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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IKZF2

Z-value: 0.76

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Transcription factors associated with IKZF2

Gene Symbol Gene ID Gene Info
IKZF2
ENSG00000030419.12 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v2_chr2_-_214013353_214013517-0.252.3e-01Click!

Activity profile of IKZF2 motif

Sorted Z-values of IKZF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_67138015 2.63 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_+_100111580 2.34 ENST00000605497.1
PALMD
palmdelphin
chr11_-_33891362 2.01 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_+_39382900 1.99 ENST00000377721.3
ENST00000455970.2
KRTAP9-2
keratin associated protein 9-2
chr21_+_17909594 1.85 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr10_-_116444371 1.81 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr8_+_97597148 1.73 ENST00000521590.1
SDC2
syndecan 2
chr4_-_186733363 1.62 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2
sorbin and SH3 domain containing 2
chr4_+_134070439 1.60 ENST00000264360.5
PCDH10
protocadherin 10
chr3_-_18480260 1.59 ENST00000454909.2
SATB1
SATB homeobox 1
chr9_+_2159850 1.49 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_-_117119243 1.45 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr3_-_149051194 1.45 ENST00000470080.1
TM4SF18
transmembrane 4 L six family member 18
chr3_-_18466026 1.38 ENST00000417717.2
SATB1
SATB homeobox 1
chr4_-_186696425 1.36 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr8_-_6420565 1.33 ENST00000338312.6
ANGPT2
angiopoietin 2
chr13_+_58206655 1.31 ENST00000377918.3
PCDH17
protocadherin 17
chr1_+_61330931 1.27 ENST00000371191.1
NFIA
nuclear factor I/A
chr8_-_6420759 1.18 ENST00000523120.1
ANGPT2
angiopoietin 2
chr8_-_6420777 1.15 ENST00000415216.1
ANGPT2
angiopoietin 2
chr18_-_53070913 1.14 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr8_-_6420930 1.13 ENST00000325203.5
ANGPT2
angiopoietin 2
chr12_-_104443890 1.11 ENST00000547583.1
ENST00000360814.4
ENST00000546851.1
GLT8D2
glycosyltransferase 8 domain containing 2
chr8_+_9046503 1.06 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr14_+_63671577 1.03 ENST00000555125.1
RHOJ
ras homolog family member J
chr2_+_189839046 1.02 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr8_-_17942432 1.01 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chrX_-_63005405 1.00 ENST00000374878.1
ENST00000437457.2
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chrX_+_28605516 0.92 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr3_-_112329110 0.92 ENST00000479368.1
CCDC80
coiled-coil domain containing 80
chr3_+_193853927 0.90 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr7_+_93551011 0.89 ENST00000248564.5
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_+_61547405 0.89 ENST00000371189.4
NFIA
nuclear factor I/A
chr5_-_111091948 0.89 ENST00000447165.2
NREP
neuronal regeneration related protein
chr7_+_79765071 0.88 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr20_+_42574317 0.87 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr15_-_82338460 0.83 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr8_-_19459993 0.79 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr14_+_63671105 0.79 ENST00000316754.3
RHOJ
ras homolog family member J
chr19_+_11200038 0.77 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chrX_+_135230712 0.74 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr2_-_101767715 0.73 ENST00000376840.4
ENST00000409318.1
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr17_+_26369865 0.71 ENST00000582037.1
NLK
nemo-like kinase
chr4_-_134070250 0.71 ENST00000505289.1
ENST00000509715.1
RP11-9G1.3
RP11-9G1.3
chrX_+_55478538 0.70 ENST00000342972.1
MAGEH1
melanoma antigen family H, 1
chr5_+_61874562 0.69 ENST00000334994.5
ENST00000409534.1
LRRC70
IPO11
leucine rich repeat containing 70
importin 11
chrX_-_24665208 0.62 ENST00000356768.4
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr3_-_27764190 0.62 ENST00000537516.1
EOMES
eomesodermin
chr2_+_27301435 0.61 ENST00000380320.4
EMILIN1
elastin microfibril interfacer 1
chrX_+_135251783 0.61 ENST00000394153.2
FHL1
four and a half LIM domains 1
chr17_-_38938786 0.59 ENST00000301656.3
KRT27
keratin 27
chr9_-_3469181 0.59 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr5_-_42812143 0.57 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr4_-_89152474 0.56 ENST00000515655.1
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr15_-_59665062 0.55 ENST00000288235.4
MYO1E
myosin IE
chrX_+_135251835 0.54 ENST00000456445.1
FHL1
four and a half LIM domains 1
chrX_+_80457442 0.54 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr2_-_45795145 0.54 ENST00000535761.1
SRBD1
S1 RNA binding domain 1
chr17_-_26127525 0.53 ENST00000313735.6
NOS2
nitric oxide synthase 2, inducible
chr6_+_123110465 0.53 ENST00000539041.1
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr21_+_17791648 0.53 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478
long intergenic non-protein coding RNA 478
chr6_+_123110302 0.51 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr21_+_17791838 0.51 ENST00000453910.1
LINC00478
long intergenic non-protein coding RNA 478
chr17_-_46688334 0.50 ENST00000239165.7
HOXB7
homeobox B7
chrX_+_135252050 0.50 ENST00000449474.1
ENST00000345434.3
FHL1
four and a half LIM domains 1
chr20_-_45981138 0.49 ENST00000446994.2
ZMYND8
zinc finger, MYND-type containing 8
chr6_+_32944119 0.49 ENST00000606059.1
BRD2
bromodomain containing 2
chr15_+_96876340 0.49 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr9_+_92219919 0.48 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr6_+_15246501 0.48 ENST00000341776.2
JARID2
jumonji, AT rich interactive domain 2
chr19_-_41859814 0.48 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr21_-_39870339 0.48 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr5_+_1225470 0.47 ENST00000324642.3
ENST00000296821.4
SLC6A18
solute carrier family 6 (neutral amino acid transporter), member 18
chr3_+_57882024 0.47 ENST00000494088.1
SLMAP
sarcolemma associated protein
chr8_+_39770803 0.46 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr22_-_50699701 0.46 ENST00000395780.1
MAPK12
mitogen-activated protein kinase 12
chr3_-_128690173 0.46 ENST00000508239.1
RP11-723O4.6
Uncharacterized protein FLJ43738
chr2_+_87808725 0.46 ENST00000413202.1
LINC00152
long intergenic non-protein coding RNA 152
chr7_+_107224364 0.45 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr15_-_20193370 0.44 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr18_-_53089723 0.43 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr12_+_9144626 0.43 ENST00000543895.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr1_-_68698197 0.43 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr3_-_114035026 0.42 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr3_+_178866199 0.42 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr14_+_32546145 0.41 ENST00000556611.1
ENST00000539826.2
ARHGAP5
Rho GTPase activating protein 5
chr12_-_56321397 0.41 ENST00000557259.1
ENST00000549939.1
WIBG
within bgcn homolog (Drosophila)
chr22_+_40297105 0.40 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr7_+_1126437 0.39 ENST00000413368.1
ENST00000397092.1
GPER1
G protein-coupled estrogen receptor 1
chr13_+_20532848 0.39 ENST00000382874.2
ZMYM2
zinc finger, MYM-type 2
chr11_-_19263145 0.39 ENST00000532666.1
ENST00000527884.1
E2F8
E2F transcription factor 8
chr12_-_127256772 0.38 ENST00000536517.1
LINC00944
long intergenic non-protein coding RNA 944
chr12_+_60058458 0.38 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr3_+_57881966 0.37 ENST00000495364.1
SLMAP
sarcolemma associated protein
chr7_+_1126461 0.37 ENST00000297469.3
GPER1
G protein-coupled estrogen receptor 1
chr1_+_162351503 0.37 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr1_-_68698222 0.37 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr18_+_50278430 0.36 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
DCC
deleted in colorectal carcinoma
chr2_+_190722119 0.36 ENST00000452382.1
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr6_+_116691001 0.36 ENST00000537543.1
DSE
dermatan sulfate epimerase
chr22_-_29107919 0.36 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chr17_+_7792101 0.35 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chrX_-_74743080 0.35 ENST00000373367.3
ZDHHC15
zinc finger, DHHC-type containing 15
chr9_-_91793675 0.35 ENST00000375835.4
ENST00000375830.1
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr19_-_14992264 0.34 ENST00000327462.2
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr6_+_106546808 0.34 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr14_+_64970662 0.34 ENST00000556965.1
ENST00000554015.1
ZBTB1
zinc finger and BTB domain containing 1
chr22_+_40297079 0.34 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr4_+_144434584 0.34 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chrX_+_135730373 0.34 ENST00000370628.2
CD40LG
CD40 ligand
chr12_+_26348582 0.33 ENST00000535504.1
SSPN
sarcospan
chr5_-_42811986 0.33 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr17_+_7387677 0.33 ENST00000322644.6
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr12_-_50677255 0.33 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr17_-_17740287 0.33 ENST00000355815.4
ENST00000261646.5
SREBF1
sterol regulatory element binding transcription factor 1
chrX_+_135730297 0.32 ENST00000370629.2
CD40LG
CD40 ligand
chr2_+_136289030 0.32 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr5_+_153418466 0.32 ENST00000522782.1
ENST00000439768.2
ENST00000436816.1
ENST00000322602.5
ENST00000522177.1
ENST00000520899.1
MFAP3
microfibrillar-associated protein 3
chr2_+_48796120 0.32 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr4_+_39184024 0.32 ENST00000399820.3
ENST00000509560.1
ENST00000512112.1
ENST00000288634.7
ENST00000506503.1
WDR19
WD repeat domain 19
chr1_+_158801095 0.31 ENST00000368141.4
MNDA
myeloid cell nuclear differentiation antigen
chrX_+_73164167 0.31 ENST00000414209.1
ENST00000602895.1
ENST00000453317.1
ENST00000602546.1
ENST00000602985.1
ENST00000415215.1
JPX
JPX transcript, XIST activator (non-protein coding)
chr1_-_110155671 0.31 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr17_-_16118835 0.31 ENST00000582357.1
ENST00000436828.1
ENST00000411510.1
ENST00000268712.3
NCOR1
nuclear receptor corepressor 1
chr1_-_169599353 0.31 ENST00000367793.2
ENST00000367794.2
ENST00000367792.2
ENST00000367791.2
ENST00000367788.2
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr2_-_73520667 0.31 ENST00000545030.1
ENST00000436467.2
EGR4
early growth response 4
chr14_+_57735614 0.31 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr10_-_11574274 0.30 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr1_-_169599314 0.30 ENST00000367786.2
ENST00000458599.2
ENST00000367795.2
ENST00000263686.6
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr10_-_94257512 0.30 ENST00000371581.5
IDE
insulin-degrading enzyme
chrY_+_16634483 0.29 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr1_+_171217622 0.29 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr15_-_83837983 0.29 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr2_+_33661382 0.29 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_+_43149903 0.28 ENST00000252050.4
ENST00000354495.3
ENST00000372647.2
CUL9
cullin 9
chrX_+_73164149 0.28 ENST00000602938.1
ENST00000602294.1
ENST00000602920.1
ENST00000602737.1
ENST00000602772.1
JPX
JPX transcript, XIST activator (non-protein coding)
chr17_-_3337135 0.28 ENST00000248384.1
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chrX_-_63425561 0.28 ENST00000374869.3
ENST00000330258.3
AMER1
APC membrane recruitment protein 1
chr1_+_230193521 0.28 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr20_-_43133491 0.28 ENST00000411544.1
SERINC3
serine incorporator 3
chr12_-_71551652 0.27 ENST00000546561.1
TSPAN8
tetraspanin 8
chr17_-_57970074 0.26 ENST00000346141.6
TUBD1
tubulin, delta 1
chr4_+_130017268 0.26 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr6_+_32605195 0.26 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr9_-_36401155 0.26 ENST00000377885.2
RNF38
ring finger protein 38
chr16_-_20911641 0.26 ENST00000564349.1
ENST00000324344.4
ERI2
DCUN1D3
ERI1 exoribonuclease family member 2
DCN1, defective in cullin neddylation 1, domain containing 3
chr9_-_74980113 0.25 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr15_+_40731920 0.25 ENST00000561234.1
BAHD1
bromo adjacent homology domain containing 1
chr3_-_178865747 0.25 ENST00000435560.1
RP11-360P21.2
RP11-360P21.2
chr3_+_136649311 0.25 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chrX_-_19689106 0.25 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chrX_+_100805496 0.25 ENST00000372829.3
ARMCX1
armadillo repeat containing, X-linked 1
chr12_-_123921256 0.24 ENST00000280571.8
RILPL2
Rab interacting lysosomal protein-like 2
chr13_+_20532900 0.24 ENST00000382871.2
ZMYM2
zinc finger, MYM-type 2
chr1_+_36038971 0.24 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr12_+_101988627 0.24 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
MYBPC1
myosin binding protein C, slow type
chr3_+_160559931 0.24 ENST00000464260.1
ENST00000295839.9
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr2_-_216257849 0.24 ENST00000456923.1
FN1
fibronectin 1
chr1_-_15850676 0.23 ENST00000440484.1
ENST00000333868.5
CASP9
caspase 9, apoptosis-related cysteine peptidase
chr6_+_106534192 0.23 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr19_+_44220247 0.23 ENST00000596627.1
IRGC
immunity-related GTPase family, cinema
chr1_+_53480598 0.23 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr5_+_43603229 0.23 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase
chr14_+_35591928 0.22 ENST00000605870.1
ENST00000557404.3
KIAA0391
KIAA0391
chr1_+_95616933 0.22 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr19_+_50433476 0.22 ENST00000596658.1
ATF5
activating transcription factor 5
chr19_-_31840438 0.22 ENST00000240587.4
TSHZ3
teashirt zinc finger homeobox 3
chr20_-_35890211 0.22 ENST00000373614.2
GHRH
growth hormone releasing hormone
chr19_-_39735646 0.22 ENST00000413851.2
IFNL3
interferon, lambda 3
chr1_-_155948218 0.21 ENST00000313667.4
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_-_131384373 0.21 ENST00000392427.3
ENST00000525271.1
ENST00000527411.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr10_-_98119030 0.21 ENST00000371172.3
ENST00000393871.1
ENST00000419479.1
OPALIN
oligodendrocytic myelin paranodal and inner loop protein
chr2_+_102686820 0.20 ENST00000409929.1
ENST00000424272.1
IL1R1
interleukin 1 receptor, type I
chr2_+_233897382 0.20 ENST00000233840.3
NEU2
sialidase 2 (cytosolic sialidase)
chr8_-_145754428 0.20 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr5_+_43602750 0.20 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr9_-_127952187 0.20 ENST00000451402.1
ENST00000415905.1
PPP6C
protein phosphatase 6, catalytic subunit
chr6_-_26056695 0.20 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr5_+_140625147 0.20 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr6_-_10412600 0.20 ENST00000379608.3
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr9_+_124062071 0.19 ENST00000373818.4
GSN
gelsolin
chr17_+_4846101 0.19 ENST00000576965.1
RNF167
ring finger protein 167
chr19_+_30863271 0.19 ENST00000355537.3
ZNF536
zinc finger protein 536
chr5_+_32710736 0.19 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr3_+_148508845 0.19 ENST00000491148.1
CPB1
carboxypeptidase B1 (tissue)
chr2_-_197791441 0.18 ENST00000409475.1
ENST00000354764.4
ENST00000374738.3
PGAP1
post-GPI attachment to proteins 1
chr14_-_106610852 0.18 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr6_-_159466042 0.18 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr14_+_22748980 0.18 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr1_+_28995258 0.18 ENST00000361872.4
ENST00000294409.2
GMEB1
glucocorticoid modulatory element binding protein 1
chrX_-_48827976 0.18 ENST00000218176.3
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr4_+_158141899 0.18 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr18_-_55253989 0.17 ENST00000262093.5
FECH
ferrochelatase
chr18_-_21852143 0.17 ENST00000399443.3
OSBPL1A
oxysterol binding protein-like 1A
chr1_+_104198377 0.17 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr4_+_124320665 0.17 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_174933899 0.17 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_151176497 0.17 ENST00000282466.3
IGSF10
immunoglobulin superfamily, member 10
chr16_-_68033356 0.17 ENST00000393847.1
ENST00000573808.1
ENST00000572624.1
DPEP2
dipeptidase 2
chr15_-_34880646 0.17 ENST00000543376.1
GOLGA8A
golgin A8 family, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.3 0.9 GO:0042668 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.3 0.8 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.2 1.7 GO:0008218 bioluminescence(GO:0008218)
0.2 0.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 0.8 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 0.8 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 0.8 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 2.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 2.5 GO:0097090 presynaptic membrane organization(GO:0097090)
0.2 0.5 GO:1900126 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.4 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 1.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 0.5 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.4 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.4 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.5 GO:0036269 swimming behavior(GO:0036269)
0.1 0.6 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.1 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 2.7 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.3 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.3 GO:1901143 insulin catabolic process(GO:1901143)
0.1 1.4 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 3.0 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.3 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.5 GO:1902952 regulation of postsynaptic density protein 95 clustering(GO:1902897) positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 1.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.2 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.3 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 0.6 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 2.2 GO:0072189 ureter development(GO:0072189)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.2 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.1 0.2 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.2 GO:0070541 response to platinum ion(GO:0070541)
0.1 0.2 GO:0060940 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.1 0.5 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.2 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.3 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.1 0.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.2 GO:0021557 oculomotor nerve development(GO:0021557)
0.0 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.6 GO:0042908 heme transport(GO:0015886) xenobiotic transport(GO:0042908)
0.0 0.6 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.5 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.0 0.1 GO:0006566 threonine metabolic process(GO:0006566)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.3 GO:0009597 detection of virus(GO:0009597)
0.0 0.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.2 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.2 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 2.4 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0 0.3 GO:1904885 mesenchymal cell differentiation involved in kidney development(GO:0072161) beta-catenin destruction complex assembly(GO:1904885) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.5 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.2 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.3 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.5 GO:0061117 positive regulation of histone H3-K9 methylation(GO:0051574) negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.7 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749) negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.1 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0072138 cell proliferation involved in mesonephros development(GO:0061209) mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct morphogenesis(GO:0072180)
0.0 0.4 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.2 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 1.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.3 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.5 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.3 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.1 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.0 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.9 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.4 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.2 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.0 GO:0000271 polysaccharide biosynthetic process(GO:0000271)
0.0 0.1 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.5 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 0.3 GO:0031213 RSF complex(GO:0031213)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.2 GO:0043293 apoptosome(GO:0043293)
0.0 2.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.4 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.5 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.0 1.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.6 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 3.0 GO:0030018 Z disc(GO:0030018)
0.0 2.6 GO:0043197 dendritic spine(GO:0043197)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.3 0.8 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.2 0.7 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 0.6 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.2 1.0 GO:0017040 ceramidase activity(GO:0017040)
0.2 0.5 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 3.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.8 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.6 GO:0042806 fucose binding(GO:0042806)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.4 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.2 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.3 GO:0043559 insulin binding(GO:0043559)
0.1 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.4 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.3 GO:0032810 sterol response element binding(GO:0032810)
0.1 1.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.6 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.2 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.1 0.5 GO:0042731 PH domain binding(GO:0042731)
0.0 1.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0016160 amylase activity(GO:0016160)
0.0 3.7 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.0 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 1.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 1.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.0 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 5.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 2.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 3.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 2.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.8 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 3.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.8 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 1.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC