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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for IKZF1
Z-value: 2.23
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Transcription factors associated with IKZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF1 | hg19_v2_chr7_+_50344289_50344378 | 0.69 | 1.4e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_31550192 Show fit | 11.49 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr9_-_123676827 Show fit | 10.04 |
ENST00000546084.1
|
TNF receptor-associated factor 1 |
|
| chr15_+_89181974 Show fit | 9.94 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr19_+_4229495 Show fit | 8.42 |
ENST00000221847.5
|
Epstein-Barr virus induced 3 |
|
| chr2_+_150187020 Show fit | 8.11 |
ENST00000334166.4
|
LY6/PLAUR domain containing 6 |
|
| chr4_+_74702214 Show fit | 8.09 |
ENST00000226317.5
ENST00000515050.1 |
chemokine (C-X-C motif) ligand 6 |
|
| chr21_+_42798094 Show fit | 7.05 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr10_-_49701686 Show fit | 6.88 |
ENST00000417247.2
|
Rho GTPase activating protein 22 |
|
| chr17_+_41158742 Show fit | 6.52 |
ENST00000415816.2
ENST00000438323.2 |
interferon-induced protein 35 |
|
| chr1_-_153521597 Show fit | 6.26 |
ENST00000368712.1
|
S100 calcium binding protein A3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 39.9 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 4.2 | 20.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.7 | 19.0 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.6 | 17.6 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 2.2 | 17.2 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 2.8 | 14.0 | GO:0003068 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 2.0 | 13.9 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.3 | 13.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 3.2 | 12.9 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 2.1 | 12.5 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 22.1 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 2.4 | 21.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 19.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 18.2 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 14.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 12.8 | GO:0032059 | bleb(GO:0032059) |
| 1.6 | 11.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.5 | 10.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 10.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.7 | 23.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.4 | 22.9 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 22.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 6.9 | 20.8 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.4 | 20.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 1.0 | 16.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.5 | 16.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.5 | 15.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 15.5 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 77.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 41.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 18.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 17.1 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 15.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 14.0 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 13.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 13.2 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.4 | 12.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 10.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 63.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 38.7 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.5 | 30.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 19.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.6 | 17.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.4 | 17.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.7 | 14.5 | REACTOME P75NTR SIGNALS VIA NFKB | Genes involved in p75NTR signals via NF-kB |
| 0.4 | 14.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.4 | 14.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 11.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |