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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HSF1

Z-value: 0.56

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Transcription factors associated with HSF1

Gene Symbol Gene ID Gene Info
ENSG00000185122.6 heat shock transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_1455152990.096.8e-01Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_152939252 0.63 ENST00000340888.3
pregnancy up-regulated nonubiquitous CaM kinase
chr1_+_15632231 0.56 ENST00000375997.4
ENST00000524761.1
ENST00000375995.3
ENST00000401090.2
forkhead-associated (FHA) phosphopeptide binding domain 1
chrX_-_152939133 0.54 ENST00000370150.1
pregnancy up-regulated nonubiquitous CaM kinase
chr19_+_37342547 0.44 ENST00000331800.4
ENST00000586646.1
zinc finger protein 345
chr1_-_60539405 0.43 ENST00000450089.2
chromosome 1 open reading frame 87
chr1_-_60539422 0.42 ENST00000371201.3
chromosome 1 open reading frame 87
chr2_-_238499303 0.42 ENST00000409576.1
RAB17, member RAS oncogene family
chr1_+_152635854 0.40 ENST00000368784.1
late cornified envelope 2D
chr21_-_31744557 0.40 ENST00000399889.2
keratin associated protein 13-2
chr3_-_39234074 0.39 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
xin actin-binding repeat containing 1
chr19_+_35417844 0.35 ENST00000601957.1
zinc finger protein 30
chr8_+_143915663 0.35 ENST00000522728.1
glycosylphosphatidylinositol anchored molecule like
chr10_-_116444371 0.34 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr19_+_35417939 0.34 ENST00000601142.1
ENST00000426813.2
zinc finger protein 30
chr2_-_191878681 0.33 ENST00000409465.1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191878874 0.33 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
signal transducer and activator of transcription 1, 91kDa
chr7_+_150264365 0.33 ENST00000255945.2
ENST00000461940.1
GTPase, IMAP family member 4
chrX_-_55515635 0.32 ENST00000500968.3
ubiquitin specific peptidase 51
chr3_-_128690173 0.32 ENST00000508239.1
Uncharacterized protein FLJ43738
chr2_-_218867711 0.31 ENST00000446903.1
tensin 1
chr6_+_32605195 0.31 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chrX_+_49020882 0.29 ENST00000454342.1
MAGI family member, X-linked
chr9_+_127054217 0.29 ENST00000394199.2
ENST00000546191.1
NIMA-related kinase 6
chr7_+_120629653 0.28 ENST00000450913.2
ENST00000340646.5
cadherin-like and PC-esterase domain containing 1
chrX_+_52511925 0.27 ENST00000375588.1
X antigen family, member 1C
chrX_-_30326445 0.27 ENST00000378963.1
nuclear receptor subfamily 0, group B, member 1
chr20_+_54823788 0.27 ENST00000243911.2
melanocortin 3 receptor
chr11_+_65190245 0.27 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr3_-_183735731 0.27 ENST00000334444.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chrX_-_52260199 0.26 ENST00000375600.1
X antigen family, member 1A
chr2_-_191878162 0.26 ENST00000540176.1
signal transducer and activator of transcription 1, 91kDa
chr19_+_36602104 0.26 ENST00000585332.1
ENST00000262637.4
ovo-like zinc finger 3
chr8_+_143916217 0.26 ENST00000220940.1
glycosylphosphatidylinositol anchored molecule like
chr2_-_27851843 0.26 ENST00000324364.3
coiled-coil domain containing 121
chr7_-_138347897 0.26 ENST00000288513.5
SVOP-like
chr5_-_43043272 0.26 ENST00000314890.3
annexin A2 receptor
chr2_+_26624775 0.26 ENST00000288710.2
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr10_-_125851961 0.25 ENST00000346248.5
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr4_+_76481258 0.25 ENST00000311623.4
ENST00000435974.2
chromosome 4 open reading frame 26
chr20_+_55841819 0.25 ENST00000412321.1
ENST00000426580.1
RP4-813D12.3
chr9_+_120466610 0.25 ENST00000394487.4
toll-like receptor 4
chr6_+_32605134 0.24 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_191885686 0.24 ENST00000432058.1
signal transducer and activator of transcription 1, 91kDa
chr18_+_77905794 0.24 ENST00000587254.1
ENST00000586421.1
Uncharacterized protein
chr15_+_89402148 0.24 ENST00000560601.1
aggrecan
chr17_-_39306054 0.24 ENST00000343246.4
keratin associated protein 4-5
chr17_+_48911942 0.24 ENST00000426127.1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr15_-_82338460 0.24 ENST00000558133.1
ENST00000329713.4
mex-3 RNA binding family member B
chrX_-_125686784 0.24 ENST00000371126.1
DDB1 and CUL4 associated factor 12-like 1
chr3_+_101443476 0.23 ENST00000327230.4
ENST00000494050.1
centrosomal protein 97kDa
chr8_-_81083890 0.23 ENST00000518937.1
tumor protein D52
chr1_-_165325449 0.23 ENST00000294816.2
LIM homeobox transcription factor 1, alpha
chr1_-_165325939 0.23 ENST00000342310.3
LIM homeobox transcription factor 1, alpha
chr21_+_35445827 0.23 ENST00000608209.1
ENST00000381151.3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr19_+_782755 0.23 ENST00000606242.1
ENST00000586061.1
AC006273.5
chr17_-_67138015 0.22 ENST00000284425.2
ENST00000590645.1
ATP-binding cassette, sub-family A (ABC1), member 6
chr9_-_97402413 0.22 ENST00000414122.1
fructose-1,6-bisphosphatase 1
chr14_+_63671105 0.22 ENST00000316754.3
ras homolog family member J
chr2_-_97405775 0.22 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
lectin, mannose-binding 2-like
chrX_+_86772787 0.22 ENST00000373114.4
kelch-like family member 4
chr12_+_51632666 0.21 ENST00000604900.1
DAZ associated protein 2
chr14_+_75988768 0.21 ENST00000286639.6
basic leucine zipper transcription factor, ATF-like
chr7_+_5919458 0.21 ENST00000416608.1
oncomodulin
chrX_+_147062844 0.21 ENST00000370467.3
fragile X mental retardation 1 neighbor
chr11_+_117063295 0.21 ENST00000525478.1
ENST00000532062.1
SID1 transmembrane family, member 2
chr1_-_147232669 0.21 ENST00000369237.1
gap junction protein, alpha 5, 40kDa
chr20_-_62168672 0.21 ENST00000217185.2
protein tyrosine kinase 6
chr7_-_5821225 0.21 ENST00000416985.1
ring finger protein 216
chr2_+_106682103 0.20 ENST00000238044.3
chromosome 2 open reading frame 40
chr9_-_21207142 0.20 ENST00000357374.2
interferon, alpha 10
chr2_-_198650961 0.20 ENST00000282278.8
boule-like RNA-binding protein
chr8_-_81083341 0.20 ENST00000519303.2
tumor protein D52
chr10_+_15001430 0.20 ENST00000407572.1
meiosis/spermiogenesis associated 1
chr9_-_13279406 0.20 ENST00000546205.1
multiple PDZ domain protein
chr7_+_150020329 0.20 ENST00000323078.7
leucine rich repeat containing 61
chr7_-_112579869 0.20 ENST00000297145.4
chromosome 7 open reading frame 60
chr2_+_61404624 0.20 ENST00000394457.3
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr1_+_15256230 0.19 ENST00000376028.4
ENST00000400798.2
kazrin, periplakin interacting protein
chr3_+_56591184 0.19 ENST00000422222.1
ENST00000394672.3
ENST00000326595.7
coiled-coil domain containing 66
chr7_+_150020363 0.19 ENST00000359623.4
ENST00000493307.1
leucine rich repeat containing 61
chr1_+_220960033 0.19 ENST00000366910.5
mitochondrial amidoxime reducing component 1
chr2_-_238499131 0.19 ENST00000538644.1
RAB17, member RAS oncogene family
chr14_-_106518922 0.19 ENST00000390598.2
immunoglobulin heavy variable 3-7
chr1_-_236030216 0.19 ENST00000389794.3
ENST00000389793.2
lysosomal trafficking regulator
chr12_+_100041527 0.19 ENST00000324341.1
family with sequence similarity 71, member C
chr1_+_35247859 0.19 ENST00000373362.3
gap junction protein, beta 3, 31kDa
chr12_+_52668394 0.19 ENST00000423955.2
keratin 86
chrX_-_52546033 0.19 ENST00000375567.3
X antigen family, member 1E
chr7_+_114562172 0.19 ENST00000393486.1
ENST00000257724.3
MyoD family inhibitor domain containing
chr11_+_33563821 0.19 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549-like
chr3_-_10334617 0.18 ENST00000429122.1
ENST00000425479.1
ENST00000335542.8
ghrelin/obestatin prepropeptide
chr1_+_47489240 0.18 ENST00000371901.3
cytochrome P450, family 4, subfamily X, polypeptide 1
chr5_+_140044261 0.18 ENST00000358337.5
WD repeat domain 55
chr14_+_23012122 0.18 ENST00000390534.1
T cell receptor alpha joining 3
chrX_-_52533139 0.18 ENST00000374959.3
X antigen family, member 1D
chr2_+_61404545 0.18 ENST00000357022.2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr7_+_13141097 0.18 ENST00000411542.1
AC011288.2
chr18_-_76738843 0.18 ENST00000575722.1
ENST00000583511.1
RP11-849I19.1
chr2_-_190627481 0.18 ENST00000264151.5
ENST00000520350.1
ENST00000521630.1
ENST00000517895.1
O-sialoglycoprotein endopeptidase-like 1
chr2_+_202316392 0.18 ENST00000194530.3
ENST00000392249.2
STE20-related kinase adaptor beta
chr19_-_17445613 0.18 ENST00000159087.4
anoctamin 8
chr9_-_114545768 0.18 ENST00000318737.4
chromosome 9 open reading frame 84
chr2_-_89513402 0.18 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr6_-_170599561 0.17 ENST00000366756.3
delta-like 1 (Drosophila)
chrX_-_73072534 0.17 ENST00000429829.1
X inactive specific transcript (non-protein coding)
chr17_-_34308524 0.17 ENST00000293275.3
chemokine (C-C motif) ligand 16
chr1_-_203144941 0.17 ENST00000255416.4
myosin binding protein H
chr2_-_11272234 0.17 ENST00000590207.1
ENST00000417697.2
ENST00000396164.1
ENST00000536743.1
ENST00000544306.1
AC062028.1
chr4_+_55524085 0.17 ENST00000412167.2
ENST00000288135.5
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr11_-_59951889 0.17 ENST00000532169.1
ENST00000534596.1
membrane-spanning 4-domains, subfamily A, member 6A
chr14_-_25045446 0.16 ENST00000216336.2
cathepsin G
chr2_+_103089756 0.16 ENST00000295269.4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr9_-_21202204 0.16 ENST00000239347.3
interferon, alpha 7
chr3_-_10334585 0.16 ENST00000430179.1
ENST00000449238.2
ENST00000437422.2
ENST00000287656.7
ENST00000457360.1
ENST00000439975.2
ENST00000446937.2
ghrelin/obestatin prepropeptide
chr2_+_241564655 0.16 ENST00000407714.1
G protein-coupled receptor 35
chr6_+_46620676 0.16 ENST00000371347.5
ENST00000411689.2
solute carrier family 25, member 27
chr14_-_106926724 0.16 ENST00000434710.1
immunoglobulin heavy variable 3-43
chrX_+_30233668 0.16 ENST00000378988.4
melanoma antigen family B, 2
chr21_+_47268058 0.16 ENST00000400310.1
poly(rC) binding protein 3
chr11_+_59480899 0.16 ENST00000300150.7
syntaxin 3
chr22_-_38699003 0.15 ENST00000451964.1
casein kinase 1, epsilon
chr19_-_6720686 0.15 ENST00000245907.6
complement component 3
chr9_-_86432547 0.15 ENST00000376365.3
ENST00000376371.2
G kinase anchoring protein 1
chr19_-_7766991 0.15 ENST00000597921.1
ENST00000346664.5
Fc fragment of IgE, low affinity II, receptor for (CD23)
chrX_+_49020121 0.15 ENST00000415364.1
ENST00000376338.3
ENST00000425285.1
MAGI family member, X-linked
chr17_-_34313685 0.15 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
chemokine (C-C motif) ligand 14
chr9_-_21187598 0.15 ENST00000421715.1
interferon, alpha 4
chr12_+_93772402 0.15 ENST00000546925.1
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr19_+_50338234 0.15 ENST00000593767.1
mediator complex subunit 25
chr7_+_150434430 0.15 ENST00000358647.3
GTPase, IMAP family member 5
chr19_+_17516909 0.15 ENST00000601007.1
ENST00000594913.1
ENST00000599975.1
ENST00000600514.1
CTD-2521M24.9
multivesicular body subunit 12A
chr20_+_36932521 0.15 ENST00000262865.4
bactericidal/permeability-increasing protein
chrX_+_54947229 0.15 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
trophinin
chr2_+_88047606 0.15 ENST00000359481.4
plasminogen-like B2
chr2_+_102624977 0.15 ENST00000441002.1
interleukin 1 receptor, type II
chr13_-_49018789 0.15 ENST00000378434.4
lysophosphatidic acid receptor 6
chrX_+_52238974 0.15 ENST00000375613.3
X antigen family, member 1B
chr9_-_138591341 0.14 ENST00000298466.5
ENST00000425225.1
spermatogenesis and oogenesis specific basic helix-loop-helix 1
chr19_+_1249869 0.14 ENST00000591446.2
midnolin
chr12_+_50366620 0.14 ENST00000315520.5
aquaporin 6, kidney specific
chr21_-_34144157 0.14 ENST00000331923.4
PAX3 and PAX7 binding protein 1
chr16_-_22012419 0.14 ENST00000537222.2
ENST00000424898.2
ENST00000286143.6
PDZ domain containing 9
chr1_-_160924589 0.14 ENST00000368029.3
intelectin 2
chr19_-_14217672 0.14 ENST00000587372.1
protein kinase, cAMP-dependent, catalytic, alpha
chr12_-_76742183 0.14 ENST00000393262.3
Bardet-Biedl syndrome 10
chr9_-_73477826 0.14 ENST00000396285.1
ENST00000396292.4
ENST00000396280.5
ENST00000358082.3
ENST00000408909.2
ENST00000377097.3
transient receptor potential cation channel, subfamily M, member 3
chr9_+_120466650 0.14 ENST00000355622.6
toll-like receptor 4
chr2_+_109403193 0.14 ENST00000412964.2
ENST00000295124.4
coiled-coil domain containing 138
chr6_-_41909191 0.14 ENST00000512426.1
ENST00000372987.4
cyclin D3
chr15_-_60771128 0.14 ENST00000558512.1
ENST00000561114.1
NMDA receptor regulated 2
chr16_+_68119764 0.14 ENST00000570212.1
ENST00000562926.1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr15_-_72490114 0.14 ENST00000309731.7
GRAM domain containing 2
chr5_+_40909354 0.14 ENST00000313164.9
complement component 7
chr22_-_47882857 0.14 ENST00000405369.3
Novel protein; Uncharacterized protein
chr19_-_43709817 0.14 ENST00000433626.2
ENST00000405312.3
pregnancy specific beta-1-glycoprotein 4
chr10_+_102222798 0.14 ENST00000343737.5
wingless-type MMTV integration site family, member 8B
chr3_-_46506563 0.14 ENST00000231751.4
lactotransferrin
chr14_+_39734482 0.14 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE family, member 5
chr3_-_46506358 0.14 ENST00000417439.1
ENST00000431944.1
lactotransferrin
chr19_-_51523412 0.14 ENST00000391805.1
ENST00000599077.1
kallikrein-related peptidase 10
chr13_+_39612485 0.14 ENST00000379599.2
NHL repeat containing 3
chr20_+_31870927 0.14 ENST00000253354.1
BPI fold containing family B, member 1
chr6_+_46620705 0.14 ENST00000452689.2
solute carrier family 25, member 27
chr2_+_28718921 0.14 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
phospholipase B1
chr17_-_76573465 0.14 ENST00000585328.1
ENST00000389840.5
dynein, axonemal, heavy chain 17
chr9_-_97402531 0.14 ENST00000415431.1
fructose-1,6-bisphosphatase 1
chrX_-_112084043 0.13 ENST00000304758.1
angiomotin
chr19_-_51523275 0.13 ENST00000309958.3
kallikrein-related peptidase 10
chr9_-_97090926 0.13 ENST00000335456.7
ENST00000253262.4
ENST00000341207.4
NUT family member 2F
chr8_-_38386175 0.13 ENST00000437935.2
ENST00000358138.1
chromosome 8 open reading frame 86
chr1_-_153935938 0.13 ENST00000368621.1
ENST00000368623.3
solute carrier family 39 (zinc transporter), member 1
chr6_+_35704804 0.13 ENST00000373869.3
armadillo repeat containing 12
chr3_+_46742823 0.13 ENST00000326431.3
transmembrane inner ear
chr21_+_45148735 0.13 ENST00000327574.4
pyridoxal (pyridoxine, vitamin B6) kinase
chr16_-_52640834 0.13 ENST00000510238.3
cancer susceptibility candidate 16 (non-protein coding)
chr20_-_43753104 0.13 ENST00000372785.3
WAP four-disulfide core domain 12
chr3_+_124223586 0.13 ENST00000393496.1
kalirin, RhoGEF kinase
chr13_+_39612442 0.13 ENST00000470258.1
ENST00000379600.3
NHL repeat containing 3
chr17_+_56315936 0.13 ENST00000543544.1
lactoperoxidase
chr6_-_29648887 0.13 ENST00000376883.1
ZFP57 zinc finger protein
chr6_-_52705641 0.13 ENST00000370989.2
glutathione S-transferase alpha 5
chr8_-_81083731 0.13 ENST00000379096.5
tumor protein D52
chr22_+_27017921 0.13 ENST00000354760.3
crystallin, beta A4
chr6_-_28220002 0.13 ENST00000377294.2
zinc finger with KRAB and SCAN domains 4
chr17_+_35732955 0.12 ENST00000300618.4
chromosome 17 open reading frame 78
chr19_-_43709703 0.12 ENST00000599391.1
ENST00000244295.9
pregnancy specific beta-1-glycoprotein 4
chr17_-_61920280 0.12 ENST00000448276.2
ENST00000577990.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr6_-_144385698 0.12 ENST00000444202.1
ENST00000437412.1
pleiomorphic adenoma gene-like 1
chr6_-_38607673 0.12 ENST00000481247.1
BTB (POZ) domain containing 9
chr12_+_119772502 0.12 ENST00000536742.1
ENST00000327554.2
coiled-coil domain containing 60
chr2_+_135011731 0.12 ENST00000281923.2
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr17_+_35732916 0.12 ENST00000586700.1
chromosome 17 open reading frame 78
chrX_-_153523462 0.12 ENST00000361930.3
ENST00000369926.1
testis expressed 28
chr12_+_120105558 0.12 ENST00000229328.5
ENST00000541640.1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chrX_+_153524024 0.12 ENST00000369915.3
ENST00000217905.7
transketolase-like 1
chr3_+_39509070 0.12 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
myelin-associated oligodendrocyte basic protein
chr1_-_153935983 0.12 ENST00000537590.1
ENST00000356205.4
solute carrier family 39 (zinc transporter), member 1
chrX_+_48380205 0.12 ENST00000446158.1
ENST00000414061.1
emopamil binding protein (sterol isomerase)
chr1_+_156117149 0.12 ENST00000435124.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_48082192 0.12 ENST00000507351.1
TXK tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.4 GO:0032707 negative regulation of interleukin-23 production(GO:0032707) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.3 GO:1904346 positive regulation of growth rate(GO:0040010) regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768)
0.1 0.3 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.1 0.2 GO:1904347 regulation of small intestine smooth muscle contraction(GO:1904347) positive regulation of small intestine smooth muscle contraction(GO:1904349) small intestine smooth muscle contraction(GO:1990770)
0.1 0.3 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.3 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 0.2 GO:0003193 pulmonary valve formation(GO:0003193) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.2 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608) positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.2 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.0 0.1 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.0 0.1 GO:1903094 enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.1 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.2 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.2 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.2 GO:2001176 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.0 0.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0060545 positive regulation of necroptotic process(GO:0060545)
0.0 0.2 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.5 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.1 GO:0019075 virus maturation(GO:0019075)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:0042126 nitrate metabolic process(GO:0042126)
0.0 0.1 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.0 0.1 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0071603 desmosome assembly(GO:0002159) endothelial cell-cell adhesion(GO:0071603)
0.0 0.2 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.1 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.2 GO:0070944 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.0 0.1 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.0 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0046959 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.0 0.0 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.1 GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.1 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.3 GO:0033327 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.4 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.0 0.0 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.0 GO:0006788 heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.1 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 0.0 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.0 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.0 GO:1902616 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.0 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.0 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.0 0.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.0 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.0 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.4 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.2 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)
0.0 0.0 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031768 ghrelin receptor binding(GO:0031768)
0.1 0.3 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.3 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.3 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.2 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.0 0.1 GO:0031403 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.0 0.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.2 GO:1902444 riboflavin binding(GO:1902444)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0052844 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 1.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.2 GO:0019863 IgE binding(GO:0019863)
0.0 0.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.0 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.1 GO:0015250 water channel activity(GO:0015250)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.0 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.0 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling