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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 9.46

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
ENSG00000168310.6 interferon regulatory factor 2
ENSG00000170581.9 signal transducer and activator of transcription 2
ENSG00000140968.6 interferon regulatory factor 8
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF2hg19_v2_chr4_-_185395672_1853957340.611.1e-03Click!
IRF8hg19_v2_chr16_+_85942594_859426350.563.6e-03Click!
IRF1hg19_v2_chr5_-_131826457_1318265140.481.6e-02Click!
STAT2hg19_v2_chr12_-_56753858_567539300.154.7e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_79086088 164.59 ENST00000370751.5
ENST00000342282.3
interferon-induced protein 44-like
chr4_-_76944621 144.04 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr6_+_32821924 132.47 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_43566301 121.83 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
epithelial stromal interaction 1 (breast)
chr2_-_7005785 116.38 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr10_+_91092241 115.18 ENST00000371811.4
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91087651 112.71 ENST00000371818.4
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42792442 105.80 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_+_91152303 105.39 ENST00000371804.3
interferon-induced protein with tetratricopeptide repeats 1
chr17_-_40264692 93.08 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr12_+_113376157 84.88 ENST00000228928.7
2'-5'-oligoadenylate synthetase 3, 100kDa
chr6_-_32821599 84.37 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_6659153 82.43 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr6_-_29527702 82.13 ENST00000377050.4
ubiquitin D
chr22_+_18632666 81.07 ENST00000215794.7
ubiquitin specific peptidase 18
chr12_+_113416191 79.64 ENST00000342315.4
ENST00000392583.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr3_+_122399444 78.26 ENST00000474629.2
poly (ADP-ribose) polymerase family, member 14
chr10_+_91174314 75.46 ENST00000371795.4
interferon-induced protein with tetratricopeptide repeats 5
chr16_-_67970990 72.94 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr3_-_122283424 71.07 ENST00000477522.2
ENST00000360356.2
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 70.31 ENST00000471785.1
ENST00000466126.1
poly (ADP-ribose) polymerase family, member 9
chr1_-_89488510 66.67 ENST00000564665.1
ENST00000370481.4
guanylate binding protein 3
chr11_-_4414880 62.59 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr3_+_122283064 61.98 ENST00000296161.4
deltex 3-like (Drosophila)
chr9_+_5510492 61.33 ENST00000397745.2
programmed cell death 1 ligand 2
chr9_-_32526184 60.47 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_+_5510558 60.35 ENST00000397747.3
programmed cell death 1 ligand 2
chr1_-_89531041 59.97 ENST00000370473.4
guanylate binding protein 1, interferon-inducible
chr6_+_26440700 59.29 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
butyrophilin, subfamily 3, member A3
chr16_+_57023406 59.11 ENST00000262510.6
ENST00000308149.7
ENST00000436936.1
NLR family, CARD domain containing 5
chr4_-_169239921 56.91 ENST00000514995.1
ENST00000393743.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_92777606 55.89 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr15_+_89182156 55.71 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 55.40 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr4_+_142557717 51.47 ENST00000320650.4
ENST00000296545.7
interleukin 15
chr2_+_7017796 50.48 ENST00000382040.3
radical S-adenosyl methionine domain containing 2
chr1_+_79115503 49.08 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr11_-_60719213 48.83 ENST00000227880.3
solute carrier family 15 (oligopeptide transporter), member 3
chr15_+_89181974 48.20 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr22_-_36556821 46.74 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
apolipoprotein L, 3
chr11_-_615942 46.68 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr4_+_142557771 45.99 ENST00000514653.1
interleukin 15
chr6_-_32806506 45.31 ENST00000374897.2
ENST00000452392.2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr12_+_113376249 44.02 ENST00000551007.1
ENST00000548514.1
2'-5'-oligoadenylate synthetase 3, 100kDa
chr21_+_42798094 43.80 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_32811885 42.03 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr12_+_113344755 41.32 ENST00000550883.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_122283100 41.12 ENST00000492382.1
ENST00000462315.1
poly (ADP-ribose) polymerase family, member 9
chr19_+_10196781 40.84 ENST00000253110.11
chromosome 19 open reading frame 66
chr12_+_113344811 40.78 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_+_142558078 40.74 ENST00000529613.1
interleukin 15
chr1_+_948803 39.87 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr11_-_57335280 39.58 ENST00000287156.4
ubiquitin-conjugating enzyme E2L 6
chr9_-_100881466 39.06 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
tripartite motif containing 14
chr2_-_231084820 38.38 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr2_-_163175133 38.35 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr11_+_69455855 36.87 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr14_+_94577074 36.20 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
interferon, alpha-inducible protein 27
chr15_-_80263506 34.43 ENST00000335661.6
BCL2-related protein A1
chr11_-_615570 34.35 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr19_+_10196981 33.06 ENST00000591813.1
chromosome 19 open reading frame 66
chr21_+_42733870 32.94 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
myxovirus (influenza virus) resistance 2 (mouse)
chr13_+_50070491 32.32 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHD finger protein 11
chr11_+_71710973 32.09 ENST00000393707.4
interleukin 18 binding protein
chr22_+_36044411 31.79 ENST00000409652.4
apolipoprotein L, 6
chr6_+_26402465 31.22 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr19_+_18284477 31.19 ENST00000407280.3
interferon, gamma-inducible protein 30
chr11_+_71709938 31.10 ENST00000393705.4
ENST00000337131.5
ENST00000531053.1
ENST00000404792.1
interleukin 18 binding protein
chr13_+_50070077 30.99 ENST00000378319.3
ENST00000426879.1
PHD finger protein 11
chr11_+_71710648 30.26 ENST00000260049.5
interleukin 18 binding protein
chr19_-_50400212 29.49 ENST00000391826.2
interleukin 4 induced 1
chr1_-_173020056 29.44 ENST00000239468.2
ENST00000404377.3
tumor necrosis factor (ligand) superfamily, member 18
chr12_+_102271129 29.44 ENST00000258534.8
DNA-damage regulated autophagy modulator 1
chr9_+_100174232 29.43 ENST00000355295.4
tudor domain containing 7
chr8_-_23540402 29.34 ENST00000523261.1
ENST00000380871.4
NK3 homeobox 1
chr6_+_26365443 29.25 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
butyrophilin, subfamily 3, member A2
chr9_+_100174344 29.00 ENST00000422139.2
tudor domain containing 7
chr12_+_113416265 28.83 ENST00000449768.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr10_+_115439282 28.14 ENST00000369321.2
ENST00000345633.4
caspase 7, apoptosis-related cysteine peptidase
chr10_+_115439699 27.51 ENST00000369315.1
caspase 7, apoptosis-related cysteine peptidase
chr12_+_113344582 27.27 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_+_126240442 27.19 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
nuclear receptor coactivator 7
chr11_-_104905840 27.18 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
caspase 1, apoptosis-related cysteine peptidase
chr1_+_110453203 27.16 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr10_+_115439630 26.95 ENST00000369318.3
caspase 7, apoptosis-related cysteine peptidase
chr22_+_36649056 26.83 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
apolipoprotein L, 1
chr2_+_102972363 26.75 ENST00000409599.1
interleukin 18 receptor 1
chr17_+_18380051 26.65 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr17_+_25958174 26.45 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr15_+_74287009 26.25 ENST00000395135.3
promyelocytic leukemia
chr3_+_187086120 25.91 ENST00000259030.2
receptor (chemosensory) transporter protein 4
chr7_+_100728720 25.85 ENST00000306085.6
ENST00000412507.1
tripartite motif containing 56
chr2_-_220252603 25.83 ENST00000322176.7
ENST00000273075.4
aspartyl aminopeptidase
chr2_-_231084617 25.82 ENST00000409815.2
SP110 nuclear body protein
chr20_-_47894569 25.37 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
zinc finger, NFX1-type containing 1
chr15_+_74287035 25.37 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
promyelocytic leukemia
chr14_+_24630465 25.23 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
interferon regulatory factor 9
chr22_+_39436862 25.10 ENST00000381565.2
ENST00000452957.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr9_-_32526299 25.06 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_32811771 24.64 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chr1_+_110453608 24.43 ENST00000369801.1
colony stimulating factor 1 (macrophage)
chr11_+_5710919 23.79 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr15_+_74287118 23.35 ENST00000563500.1
promyelocytic leukemia
chr2_+_201981527 23.34 ENST00000441224.1
CASP8 and FADD-like apoptosis regulator
chr1_+_110453109 23.24 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr2_-_231084659 23.24 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr10_+_91061712 22.04 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_33282163 21.23 ENST00000434618.2
ENST00000456592.2
TAP binding protein (tapasin)
chr6_+_32811861 21.09 ENST00000453426.1
TAP1 and PSMB8 antisense RNA 1
chr4_-_169401628 20.69 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr7_+_18535786 20.69 ENST00000406072.1
histone deacetylase 9
chr2_+_231280908 19.43 ENST00000427101.2
ENST00000432979.1
SP100 nuclear antigen
chr11_+_93861993 19.40 ENST00000227638.3
ENST00000436171.2
pannexin 1
chr1_+_110453462 18.86 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr5_+_96212185 18.45 ENST00000379904.4
endoplasmic reticulum aminopeptidase 2
chr5_-_96143796 18.38 ENST00000296754.3
endoplasmic reticulum aminopeptidase 1
chr6_+_127439749 18.08 ENST00000356698.4
R-spondin 3
chr5_+_96211643 17.94 ENST00000437043.3
ENST00000510373.1
endoplasmic reticulum aminopeptidase 2
chr1_-_154580616 17.80 ENST00000368474.4
adenosine deaminase, RNA-specific
chr21_+_43619796 17.48 ENST00000398457.2
ATP-binding cassette, sub-family G (WHITE), member 1
chr17_+_41363854 17.35 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
transmembrane protein 106A
chr22_-_36635684 17.25 ENST00000358502.5
apolipoprotein L, 2
chr17_+_41158742 16.99 ENST00000415816.2
ENST00000438323.2
interferon-induced protein 35
chr5_-_96143602 16.96 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
endoplasmic reticulum aminopeptidase 1
chr2_+_231280954 16.91 ENST00000409824.1
ENST00000409341.1
ENST00000409112.1
ENST00000340126.4
ENST00000341950.4
SP100 nuclear antigen
chr4_+_186990298 16.78 ENST00000296795.3
ENST00000513189.1
toll-like receptor 3
chr22_+_41697520 16.50 ENST00000352645.4
zinc finger CCCH-type containing 7B
chr1_+_165864800 16.11 ENST00000469256.2
uridine-cytidine kinase 2
chr1_+_165864821 16.10 ENST00000470820.1
uridine-cytidine kinase 2
chr14_+_58711539 15.93 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_-_20370847 15.69 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr4_+_37892682 15.65 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr4_-_185395672 15.51 ENST00000393593.3
interferon regulatory factor 2
chr20_+_388935 15.42 ENST00000382181.2
ENST00000400247.3
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_150738261 15.17 ENST00000448301.2
ENST00000368985.3
cathepsin S
chr20_+_388679 14.95 ENST00000356286.5
ENST00000475269.1
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_64764435 14.90 ENST00000534177.1
ENST00000301887.4
basic leucine zipper transcription factor, ATF-like 2
chr21_+_43933946 14.81 ENST00000352133.2
solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr6_+_26402517 14.63 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr6_-_31324943 14.58 ENST00000412585.2
ENST00000434333.1
major histocompatibility complex, class I, B
chr6_+_116782527 14.03 ENST00000368606.3
ENST00000368605.1
family with sequence similarity 26, member F
chr2_-_152146385 13.83 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr3_+_48507210 13.72 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
three prime repair exonuclease 1
chr1_-_149908710 13.71 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
myotubularin related protein 11
chr20_+_61436146 13.67 ENST00000290291.6
opioid growth factor receptor
chr6_-_87804815 13.54 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chr11_-_104972158 13.47 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr5_+_125695805 13.40 ENST00000513040.1
GRAM domain containing 3
chr2_+_231191875 13.34 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
SP140 nuclear body protein-like
chr1_+_113217345 13.33 ENST00000357443.2
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_6561190 13.16 ENST00000544021.1
ENST00000266556.7
TAP binding protein-like
chr1_+_113217309 13.10 ENST00000544796.1
ENST00000369644.1
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr17_-_4167142 13.04 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ankyrin repeat and FYVE domain containing 1
chr1_+_113217043 13.00 ENST00000413052.2
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr5_+_118690466 12.69 ENST00000503646.1
tumor necrosis factor, alpha-induced protein 8
chr9_+_74764278 12.64 ENST00000238018.4
ENST00000376989.3
guanine deaminase
chr1_+_113217073 12.53 ENST00000369645.1
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr6_-_33282024 12.39 ENST00000475304.1
ENST00000489157.1
TAP binding protein (tapasin)
chr7_-_77045617 12.21 ENST00000257626.7
gamma-secretase activating protein
chr17_-_4643114 12.20 ENST00000293778.6
chemokine (C-X-C motif) ligand 16
chr20_+_53092123 11.90 ENST00000262593.5
docking protein 5
chr17_+_78234625 11.83 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
ring finger protein 213
chr3_-_123339343 11.68 ENST00000578202.1
myosin light chain kinase
chr3_-_123339418 11.62 ENST00000583087.1
myosin light chain kinase
chr2_-_231989808 11.52 ENST00000258400.3
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr7_+_4815238 11.34 ENST00000348624.4
ENST00000401897.1
adaptor-related protein complex 5, zeta 1 subunit
chr1_-_173176452 11.19 ENST00000281834.3
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_201994208 11.16 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr6_-_82462425 11.15 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
family with sequence similarity 46, member A
chr14_-_24615523 10.96 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_-_24615805 10.83 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_+_24605389 10.82 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr6_+_153552455 10.81 ENST00000392385.2
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr10_+_24497704 10.80 ENST00000376456.4
ENST00000458595.1
KIAA1217
chr16_+_50776021 10.70 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chr14_+_24605361 10.68 ENST00000206451.6
ENST00000559123.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_+_154622652 10.51 ENST00000260010.6
toll-like receptor 2
chr9_+_116917807 10.47 ENST00000356083.3
collagen, type XXVII, alpha 1
chr7_-_92747269 10.41 ENST00000446617.1
ENST00000379958.2
sterile alpha motif domain containing 9
chr17_+_7358889 10.21 ENST00000575379.1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr7_+_18535346 10.18 ENST00000405010.3
ENST00000406451.4
ENST00000428307.2
histone deacetylase 9
chr19_-_49371711 10.16 ENST00000355496.5
ENST00000263265.6
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr8_-_145060593 10.15 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
poly (ADP-ribose) polymerase family, member 10
chr6_-_30181133 10.14 ENST00000454678.2
ENST00000434785.1
tripartite motif containing 26
chr17_-_34207295 10.03 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr3_+_48507621 9.98 ENST00000456089.1
three prime repair exonuclease 1
chr2_+_201994569 9.95 ENST00000457277.1
CASP8 and FADD-like apoptosis regulator
chr20_+_388791 9.78 ENST00000441733.1
ENST00000353660.3
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_27998689 9.74 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
interferon, alpha-inducible protein 6
chr2_-_55920952 9.54 ENST00000447944.2
polyribonucleotide nucleotidyltransferase 1
chr6_-_30181156 9.35 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
tripartite motif containing 26
chr7_+_134551583 9.29 ENST00000435928.1
caldesmon 1
chr20_+_44746939 9.27 ENST00000372276.3
CD40 molecule, TNF receptor superfamily member 5
chr5_+_49962495 9.26 ENST00000515175.1
poly (ADP-ribose) polymerase family, member 8
chr19_-_4338838 9.25 ENST00000594605.1
signal transducing adaptor family member 2
chr19_-_47735918 9.05 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BCL2 binding component 3
chr15_+_67418047 8.93 ENST00000540846.2
SMAD family member 3
chr1_+_110453514 8.90 ENST00000369802.3
ENST00000420111.2
colony stimulating factor 1 (macrophage)
chr16_+_50775971 8.70 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
cylindromatosis (turban tumor syndrome)
chr6_-_33281979 8.57 ENST00000426633.2
ENST00000467025.1
TAP binding protein (tapasin)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
46.1 138.2 GO:0045062 extrathymic T cell selection(GO:0045062)
38.8 116.4 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
37.4 149.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
35.2 140.7 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
35.1 105.4 GO:0051097 negative regulation of helicase activity(GO:0051097)
31.9 159.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
30.9 123.5 GO:0046967 cytosol to ER transport(GO:0046967)
20.5 102.6 GO:0060611 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
20.4 204.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
19.2 249.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
18.2 200.5 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
18.2 91.1 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
16.6 182.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
16.4 82.1 GO:0070842 aggresome assembly(GO:0070842)
15.6 62.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
15.0 60.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
14.1 42.2 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
13.6 108.5 GO:0018377 protein myristoylation(GO:0018377)
13.2 131.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
13.2 13.2 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
13.1 130.7 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
12.6 62.9 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
10.3 82.6 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
10.1 50.5 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
9.2 27.5 GO:1990108 protein linear deubiquitination(GO:1990108)
9.1 36.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
8.8 26.4 GO:0002519 natural killer cell tolerance induction(GO:0002519) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
8.1 32.2 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
7.4 29.4 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
7.0 69.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
6.7 46.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
6.6 99.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
6.6 79.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
5.9 17.8 GO:1900369 negative regulation of RNA interference(GO:1900369)
5.0 40.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
4.9 29.3 GO:2000834 androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
4.7 52.0 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
4.6 13.8 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
4.4 17.5 GO:0009726 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
4.2 25.1 GO:0070383 DNA cytosine deamination(GO:0070383)
4.2 16.7 GO:0033590 response to cobalamin(GO:0033590)
3.8 41.5 GO:0070141 response to UV-A(GO:0070141)
3.7 11.2 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
3.6 32.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
3.5 7.1 GO:0046110 xanthine metabolic process(GO:0046110)
3.5 10.5 GO:0070340 central nervous system myelin formation(GO:0032289) regulation of interleukin-18 production(GO:0032661) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
3.4 75.1 GO:0072643 interferon-gamma secretion(GO:0072643)
3.4 94.3 GO:1900115 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
3.3 16.3 GO:0006145 purine nucleobase catabolic process(GO:0006145)
3.2 330.7 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
3.2 9.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
2.9 11.8 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
2.9 26.4 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
2.9 281.2 GO:0034340 response to type I interferon(GO:0034340)
2.7 5.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
2.7 13.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
2.7 23.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.6 7.9 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
2.6 7.7 GO:0035915 pore formation in membrane of other organism(GO:0035915)
2.4 12.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
2.4 26.7 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
2.4 7.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
2.4 11.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.3 6.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.2 8.8 GO:0003409 optic cup structural organization(GO:0003409)
2.2 6.6 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
2.2 6.6 GO:0006624 vacuolar protein processing(GO:0006624)
2.2 6.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
2.1 8.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.1 60.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
2.0 14.3 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
2.0 8.0 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
2.0 29.5 GO:0006559 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
1.9 19.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
1.8 5.5 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
1.8 59.7 GO:0010390 histone monoubiquitination(GO:0010390)
1.8 7.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.7 5.2 GO:0070541 response to platinum ion(GO:0070541)
1.7 6.7 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.6 1.6 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
1.6 6.2 GO:0044111 development involved in symbiotic interaction(GO:0044111)
1.6 12.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
1.5 4.6 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
1.5 18.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.5 10.5 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
1.5 8.9 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
1.4 7.2 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
1.4 27.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.4 4.2 GO:0006566 threonine metabolic process(GO:0006566)
1.4 5.4 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
1.3 5.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
1.3 2.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.3 3.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.3 1.3 GO:0051595 response to methylglyoxal(GO:0051595)
1.3 34.4 GO:0008053 mitochondrial fusion(GO:0008053)
1.3 39.1 GO:0032897 negative regulation of viral transcription(GO:0032897)
1.3 3.8 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
1.2 6.1 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
1.1 7.7 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.1 2.1 GO:0033078 extrathymic T cell differentiation(GO:0033078)
1.0 5.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.0 5.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
1.0 6.0 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
1.0 13.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
1.0 13.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
1.0 6.8 GO:0080009 mRNA methylation(GO:0080009)
1.0 3.8 GO:0098886 modification of dendritic spine(GO:0098886)
0.9 230.1 GO:0051607 defense response to virus(GO:0051607)
0.9 2.8 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.9 10.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.9 1.8 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.9 5.5 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.9 13.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.9 4.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.9 7.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.9 12.2 GO:0010818 T cell chemotaxis(GO:0010818)
0.9 5.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.9 2.6 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.9 6.9 GO:0021564 vagus nerve development(GO:0021564)
0.9 6.0 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.9 3.4 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.8 6.8 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.8 5.9 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.8 3.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.8 2.5 GO:0007518 myoblast fate determination(GO:0007518)
0.8 1.6 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.8 13.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.8 3.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.8 14.0 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.8 4.6 GO:0002158 osteoclast proliferation(GO:0002158)
0.8 12.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.7 3.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.7 4.7 GO:0035799 ureter maturation(GO:0035799)
0.7 10.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.7 15.9 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.7 6.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6 2.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.6 3.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.6 1.9 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.6 3.1 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.6 16.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 1.8 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.6 0.6 GO:0015747 urate transport(GO:0015747)
0.6 0.6 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.6 8.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.6 50.6 GO:0002456 T cell mediated immunity(GO:0002456)
0.6 8.8 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.6 3.3 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.6 7.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.5 7.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.5 2.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 1.6 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.5 6.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.5 3.0 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.5 2.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 1.4 GO:0051598 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.5 1.9 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.5 0.9 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.5 7.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.5 4.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.5 1.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 20.7 GO:0019835 cytolysis(GO:0019835)
0.5 1.4 GO:1902871 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.5 4.6 GO:0002051 osteoblast fate commitment(GO:0002051)
0.4 5.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.4 1.7 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.4 2.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.4 6.3 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.4 2.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4 0.4 GO:1902869 regulation of neural retina development(GO:0061074) regulation of amacrine cell differentiation(GO:1902869)
0.4 1.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.4 0.8 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.4 4.3 GO:0060013 righting reflex(GO:0060013)
0.4 2.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.4 1.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.4 1.1 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.4 2.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.4 8.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.4 4.3 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.4 5.7 GO:0051639 actin filament network formation(GO:0051639)
0.4 1.8 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.4 1.1 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.4 88.0 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.4 2.1 GO:0051012 microtubule sliding(GO:0051012)
0.3 1.7 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.3 8.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.3 5.8 GO:0006828 manganese ion transport(GO:0006828)
0.3 1.4 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.3 2.0 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.3 2.0 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of synaptic vesicle clustering(GO:2000809)
0.3 1.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 3.2 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.3 1.0 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.3 3.5 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.3 2.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.3 3.4 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.3 0.9 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.3 0.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3 0.9 GO:0048627 myoblast development(GO:0048627)
0.3 4.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.3 0.6 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.3 1.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.3 12.0 GO:0016486 peptide hormone processing(GO:0016486)
0.3 6.4 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.3 2.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 1.4 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.3 7.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.3 1.6 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3 8.1 GO:0006294 nucleotide-excision repair, preincision complex assembly(GO:0006294)
0.3 1.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.3 7.4 GO:0070207 protein homotrimerization(GO:0070207)
0.3 4.9 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 0.8 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.3 3.6 GO:0002360 T cell lineage commitment(GO:0002360)
0.3 1.5 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.3 1.0 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.3 2.0 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.2 17.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 13.3 GO:0006298 mismatch repair(GO:0006298)
0.2 7.8 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.2 3.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 1.0 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.5 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.2 26.1 GO:0009615 response to virus(GO:0009615)
0.2 2.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 2.0 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.2 11.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 1.3 GO:0021678 third ventricle development(GO:0021678)
0.2 7.8 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.2 2.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 1.7 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.2 9.4 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.2 4.8 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 1.9 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.2 1.4 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.2 40.8 GO:0015992 proton transport(GO:0015992)
0.2 0.6 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 1.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 0.4 GO:0035989 tendon development(GO:0035989)
0.2 0.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.2 1.0 GO:0070836 caveola assembly(GO:0070836)
0.2 1.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 2.9 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 0.5 GO:0046968 peptide antigen transport(GO:0046968)
0.2 0.5 GO:0033685 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) negative regulation of luteinizing hormone secretion(GO:0033685)
0.2 1.0 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.2 2.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.2 0.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.2 2.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.2 4.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 2.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 0.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.2 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.2 4.1 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 0.5 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.2 1.2 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2 0.6 GO:0060022 hard palate development(GO:0060022)
0.2 4.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 4.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.0 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 2.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 1.4 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 4.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.5 GO:0090383 phagosome acidification(GO:0090383)
0.1 1.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 1.2 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.4 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 2.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.5 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 3.1 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 2.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.5 GO:0043335 protein unfolding(GO:0043335)
0.1 1.8 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 2.9 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.5 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 1.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 4.5 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.1 4.9 GO:0060411 cardiac septum morphogenesis(GO:0060411)
0.1 0.5 GO:0060336 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336) regulation of cholesterol transporter activity(GO:0060694) pancreatic stellate cell proliferation(GO:0072343) response to metformin(GO:1901558) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.8 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.5 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 2.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 13.8 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 1.0 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.6 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.1 0.7 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 6.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 7.1 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.4 GO:0042335 cuticle development(GO:0042335)
0.1 1.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 1.8 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 6.0 GO:0006400 tRNA modification(GO:0006400)
0.1 0.7 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.1 0.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 1.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 1.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.8 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.1 2.1 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.4 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 0.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 2.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 7.5 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.1 0.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 2.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1 8.6 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 5.3 GO:0048477 oogenesis(GO:0048477)
0.1 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155) fasciculation of motor neuron axon(GO:0097156)
0.1 0.8 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 1.7 GO:0033344 cholesterol efflux(GO:0033344)
0.1 20.1 GO:0010506 regulation of autophagy(GO:0010506)
0.1 7.7 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 1.8 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1 1.6 GO:0007520 myoblast fusion(GO:0007520)
0.1 3.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.6 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 6.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.3 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.4 GO:0043921 modulation by host of viral transcription(GO:0043921) modulation by host of symbiont transcription(GO:0052472)
0.1 1.4 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.1 0.7 GO:0061436 regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 3.5 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.6 GO:0098743 cell aggregation(GO:0098743)
0.0 0.5 GO:0051798 positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0 1.3 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 3.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.6 GO:0015671 oxygen transport(GO:0015671)
0.0 1.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 1.2 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.0 2.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.0 0.8 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.5 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.1 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.8 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 1.6 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.1 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.2 GO:0050918 positive chemotaxis(GO:0050918)
0.0 1.3 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.1 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 0.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 2.3 GO:0030879 mammary gland development(GO:0030879)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.8 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0035902 response to immobilization stress(GO:0035902)
0.0 1.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.4 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 1.2 GO:0007030 Golgi organization(GO:0007030)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
30.2 272.1 GO:1990111 spermatoproteasome complex(GO:1990111)
23.7 165.7 GO:0042825 TAP complex(GO:0042825)
17.1 102.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
10.7 75.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
8.4 25.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
8.0 40.2 GO:0071797 LUBAC complex(GO:0071797)
7.2 43.3 GO:0008537 proteasome activator complex(GO:0008537)
6.0 36.1 GO:0097179 protease inhibitor complex(GO:0097179)
4.1 36.8 GO:0030870 Mre11 complex(GO:0030870)
3.7 58.6 GO:0008385 IkappaB kinase complex(GO:0008385)
3.6 17.8 GO:0044530 supraspliceosomal complex(GO:0044530)
3.5 10.5 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
3.1 21.7