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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXD1

Z-value: 0.37

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.11 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_177053402-0.096.5e-01Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102651343 0.64 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr4_+_144354644 0.53 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr4_+_86525299 0.49 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr5_+_66300446 0.47 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_-_50418972 0.41 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr20_-_50418947 0.40 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr15_-_55562479 0.32 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55562582 0.31 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55563072 0.29 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr4_-_119759795 0.28 ENST00000419654.2
SEC24D
SEC24 family member D
chr3_+_111717511 0.27 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr3_+_111717600 0.26 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111718036 0.24 ENST00000455401.2
TAGLN3
transgelin 3
chr1_+_117544366 0.23 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr11_-_71823266 0.23 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr11_-_62521614 0.19 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr11_-_71823796 0.19 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr7_-_81399411 0.18 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_-_71823715 0.18 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr20_-_50419055 0.18 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr11_+_60163775 0.18 ENST00000300187.6
ENST00000395005.2
MS4A14
membrane-spanning 4-domains, subfamily A, member 14
chr3_-_99569821 0.17 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr7_-_73256838 0.16 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr2_+_228736335 0.14 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr7_-_99717463 0.13 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr11_-_26593779 0.13 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr11_-_26593677 0.12 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr8_+_55528627 0.12 ENST00000220676.1
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr20_+_43990576 0.12 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr13_+_36050881 0.11 ENST00000537702.1
NBEA
neurobeachin
chr18_-_33709268 0.11 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr11_+_71900572 0.11 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr11_+_71900703 0.11 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr7_+_99717230 0.10 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr19_+_50016610 0.09 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_+_15699286 0.08 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr19_-_3557570 0.08 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr14_+_32798462 0.07 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr4_-_139051839 0.06 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
LINC00616
long intergenic non-protein coding RNA 616
chr8_+_92261516 0.06 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr4_-_74486109 0.06 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr7_+_133812052 0.06 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr7_-_99716952 0.06 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr11_+_65554493 0.06 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr4_-_74486347 0.05 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_176811431 0.05 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr3_-_101039402 0.05 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr14_+_32798547 0.05 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr3_+_2933893 0.05 ENST00000397459.2
CNTN4
contactin 4
chr5_+_63802109 0.05 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr15_-_37393406 0.04 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr12_-_52761262 0.04 ENST00000257901.3
KRT85
keratin 85
chr4_+_113568207 0.04 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr14_+_56584414 0.04 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr11_+_118398178 0.04 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr22_+_24951949 0.04 ENST00000402849.1
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr1_-_151431909 0.03 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr12_-_22063787 0.03 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr17_-_27418537 0.03 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr10_+_99205894 0.03 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_-_25865159 0.02 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_-_190446759 0.02 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr3_-_151034734 0.02 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr3_-_164796269 0.02 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr9_+_124329336 0.02 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr2_+_135596106 0.02 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr7_-_81399329 0.02 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr10_+_99205959 0.01 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr12_+_109577202 0.01 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr7_-_81399438 0.01 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr12_-_118796910 0.01 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr3_-_191000172 0.01 ENST00000427544.2
UTS2B
urotensin 2B
chr2_+_187371440 0.01 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr11_+_73498898 0.00 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr2_+_135596180 0.00 ENST00000283054.4
ENST00000392928.1
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_+_11682790 0.00 ENST00000389825.3
ENST00000381483.2
GREB1
growth regulation by estrogen in breast cancer 1
chr4_-_150736962 0.00 ENST00000502345.1
ENST00000510975.1
ENST00000511993.1
RP11-526A4.1
RP11-526A4.1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 1.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0042670 photoreceptor cell outer segment organization(GO:0035845) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.0 GO:0071209 U7 snRNA binding(GO:0071209)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR