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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 9.46
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.61 | 1.1e-03 | Click! |
| IRF8 | hg19_v2_chr16_+_85942594_85942635 | 0.56 | 3.6e-03 | Click! |
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.48 | 1.6e-02 | Click! |
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.15 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_79086088 Show fit | 164.59 |
ENST00000370751.5
ENST00000342282.3 |
interferon-induced protein 44-like |
|
| chr4_-_76944621 Show fit | 144.04 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr6_+_32821924 Show fit | 132.47 |
ENST00000374859.2
ENST00000453265.2 |
proteasome (prosome, macropain) subunit, beta type, 9 |
|
| chr13_-_43566301 Show fit | 121.83 |
ENST00000398762.3
ENST00000313640.7 ENST00000313624.7 |
epithelial stromal interaction 1 (breast) |
|
| chr2_-_7005785 Show fit | 116.38 |
ENST00000256722.5
ENST00000404168.1 ENST00000458098.1 |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
|
| chr10_+_91092241 Show fit | 115.18 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr10_+_91087651 Show fit | 112.71 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr21_+_42792442 Show fit | 105.80 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr10_+_91152303 Show fit | 105.39 |
ENST00000371804.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
|
| chr17_-_40264692 Show fit | 93.08 |
ENST00000591220.1
ENST00000251642.3 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 330.7 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 2.9 | 281.2 | GO:0034340 | response to type I interferon(GO:0034340) |
| 19.2 | 249.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.9 | 230.1 | GO:0051607 | defense response to virus(GO:0051607) |
| 20.4 | 204.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 18.2 | 200.5 | GO:1901740 | negative regulation of myoblast fusion(GO:1901740) |
| 16.6 | 182.5 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 31.9 | 159.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 37.4 | 149.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 35.2 | 140.7 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 676.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 30.2 | 272.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.6 | 239.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 2.4 | 190.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 187.3 | GO:0009986 | cell surface(GO:0009986) |
| 23.7 | 165.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 148.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 133.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 126.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.6 | 122.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.2 | 354.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 7.4 | 294.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.3 | 286.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 9.2 | 283.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.8 | 276.5 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.5 | 220.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 5.3 | 174.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 20.7 | 165.7 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 53.1 | 159.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 28.6 | 143.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 134.9 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.7 | 110.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 103.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 2.7 | 89.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.7 | 86.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.8 | 80.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 2.3 | 78.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.4 | 69.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.2 | 65.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 1.0 | 58.8 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.7 | 1370.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 4.2 | 304.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 3.4 | 171.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 2.5 | 162.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 5.0 | 146.2 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.6 | 137.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 9.1 | 126.8 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 2.8 | 124.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 3.7 | 107.4 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 2.5 | 90.8 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |