ISMARA results: IRF2_STAT2_IRF8

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 9.46

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol	Gene ID	Gene Info
IRF2 Ensembl NCBI GeneCards UniProt	ENSG00000168310.6	interferon regulatory factor 2
STAT2 Ensembl NCBI GeneCards UniProt	ENSG00000170581.9	signal transducer and activator of transcription 2
IRF8 Ensembl NCBI GeneCards UniProt	ENSG00000140968.6	interferon regulatory factor 8
IRF1 Ensembl NCBI GeneCards UniProt	ENSG00000125347.9	interferon regulatory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF2	hg19_v2_chr4_-_185395672_185395734	0.61	1.1e-03	Click!
IRF8	hg19_v2_chr16_+_85942594_85942635	0.56	3.6e-03	Click!
IRF1	hg19_v2_chr5_-_131826457_131826514	0.48	1.6e-02	Click!
STAT2	hg19_v2_chr12_-_56753858_56753930	0.15	4.7e-01	Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_79086088 Show fit	164.59	ENST00000370751.5 ENST00000342282.3	IFI44L Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 44-like
chr4_-_76944621 Show fit	144.04	ENST00000306602.1	CXCL10 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-X-C motif) ligand 10
chr6_+_32821924 Show fit	132.47	ENST00000374859.2 ENST00000453265.2	PSMB9 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_43566301 Show fit	121.83	ENST00000398762.3 ENST00000313640.7 ENST00000313624.7	EPSTI1 Ensembl NCBI GeneCards UniProt Show fit	epithelial stromal interaction 1 (breast)
chr2_-_7005785 Show fit	116.38	ENST00000256722.5 ENST00000404168.1 ENST00000458098.1	CMPK2 Ensembl NCBI GeneCards UniProt Show fit	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr10_+_91092241 Show fit	115.18	ENST00000371811.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91087651 Show fit	112.71	ENST00000371818.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42792442 Show fit	105.80	ENST00000398600.2	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_+_91152303 Show fit	105.39	ENST00000371804.3	IFIT1 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr17_-_40264692 Show fit	93.08	ENST00000591220.1 ENST00000251642.3	DHX58 Ensembl NCBI GeneCards UniProt Show fit	DEXH (Asp-Glu-X-His) box polypeptide 58
chr12_+_113376157 Show fit	84.88	ENST00000228928.7	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3, 100kDa
chr6_-_32821599 Show fit	84.37	ENST00000354258.4	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_6659153 Show fit	82.43	ENST00000441631.1 ENST00000438512.1 ENST00000346752.4 ENST00000361842.3	XAF1 Ensembl NCBI GeneCards UniProt Show fit	XIAP associated factor 1
chr6_-_29527702 Show fit	82.13	ENST00000377050.4	UBD Ensembl NCBI GeneCards UniProt Show fit	ubiquitin D
chr22_+_18632666 Show fit	81.07	ENST00000215794.7	USP18 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin specific peptidase 18
chr12_+_113416191 Show fit	79.64	ENST00000342315.4 ENST00000392583.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr3_+_122399444 Show fit	78.26	ENST00000474629.2	PARP14 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 14
chr10_+_91174314 Show fit	75.46	ENST00000371795.4	IFIT5 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 5
chr16_-_67970990 Show fit	72.94	ENST00000358514.4	PSMB10 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) subunit, beta type, 10
chr3_-_122283424 Show fit	71.07	ENST00000477522.2 ENST00000360356.2	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 Show fit	70.31	ENST00000471785.1 ENST00000466126.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr1_-_89488510 Show fit	66.67	ENST00000564665.1 ENST00000370481.4	GBP3 Ensembl NCBI GeneCards UniProt Show fit	guanylate binding protein 3
chr11_-_4414880 Show fit	62.59	ENST00000254436.7 ENST00000543625.1	TRIM21 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 21
chr3_+_122283064 Show fit	61.98	ENST00000296161.4	DTX3L Ensembl NCBI GeneCards UniProt Show fit	deltex 3-like (Drosophila)
chr9_+_5510492 Show fit	61.33	ENST00000397745.2	PDCD1LG2 Ensembl NCBI GeneCards UniProt Show fit	programmed cell death 1 ligand 2
chr9_-_32526184 Show fit	60.47	ENST00000545044.1 ENST00000379868.1	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_+_5510558 Show fit	60.35	ENST00000397747.3	PDCD1LG2 Ensembl NCBI GeneCards UniProt Show fit	programmed cell death 1 ligand 2
chr1_-_89531041 Show fit	59.97	ENST00000370473.4	GBP1 Ensembl NCBI GeneCards UniProt Show fit	guanylate binding protein 1, interferon-inducible
chr6_+_26440700 Show fit	59.29	ENST00000494393.1 ENST00000482451.1 ENST00000244519.2 ENST00000339789.4 ENST00000471353.1 ENST00000361232.3 ENST00000487627.1 ENST00000496719.1 ENST00000490254.1 ENST00000487272.1	BTN3A3 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A3
chr16_+_57023406 Show fit	59.11	ENST00000262510.6 ENST00000308149.7 ENST00000436936.1	NLRC5 Ensembl NCBI GeneCards UniProt Show fit	NLR family, CARD domain containing 5
chr4_-_169239921 Show fit	56.91	ENST00000514995.1 ENST00000393743.3	DDX60 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_92777606 Show fit	55.89	ENST00000437805.1 ENST00000446959.1 ENST00000439952.1 ENST00000414791.1 ENST00000446033.1 ENST00000411955.1 ENST00000318238.4	SAMD9L Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9-like
chr15_+_89182156 Show fit	55.71	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 Show fit	55.40	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr4_+_142557717 Show fit	51.47	ENST00000320650.4 ENST00000296545.7	IL15 Ensembl NCBI GeneCards UniProt Show fit	interleukin 15
chr2_+_7017796 Show fit	50.48	ENST00000382040.3	RSAD2 Ensembl NCBI GeneCards UniProt Show fit	radical S-adenosyl methionine domain containing 2
chr1_+_79115503 Show fit	49.08	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 44
chr11_-_60719213 Show fit	48.83	ENST00000227880.3	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 (oligopeptide transporter), member 3
chr15_+_89181974 Show fit	48.20	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr22_-_36556821 Show fit	46.74	ENST00000531095.1 ENST00000397293.2 ENST00000349314.2	APOL3 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 3
chr11_-_615942 Show fit	46.68	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr4_+_142557771 Show fit	45.99	ENST00000514653.1	IL15 Ensembl NCBI GeneCards UniProt Show fit	interleukin 15
chr6_-_32806506 Show fit	45.31	ENST00000374897.2 ENST00000452392.2	TAP2 Ensembl NCBI GeneCards UniProt Show fit TAP2 Ensembl NCBI GeneCards UniProt Show fit	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Uncharacterized protein
chr12_+_113376249 Show fit	44.02	ENST00000551007.1 ENST00000548514.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3, 100kDa
chr21_+_42798094 Show fit	43.80	ENST00000398598.3 ENST00000455164.2 ENST00000424365.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_32811885 Show fit	42.03	ENST00000458296.1 ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1	TAPSAR1 Ensembl NCBI GeneCards UniProt Show fit PSMB9 Ensembl NCBI GeneCards UniProt Show fit	TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9
chr12_+_113344755 Show fit	41.32	ENST00000550883.1	OAS1 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_122283100 Show fit	41.12	ENST00000492382.1 ENST00000462315.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr19_+_10196781 Show fit	40.84	ENST00000253110.11	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr12_+_113344811 Show fit	40.78	ENST00000551241.1 ENST00000553185.1 ENST00000550689.1	OAS1 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_+_142558078 Show fit	40.74	ENST00000529613.1	IL15 Ensembl NCBI GeneCards UniProt Show fit	interleukin 15
chr1_+_948803 Show fit	39.87	ENST00000379389.4	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin-like modifier
chr11_-_57335280 Show fit	39.58	ENST00000287156.4	UBE2L6 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin-conjugating enzyme E2L 6
chr9_-_100881466 Show fit	39.06	ENST00000341469.2 ENST00000342043.3 ENST00000375098.3	TRIM14 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 14
chr2_-_231084820 Show fit	38.38	ENST00000258382.5 ENST00000338556.3	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr2_-_163175133 Show fit	38.35	ENST00000421365.2 ENST00000263642.2	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr11_+_69455855 Show fit	36.87	ENST00000227507.2 ENST00000536559.1	CCND1 Ensembl NCBI GeneCards UniProt Show fit	cyclin D1
chr14_+_94577074 Show fit	36.20	ENST00000444961.1 ENST00000448882.1 ENST00000557098.1 ENST00000554800.1 ENST00000556544.1 ENST00000298902.5 ENST00000555819.1 ENST00000557634.1 ENST00000555744.1	IFI27 Ensembl NCBI GeneCards UniProt Show fit	interferon, alpha-inducible protein 27
chr15_-_80263506 Show fit	34.43	ENST00000335661.6	BCL2A1 Ensembl NCBI GeneCards UniProt Show fit	BCL2-related protein A1
chr11_-_615570 Show fit	34.35	ENST00000525445.1 ENST00000348655.6 ENST00000397566.1	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr19_+_10196981 Show fit	33.06	ENST00000591813.1	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr21_+_42733870 Show fit	32.94	ENST00000330714.3 ENST00000436410.1 ENST00000435611.1	MX2 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 2 (mouse)
chr13_+_50070491 Show fit	32.32	ENST00000496612.1 ENST00000357596.3 ENST00000485919.1 ENST00000442195.1	PHF11 Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 11
chr11_+_71710973 Show fit	32.09	ENST00000393707.4	IL18BP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 binding protein
chr22_+_36044411 Show fit	31.79	ENST00000409652.4	APOL6 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 6
chr6_+_26402465 Show fit	31.22	ENST00000476549.2 ENST00000289361.6 ENST00000450085.2 ENST00000425234.2 ENST00000427334.1 ENST00000506698.1	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A1
chr19_+_18284477 Show fit	31.19	ENST00000407280.3	IFI30 Ensembl NCBI GeneCards UniProt Show fit	interferon, gamma-inducible protein 30
chr11_+_71709938 Show fit	31.10	ENST00000393705.4 ENST00000337131.5 ENST00000531053.1 ENST00000404792.1	IL18BP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 binding protein
chr13_+_50070077 Show fit	30.99	ENST00000378319.3 ENST00000426879.1	PHF11 Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 11
chr11_+_71710648 Show fit	30.26	ENST00000260049.5	IL18BP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 binding protein
chr19_-_50400212 Show fit	29.49	ENST00000391826.2	IL4I1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 4 induced 1
chr1_-_173020056 Show fit	29.44	ENST00000239468.2 ENST00000404377.3	TNFSF18 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 18
chr12_+_102271129 Show fit	29.44	ENST00000258534.8	DRAM1 Ensembl NCBI GeneCards UniProt Show fit	DNA-damage regulated autophagy modulator 1
chr9_+_100174232 Show fit	29.43	ENST00000355295.4	TDRD7 Ensembl NCBI GeneCards UniProt Show fit	tudor domain containing 7
chr8_-_23540402 Show fit	29.34	ENST00000523261.1 ENST00000380871.4	NKX3-1 Ensembl NCBI GeneCards UniProt Show fit	NK3 homeobox 1
chr6_+_26365443 Show fit	29.25	ENST00000527422.1 ENST00000356386.2 ENST00000396934.3 ENST00000377708.2 ENST00000396948.1 ENST00000508906.2	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A2
chr9_+_100174344 Show fit	29.00	ENST00000422139.2	TDRD7 Ensembl NCBI GeneCards UniProt Show fit	tudor domain containing 7
chr12_+_113416265 Show fit	28.83	ENST00000449768.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr10_+_115439282 Show fit	28.14	ENST00000369321.2 ENST00000345633.4	CASP7 Ensembl NCBI GeneCards UniProt Show fit	caspase 7, apoptosis-related cysteine peptidase
chr10_+_115439699 Show fit	27.51	ENST00000369315.1	CASP7 Ensembl NCBI GeneCards UniProt Show fit	caspase 7, apoptosis-related cysteine peptidase
chr12_+_113344582 Show fit	27.27	ENST00000202917.5 ENST00000445409.2 ENST00000452357.2	OAS1 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_+_126240442 Show fit	27.19	ENST00000448104.1 ENST00000438495.1 ENST00000444128.1	NCOA7 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor coactivator 7
chr11_-_104905840 Show fit	27.18	ENST00000526568.1 ENST00000393136.4 ENST00000531166.1 ENST00000534497.1 ENST00000527979.1 ENST00000446369.1 ENST00000353247.5 ENST00000528974.1 ENST00000533400.1 ENST00000525825.1 ENST00000436863.3	CASP1 Ensembl NCBI GeneCards UniProt Show fit	caspase 1, apoptosis-related cysteine peptidase
chr1_+_110453203 Show fit	27.16	ENST00000357302.4 ENST00000344188.5 ENST00000329608.6	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1 (macrophage)
chr10_+_115439630 Show fit	26.95	ENST00000369318.3	CASP7 Ensembl NCBI GeneCards UniProt Show fit	caspase 7, apoptosis-related cysteine peptidase
chr22_+_36649056 Show fit	26.83	ENST00000397278.3 ENST00000422706.1 ENST00000426053.1 ENST00000319136.4	APOL1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 1
chr2_+_102972363 Show fit	26.75	ENST00000409599.1	IL18R1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 receptor 1
chr17_+_18380051 Show fit	26.65	ENST00000581545.1 ENST00000582333.1 ENST00000328114.6 ENST00000412421.2 ENST00000583322.1 ENST00000584941.1	LGALS9C Ensembl NCBI GeneCards UniProt Show fit	lectin, galactoside-binding, soluble, 9C
chr17_+_25958174 Show fit	26.45	ENST00000313648.6 ENST00000577392.1 ENST00000584661.1 ENST00000413914.2	LGALS9 Ensembl NCBI GeneCards UniProt Show fit	lectin, galactoside-binding, soluble, 9
chr15_+_74287009 Show fit	26.25	ENST00000395135.3	PML Ensembl NCBI GeneCards UniProt Show fit	promyelocytic leukemia
chr3_+_187086120 Show fit	25.91	ENST00000259030.2	RTP4 Ensembl NCBI GeneCards UniProt Show fit	receptor (chemosensory) transporter protein 4
chr7_+_100728720 Show fit	25.85	ENST00000306085.6 ENST00000412507.1	TRIM56 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 56
chr2_-_220252603 Show fit	25.83	ENST00000322176.7 ENST00000273075.4	DNPEP Ensembl NCBI GeneCards UniProt Show fit	aspartyl aminopeptidase
chr2_-_231084617 Show fit	25.82	ENST00000409815.2	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr20_-_47894569 Show fit	25.37	ENST00000371744.1 ENST00000371752.1 ENST00000396105.1	ZNFX1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger, NFX1-type containing 1
chr15_+_74287035 Show fit	25.37	ENST00000395132.2 ENST00000268059.6 ENST00000354026.6 ENST00000268058.3 ENST00000565898.1 ENST00000569477.1 ENST00000569965.1 ENST00000567543.1 ENST00000436891.3 ENST00000435786.2 ENST00000564428.1 ENST00000359928.4	PML Ensembl NCBI GeneCards UniProt Show fit	promyelocytic leukemia
chr14_+_24630465 Show fit	25.23	ENST00000557894.1 ENST00000559284.1 ENST00000560275.1	IRF9 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 9
chr22_+_39436862 Show fit	25.10	ENST00000381565.2 ENST00000452957.2	APOBEC3F Ensembl NCBI GeneCards UniProt Show fit APOBEC3G Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr9_-_32526299 Show fit	25.06	ENST00000379882.1 ENST00000379883.2	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_32811771 Show fit	24.64	ENST00000395339.3 ENST00000374882.3	PSMB8 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) subunit, beta type, 8
chr1_+_110453608 Show fit	24.43	ENST00000369801.1	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1 (macrophage)
chr11_+_5710919 Show fit	23.79	ENST00000379965.3 ENST00000425490.1	TRIM22 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 22
chr15_+_74287118 Show fit	23.35	ENST00000563500.1	PML Ensembl NCBI GeneCards UniProt Show fit	promyelocytic leukemia
chr2_+_201981527 Show fit	23.34	ENST00000441224.1	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD-like apoptosis regulator
chr1_+_110453109 Show fit	23.24	ENST00000525659.1	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1 (macrophage)
chr2_-_231084659 Show fit	23.24	ENST00000258381.6 ENST00000358662.4 ENST00000455674.1 ENST00000392048.3	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr10_+_91061712 Show fit	22.04	ENST00000371826.3	IFIT2 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 2
chr6_-_33282163 Show fit	21.23	ENST00000434618.2 ENST00000456592.2	TAPBP Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein (tapasin)
chr6_+_32811861 Show fit	21.09	ENST00000453426.1	TAPSAR1 Ensembl NCBI GeneCards UniProt Show fit	TAP1 and PSMB8 antisense RNA 1
chr4_-_169401628 Show fit	20.69	ENST00000514748.1 ENST00000512371.1 ENST00000260184.7 ENST00000505890.1 ENST00000511577.1	DDX60L Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr7_+_18535786 Show fit	20.69	ENST00000406072.1	HDAC9 Ensembl NCBI GeneCards UniProt Show fit	histone deacetylase 9
chr2_+_231280908 Show fit	19.43	ENST00000427101.2 ENST00000432979.1	SP100 Ensembl NCBI GeneCards UniProt Show fit	SP100 nuclear antigen
chr11_+_93861993 Show fit	19.40	ENST00000227638.3 ENST00000436171.2	PANX1 Ensembl NCBI GeneCards UniProt Show fit	pannexin 1
chr1_+_110453462 Show fit	18.86	ENST00000488198.1	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1 (macrophage)
chr5_+_96212185 Show fit	18.45	ENST00000379904.4	ERAP2 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 2
chr5_-_96143796 Show fit	18.38	ENST00000296754.3	ERAP1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr6_+_127439749 Show fit	18.08	ENST00000356698.4	RSPO3 Ensembl NCBI GeneCards UniProt Show fit	R-spondin 3
chr5_+_96211643 Show fit	17.94	ENST00000437043.3 ENST00000510373.1	ERAP2 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 2
chr1_-_154580616 Show fit	17.80	ENST00000368474.4	ADAR Ensembl NCBI GeneCards UniProt Show fit	adenosine deaminase, RNA-specific
chr21_+_43619796 Show fit	17.48	ENST00000398457.2	ABCG1 Ensembl NCBI GeneCards UniProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 1
chr17_+_41363854 Show fit	17.35	ENST00000588693.1 ENST00000588659.1 ENST00000541594.1 ENST00000536052.1 ENST00000331615.3	TMEM106A Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 106A
chr22_-_36635684 Show fit	17.25	ENST00000358502.5	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 2
chr17_+_41158742 Show fit	16.99	ENST00000415816.2 ENST00000438323.2	IFI35 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 35
chr5_-_96143602 Show fit	16.96	ENST00000443439.2 ENST00000503921.1 ENST00000508227.1 ENST00000507154.1	ERAP1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr2_+_231280954 Show fit	16.91	ENST00000409824.1 ENST00000409341.1 ENST00000409112.1 ENST00000340126.4 ENST00000341950.4	SP100 Ensembl NCBI GeneCards UniProt Show fit	SP100 nuclear antigen
chr4_+_186990298 Show fit	16.78	ENST00000296795.3 ENST00000513189.1	TLR3 Ensembl NCBI GeneCards UniProt Show fit	toll-like receptor 3
chr22_+_41697520 Show fit	16.50	ENST00000352645.4	ZC3H7B Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing 7B
chr1_+_165864800 Show fit	16.11	ENST00000469256.2	UCK2 Ensembl NCBI GeneCards UniProt Show fit	uridine-cytidine kinase 2
chr1_+_165864821 Show fit	16.10	ENST00000470820.1	UCK2 Ensembl NCBI GeneCards UniProt Show fit	uridine-cytidine kinase 2
chr14_+_58711539 Show fit	15.93	ENST00000216455.4 ENST00000412908.2 ENST00000557508.1	PSMA3 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) subunit, alpha type, 3
chr17_-_20370847 Show fit	15.69	ENST00000423676.3 ENST00000324290.5	LGALS9B Ensembl NCBI GeneCards UniProt Show fit	lectin, galactoside-binding, soluble, 9B
chr4_+_37892682 Show fit	15.65	ENST00000508802.1 ENST00000261439.4 ENST00000402522.1	TBC1D1 Ensembl NCBI GeneCards UniProt Show fit	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr4_-_185395672 Show fit	15.51	ENST00000393593.3	IRF2 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 2
chr20_+_388935 Show fit	15.42	ENST00000382181.2 ENST00000400247.3	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_150738261 Show fit	15.17	ENST00000448301.2 ENST00000368985.3	CTSS Ensembl NCBI GeneCards UniProt Show fit	cathepsin S
chr20_+_388679 Show fit	14.95	ENST00000356286.5 ENST00000475269.1	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_64764435 Show fit	14.90	ENST00000534177.1 ENST00000301887.4	BATF2 Ensembl NCBI GeneCards UniProt Show fit	basic leucine zipper transcription factor, ATF-like 2
chr21_+_43933946 Show fit	14.81	ENST00000352133.2	SLC37A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr6_+_26402517 Show fit	14.63	ENST00000414912.2	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A1
chr6_-_31324943 Show fit	14.58	ENST00000412585.2 ENST00000434333.1	HLA-B Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, B
chr6_+_116782527 Show fit	14.03	ENST00000368606.3 ENST00000368605.1	FAM26F Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 26, member F
chr2_-_152146385 Show fit	13.83	ENST00000414946.1 ENST00000243346.5	NMI Ensembl NCBI GeneCards UniProt Show fit	N-myc (and STAT) interactor
chr3_+_48507210 Show fit	13.72	ENST00000433541.1 ENST00000422277.2 ENST00000436480.2 ENST00000444177.1	TREX1 Ensembl NCBI GeneCards UniProt Show fit	three prime repair exonuclease 1
chr1_-_149908710 Show fit	13.71	ENST00000439741.2 ENST00000361405.6 ENST00000406732.3	MTMR11 Ensembl NCBI GeneCards UniProt Show fit	myotubularin related protein 11
chr20_+_61436146 Show fit	13.67	ENST00000290291.6	OGFR Ensembl NCBI GeneCards UniProt Show fit	opioid growth factor receptor
chr6_-_87804815 Show fit	13.54	ENST00000369582.2	CGA Ensembl NCBI GeneCards UniProt Show fit	glycoprotein hormones, alpha polypeptide
chr11_-_104972158 Show fit	13.47	ENST00000598974.1 ENST00000593315.1 ENST00000594519.1 ENST00000415981.2 ENST00000525374.1 ENST00000375707.1	CASP1 Ensembl NCBI GeneCards UniProt Show fit CARD16 Ensembl NCBI GeneCards UniProt Show fit CARD17 Ensembl NCBI GeneCards UniProt Show fit	caspase 1, apoptosis-related cysteine peptidase caspase recruitment domain family, member 16 caspase recruitment domain family, member 17
chr5_+_125695805 Show fit	13.40	ENST00000513040.1	GRAMD3 Ensembl NCBI GeneCards UniProt Show fit	GRAM domain containing 3
chr2_+_231191875 Show fit	13.34	ENST00000444636.1 ENST00000415673.2 ENST00000243810.6 ENST00000396563.4	SP140L Ensembl NCBI GeneCards UniProt Show fit	SP140 nuclear body protein-like
chr1_+_113217345 Show fit	13.33	ENST00000357443.2	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_6561190 Show fit	13.16	ENST00000544021.1 ENST00000266556.7	TAPBPL Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein-like
chr1_+_113217309 Show fit	13.10	ENST00000544796.1 ENST00000369644.1	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr17_-_4167142 Show fit	13.04	ENST00000570535.1 ENST00000574367.1 ENST00000341657.4 ENST00000433651.1	ANKFY1 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and FYVE domain containing 1
chr1_+_113217043 Show fit	13.00	ENST00000413052.2	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr5_+_118690466 Show fit	12.69	ENST00000503646.1	TNFAIP8 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor, alpha-induced protein 8
chr9_+_74764278 Show fit	12.64	ENST00000238018.4 ENST00000376989.3	GDA Ensembl NCBI GeneCards UniProt Show fit	guanine deaminase
chr1_+_113217073 Show fit	12.53	ENST00000369645.1	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr6_-_33282024 Show fit	12.39	ENST00000475304.1 ENST00000489157.1	TAPBP Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein (tapasin)
chr7_-_77045617 Show fit	12.21	ENST00000257626.7	GSAP Ensembl NCBI GeneCards UniProt Show fit	gamma-secretase activating protein
chr17_-_4643114 Show fit	12.20	ENST00000293778.6	CXCL16 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-X-C motif) ligand 16
chr20_+_53092123 Show fit	11.90	ENST00000262593.5	DOK5 Ensembl NCBI GeneCards UniProt Show fit	docking protein 5
chr17_+_78234625 Show fit	11.83	ENST00000508628.2 ENST00000582970.1 ENST00000456466.1 ENST00000319921.4	RNF213 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 213
chr3_-_123339343 Show fit	11.68	ENST00000578202.1	MYLK Ensembl NCBI GeneCards UniProt Show fit	myosin light chain kinase
chr3_-_123339418 Show fit	11.62	ENST00000583087.1	MYLK Ensembl NCBI GeneCards UniProt Show fit	myosin light chain kinase
chr2_-_231989808 Show fit	11.52	ENST00000258400.3	HTR2B Ensembl NCBI GeneCards UniProt Show fit	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr7_+_4815238 Show fit	11.34	ENST00000348624.4 ENST00000401897.1	AP5Z1 Ensembl NCBI GeneCards UniProt Show fit	adaptor-related protein complex 5, zeta 1 subunit
chr1_-_173176452 Show fit	11.19	ENST00000281834.3	TNFSF4 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 4
chr2_+_201994208 Show fit	11.16	ENST00000440180.1	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD-like apoptosis regulator
chr6_-_82462425 Show fit	11.15	ENST00000369754.3 ENST00000320172.6 ENST00000369756.3	FAM46A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 46, member A
chr14_-_24615523 Show fit	10.96	ENST00000559056.1	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_-_24615805 Show fit	10.83	ENST00000560410.1	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_+_24605389 Show fit	10.82	ENST00000382708.3 ENST00000561435.1	PSME1 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr6_+_153552455 Show fit	10.81	ENST00000392385.2	AL590867.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr10_+_24497704 Show fit	10.80	ENST00000376456.4 ENST00000458595.1	KIAA1217 Ensembl NCBI GeneCards UniProt Show fit	KIAA1217
chr16_+_50776021 Show fit	10.70	ENST00000566679.2 ENST00000564634.1 ENST00000398568.2	CYLD Ensembl NCBI GeneCards UniProt Show fit	cylindromatosis (turban tumor syndrome)
chr14_+_24605361 Show fit	10.68	ENST00000206451.6 ENST00000559123.1	PSME1 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_+_154622652 Show fit	10.51	ENST00000260010.6	TLR2 Ensembl NCBI GeneCards UniProt Show fit	toll-like receptor 2
chr9_+_116917807 Show fit	10.47	ENST00000356083.3	COL27A1 Ensembl NCBI GeneCards UniProt Show fit	collagen, type XXVII, alpha 1
chr7_-_92747269 Show fit	10.41	ENST00000446617.1 ENST00000379958.2	SAMD9 Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9
chr17_+_7358889 Show fit	10.21	ENST00000575379.1	CHRNB1 Ensembl NCBI GeneCards UniProt Show fit	cholinergic receptor, nicotinic, beta 1 (muscle)
chr7_+_18535346 Show fit	10.18	ENST00000405010.3 ENST00000406451.4 ENST00000428307.2	HDAC9 Ensembl NCBI GeneCards UniProt Show fit	histone deacetylase 9
chr19_-_49371711 Show fit	10.16	ENST00000355496.5 ENST00000263265.6	PLEKHA4 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr8_-_145060593 Show fit	10.15	ENST00000313059.5 ENST00000524918.1 ENST00000313028.7 ENST00000525773.1	PARP10 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 10
chr6_-_30181133 Show fit	10.14	ENST00000454678.2 ENST00000434785.1	TRIM26 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 26
chr17_-_34207295 Show fit	10.03	ENST00000463941.1 ENST00000293272.3	CCL5 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-C motif) ligand 5
chr3_+_48507621 Show fit	9.98	ENST00000456089.1	TREX1 Ensembl NCBI GeneCards UniProt Show fit	three prime repair exonuclease 1
chr2_+_201994569 Show fit	9.95	ENST00000457277.1	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD-like apoptosis regulator
chr20_+_388791 Show fit	9.78	ENST00000441733.1 ENST00000353660.3	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_27998689 Show fit	9.74	ENST00000339145.4 ENST00000362020.4 ENST00000361157.6	IFI6 Ensembl NCBI GeneCards UniProt Show fit	interferon, alpha-inducible protein 6
chr2_-_55920952 Show fit	9.54	ENST00000447944.2	PNPT1 Ensembl NCBI GeneCards UniProt Show fit	polyribonucleotide nucleotidyltransferase 1
chr6_-_30181156 Show fit	9.35	ENST00000418026.1 ENST00000416596.1 ENST00000453195.1	TRIM26 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 26
chr7_+_134551583 Show fit	9.29	ENST00000435928.1	CALD1 Ensembl NCBI GeneCards UniProt Show fit	caldesmon 1
chr20_+_44746939 Show fit	9.27	ENST00000372276.3	CD40 Ensembl NCBI GeneCards UniProt Show fit	CD40 molecule, TNF receptor superfamily member 5
chr5_+_49962495 Show fit	9.26	ENST00000515175.1	PARP8 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 8
chr19_-_4338838 Show fit	9.25	ENST00000594605.1	STAP2 Ensembl NCBI GeneCards UniProt Show fit	signal transducing adaptor family member 2
chr19_-_47735918 Show fit	9.05	ENST00000449228.1 ENST00000300880.7 ENST00000341983.4	BBC3 Ensembl NCBI GeneCards UniProt Show fit	BCL2 binding component 3
chr15_+_67418047 Show fit	8.93	ENST00000540846.2	SMAD3 Ensembl NCBI GeneCards UniProt Show fit	SMAD family member 3
chr1_+_110453514 Show fit	8.90	ENST00000369802.3 ENST00000420111.2	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1 (macrophage)
chr16_+_50775971 Show fit	8.70	ENST00000311559.9 ENST00000564326.1 ENST00000566206.1	CYLD Ensembl NCBI GeneCards UniProt Show fit	cylindromatosis (turban tumor syndrome)
chr6_-_33281979 Show fit	8.57	ENST00000426633.2 ENST00000467025.1	TAPBP Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein (tapasin)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
46.1	138.2	GO:0045062	extrathymic T cell selection(GO:0045062)
38.8	116.4	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
37.4	149.5	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
35.2	140.7	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
35.1	105.4	GO:0051097	negative regulation of helicase activity(GO:0051097)
31.9	159.3	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
30.9	123.5	GO:0046967	cytosol to ER transport(GO:0046967)
20.5	102.6	GO:0060611	mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
20.4	204.3	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
19.2	249.9	GO:0035457	cellular response to interferon-alpha(GO:0035457)
18.2	200.5	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
18.2	91.1	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
16.6	182.5	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
16.4	82.1	GO:0070842	aggresome assembly(GO:0070842)
15.6	62.3	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
15.0	60.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
14.1	42.2	GO:0050822	peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
13.6	108.5	GO:0018377	protein myristoylation(GO:0018377)
13.2	131.6	GO:0060700	regulation of ribonuclease activity(GO:0060700)
13.2	13.2	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
13.1	130.7	GO:0045345	positive regulation of MHC class I biosynthetic process(GO:0045345)
12.6	62.9	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
10.3	82.6	GO:0072734	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
10.1	50.5	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
9.2	27.5	GO:1990108	protein linear deubiquitination(GO:1990108)
9.1	36.3	GO:1902044	regulation of Fas signaling pathway(GO:1902044)
8.8	26.4	GO:0002519	natural killer cell tolerance induction(GO:0002519) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
8.1	32.2	GO:0046035	CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
7.4	29.4	GO:2000329	negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
7.0	69.9	GO:0032020	ISG15-protein conjugation(GO:0032020)
6.7	46.7	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
6.6	99.7	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
6.6	79.3	GO:0034058	endosomal vesicle fusion(GO:0034058)
5.9	17.8	GO:1900369	negative regulation of RNA interference(GO:1900369)
5.0	40.2	GO:0097039	protein linear polyubiquitination(GO:0097039)
4.9	29.3	GO:2000834	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
4.7	52.0	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
4.6	13.8	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
4.4	17.5	GO:0009726	detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
4.2	25.1	GO:0070383	DNA cytosine deamination(GO:0070383)
4.2	16.7	GO:0033590	response to cobalamin(GO:0033590)
3.8	41.5	GO:0070141	response to UV-A(GO:0070141)
3.7	11.2	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
3.6	32.2	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
3.5	7.1	GO:0046110	xanthine metabolic process(GO:0046110)
3.5	10.5	GO:0070340	central nervous system myelin formation(GO:0032289) regulation of interleukin-18 production(GO:0032661) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
3.4	75.1	GO:0072643	interferon-gamma secretion(GO:0072643)
3.4	94.3	GO:1900115	extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
3.3	16.3	GO:0006145	purine nucleobase catabolic process(GO:0006145)
3.2	330.7	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
3.2	9.5	GO:0035928	rRNA import into mitochondrion(GO:0035928)
2.9	11.8	GO:1903659	regulation of complement-dependent cytotoxicity(GO:1903659)
2.9	26.4	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
2.9	281.2	GO:0034340	response to type I interferon(GO:0034340)
2.7	5.4	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
2.7	13.5	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
2.7	23.9	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
2.6	7.9	GO:2000661	positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
2.6	7.7	GO:0035915	pore formation in membrane of other organism(GO:0035915)
2.4	12.2	GO:2000638	regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
2.4	26.7	GO:0035655	interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
2.4	7.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
2.4	11.8	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.3	6.8	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.2	8.8	GO:0003409	optic cup structural organization(GO:0003409)
2.2	6.6	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
2.2	6.6	GO:0006624	vacuolar protein processing(GO:0006624)
2.2	6.5	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
2.1	8.5	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.1	60.2	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
2.0	14.3	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
2.0	8.0	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
2.0	29.5	GO:0006559	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
1.9	19.3	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
1.8	5.5	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
1.8	59.7	GO:0010390	histone monoubiquitination(GO:0010390)
1.8	7.1	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
1.7	5.2	GO:0070541	response to platinum ion(GO:0070541)
1.7	6.7	GO:0051083	'de novo' cotranslational protein folding(GO:0051083)
1.6	1.6	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
1.6	6.2	GO:0044111	development involved in symbiotic interaction(GO:0044111)
1.6	12.5	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
1.5	4.6	GO:0048691	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
1.5	18.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.5	10.5	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
1.5	8.9	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
1.4	7.2	GO:0072008	glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
1.4	27.2	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.4	4.2	GO:0006566	threonine metabolic process(GO:0006566)
1.4	5.4	GO:0015960	diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
1.3	5.2	GO:0009257	10-formyltetrahydrofolate biosynthetic process(GO:0009257)
1.3	2.6	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
1.3	3.9	GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.3	1.3	GO:0051595	response to methylglyoxal(GO:0051595)
1.3	34.4	GO:0008053	mitochondrial fusion(GO:0008053)
1.3	39.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
1.3	3.8	GO:0009443	pyridoxal 5'-phosphate salvage(GO:0009443)
1.2	6.1	GO:0035795	negative regulation of mitochondrial membrane permeability(GO:0035795)
1.1	7.7	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
1.1	2.1	GO:0033078	extrathymic T cell differentiation(GO:0033078)
1.0	5.1	GO:1904274	tricellular tight junction assembly(GO:1904274)
1.0	5.1	GO:0036149	phosphatidylinositol acyl-chain remodeling(GO:0036149)
1.0	6.0	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
1.0	13.9	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
1.0	13.7	GO:0038003	opioid receptor signaling pathway(GO:0038003)
1.0	6.8	GO:0080009	mRNA methylation(GO:0080009)
1.0	3.8	GO:0098886	modification of dendritic spine(GO:0098886)
0.9	230.1	GO:0051607	defense response to virus(GO:0051607)
0.9	2.8	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.9	10.2	GO:0035095	behavioral response to nicotine(GO:0035095)
0.9	1.8	GO:1903862	positive regulation of oxidative phosphorylation(GO:1903862)
0.9	5.5	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.9	13.2	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.9	4.4	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.9	7.9	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.9	12.2	GO:0010818	T cell chemotaxis(GO:0010818)
0.9	5.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.9	2.6	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.9	6.9	GO:0021564	vagus nerve development(GO:0021564)
0.9	6.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.9	3.4	GO:0044837	assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.8	6.8	GO:0043696	dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.8	5.9	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.8	3.4	GO:1905244	regulation of modification of synaptic structure(GO:1905244)
0.8	2.5	GO:0007518	myoblast fate determination(GO:0007518)
0.8	1.6	GO:1903422	negative regulation of synaptic vesicle recycling(GO:1903422)
0.8	13.8	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.8	3.9	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.8	14.0	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.8	4.6	GO:0002158	osteoclast proliferation(GO:0002158)
0.8	12.2	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004)
0.7	3.5	GO:0045204	MAPK export from nucleus(GO:0045204)
0.7	4.7	GO:0035799	ureter maturation(GO:0035799)
0.7	10.7	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.7	15.9	GO:0043011	myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.7	6.0	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6	2.5	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.6	3.8	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.6	1.9	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.6	3.1	GO:0031959	mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.6	16.0	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.6	1.8	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.6	0.6	GO:0015747	urate transport(GO:0015747)
0.6	0.6	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.6	8.5	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.6	50.6	GO:0002456	T cell mediated immunity(GO:0002456)
0.6	8.8	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.6	3.3	GO:0090070	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.6	7.7	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.5	7.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.5	2.2	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.5	1.6	GO:0002905	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.5	6.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.5	3.0	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.5	2.9	GO:0034421	post-translational protein acetylation(GO:0034421)
0.5	1.4	GO:0051598	meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.5	1.9	GO:0090234	regulation of kinetochore assembly(GO:0090234)
0.5	0.9	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.5	7.1	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.5	4.2	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.5	1.4	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5	20.7	GO:0019835	cytolysis(GO:0019835)
0.5	1.4	GO:1902871	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.5	4.6	GO:0002051	osteoblast fate commitment(GO:0002051)
0.4	5.2	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.4	1.7	GO:1902361	mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.4	2.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.4	6.3	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.4	2.4	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4	0.4	GO:1902869	regulation of neural retina development(GO:0061074) regulation of amacrine cell differentiation(GO:1902869)
0.4	1.2	GO:0003366	cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.4	0.8	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.4	4.3	GO:0060013	righting reflex(GO:0060013)
0.4	2.3	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.4	1.1	GO:1904383	response to sodium phosphate(GO:1904383)
0.4	1.1	GO:0048075	positive regulation of eye pigmentation(GO:0048075)
0.4	2.2	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.4	8.6	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.4	4.3	GO:2000172	regulation of branching morphogenesis of a nerve(GO:2000172)
0.4	5.7	GO:0051639	actin filament network formation(GO:0051639)
0.4	1.8	GO:2000543	positive regulation of gastrulation(GO:2000543)
0.4	1.1	GO:0002439	chronic inflammatory response to antigenic stimulus(GO:0002439)
0.4	88.0	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.4	2.1	GO:0051012	microtubule sliding(GO:0051012)
0.3	1.7	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.3	8.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.3	5.8	GO:0006828	manganese ion transport(GO:0006828)
0.3	1.4	GO:1903899	positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.3	2.0	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.3	2.0	GO:0070445	oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of synaptic vesicle clustering(GO:2000809)
0.3	1.6	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.3	3.2	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.3	1.0	GO:0021650	vestibulocochlear nerve formation(GO:0021650)
0.3	3.5	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.3	2.5	GO:0036438	maintenance of lens transparency(GO:0036438)
0.3	3.4	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636)
0.3	0.9	GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.3	0.9	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3	0.9	GO:0048627	myoblast development(GO:0048627)
0.3	4.0	GO:0060155	platelet dense granule organization(GO:0060155)
0.3	0.6	GO:0045994	positive regulation of translational initiation by iron(GO:0045994)
0.3	1.7	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
0.3	12.0	GO:0016486	peptide hormone processing(GO:0016486)
0.3	6.4	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.3	2.2	GO:0042256	mature ribosome assembly(GO:0042256)
0.3	1.4	GO:0010609	mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.3	7.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.3	1.6	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3	8.1	GO:0006294	nucleotide-excision repair, preincision complex assembly(GO:0006294)
0.3	1.1	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.3	7.4	GO:0070207	protein homotrimerization(GO:0070207)
0.3	4.9	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3	0.8	GO:0007060	male meiosis chromosome segregation(GO:0007060)
0.3	3.6	GO:0002360	T cell lineage commitment(GO:0002360)
0.3	1.5	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.3	1.0	GO:0052405	negative regulation by host of symbiont molecular function(GO:0052405)
0.3	2.0	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.2	17.5	GO:0051865	protein autoubiquitination(GO:0051865)
0.2	13.3	GO:0006298	mismatch repair(GO:0006298)
0.2	7.8	GO:0036150	phosphatidylserine acyl-chain remodeling(GO:0036150)
0.2	3.4	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.2	1.0	GO:1904219	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2	0.5	GO:0052151	positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.2	26.1	GO:0009615	response to virus(GO:0009615)
0.2	2.0	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.2	2.0	GO:0060754	positive regulation of mast cell chemotaxis(GO:0060754)
0.2	11.4	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.2	1.3	GO:0021678	third ventricle development(GO:0021678)
0.2	7.8	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.2	2.6	GO:0045793	positive regulation of cell size(GO:0045793)
0.2	1.7	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.2	9.4	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.2	4.8	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2	1.9	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.2	1.4	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
0.2	40.8	GO:0015992	proton transport(GO:0015992)
0.2	0.6	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2	1.4	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.2	0.4	GO:0035989	tendon development(GO:0035989)
0.2	0.6	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.2	1.0	GO:0070836	caveola assembly(GO:0070836)
0.2	1.3	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2	2.9	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2	0.5	GO:0046968	peptide antigen transport(GO:0046968)
0.2	0.5	GO:0033685	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) negative regulation of luteinizing hormone secretion(GO:0033685)
0.2	1.0	GO:0001712	ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.2	2.2	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.2	0.7	GO:0042357	thiamine diphosphate metabolic process(GO:0042357)
0.2	2.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.2	4.3	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.2	2.8	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.2	0.3	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.2	0.6	GO:0007296	vitellogenesis(GO:0007296)
0.2	4.1	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2	0.5	GO:0033385	geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.2	1.2	GO:0090154	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2	0.6	GO:0060022	hard palate development(GO:0060022)
0.2	4.6	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1	4.9	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.1	1.5	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.1	1.0	GO:1902031	regulation of NADP metabolic process(GO:1902031)
0.1	2.9	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.1	1.7	GO:0006657	CDP-choline pathway(GO:0006657)
0.1	0.7	GO:0035881	amacrine cell differentiation(GO:0035881)
0.1	1.4	GO:0019896	axonal transport of mitochondrion(GO:0019896)
0.1	4.4	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1	0.5	GO:0090383	phagosome acidification(GO:0090383)
0.1	1.8	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.1	1.2	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1	0.4	GO:0048200	COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1	2.4	GO:1903504	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1	0.5	GO:0048698	negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1	3.1	GO:0016048	detection of temperature stimulus(GO:0016048)
0.1	2.7	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.1	1.8	GO:0034501	protein localization to kinetochore(GO:0034501)
0.1	0.5	GO:0043335	protein unfolding(GO:0043335)
0.1	1.8	GO:0010664	negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1	2.9	GO:0035994	response to muscle stretch(GO:0035994)
0.1	0.5	GO:0072695	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1	1.9	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.1	0.8	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	4.5	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.1	4.9	GO:0060411	cardiac septum morphogenesis(GO:0060411)
0.1	0.5	GO:0060336	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336) regulation of cholesterol transporter activity(GO:0060694) pancreatic stellate cell proliferation(GO:0072343) response to metformin(GO:1901558) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1	0.8	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	1.0	GO:0000722	telomere maintenance via recombination(GO:0000722)
0.1	0.5	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	2.2	GO:1902259	regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1	13.8	GO:0048706	embryonic skeletal system development(GO:0048706)
0.1	1.0	GO:0006776	vitamin A metabolic process(GO:0006776)
0.1	1.6	GO:0002053	positive regulation of mesenchymal cell proliferation(GO:0002053)
0.1	0.7	GO:0032971	regulation of muscle filament sliding(GO:0032971)
0.1	6.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	1.5	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1	7.1	GO:0030574	collagen catabolic process(GO:0030574)
0.1	0.4	GO:0042335	cuticle development(GO:0042335)
0.1	1.5	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1	1.8	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1	2.9	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	6.0	GO:0006400	tRNA modification(GO:0006400)
0.1	0.7	GO:1901660	calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.1	0.3	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.1	1.1	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.1	1.6	GO:0006450	regulation of translational fidelity(GO:0006450)
0.1	1.8	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.1	2.1	GO:0071539	protein localization to centrosome(GO:0071539)
0.1	0.4	GO:0033227	dsRNA transport(GO:0033227)
0.1	0.2	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.1	0.6	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1	2.7	GO:0060395	SMAD protein signal transduction(GO:0060395)
0.1	7.5	GO:0000724	double-strand break repair via homologous recombination(GO:0000724)
0.1	0.7	GO:0006600	creatine metabolic process(GO:0006600)
0.1	2.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1	8.6	GO:0006661	phosphatidylinositol biosynthetic process(GO:0006661)
0.1	5.3	GO:0048477	oogenesis(GO:0048477)
0.1	0.1	GO:0097155	fasciculation of sensory neuron axon(GO:0097155) fasciculation of motor neuron axon(GO:0097156)
0.1	0.8	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1	1.7	GO:0033344	cholesterol efflux(GO:0033344)
0.1	20.1	GO:0010506	regulation of autophagy(GO:0010506)
0.1	7.7	GO:0051092	positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1	1.8	GO:0050974	detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1	1.6	GO:0007520	myoblast fusion(GO:0007520)
0.1	3.0	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.1	0.6	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134)
0.1	0.4	GO:0043248	proteasome assembly(GO:0043248)
0.1	0.7	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.1	6.1	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	1.3	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.1	0.4	GO:0043921	modulation by host of viral transcription(GO:0043921) modulation by host of symbiont transcription(GO:0052472)
0.1	1.4	GO:0009948	anterior/posterior axis specification(GO:0009948)
0.1	0.7	GO:0061436	regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436)
0.1	0.6	GO:0007000	nucleolus organization(GO:0007000)
0.1	3.5	GO:0032204	regulation of telomere maintenance(GO:0032204)
0.0	0.2	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0	0.6	GO:0098743	cell aggregation(GO:0098743)
0.0	0.5	GO:0051798	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	1.3	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
0.0	0.2	GO:0000270	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0	3.5	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.6	GO:0015671	oxygen transport(GO:0015671)
0.0	1.1	GO:0045124	regulation of bone resorption(GO:0045124)
0.0	1.2	GO:0016445	somatic diversification of immunoglobulins(GO:0016445)
0.0	2.5	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:1902410	mitotic cytokinetic process(GO:1902410)
0.0	0.8	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.5	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	1.1	GO:0031640	killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0	0.8	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	1.6	GO:0030521	androgen receptor signaling pathway(GO:0030521)
0.0	1.0	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	1.1	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	2.6	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	1.2	GO:0050918	positive chemotaxis(GO:0050918)
0.0	1.3	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.4	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.4	GO:0000132	establishment of mitotic spindle orientation(GO:0000132)
0.0	0.1	GO:0051610	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.2	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.8	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.5	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	2.3	GO:0030879	mammary gland development(GO:0030879)
0.0	0.3	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.0	1.8	GO:0030193	regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0	0.3	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	1.6	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	0.6	GO:0046473	phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0	0.3	GO:0035902	response to immobilization stress(GO:0035902)
0.0	1.7	GO:0006635	fatty acid beta-oxidation(GO:0006635)
0.0	0.3	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.0	0.6	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.0	0.3	GO:0006825	copper ion transport(GO:0006825)
0.0	0.2	GO:0071173	mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0	0.1	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.5	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0	1.0	GO:1902017	regulation of cilium assembly(GO:1902017)
0.0	0.4	GO:0006692	prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0	1.2	GO:0007030	Golgi organization(GO:0007030)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
30.2	272.1	GO:1990111	spermatoproteasome complex(GO:1990111)
23.7	165.7	GO:0042825	TAP complex(GO:0042825)
17.1	102.6	GO:1990682	CSF1-CSF1R complex(GO:1990682)
10.7	75.0	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
8.4	25.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
8.0	40.2	GO:0071797	LUBAC complex(GO:0071797)
7.2	43.3	GO:0008537	proteasome activator complex(GO:0008537)
6.0	36.1	GO:0097179	protease inhibitor complex(GO:0097179)
4.1	36.8	GO:0030870	Mre11 complex(GO:0030870)
3.7	58.6	GO:0008385	IkappaB kinase complex(GO:0008385)
3.6	17.8	GO:0044530	supraspliceosomal complex(GO:0044530)
3.5	10.5	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
3.1	21.7	GO:0036021	endolysosome lumen(GO:0036021)
3.1	59.0	GO:0033391	chromatoid body(GO:0033391)
2.5	9.9	GO:0070985	TFIIK complex(GO:0070985)
2.4	26.9	GO:0035631	CD40 receptor complex(GO:0035631)
2.4	50.8	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
2.4	190.5	GO:0015030	Cajal body(GO:0015030)
2.2	6.6	GO:1990622	CHOP-ATF3 complex(GO:1990622)
1.9	13.0	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
1.7	12.2	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
1.6	8.0	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.4	93.4	GO:0016235	aggresome(GO:0016235)
1.3	16.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
1.3	5.3	GO:0005600	collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
1.3	3.8	GO:0097444	spine apparatus(GO:0097444)
1.2	9.5	GO:0042788	polysomal ribosome(GO:0042788)
1.1	8.9	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
1.0	19.4	GO:0032059	bleb(GO:0032059)
1.0	13.8	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9	63.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.9	6.5	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.9	13.8	GO:0030478	actin cap(GO:0030478)
0.9	16.8	GO:0036020	endolysosome membrane(GO:0036020)
0.9	30.6	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.9	3.5	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)
0.8	4.2	GO:0097454	Schwann cell microvillus(GO:0097454)
0.8	13.1	GO:0071439	clathrin complex(GO:0071439)
0.8	53.4	GO:0005643	nuclear pore(GO:0005643)
0.8	6.8	GO:0031258	lamellipodium membrane(GO:0031258)
0.7	25.5	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.7	3.4	GO:0097149	centralspindlin complex(GO:0097149)
0.7	4.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.6	122.5	GO:0005923	bicellular tight junction(GO:0005923)
0.6	67.1	GO:0018995	host(GO:0018995) host cell(GO:0043657)
0.6	14.5	GO:0005614	interstitial matrix(GO:0005614)
0.6	7.7	GO:0005916	fascia adherens(GO:0005916)
0.6	239.0	GO:0031965	nuclear membrane(GO:0031965)
0.6	3.4	GO:0098837	postsynaptic recycling endosome(GO:0098837)
0.5	1.6	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.5	5.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.4	13.9	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4	24.4	GO:0097542	ciliary tip(GO:0097542)
0.4	9.3	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.4	88.7	GO:0031968	mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.4	133.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	1.1	GO:0097443	sorting endosome(GO:0097443)
0.4	13.2	GO:0005796	Golgi lumen(GO:0005796)
0.4	3.9	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.3	2.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.3	2.3	GO:0072487	MSL complex(GO:0072487)
0.3	1.0	GO:0031905	early endosome lumen(GO:0031905)
0.3	4.9	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.3	2.2	GO:0097422	tubular endosome(GO:0097422)
0.3	676.0	GO:0005739	mitochondrion(GO:0005739)
0.3	1.2	GO:0034669	integrin alpha4-beta7 complex(GO:0034669)
0.3	2.7	GO:0042587	glycogen granule(GO:0042587)
0.3	41.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.3	6.5	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.3	31.6	GO:0035097	histone methyltransferase complex(GO:0035097)
0.3	1.4	GO:0046930	membrane attack complex(GO:0005579) pore complex(GO:0046930)
0.3	1.1	GO:0031085	BLOC-3 complex(GO:0031085)
0.3	3.9	GO:0005581	collagen trimer(GO:0005581)
0.3	1.9	GO:0070852	cell body fiber(GO:0070852)
0.3	8.6	GO:0002080	acrosomal membrane(GO:0002080)
0.3	187.3	GO:0009986	cell surface(GO:0009986)
0.3	2.6	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.3	2.9	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.3	8.1	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.3	54.0	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.2	1.5	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.2	2.7	GO:0000137	Golgi cis cisterna(GO:0000137)
0.2	5.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	5.8	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.2	6.6	GO:0016580	Sin3 complex(GO:0016580)
0.2	10.6	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
0.2	3.3	GO:0031089	platelet dense granule lumen(GO:0031089)
0.2	15.5	GO:0035580	specific granule lumen(GO:0035580)
0.2	12.2	GO:0005802	trans-Golgi network(GO:0005802)
0.2	2.4	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.2	1.0	GO:0035061	interchromatin granule(GO:0035061)
0.2	24.6	GO:0005635	nuclear envelope(GO:0005635)
0.2	59.1	GO:0005769	early endosome(GO:0005769)
0.2	97.6	GO:0005774	vacuolar membrane(GO:0005774)
0.2	3.1	GO:0031904	endosome lumen(GO:0031904)
0.2	126.9	GO:0000139	Golgi membrane(GO:0000139)
0.2	1.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.2	3.3	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.2	0.7	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.2	20.4	GO:0072562	blood microparticle(GO:0072562)
0.2	2.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2	1.8	GO:0030014	CCR4-NOT complex(GO:0030014)
0.1	10.7	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.1	1.1	GO:0097225	sperm midpiece(GO:0097225)
0.1	37.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	0.8	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.1	0.7	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	12.1	GO:0043209	myelin sheath(GO:0043209)
0.1	148.2	GO:0005615	extracellular space(GO:0005615)
0.1	1.1	GO:0032432	actin filament bundle(GO:0032432)
0.1	3.0	GO:0005921	gap junction(GO:0005921)
0.1	0.4	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1	2.1	GO:0000242	pericentriolar material(GO:0000242)
0.1	1.0	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	0.3	GO:0097447	dendritic tree(GO:0097447)
0.1	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.1	1.0	GO:0001520	outer dense fiber(GO:0001520)
0.1	0.2	GO:0036398	TCR signalosome(GO:0036398)
0.1	4.1	GO:0005903	brush border(GO:0005903)
0.1	0.2	GO:0097165	nuclear stress granule(GO:0097165)
0.1	4.8	GO:0000922	spindle pole(GO:0000922)
0.1	0.2	GO:0033270	paranode region of axon(GO:0033270)
0.1	1.7	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	6.4	GO:0031225	anchored component of membrane(GO:0031225)
0.1	2.3	GO:0005844	polysome(GO:0005844)
0.1	27.3	GO:0005813	centrosome(GO:0005813)
0.1	4.8	GO:0034707	chloride channel complex(GO:0034707)
0.1	0.7	GO:0001673	male germ cell nucleus(GO:0001673)
0.1	0.4	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.6	GO:0030057	desmosome(GO:0030057)
0.0	1.5	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.6	GO:0045171	intercellular bridge(GO:0045171)
0.0	1.4	GO:0000795	synaptonemal complex(GO:0000795)
0.0	0.6	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.0	1.1	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	1.9	GO:0005604	basement membrane(GO:0005604)
0.0	0.8	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	4.5	GO:0005874	microtubule(GO:0005874)
0.0	1.1	GO:0016459	myosin complex(GO:0016459)
0.0	0.6	GO:1902562	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	1.0	GO:0001772	immunological synapse(GO:0001772)
0.0	0.5	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.3	GO:0005776	autophagosome(GO:0005776)
0.0	0.6	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.2	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.3	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	2.1	GO:0005875	microtubule associated complex(GO:0005875)
0.0	1.0	GO:0042383	sarcolemma(GO:0042383)
0.0	1.0	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	41.9	GO:0005576	extracellular region(GO:0005576)
0.0	2.2	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	97.3	GO:0005829	cytosol(GO:0005829)
0.0	0.1	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
53.1	159.3	GO:0008859	exoribonuclease II activity(GO:0008859)
32.2	354.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
31.2	93.5	GO:0042007	interleukin-18 binding(GO:0042007)
29.1	116.4	GO:0009041	uridylate kinase activity(GO:0009041)
28.6	143.1	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
20.7	165.7	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
13.3	106.0	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
12.2	48.8	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
9.8	29.5	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
9.2	283.9	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
8.8	35.3	GO:0005151	interleukin-1, Type II receptor binding(GO:0005151)
7.4	294.8	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
6.5	25.9	GO:0031849	olfactory receptor binding(GO:0031849)
6.4	32.2	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
5.8	17.5	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
5.8	11.5	GO:0046979	TAP2 binding(GO:0046979)
5.5	43.9	GO:0042296	ISG15 transferase activity(GO:0042296)
5.4	43.3	GO:0061133	endopeptidase activator activity(GO:0061133)
5.3	26.4	GO:0048030	disaccharide binding(GO:0048030)
5.3	174.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
4.9	29.3	GO:0004882	androgen receptor activity(GO:0004882)
4.5	36.3	GO:0070087	chromo shadow domain binding(GO:0070087)
4.1	82.1	GO:0070628	proteasome binding(GO:0070628)
4.0	88.8	GO:0032183	SUMO binding(GO:0032183)
3.9	19.4	GO:0055077	gap junction hemi-channel activity(GO:0055077)
3.6	32.2	GO:0004849	uridine kinase activity(GO:0004849)
3.3	39.9	GO:0031386	protein tag(GO:0031386)
3.0	96.7	GO:0008266	poly(U) RNA binding(GO:0008266)
3.0	62.8	GO:0070006	metalloaminopeptidase activity(GO:0070006)
2.9	17.2	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
2.8	8.4	GO:0098770	FBXO family protein binding(GO:0098770)
2.8	276.5	GO:0003727	single-stranded RNA binding(GO:0003727)
2.4	38.6	GO:0004908	interleukin-1 receptor activity(GO:0004908)
2.3	23.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
2.3	18.4	GO:0050816	phosphothreonine binding(GO:0050816)
2.2	15.2	GO:0061649	ubiquitinated histone binding(GO:0061649)
2.1	6.4	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
2.1	27.5	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
1.9	7.7	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
1.8	5.4	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.8	8.9	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
1.6	6.3	GO:0004074	biliverdin reductase activity(GO:0004074)
1.6	34.4	GO:0051400	BH domain binding(GO:0051400)
1.5	12.3	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
1.5	4.6	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
1.4	4.3	GO:0102008	cytosolic dipeptidase activity(GO:0102008)
1.4	10.0	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
1.4	26.4	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.4	4.1	GO:0005136	interleukin-4 receptor binding(GO:0005136)
1.3	36.9	GO:0070064	proline-rich region binding(GO:0070064)
1.3	5.2	GO:0004329	formate-tetrahydrofolate ligase activity(GO:0004329)
1.3	60.8	GO:0051879	Hsp90 protein binding(GO:0051879)
1.3	3.8	GO:0008478	pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
1.2	8.6	GO:0052739	phosphatidylserine 1-acylhydrolase activity(GO:0052739)
1.1	102.1	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.1	12.9	GO:0051378	amine binding(GO:0043176) serotonin binding(GO:0051378)
1.0	4.0	GO:0008281	sulfonylurea receptor activity(GO:0008281)
1.0	13.7	GO:0004985	opioid receptor activity(GO:0004985)
1.0	2.9	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.0	6.8	GO:0008174	mRNA methyltransferase activity(GO:0008174)
1.0	5.7	GO:0045569	TRAIL binding(GO:0045569)
0.9	26.4	GO:0005521	lamin binding(GO:0005521)
0.9	14.0	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.9	6.5	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.9	47.9	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.9	7.7	GO:1901612	cardiolipin binding(GO:1901612)
0.8	45.0	GO:0032813	tumor necrosis factor receptor superfamily binding(GO:0032813)
0.8	7.9	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.8	4.6	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.8	6.1	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.7	2.0	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6	5.6	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6	3.0	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.6	4.2	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.6	11.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.6	3.5	GO:0004977	melanocortin receptor activity(GO:0004977)
0.6	8.6	GO:0031996	thioesterase binding(GO:0031996)
0.6	8.6	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.6	3.9	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6	2.8	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.5	5.9	GO:0004969	histamine receptor activity(GO:0004969)
0.5	59.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5	32.7	GO:0001047	core promoter binding(GO:0001047)
0.5	220.6	GO:0003924	GTPase activity(GO:0003924)
0.5	2.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.5	6.0	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.5	2.9	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.5	14.0	GO:0005523	tropomyosin binding(GO:0005523)
0.5	2.7	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.5	5.5	GO:0042301	phosphate ion binding(GO:0042301)
0.5	18.1	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.4	0.4	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4	4.9	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.4	6.5	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.4	9.0	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.4	0.8	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.4	19.0	GO:0005109	frizzled binding(GO:0005109)
0.4	2.5	GO:0043515	kinetochore binding(GO:0043515)
0.4	33.0	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.4	2.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.4	11.4	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4	9.3	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.4	8.5	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.4	71.9	GO:0004386	helicase activity(GO:0004386)
0.4	5.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.4	12.2	GO:0001968	fibronectin binding(GO:0001968)
0.4	2.5	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.4	4.6	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.4	3.2	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.3	7.0	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.3	2.4	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3	2.0	GO:0005499	vitamin D binding(GO:0005499)
0.3	1.3	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3	10.1	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3	57.4	GO:0042393	histone binding(GO:0042393)
0.3	2.9	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3	8.6	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.3	0.9	GO:0030984	kininogen binding(GO:0030984)
0.3	5.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.3	2.4	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3	2.1	GO:0034618	arginine binding(GO:0034618)
0.3	5.4	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.3	5.3	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.3	6.5	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.3	1.5	GO:0047374	methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.3	4.6	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.3	286.5	GO:0008270	zinc ion binding(GO:0008270)
0.3	46.8	GO:0005319	lipid transporter activity(GO:0005319)
0.3	73.6	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3	1.6	GO:0001515	opioid peptide activity(GO:0001515)
0.3	4.8	GO:0005549	odorant binding(GO:0005549)
0.2	5.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.2	1.1	GO:0015639	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2	1.8	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.2	2.4	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.2	0.7	GO:0048019	receptor antagonist activity(GO:0048019)
0.2	1.7	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.2	7.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.2	0.8	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2	4.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.2	13.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.2	11.1	GO:0003725	double-stranded RNA binding(GO:0003725)
0.2	0.6	GO:0050692	DBD domain binding(GO:0050692)
0.2	0.8	GO:0089720	caspase binding(GO:0089720)
0.2	12.4	GO:0001540	beta-amyloid binding(GO:0001540)
0.2	6.0	GO:0051018	protein kinase A binding(GO:0051018)
0.2	40.2	GO:0005125	cytokine activity(GO:0005125)
0.2	2.0	GO:0045294	alpha-catenin binding(GO:0045294)
0.2	1.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2	5.5	GO:0042605	peptide antigen binding(GO:0042605)
0.2	7.6	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2	1.0	GO:0001225	RNA polymerase II transcription coactivator binding(GO:0001225)
0.2	1.0	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2	2.2	GO:0034452	dynactin binding(GO:0034452)
0.2	1.0	GO:0001849	complement component C1q binding(GO:0001849)
0.2	5.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.2	0.7	GO:0008732	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2	2.8	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.2	1.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2	7.0	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.2	0.5	GO:0051500	D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1	3.6	GO:0001786	phosphatidylserine binding(GO:0001786)
0.1	17.6	GO:0005254	chloride channel activity(GO:0005254)
0.1	2.5	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.1	1.0	GO:0005502	11-cis retinal binding(GO:0005502)
0.1	1.0	GO:0005353	fructose transmembrane transporter activity(GO:0005353)
0.1	4.1	GO:0070566	adenylyltransferase activity(GO:0070566)
0.1	1.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.1	1.9	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	2.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1	0.6	GO:0019534	toxin transporter activity(GO:0019534)
0.1	3.8	GO:0070034	telomerase RNA binding(GO:0070034)
0.1	2.7	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	3.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	12.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	2.8	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	4.0	GO:0043015	gamma-tubulin binding(GO:0043015)
0.1	1.8	GO:0001223	transcription coactivator binding(GO:0001223)
0.1	0.3	GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1	0.5	GO:0004995	tachykinin receptor activity(GO:0004995)
0.1	0.6	GO:0030492	hemoglobin binding(GO:0030492)
0.1	21.1	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	1.5	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.1	1.2	GO:0002161	aminoacyl-tRNA editing activity(GO:0002161)
0.1	1.5	GO:0005537	mannose binding(GO:0005537)
0.1	0.4	GO:0097322	7SK snRNA binding(GO:0097322)
0.1	0.5	GO:0004161	dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1	0.7	GO:0099580	ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1	2.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.1	8.0	GO:0051117	ATPase binding(GO:0051117)
0.1	1.4	GO:0050811	GABA receptor binding(GO:0050811)
0.1	3.6	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	2.1	GO:0036442	hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1	2.8	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.1	0.7	GO:0016778	diphosphotransferase activity(GO:0016778)
0.1	0.5	GO:0030911	TPR domain binding(GO:0030911)
0.1	0.7	GO:0004111	creatine kinase activity(GO:0004111)
0.1	1.0	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1	0.5	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.1	0.7	GO:0015386	potassium:proton antiporter activity(GO:0015386)
0.1	3.1	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.1	2.0	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.1	0.7	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.1	2.2	GO:0042162	telomeric DNA binding(GO:0042162)
0.1	3.6	GO:0016279	protein-lysine N-methyltransferase activity(GO:0016279)
0.1	2.9	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	0.8	GO:0003951	NAD+ kinase activity(GO:0003951)
0.1	3.6	GO:0043022	ribosome binding(GO:0043022)
0.1	0.8	GO:0004568	chitinase activity(GO:0004568)
0.1	2.3	GO:0004623	phospholipase A2 activity(GO:0004623)
0.1	3.1	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.1	1.0	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	1.4	GO:0031369	translation initiation factor binding(GO:0031369)
0.1	0.3	GO:0031208	POZ domain binding(GO:0031208)
0.1	1.8	GO:0047555	cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1	1.9	GO:0050681	androgen receptor binding(GO:0050681)
0.1	3.5	GO:0019843	rRNA binding(GO:0019843)
0.1	0.9	GO:0019864	IgG binding(GO:0019864)
0.1	1.8	GO:0015485	cholesterol binding(GO:0015485)
0.1	1.9	GO:0004407	histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.1	2.3	GO:0008536	Ran GTPase binding(GO:0008536)
0.1	11.1	GO:0003823	antigen binding(GO:0003823)
0.1	94.1	GO:0042802	identical protein binding(GO:0042802)
0.1	2.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	1.9	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	3.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	1.2	GO:0042056	chemoattractant activity(GO:0042056)
0.1	0.6	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	1.7	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	0.4	GO:0051059	NF-kappaB binding(GO:0051059)
0.1	1.2	GO:0002039	p53 binding(GO:0002039)
0.1	1.1	GO:0038191	neuropilin binding(GO:0038191)
0.1	0.3	GO:0042165	neurotransmitter binding(GO:0042165)
0.0	1.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	1.8	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.2	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.0	0.1	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0	0.3	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	2.3	GO:0043130	ubiquitin binding(GO:0043130)
0.0	0.8	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.6	GO:0001054	RNA polymerase I activity(GO:0001054)
0.0	0.6	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	44.0	GO:0003723	RNA binding(GO:0003723)
0.0	0.6	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.5	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.4	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.8	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	0.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	1.0	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.4	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	0.1	GO:0035325	Toll-like receptor binding(GO:0035325)
0.0	1.3	GO:0004984	olfactory receptor activity(GO:0004984)
0.0	3.1	GO:0005261	cation channel activity(GO:0005261)
0.0	1.3	GO:0005539	glycosaminoglycan binding(GO:0005539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	25.2	PID IFNG PATHWAY	IFN-gamma pathway
2.7	89.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.3	78.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
2.3	56.6	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
2.0	40.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
2.0	38.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.8	134.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
1.7	86.4	PID MYC PATHWAY	C-MYC pathway
1.2	65.8	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
1.0	58.8	PID AURORA A PATHWAY	Aurora A signaling
1.0	36.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.8	80.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.8	26.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.8	9.4	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.8	16.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.7	110.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.7	34.4	PID BCR 5PATHWAY	BCR signaling pathway
0.7	31.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.7	26.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.6	10.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.6	20.7	SIG CHEMOTAXIS	Genes related to chemotaxis
0.6	36.6	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.6	34.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	29.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.4	16.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.4	69.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.4	28.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.4	20.6	NABA COLLAGENS	Genes encoding collagen proteins
0.4	11.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.3	8.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.3	12.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	8.6	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.3	7.2	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.3	103.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	1.0	ST ADRENERGIC	Adrenergic Pathway
0.2	7.3	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	5.8	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	6.7	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.2	2.2	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.2	1.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	9.3	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.2	2.7	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	13.3	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	6.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	29.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	8.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	8.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	0.5	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	2.9	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	3.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	2.0	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	2.9	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	3.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	24.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	1.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	2.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	3.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	1.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	4.4	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	1.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	0.9	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.5	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	12.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	1.0	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.6	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.6	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	0.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
14.7	1370.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
9.1	126.8	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
5.4	16.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
5.0	146.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
4.2	304.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
3.7	107.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
3.4	171.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
3.2	90.3	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
2.8	25.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
2.8	124.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
2.6	39.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
2.5	90.8	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
2.5	162.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
2.3	58.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
2.1	78.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.8	23.4	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
1.0	15.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
1.0	13.5	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.9	32.2	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.9	12.9	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.7	17.9	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.6	50.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.6	137.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	2.7	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.4	11.7	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.4	9.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.4	2.8	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.4	5.8	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.4	10.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.4	9.5	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3	17.2	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3	8.6	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.3	19.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	22.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	7.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	11.5	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.3	13.0	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3	6.4	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	3.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	7.9	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.2	4.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	5.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	3.9	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.2	6.6	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.2	1.6	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.2	5.9	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.2	3.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	4.6	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2	16.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	3.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.2	4.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	2.6	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	8.8	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	2.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1	5.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	2.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	2.9	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	2.7	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.1	2.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	1.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	2.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	6.1	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	2.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	2.7	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.1	3.9	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1	2.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	2.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	5.8	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.1	8.1	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	2.5	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	2.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	4.0	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.1	5.0	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	1.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	2.2	REACTOME INTERFERON SIGNALING	Genes involved in Interferon Signaling
0.1	1.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.1	1.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	5.7	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	1.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	0.9	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	7.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	2.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.8	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	1.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	1.0	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.8	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.4	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	2.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.5	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	2.1	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.5	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	2.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	1.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.4	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Results for IRF2_STAT2_IRF8_IRF1

Z-value: 9.46

Motif logo

Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Activity-expression correlation:

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: