhophilin associated tail protein 1
chr19_-_49843539 0.17 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
chr1_+_32042105 0.17 ENST00000457433.2
ENST00000441210.2
tubulointerstitial nephritis antigen-like 1
chr12_+_48099858 0.17 ENST00000547799.1
RP1-197B17.3
chr10_-_50970382 0.17 ENST00000419399.1
ENST00000432695.1
oxoglutarate dehydrogenase-like
chr20_+_30193083 0.16 ENST00000376112.3
ENST00000376105.3
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
chr8_+_52730143 0.16 ENST00000415643.1
Uncharacterized protein
chr11_+_64879317 0.16 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
transmembrane 7 superfamily member 2
chr1_+_32042131 0.16 ENST00000271064.7
ENST00000537531.1
tubulointerstitial nephritis antigen-like 1
chr16_-_20338748 0.16 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
glycoprotein 2 (zymogen granule membrane)
chr1_-_161208013 0.16 ENST00000515452.1
ENST00000367983.4
nuclear receptor subfamily 1, group I, member 3
chr4_-_39033963 0.16 ENST00000381938.3
transmembrane protein 156
chr7_-_72992865 0.16 ENST00000452475.1
transducin (beta)-like 2
chr16_-_20339123 0.16 ENST00000381360.5
glycoprotein 2 (zymogen granule membrane)
chr9_+_44868935 0.16 ENST00000448436.2
RP11-160N1.10
chr17_+_34391625 0.16 ENST00000004921.3
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chr1_+_211432593 0.16 ENST00000367006.4
REST corepressor 3
chr5_-_94417314 0.16 ENST00000505208.1
multiple C2 domains, transmembrane 1
chr5_+_7654057 0.16 ENST00000537121.1
adenylate cyclase 2 (brain)
chrX_+_65384182 0.16 ENST00000441993.2
ENST00000419594.1
hephaestin
chr14_+_23012122 0.15 ENST00000390534.1
T cell receptor alpha joining 3
chr1_-_161207986 0.15 ENST00000506209.1
ENST00000367980.2
nuclear receptor subfamily 1, group I, member 3
chr7_+_134430212 0.15 ENST00000436461.2
caldesmon 1
chr17_-_38821373 0.15 ENST00000394052.3
keratin 222
chr2_+_169923577 0.15 ENST00000432060.2
dehydrogenase/reductase (SDR family) member 9
chr20_+_3052264 0.15 ENST00000217386.2
oxytocin/neurophysin I prepropeptide
chrX_+_65384052 0.15 ENST00000336279.5
ENST00000458621.1
hephaestin
chr12_-_96184533 0.15 ENST00000343702.4
ENST00000344911.4
netrin 4
chr15_+_25101698 0.15 ENST00000400097.1
small nuclear ribonucleoprotein polypeptide N
chr3_-_12200851 0.15 ENST00000287814.4
TIMP metallopeptidase inhibitor 4
chrX_-_108725301 0.15 ENST00000218006.2
guanylate cyclase 2F, retinal
chr3_+_107096188 0.15 ENST00000261058.1
coiled-coil domain containing 54
chr11_+_118401706 0.14 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
transmembrane protein 25
chr7_-_36634181 0.14 ENST00000538464.1
acyloxyacyl hydrolase (neutrophil)
chr1_+_52082751 0.14 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
oxysterol binding protein-like 9
chr19_-_54676884 0.14 ENST00000376591.4
transmembrane channel-like 4
chr5_+_147582348 0.14 ENST00000514389.1
serine peptidase inhibitor, Kazal type 6
chr19_-_54676846 0.14 ENST00000301187.4
transmembrane channel-like 4
chr12_-_91576561 0.14 ENST00000547568.2
ENST00000552962.1
decorin
chr3_+_57882024 0.14 ENST00000494088.1
sarcolemma associated protein
chr21_-_31588365 0.14 ENST00000399899.1
claudin 8
chr12_-_117799446 0.14 ENST00000317775.6
ENST00000344089.3
nitric oxide synthase 1 (neuronal)
chr19_-_10420459 0.14 ENST00000403352.1
ENST00000403903.3
zinc finger, GATA-like protein 1
chr11_+_118401899 0.14 ENST00000528373.1
ENST00000544878.1
ENST00000354284.4
ENST00000533137.1
ENST00000532762.1
ENST00000526973.1
ENST00000354064.7
ENST00000533102.1
ENST00000313236.5
ENST00000527267.1
ENST00000524725.1
ENST00000533689.1
transmembrane protein 25
chr3_-_49314640 0.14 ENST00000436325.1
chromosome 3 open reading frame 62
chr11_-_76155618 0.14 ENST00000530759.1
RP11-111M22.3
chr19_-_19626351 0.14 ENST00000585580.3
testis-specific serine kinase 6
chrX_+_84498989 0.14 ENST00000395402.1
zinc finger protein 711
chr4_-_110723134 0.14 ENST00000510800.1
ENST00000512148.1
complement factor I
chr4_-_110723194 0.14 ENST00000394635.3
complement factor I
chr3_+_30647994 0.13 ENST00000295754.5
transforming growth factor, beta receptor II (70/80kDa)
chr12_+_93096759 0.13 ENST00000544406.2
chromosome 12 open reading frame 74
chr12_+_52056548 0.13 ENST00000545061.1
ENST00000355133.3
sodium channel, voltage gated, type VIII, alpha subunit
chr2_+_138722028 0.13 ENST00000280096.5
histamine N-methyltransferase
chr12_-_111358372 0.13 ENST00000548438.1
ENST00000228841.8
myosin, light chain 2, regulatory, cardiac, slow
chr17_-_39471947 0.13 ENST00000334202.3
keratin associated protein 17-1
chr15_-_58571445 0.13 ENST00000558231.1
aldehyde dehydrogenase 1 family, member A2
chrX_+_84499038 0.13 ENST00000373165.3
zinc finger protein 711
chr4_+_169013666 0.13 ENST00000359299.3
annexin A10
chr5_-_107703556 0.13 ENST00000496714.1
F-box and leucine-rich repeat protein 17
chr21_+_34398153 0.13 ENST00000382357.3
ENST00000430860.1
ENST00000333337.3
oligodendrocyte lineage transcription factor 2
chr4_-_110723335 0.13 ENST00000394634.2
complement factor I
chr10_-_69597828 0.13 ENST00000339758.7
DnaJ (Hsp40) homolog, subfamily C, member 12
chr14_-_106926724 0.13 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr17_-_39553844 0.13 ENST00000251645.2
keratin 31
chr20_+_16729003 0.13 ENST00000246081.2
otoraplin
chr9_+_75229616 0.13 ENST00000340019.3
transmembrane channel-like 1
chr6_+_88054530 0.13 ENST00000388923.4
chromosome 6 open reading frame 163
chr14_-_55369525 0.13 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GTP cyclohydrolase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC10_HOXD13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.2 1.3 GO:0097338 response to clozapine(GO:0097338)
0.1 0.8 GO:2000332 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 1.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.2 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.1 0.2 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 0.5 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.1 0.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.2 GO:1990737 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.3 GO:0001555 oocyte growth(GO:0001555)
0.1 0.2 GO:0002125 maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
0.0 0.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.2 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.1 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.2 GO:1902159 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 0.2 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.0 0.3 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.0 0.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 0.1 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.2 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.7 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.0 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.0 0.1 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.0 0.3 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.2 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.1 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.3 GO:0060352 cell adhesion molecule production(GO:0060352)
0.0 1.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.0 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.3 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.1 GO:0090675 intermicrovillar adhesion(GO:0090675)
0.0 0.4 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.3 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.8 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.1 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.1 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.0 0.1 GO:0002086 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.0 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.4 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.0 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.0 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 0.1 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 0.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.9 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.1 GO:0046098 guanine metabolic process(GO:0046098)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.0 GO:1903991 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0070695 FHF complex(GO:0070695)
0.1 1.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.5 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.2 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0005687 U4 snRNP(GO:0005687)
0.0 1.8 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.0 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.2 1.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.8 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.7 GO:0004882 androgen receptor activity(GO:0004882)
0.1 1.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.3 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.2 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.1 1.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.2 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0050436 microfibril binding(GO:0050436)
0.0 0.5 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.2 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.2 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 1.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.0 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.0 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 1.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling