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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HSF4

Z-value: 0.47

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF4hg19_v2_chr16_+_67198683_671987150.048.7e-01Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_56118981 1.44 ENST00000419984.2
ENST00000413218.1
ENST00000424596.1
PSPH
phosphoserine phosphatase
chr7_-_56119156 1.41 ENST00000421312.1
ENST00000416592.1
PSPH
phosphoserine phosphatase
chr21_-_31744557 1.18 ENST00000399889.2
KRTAP13-2
keratin associated protein 13-2
chr2_+_228678550 0.68 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr11_-_111782484 0.51 ENST00000533971.1
CRYAB
crystallin, alpha B
chr4_-_84406218 0.38 ENST00000515303.1
FAM175A
family with sequence similarity 175, member A
chr13_-_31736132 0.36 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr1_-_60539405 0.36 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 0.36 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr2_-_100759037 0.34 ENST00000317233.4
ENST00000423966.1
ENST00000416492.1
AFF3
AF4/FMR2 family, member 3
chrX_+_108779870 0.28 ENST00000372107.1
NXT2
nuclear transport factor 2-like export factor 2
chr2_+_201170703 0.28 ENST00000358677.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr19_+_45971246 0.27 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr11_-_111782696 0.27 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr3_+_101443476 0.27 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr11_-_111794446 0.27 ENST00000527950.1
CRYAB
crystallin, alpha B
chr7_-_56119238 0.24 ENST00000275605.3
ENST00000395471.3
PSPH
phosphoserine phosphatase
chr10_-_74856608 0.24 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr14_-_52535712 0.24 ENST00000216286.5
ENST00000541773.1
NID2
nidogen 2 (osteonidogen)
chr20_+_18794370 0.23 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr18_-_76738843 0.23 ENST00000575722.1
ENST00000583511.1
RP11-849I19.1
RP11-849I19.1
chr8_+_143916217 0.23 ENST00000220940.1
GML
glycosylphosphatidylinositol anchored molecule like
chrX_-_154563889 0.22 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr20_-_60573188 0.22 ENST00000474089.1
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr15_-_58357866 0.22 ENST00000537372.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr13_-_31736478 0.22 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr18_-_71815051 0.21 ENST00000582526.1
ENST00000419743.2
FBXO15
F-box protein 15
chr18_-_71814999 0.21 ENST00000269500.5
FBXO15
F-box protein 15
chr9_-_137809718 0.20 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr7_-_3083573 0.20 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr11_-_111781610 0.20 ENST00000525823.1
CRYAB
crystallin, alpha B
chr11_-_111781454 0.20 ENST00000533280.1
CRYAB
crystallin, alpha B
chr11_-_111781554 0.19 ENST00000526167.1
ENST00000528961.1
CRYAB
crystallin, alpha B
chr19_+_41509851 0.19 ENST00000593831.1
ENST00000330446.5
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr12_-_48500085 0.19 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr19_-_49565254 0.19 ENST00000593537.1
NTF4
neurotrophin 4
chr5_+_159895275 0.18 ENST00000517927.1
MIR146A
microRNA 146a
chr3_-_36781352 0.18 ENST00000416516.2
DCLK3
doublecortin-like kinase 3
chr2_+_223162866 0.17 ENST00000295226.1
CCDC140
coiled-coil domain containing 140
chrX_-_39923656 0.17 ENST00000413905.1
BCOR
BCL6 corepressor
chr11_+_107799118 0.17 ENST00000320578.2
RAB39A
RAB39A, member RAS oncogene family
chr21_+_44394742 0.16 ENST00000432907.2
PKNOX1
PBX/knotted 1 homeobox 1
chr8_+_37594185 0.16 ENST00000518586.1
ENST00000335171.6
ENST00000521644.1
ERLIN2
ER lipid raft associated 2
chr22_+_48972118 0.16 ENST00000358295.5
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr19_-_17958832 0.16 ENST00000458235.1
JAK3
Janus kinase 3
chr2_-_69180012 0.15 ENST00000481498.1
GKN2
gastrokine 2
chr11_+_67007518 0.14 ENST00000530342.1
ENST00000308783.5
KDM2A
lysine (K)-specific demethylase 2A
chr13_-_31736027 0.14 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chrX_-_152939252 0.14 ENST00000340888.3
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr17_+_74722912 0.13 ENST00000589977.1
ENST00000591571.1
ENST00000592849.1
ENST00000586738.1
ENST00000588783.1
ENST00000588563.1
ENST00000586752.1
ENST00000588302.1
ENST00000590964.1
ENST00000341249.6
ENST00000588822.1
METTL23
methyltransferase like 23
chr15_-_89755034 0.13 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr1_+_156308245 0.13 ENST00000368253.2
ENST00000470342.1
ENST00000368254.1
TSACC
TSSK6 activating co-chaperone
chr1_+_156308403 0.13 ENST00000481479.1
ENST00000368252.1
ENST00000466306.1
ENST00000368251.1
TSACC
TSSK6 activating co-chaperone
chr12_-_9885702 0.12 ENST00000542530.1
CLECL1
C-type lectin-like 1
chr10_+_24528108 0.12 ENST00000438429.1
KIAA1217
KIAA1217
chr4_+_5527117 0.12 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr17_+_34087888 0.12 ENST00000586491.1
ENST00000588628.1
ENST00000285023.4
C17orf50
chromosome 17 open reading frame 50
chr22_+_41253080 0.12 ENST00000541156.1
ENST00000414396.1
ENST00000357137.4
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chrX_+_15767971 0.12 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr11_+_193065 0.11 ENST00000342878.2
SCGB1C1
secretoglobin, family 1C, member 1
chr1_-_205904950 0.11 ENST00000340781.4
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr19_-_344786 0.11 ENST00000264819.4
MIER2
mesoderm induction early response 1, family member 2
chr19_+_751122 0.11 ENST00000215582.6
MISP
mitotic spindle positioning
chr1_-_149459549 0.11 ENST00000369175.3
FAM72C
family with sequence similarity 72, member C
chr17_-_76573465 0.11 ENST00000585328.1
ENST00000389840.5
DNAH17
dynein, axonemal, heavy chain 17
chr12_-_4754339 0.11 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_154947148 0.11 ENST00000368436.1
ENST00000308987.5
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_+_10250328 0.11 ENST00000515390.1
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr1_-_26633067 0.10 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
UBXN11
UBX domain protein 11
chr17_+_74723031 0.10 ENST00000586200.1
METTL23
methyltransferase like 23
chr4_+_41258786 0.10 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_-_185269050 0.10 ENST00000511465.1
RP11-290F5.2
RP11-290F5.2
chr14_-_102553371 0.10 ENST00000553585.1
ENST00000216281.8
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr1_+_196743912 0.10 ENST00000367425.4
CFHR3
complement factor H-related 3
chrX_+_108780062 0.10 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2
chr20_+_10015678 0.10 ENST00000378392.1
ENST00000378380.3
ANKEF1
ankyrin repeat and EF-hand domain containing 1
chr15_+_89921280 0.10 ENST00000560596.1
ENST00000558692.1
ENST00000538734.2
ENST00000559235.1
LINC00925
long intergenic non-protein coding RNA 925
chrX_-_152939133 0.10 ENST00000370150.1
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr1_+_53925063 0.10 ENST00000371445.3
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr7_-_100493744 0.10 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr1_+_154947126 0.10 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr6_+_31683117 0.09 ENST00000375825.3
ENST00000375824.1
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr21_+_45148735 0.09 ENST00000327574.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr2_+_201171242 0.09 ENST00000360760.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr17_-_61850894 0.09 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr11_-_14913765 0.09 ENST00000334636.5
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chrX_+_150866779 0.09 ENST00000370353.3
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr5_+_118690466 0.09 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr2_-_208994548 0.09 ENST00000282141.3
CRYGC
crystallin, gamma C
chr19_-_52133588 0.09 ENST00000570106.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr2_+_201171372 0.09 ENST00000409140.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_+_201170770 0.09 ENST00000409988.3
ENST00000409385.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr15_-_58357932 0.09 ENST00000347587.3
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr9_-_86322831 0.09 ENST00000257468.7
UBQLN1
ubiquilin 1
chr4_-_159644507 0.08 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr5_-_13944652 0.08 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr7_-_139763521 0.08 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr1_+_196857144 0.08 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
CFHR4
complement factor H-related 4
chr19_-_17958771 0.08 ENST00000534444.1
JAK3
Janus kinase 3
chr17_+_45401308 0.08 ENST00000331493.2
ENST00000519772.1
ENST00000517484.1
EFCAB13
EF-hand calcium binding domain 13
chr20_+_55904815 0.08 ENST00000371263.3
ENST00000345868.4
ENST00000371260.4
ENST00000418127.1
SPO11
SPO11 meiotic protein covalently bound to DSB
chr2_+_85766280 0.08 ENST00000306434.3
MAT2A
methionine adenosyltransferase II, alpha
chr11_-_89956227 0.08 ENST00000457199.2
ENST00000530765.1
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr11_+_65154070 0.08 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
FRMD8
FERM domain containing 8
chr4_+_76932326 0.07 ENST00000513353.1
ENST00000341029.5
ART3
ADP-ribosyltransferase 3
chr6_+_44215603 0.07 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_-_9714644 0.07 ENST00000377320.3
C1orf200
chromosome 1 open reading frame 200
chr3_+_138066539 0.07 ENST00000289104.4
MRAS
muscle RAS oncogene homolog
chr1_+_28586006 0.07 ENST00000253063.3
SESN2
sestrin 2
chr2_-_62115659 0.07 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr18_+_57567180 0.07 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr11_-_89956461 0.07 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr9_+_34989638 0.07 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr14_-_23540826 0.07 ENST00000357481.2
ACIN1
apoptotic chromatin condensation inducer 1
chr19_-_474880 0.07 ENST00000382696.3
ENST00000315489.4
ODF3L2
outer dense fiber of sperm tails 3-like 2
chr14_-_23540747 0.07 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
ACIN1
apoptotic chromatin condensation inducer 1
chrX_-_106243451 0.07 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr12_-_110883346 0.07 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr6_-_76782371 0.06 ENST00000369950.3
ENST00000369963.3
IMPG1
interphotoreceptor matrix proteoglycan 1
chrX_-_20236970 0.06 ENST00000379548.4
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr6_-_32339649 0.06 ENST00000527965.1
ENST00000532023.1
ENST00000447241.2
ENST00000375007.4
ENST00000534588.1
C6orf10
chromosome 6 open reading frame 10
chr7_+_130020180 0.06 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1
carboxypeptidase A1 (pancreatic)
chr12_-_9885888 0.06 ENST00000327839.3
CLECL1
C-type lectin-like 1
chr2_-_62115725 0.06 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr17_-_74137374 0.06 ENST00000322957.6
FOXJ1
forkhead box J1
chr21_+_31768348 0.06 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr1_+_161494036 0.06 ENST00000309758.4
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr6_-_32339671 0.06 ENST00000442822.2
ENST00000375015.4
ENST00000533191.1
C6orf10
chromosome 6 open reading frame 10
chr20_+_19867150 0.06 ENST00000255006.6
RIN2
Ras and Rab interactor 2
chr6_+_42531798 0.06 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr16_+_29911666 0.06 ENST00000563177.1
ENST00000483405.1
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr9_-_6015607 0.06 ENST00000259569.5
RANBP6
RAN binding protein 6
chrX_-_102942961 0.05 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr5_+_147258266 0.05 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr5_-_140053152 0.05 ENST00000542735.1
DND1
DND microRNA-mediated repression inhibitor 1
chr7_-_151107767 0.05 ENST00000477459.1
WDR86
WD repeat domain 86
chrX_-_102943022 0.05 ENST00000433176.2
MORF4L2
mortality factor 4 like 2
chr4_+_5526883 0.05 ENST00000195455.2
C4orf6
chromosome 4 open reading frame 6
chr12_-_57505121 0.05 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr3_+_136676851 0.05 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr8_+_143781883 0.05 ENST00000522591.1
LY6K
lymphocyte antigen 6 complex, locus K
chr22_+_29664248 0.05 ENST00000406548.1
ENST00000437155.2
ENST00000415761.1
ENST00000331029.7
EWSR1
EWS RNA-binding protein 1
chrX_-_100548045 0.04 ENST00000372907.3
ENST00000372905.2
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr1_-_24469602 0.04 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr4_-_152147579 0.04 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr20_+_55108302 0.04 ENST00000371325.1
FAM209B
family with sequence similarity 209, member B
chr12_+_6644443 0.04 ENST00000396858.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr1_-_146054494 0.04 ENST00000401009.2
NBPF11
neuroblastoma breakpoint family, member 11
chr14_-_23388338 0.04 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr10_-_90611566 0.04 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr11_-_47870091 0.04 ENST00000526870.1
NUP160
nucleoporin 160kDa
chr11_+_63953691 0.04 ENST00000543847.1
STIP1
stress-induced-phosphoprotein 1
chr22_-_24181174 0.04 ENST00000318109.7
ENST00000406855.3
ENST00000404056.1
ENST00000476077.1
DERL3
derlin 3
chr20_+_36149602 0.04 ENST00000062104.2
ENST00000346199.2
NNAT
neuronatin
chr9_-_138591341 0.04 ENST00000298466.5
ENST00000425225.1
SOHLH1
spermatogenesis and oogenesis specific basic helix-loop-helix 1
chr19_+_859425 0.04 ENST00000327726.6
CFD
complement factor D (adipsin)
chr1_-_6453399 0.04 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chrX_-_152989798 0.04 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
BCAP31
B-cell receptor-associated protein 31
chrX_-_152989531 0.04 ENST00000458587.2
ENST00000416815.1
BCAP31
B-cell receptor-associated protein 31
chr1_+_154966058 0.04 ENST00000392487.1
LENEP
lens epithelial protein
chr7_+_142378566 0.04 ENST00000390398.3
TRBV25-1
T cell receptor beta variable 25-1
chr2_+_201171064 0.04 ENST00000451764.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr11_-_47870019 0.04 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr14_-_68141535 0.04 ENST00000554659.1
VTI1B
vesicle transport through interaction with t-SNAREs 1B
chr11_+_111782934 0.04 ENST00000304298.3
HSPB2
Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA.
chr15_+_79165151 0.03 ENST00000331268.5
MORF4L1
mortality factor 4 like 1
chr8_+_143781513 0.03 ENST00000292430.6
ENST00000561179.1
ENST00000518841.1
ENST00000519387.1
LY6K
lymphocyte antigen 6 complex, locus K
chr1_-_228613026 0.03 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr1_-_242162375 0.03 ENST00000357246.3
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr19_-_55672037 0.03 ENST00000588076.1
DNAAF3
dynein, axonemal, assembly factor 3
chr19_+_859654 0.03 ENST00000592860.1
CFD
complement factor D (adipsin)
chr11_-_108408895 0.03 ENST00000443411.1
ENST00000533052.1
EXPH5
exophilin 5
chr17_-_54911250 0.03 ENST00000575658.1
ENST00000397861.2
C17orf67
chromosome 17 open reading frame 67
chr1_+_67773044 0.03 ENST00000262345.1
ENST00000371000.1
IL12RB2
interleukin 12 receptor, beta 2
chr15_+_45028753 0.03 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr9_-_86593238 0.03 ENST00000351839.3
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr15_+_79165112 0.03 ENST00000426013.2
MORF4L1
mortality factor 4 like 1
chr11_-_47869865 0.03 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr20_-_23807358 0.03 ENST00000304725.2
CST2
cystatin SA
chr3_+_136676707 0.03 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr2_+_198365095 0.03 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr14_-_57277163 0.03 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr20_+_5451845 0.02 ENST00000430097.2
RP5-828H9.1
RP5-828H9.1
chr11_+_63953587 0.02 ENST00000305218.4
ENST00000538945.1
STIP1
stress-induced-phosphoprotein 1
chr9_+_123970052 0.02 ENST00000373823.3
GSN
gelsolin
chr11_+_66512303 0.02 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr11_+_124492749 0.02 ENST00000531667.1
ENST00000441174.3
ENST00000375005.4
TBRG1
transforming growth factor beta regulator 1
chr11_-_82997371 0.02 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chr16_-_23568651 0.02 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
EARS2
glutamyl-tRNA synthetase 2, mitochondrial
chr11_+_76092353 0.02 ENST00000530460.1
ENST00000321844.4
RP11-111M22.2
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr8_+_62200509 0.02 ENST00000519846.1
ENST00000518592.1
ENST00000325897.4
CLVS1
clavesin 1
chr1_+_27248203 0.02 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr8_-_52721975 0.02 ENST00000356297.4
ENST00000543296.1
PXDNL
peroxidasin homolog (Drosophila)-like
chr22_+_29168652 0.02 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
CCDC117
coiled-coil domain containing 117
chr3_+_39509163 0.02 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP
myelin-associated oligodendrocyte basic protein
chr22_+_32871224 0.02 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chr12_+_110940005 0.02 ENST00000409246.1
ENST00000392672.4
ENST00000409300.1
ENST00000409425.1
RAD9B
RAD9 homolog B (S. pombe)
chr11_+_65769550 0.02 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
BANF1
barrier to autointegration factor 1
chr11_+_65769946 0.02 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr12_+_110940111 0.02 ENST00000409778.3
RAD9B
RAD9 homolog B (S. pombe)

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 1.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.7 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 0.2 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
0.1 0.2 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.3 GO:0035799 ureter maturation(GO:0035799)
0.0 0.1 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.1 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.0 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) meiotic DNA double-strand break formation(GO:0042138) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 0.2 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.2 GO:0070970 interleukin-2 secretion(GO:0070970)
0.0 0.0 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.1 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.2 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.1 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0 0.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 0.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0008478 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.0 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics