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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 9.46

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
IRF2
ENSG00000168310.6 interferon regulatory factor 2
STAT2
ENSG00000170581.9 signal transducer and activator of transcription 2
IRF8
ENSG00000140968.6 interferon regulatory factor 8
IRF1
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF2hg19_v2_chr4_-_185395672_1853957340.611.1e-03Click!
IRF8hg19_v2_chr16_+_85942594_859426350.563.6e-03Click!
IRF1hg19_v2_chr5_-_131826457_1318265140.481.6e-02Click!
STAT2hg19_v2_chr12_-_56753858_567539300.154.7e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_79086088 164.59 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr4_-_76944621 144.04 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_32821924 132.47 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_43566301 121.83 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr2_-_7005785 116.38 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr10_+_91092241 115.18 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91087651 112.71 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42792442 105.80 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_+_91152303 105.39 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr17_-_40264692 93.08 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr12_+_113376157 84.88 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr6_-_32821599 84.37 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_6659153 82.43 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr6_-_29527702 82.13 ENST00000377050.4
UBD
ubiquitin D
chr22_+_18632666 81.07 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr12_+_113416191 79.64 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr3_+_122399444 78.26 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr10_+_91174314 75.46 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr16_-_67970990 72.94 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr3_-_122283424 71.07 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 70.31 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr1_-_89488510 66.67 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr11_-_4414880 62.59 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr3_+_122283064 61.98 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr9_+_5510492 61.33 ENST00000397745.2
PDCD1LG2
programmed cell death 1 ligand 2
chr9_-_32526184 60.47 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_+_5510558 60.35 ENST00000397747.3
PDCD1LG2
programmed cell death 1 ligand 2
chr1_-_89531041 59.97 ENST00000370473.4
GBP1
guanylate binding protein 1, interferon-inducible
chr6_+_26440700 59.29 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr16_+_57023406 59.11 ENST00000262510.6
ENST00000308149.7
ENST00000436936.1
NLRC5
NLR family, CARD domain containing 5
chr4_-_169239921 56.91 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_92777606 55.89 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr15_+_89182156 55.71 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 55.40 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr4_+_142557717 51.47 ENST00000320650.4
ENST00000296545.7
IL15
interleukin 15
chr2_+_7017796 50.48 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_+_79115503 49.08 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr11_-_60719213 48.83 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr15_+_89181974 48.20 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr22_-_36556821 46.74 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr11_-_615942 46.68 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr4_+_142557771 45.99 ENST00000514653.1
IL15
interleukin 15
chr6_-_32806506 45.31 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr12_+_113376249 44.02 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr21_+_42798094 43.80 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_32811885 42.03 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1
PSMB9
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr12_+_113344755 41.32 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_122283100 41.12 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr19_+_10196781 40.84 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr12_+_113344811 40.78 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_+_142558078 40.74 ENST00000529613.1
IL15
interleukin 15
chr1_+_948803 39.87 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr11_-_57335280 39.58 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr9_-_100881466 39.06 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr2_-_231084820 38.38 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr2_-_163175133 38.35 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr11_+_69455855 36.87 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr14_+_94577074 36.20 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr15_-_80263506 34.43 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr11_-_615570 34.35 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr19_+_10196981 33.06 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr21_+_42733870 32.94 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr13_+_50070491 32.32 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr11_+_71710973 32.09 ENST00000393707.4
IL18BP
interleukin 18 binding protein
chr22_+_36044411 31.79 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr6_+_26402465 31.22 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr19_+_18284477 31.19 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr11_+_71709938 31.10 ENST00000393705.4
ENST00000337131.5
ENST00000531053.1
ENST00000404792.1
IL18BP
interleukin 18 binding protein
chr13_+_50070077 30.99 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr11_+_71710648 30.26 ENST00000260049.5
IL18BP
interleukin 18 binding protein
chr19_-_50400212 29.49 ENST00000391826.2
IL4I1
interleukin 4 induced 1
chr1_-_173020056 29.44 ENST00000239468.2
ENST00000404377.3
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr12_+_102271129 29.44 ENST00000258534.8
DRAM1
DNA-damage regulated autophagy modulator 1
chr9_+_100174232 29.43 ENST00000355295.4
TDRD7
tudor domain containing 7
chr8_-_23540402 29.34 ENST00000523261.1
ENST00000380871.4
NKX3-1
NK3 homeobox 1
chr6_+_26365443 29.25 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr9_+_100174344 29.00 ENST00000422139.2
TDRD7
tudor domain containing 7
chr12_+_113416265 28.83 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr10_+_115439282 28.14 ENST00000369321.2
ENST00000345633.4
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr10_+_115439699 27.51 ENST00000369315.1
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr12_+_113344582 27.27 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_+_126240442 27.19 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr11_-_104905840 27.18 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr1_+_110453203 27.16 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr10_+_115439630 26.95 ENST00000369318.3
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr22_+_36649056 26.83 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr2_+_102972363 26.75 ENST00000409599.1
IL18R1
interleukin 18 receptor 1
chr17_+_18380051 26.65 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr17_+_25958174 26.45 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr15_+_74287009 26.25 ENST00000395135.3
PML
promyelocytic leukemia
chr3_+_187086120 25.91 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr7_+_100728720 25.85 ENST00000306085.6
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr2_-_220252603 25.83 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr2_-_231084617 25.82 ENST00000409815.2
SP110
SP110 nuclear body protein
chr20_-_47894569 25.37 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr15_+_74287035 25.37 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr14_+_24630465 25.23 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr22_+_39436862 25.10 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr9_-_32526299 25.06 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_32811771 24.64 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr1_+_110453608 24.43 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chr11_+_5710919 23.79 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr15_+_74287118 23.35 ENST00000563500.1
PML
promyelocytic leukemia
chr2_+_201981527 23.34 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_+_110453109 23.24 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr2_-_231084659 23.24 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr10_+_91061712 22.04 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_33282163 21.23 ENST00000434618.2
ENST00000456592.2
TAPBP
TAP binding protein (tapasin)
chr6_+_32811861 21.09 ENST00000453426.1
TAPSAR1
TAP1 and PSMB8 antisense RNA 1
chr4_-_169401628 20.69 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr7_+_18535786 20.69 ENST00000406072.1
HDAC9
histone deacetylase 9
chr2_+_231280908 19.43 ENST00000427101.2
ENST00000432979.1
SP100
SP100 nuclear antigen
chr11_+_93861993 19.40 ENST00000227638.3
ENST00000436171.2
PANX1
pannexin 1
chr1_+_110453462 18.86 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr5_+_96212185 18.45 ENST00000379904.4
ERAP2
endoplasmic reticulum aminopeptidase 2
chr5_-_96143796 18.38 ENST00000296754.3
ERAP1
endoplasmic reticulum aminopeptidase 1
chr6_+_127439749 18.08 ENST00000356698.4
RSPO3
R-spondin 3
chr5_+_96211643 17.94 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr1_-_154580616 17.80 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr21_+_43619796 17.48 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr17_+_41363854 17.35 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr22_-_36635684 17.25 ENST00000358502.5
APOL2
apolipoprotein L, 2
chr17_+_41158742 16.99 ENST00000415816.2
ENST00000438323.2
IFI35
interferon-induced protein 35
chr5_-_96143602 16.96 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr2_+_231280954 16.91 ENST00000409824.1
ENST00000409341.1
ENST00000409112.1
ENST00000340126.4
ENST00000341950.4
SP100
SP100 nuclear antigen
chr4_+_186990298 16.78 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr22_+_41697520 16.50 ENST00000352645.4
ZC3H7B
zinc finger CCCH-type containing 7B
chr1_+_165864800 16.11 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr1_+_165864821 16.10 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr14_+_58711539 15.93 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_-_20370847 15.69 ENST00000423676.3
ENST00000324290.5
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr4_+_37892682 15.65 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr4_-_185395672 15.51 ENST00000393593.3
IRF2
interferon regulatory factor 2
chr20_+_388935 15.42 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_150738261 15.17 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr20_+_388679 14.95 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_64764435 14.90 ENST00000534177.1
ENST00000301887.4
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr21_+_43933946 14.81 ENST00000352133.2
SLC37A1
solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr6_+_26402517 14.63 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_-_31324943 14.58 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr6_+_116782527 14.03 ENST00000368606.3
ENST00000368605.1
FAM26F
family with sequence similarity 26, member F
chr2_-_152146385 13.83 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr3_+_48507210 13.72 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr1_-_149908710 13.71 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11
chr20_+_61436146 13.67 ENST00000290291.6
OGFR
opioid growth factor receptor
chr6_-_87804815 13.54 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr11_-_104972158 13.47 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr5_+_125695805 13.40 ENST00000513040.1
GRAMD3
GRAM domain containing 3
chr2_+_231191875 13.34 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
SP140L
SP140 nuclear body protein-like
chr1_+_113217345 13.33 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_6561190 13.16 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr1_+_113217309 13.10 ENST00000544796.1
ENST00000369644.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr17_-_4167142 13.04 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr1_+_113217043 13.00 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr5_+_118690466 12.69 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr9_+_74764278 12.64 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr1_+_113217073 12.53 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr6_-_33282024 12.39 ENST00000475304.1
ENST00000489157.1
TAPBP
TAP binding protein (tapasin)
chr7_-_77045617 12.21 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr17_-_4643114 12.20 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr20_+_53092123 11.90 ENST00000262593.5
DOK5
docking protein 5
chr17_+_78234625 11.83 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr3_-_123339343 11.68 ENST00000578202.1
MYLK
myosin light chain kinase
chr3_-_123339418 11.62 ENST00000583087.1
MYLK
myosin light chain kinase
chr2_-_231989808 11.52 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr7_+_4815238 11.34 ENST00000348624.4
ENST00000401897.1
AP5Z1
adaptor-related protein complex 5, zeta 1 subunit
chr1_-_173176452 11.19 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_201994208 11.16 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr6_-_82462425 11.15 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr14_-_24615523 10.96 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_-_24615805 10.83 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_+_24605389 10.82 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr6_+_153552455 10.81 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr10_+_24497704 10.80 ENST00000376456.4
ENST00000458595.1
KIAA1217
KIAA1217
chr16_+_50776021 10.70 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr14_+_24605361 10.68 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_+_154622652 10.51 ENST00000260010.6
TLR2
toll-like receptor 2
chr9_+_116917807 10.47 ENST00000356083.3
COL27A1
collagen, type XXVII, alpha 1
chr7_-_92747269 10.41 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr17_+_7358889 10.21 ENST00000575379.1
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr7_+_18535346 10.18 ENST00000405010.3
ENST00000406451.4
ENST00000428307.2
HDAC9
histone deacetylase 9
chr19_-_49371711 10.16 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr8_-_145060593 10.15 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr6_-_30181133 10.14 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr17_-_34207295 10.03 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr3_+_48507621 9.98 ENST00000456089.1
TREX1
three prime repair exonuclease 1
chr2_+_201994569 9.95 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr20_+_388791 9.78 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_27998689 9.74 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr2_-_55920952 9.54 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr6_-_30181156 9.35 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr7_+_134551583 9.29 ENST00000435928.1
CALD1
caldesmon 1
chr20_+_44746939 9.27 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr5_+_49962495 9.26 ENST00000515175.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr19_-_4338838 9.25 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr19_-_47735918 9.05 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr15_+_67418047 8.93 ENST00000540846.2
SMAD3
SMAD family member 3
chr1_+_110453514 8.90 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr16_+_50775971 8.70 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD
cylindromatosis (turban tumor syndrome)
chr6_-_33281979 8.57 ENST00000426633.2
ENST00000467025.1
TAPBP
TAP binding protein (tapasin)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
46.1 138.2 GO:0045062 extrathymic T cell selection(GO:0045062)
38.8 116.4 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
37.4 149.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
35.2 140.7 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
35.1 105.4 GO:0051097 negative regulation of helicase activity(GO:0051097)
31.9 159.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
30.9 123.5 GO:0046967 cytosol to ER transport(GO:0046967)
20.5 102.6 GO:0060611 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
20.4 204.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
19.2 249.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
18.2 200.5 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
18.2 91.1 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
16.6 182.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
16.4 82.1 GO:0070842 aggresome assembly(GO:0070842)
15.6 62.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
15.0 60.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
14.1 42.2 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
13.6 108.5 GO:0018377 protein myristoylation(GO:0018377)
13.2 131.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
13.2 13.2 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
13.1 130.7 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
12.6 62.9 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
10.3 82.6 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
10.1 50.5 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
9.2 27.5 GO:1990108 protein linear deubiquitination(GO:1990108)
9.1 36.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
8.8 26.4 GO:0002519 natural killer cell tolerance induction(GO:0002519) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
8.1 32.2 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
7.4 29.4 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
7.0 69.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
6.7 46.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
6.6 99.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
6.6 79.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
5.9 17.8 GO:1900369 negative regulation of RNA interference(GO:1900369)
5.0 40.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
4.9 29.3 GO:2000834 androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
4.7 52.0 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
4.6 13.8 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
4.4 17.5 GO:0009726 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
4.2 25.1 GO:0070383 DNA cytosine deamination(GO:0070383)
4.2 16.7 GO:0033590 response to cobalamin(GO:0033590)
3.8 41.5 GO:0070141 response to UV-A(GO:0070141)
3.7 11.2 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
3.6 32.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
3.5 7.1 GO:0046110 xanthine metabolic process(GO:0046110)
3.5 10.5 GO:0070340 central nervous system myelin formation(GO:0032289) regulation of interleukin-18 production(GO:0032661) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
3.4 75.1 GO:0072643 interferon-gamma secretion(GO:0072643)
3.4 94.3 GO:1900115 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
3.3 16.3 GO:0006145 purine nucleobase catabolic process(GO:0006145)
3.2 330.7 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
3.2 9.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
2.9 11.8 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
2.9 26.4 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
2.9 281.2 GO:0034340 response to type I interferon(GO:0034340)
2.7 5.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
2.7 13.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
2.7 23.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.6 7.9 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
2.6 7.7 GO:0035915 pore formation in membrane of other organism(GO:0035915)
2.4 12.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
2.4 26.7 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
2.4 7.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
2.4 11.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.3 6.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.2 8.8 GO:0003409 optic cup structural organization(GO:0003409)
2.2 6.6 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
2.2 6.6 GO:0006624 vacuolar protein processing(GO:0006624)
2.2 6.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
2.1 8.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.1 60.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
2.0 14.3 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
2.0 8.0 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
2.0 29.5 GO:0006559 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
1.9 19.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
1.8 5.5 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
1.8 59.7 GO:0010390 histone monoubiquitination(GO:0010390)
1.8 7.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.7 5.2 GO:0070541 response to platinum ion(GO:0070541)
1.7 6.7 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.6 1.6 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
1.6 6.2 GO:0044111 development involved in symbiotic interaction(GO:0044111)
1.6 12.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
1.5 4.6 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
1.5 18.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.5 10.5 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
1.5 8.9 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
1.4 7.2 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
1.4 27.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.4 4.2 GO:0006566 threonine metabolic process(GO:0006566)
1.4 5.4 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
1.3 5.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
1.3 2.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.3 3.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.3 1.3 GO:0051595 response to methylglyoxal(GO:0051595)
1.3 34.4 GO:0008053 mitochondrial fusion(GO:0008053)
1.3 39.1 GO:0032897 negative regulation of viral transcription(GO:0032897)
1.3 3.8 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
1.2 6.1 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
1.1 7.7 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.1 2.1 GO:0033078 extrathymic T cell differentiation(GO:0033078)
1.0 5.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.0 5.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
1.0 6.0 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
1.0 13.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
1.0 13.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
1.0 6.8 GO:0080009 mRNA methylation(GO:0080009)
1.0 3.8 GO:0098886 modification of dendritic spine(GO:0098886)
0.9 230.1 GO:0051607 defense response to virus(GO:0051607)
0.9 2.8 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.9 10.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.9 1.8 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.9 5.5 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.9 13.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.9 4.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.9 7.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.9 12.2 GO:0010818 T cell chemotaxis(GO:0010818)
0.9 5.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.9 2.6 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.9 6.9 GO:0021564 vagus nerve development(GO:0021564)
0.9 6.0 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.9 3.4 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.8 6.8 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.8 5.9 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.8 3.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.8 2.5 GO:0007518 myoblast fate determination(GO:0007518)
0.8 1.6 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.8 13.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.8 3.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.8 14.0 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.8 4.6 GO:0002158 osteoclast proliferation(GO:0002158)
0.8 12.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.7 3.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.7 4.7 GO:0035799 ureter maturation(GO:0035799)
0.7 10.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.7 15.9 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.7 6.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6 2.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.6 3.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.6 1.9 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.6 3.1 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.6 16.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 1.8 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.6 0.6 GO:0015747 urate transport(GO:0015747)
0.6 0.6 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.6 8.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.6 50.6 GO:0002456 T cell mediated immunity(GO:0002456)
0.6 8.8 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.6 3.3 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.6 7.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.5 7.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.5 2.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 1.6 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.5 6.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.5 3.0 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.5 2.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 1.4 GO:0051598 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.5 1.9 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.5 0.9 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.5 7.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.5 4.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.5 1.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 20.7 GO:0019835 cytolysis(GO:0019835)
0.5 1.4 GO:1902871 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.5 4.6 GO:0002051 osteoblast fate commitment(GO:0002051)
0.4 5.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.4 1.7 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.4 2.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.4 6.3 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.4 2.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4 0.4 GO:1902869 regulation of neural retina development(GO:0061074) regulation of amacrine cell differentiation(GO:1902869)
0.4 1.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.4 0.8 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.4 4.3 GO:0060013 righting reflex(GO:0060013)
0.4 2.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.4 1.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.4 1.1 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.4 2.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.4 8.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.4 4.3 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.4 5.7 GO:0051639 actin filament network formation(GO:0051639)
0.4 1.8 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.4 1.1 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.4 88.0 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.4 2.1 GO:0051012 microtubule sliding(GO:0051012)
0.3 1.7 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.3 8.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.3 5.8 GO:0006828 manganese ion transport(GO:0006828)
0.3 1.4 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.3 2.0 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.3 2.0 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of synaptic vesicle clustering(GO:2000809)
0.3 1.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 3.2 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.3 1.0 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.3 3.5 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.3 2.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.3 3.4 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.3 0.9 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.3 0.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3 0.9 GO:0048627 myoblast development(GO:0048627)
0.3 4.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.3 0.6 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.3 1.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.3 12.0 GO:0016486 peptide hormone processing(GO:0016486)
0.3 6.4 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.3 2.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 1.4 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.3 7.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.3 1.6 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3 8.1 GO:0006294 nucleotide-excision repair, preincision complex assembly(GO:0006294)
0.3 1.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.3 7.4 GO:0070207 protein homotrimerization(GO:0070207)
0.3 4.9 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 0.8 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.3 3.6 GO:0002360 T cell lineage commitment(GO:0002360)
0.3 1.5 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.3 1.0 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.3 2.0 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.2 17.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 13.3 GO:0006298 mismatch repair(GO:0006298)
0.2 7.8 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.2 3.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 1.0 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.5 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.2 26.1 GO:0009615 response to virus(GO:0009615)
0.2 2.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 2.0 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.2 11.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 1.3 GO:0021678 third ventricle development(GO:0021678)
0.2 7.8 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.2 2.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 1.7 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.2 9.4 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.2 4.8 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 1.9 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.2 1.4 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.2 40.8 GO:0015992 proton transport(GO:0015992)
0.2 0.6 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 1.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 0.4 GO:0035989 tendon development(GO:0035989)
0.2 0.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.2 1.0 GO:0070836 caveola assembly(GO:0070836)
0.2 1.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 2.9 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 0.5 GO:0046968 peptide antigen transport(GO:0046968)
0.2 0.5 GO:0033685 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) negative regulation of luteinizing hormone secretion(GO:0033685)
0.2 1.0 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.2 2.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.2 0.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.2 2.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.2 4.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 2.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 0.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.2 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.2 4.1 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 0.5 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.2 1.2 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2 0.6 GO:0060022 hard palate development(GO:0060022)
0.2 4.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 4.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.0 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 2.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 1.4 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 4.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.5 GO:0090383 phagosome acidification(GO:0090383)
0.1 1.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 1.2 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.4 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 2.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.5 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 3.1 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 2.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.5 GO:0043335 protein unfolding(GO:0043335)
0.1 1.8 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 2.9 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.5 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 1.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 4.5 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.1 4.9 GO:0060411 cardiac septum morphogenesis(GO:0060411)
0.1 0.5 GO:0060336 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336) regulation of cholesterol transporter activity(GO:0060694) pancreatic stellate cell proliferation(GO:0072343) response to metformin(GO:1901558) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.8 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.5 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 2.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 13.8 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 1.0 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.6 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.1 0.7 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 6.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 7.1 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.4 GO:0042335 cuticle development(GO:0042335)
0.1 1.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 1.8 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 6.0 GO:0006400 tRNA modification(GO:0006400)
0.1 0.7 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.1 0.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 1.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 1.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.8 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.1 2.1 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.4 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 0.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 2.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 7.5 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.1 0.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 2.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1 8.6 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 5.3 GO:0048477 oogenesis(GO:0048477)
0.1 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155) fasciculation of motor neuron axon(GO:0097156)
0.1 0.8 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 1.7 GO:0033344 cholesterol efflux(GO:0033344)
0.1 20.1 GO:0010506 regulation of autophagy(GO:0010506)
0.1 7.7 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 1.8 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1 1.6 GO:0007520 myoblast fusion(GO:0007520)
0.1 3.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.6 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 6.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.3 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.4 GO:0043921 modulation by host of viral transcription(GO:0043921) modulation by host of symbiont transcription(GO:0052472)
0.1 1.4 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.1 0.7 GO:0061436 regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 3.5 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.6 GO:0098743 cell aggregation(GO:0098743)
0.0 0.5 GO:0051798 positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0 1.3 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 3.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.6 GO:0015671 oxygen transport(GO:0015671)
0.0 1.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 1.2 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.0 2.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.0 0.8 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.5 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.1 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.8 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 1.6 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.1 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.2 GO:0050918 positive chemotaxis(GO:0050918)
0.0 1.3 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.1 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 0.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 2.3 GO:0030879 mammary gland development(GO:0030879)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.8 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0035902 response to immobilization stress(GO:0035902)
0.0 1.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.4 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 1.2 GO:0007030 Golgi organization(GO:0007030)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
30.2 272.1 GO:1990111 spermatoproteasome complex(GO:1990111)
23.7 165.7 GO:0042825 TAP complex(GO:0042825)
17.1 102.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
10.7 75.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
8.4 25.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
8.0 40.2 GO:0071797 LUBAC complex(GO:0071797)
7.2 43.3 GO:0008537 proteasome activator complex(GO:0008537)
6.0 36.1 GO:0097179 protease inhibitor complex(GO:0097179)
4.1 36.8 GO:0030870 Mre11 complex(GO:0030870)
3.7 58.6 GO:0008385 IkappaB kinase complex(GO:0008385)
3.6 17.8 GO:0044530 supraspliceosomal complex(GO:0044530)
3.5 10.5 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
3.1 21.7 GO:0036021 endolysosome lumen(GO:0036021)
3.1 59.0 GO:0033391 chromatoid body(GO:0033391)
2.5 9.9 GO:0070985 TFIIK complex(GO:0070985)
2.4 26.9 GO:0035631 CD40 receptor complex(GO:0035631)
2.4 50.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
2.4 190.5 GO:0015030 Cajal body(GO:0015030)
2.2 6.6 GO:1990622 CHOP-ATF3 complex(GO:1990622)
1.9 13.0 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
1.7 12.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
1.6 8.0 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.4 93.4 GO:0016235 aggresome(GO:0016235)
1.3 16.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.3 5.3 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
1.3 3.8 GO:0097444 spine apparatus(GO:0097444)
1.2 9.5 GO:0042788 polysomal ribosome(GO:0042788)
1.1 8.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
1.0 19.4 GO:0032059 bleb(GO:0032059)
1.0 13.8 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9 63.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.9 6.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.9 13.8 GO:0030478 actin cap(GO:0030478)
0.9 16.8 GO:0036020 endolysosome membrane(GO:0036020)
0.9 30.6 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.9 3.5 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.8 4.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.8 13.1 GO:0071439 clathrin complex(GO:0071439)
0.8 53.4 GO:0005643 nuclear pore(GO:0005643)
0.8 6.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.7 25.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.7 3.4 GO:0097149 centralspindlin complex(GO:0097149)
0.7 4.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.6 122.5 GO:0005923 bicellular tight junction(GO:0005923)
0.6 67.1 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.6 14.5 GO:0005614 interstitial matrix(GO:0005614)
0.6 7.7 GO:0005916 fascia adherens(GO:0005916)
0.6 239.0 GO:0031965 nuclear membrane(GO:0031965)
0.6 3.4 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.5 1.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.5 5.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 13.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 24.4 GO:0097542 ciliary tip(GO:0097542)
0.4 9.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.4 88.7 GO:0031968 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.4 133.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 1.1 GO:0097443 sorting endosome(GO:0097443)
0.4 13.2 GO:0005796 Golgi lumen(GO:0005796)
0.4 3.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.3 2.0 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.3 2.3 GO:0072487 MSL complex(GO:0072487)
0.3 1.0 GO:0031905 early endosome lumen(GO:0031905)
0.3 4.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 2.2 GO:0097422 tubular endosome(GO:0097422)
0.3 676.0 GO:0005739 mitochondrion(GO:0005739)
0.3 1.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.3 2.7 GO:0042587 glycogen granule(GO:0042587)
0.3 41.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 6.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 31.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.3 1.4 GO:0046930 membrane attack complex(GO:0005579) pore complex(GO:0046930)
0.3 1.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.3 3.9 GO:0005581 collagen trimer(GO:0005581)
0.3 1.9 GO:0070852 cell body fiber(GO:0070852)
0.3 8.6 GO:0002080 acrosomal membrane(GO:0002080)
0.3 187.3 GO:0009986 cell surface(GO:0009986)
0.3 2.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 2.9 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 8.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 54.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.2 1.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 2.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 5.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 5.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 6.6 GO:0016580 Sin3 complex(GO:0016580)
0.2 10.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.2 3.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 15.5 GO:0035580 specific granule lumen(GO:0035580)
0.2 12.2 GO:0005802 trans-Golgi network(GO:0005802)
0.2 2.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 1.0 GO:0035061 interchromatin granule(GO:0035061)
0.2 24.6 GO:0005635 nuclear envelope(GO:0005635)
0.2 59.1 GO:0005769 early endosome(GO:0005769)
0.2 97.6 GO:0005774 vacuolar membrane(GO:0005774)
0.2 3.1 GO:0031904 endosome lumen(GO:0031904)
0.2 126.9 GO:0000139 Golgi membrane(GO:0000139)
0.2 1.2 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.2 3.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 0.7 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.2 20.4 GO:0072562 blood microparticle(GO:0072562)
0.2 2.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 1.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 10.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 1.1 GO:0097225 sperm midpiece(GO:0097225)
0.1 37.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 12.1 GO:0043209 myelin sheath(GO:0043209)
0.1 148.2 GO:0005615 extracellular space(GO:0005615)
0.1 1.1 GO:0032432 actin filament bundle(GO:0032432)
0.1 3.0 GO:0005921 gap junction(GO:0005921)
0.1 0.4 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 2.1 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.3 GO:0097447 dendritic tree(GO:0097447)
0.1 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.2 GO:0036398 TCR signalosome(GO:0036398)
0.1 4.1 GO:0005903 brush border(GO:0005903)
0.1 0.2 GO:0097165 nuclear stress granule(GO:0097165)
0.1 4.8 GO:0000922 spindle pole(GO:0000922)
0.1 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.1 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 6.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.3 GO:0005844 polysome(GO:0005844)
0.1 27.3 GO:0005813 centrosome(GO:0005813)
0.1 4.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 4.5 GO:0005874 microtubule(GO:0005874)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.0 0.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 2.1 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.0 GO:0042383 sarcolemma(GO:0042383)
0.0 1.0 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 41.9 GO:0005576 extracellular region(GO:0005576)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 97.3 GO:0005829 cytosol(GO:0005829)
0.0 0.1 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
53.1 159.3 GO:0008859 exoribonuclease II activity(GO:0008859)
32.2 354.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
31.2 93.5 GO:0042007 interleukin-18 binding(GO:0042007)
29.1 116.4 GO:0009041 uridylate kinase activity(GO:0009041)
28.6 143.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
20.7 165.7 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
13.3 106.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
12.2 48.8 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
9.8 29.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
9.2 283.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
8.8 35.3 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
7.4 294.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
6.5 25.9 GO:0031849 olfactory receptor binding(GO:0031849)
6.4 32.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
5.8 17.5 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
5.8 11.5 GO:0046979 TAP2 binding(GO:0046979)
5.5 43.9 GO:0042296 ISG15 transferase activity(GO:0042296)
5.4 43.3 GO:0061133 endopeptidase activator activity(GO:0061133)
5.3 26.4 GO:0048030 disaccharide binding(GO:0048030)
5.3 174.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
4.9 29.3 GO:0004882 androgen receptor activity(GO:0004882)
4.5 36.3 GO:0070087 chromo shadow domain binding(GO:0070087)
4.1 82.1 GO:0070628 proteasome binding(GO:0070628)
4.0 88.8 GO:0032183 SUMO binding(GO:0032183)
3.9 19.4 GO:0055077 gap junction hemi-channel activity(GO:0055077)
3.6 32.2 GO:0004849 uridine kinase activity(GO:0004849)
3.3 39.9 GO:0031386 protein tag(GO:0031386)
3.0 96.7 GO:0008266 poly(U) RNA binding(GO:0008266)
3.0 62.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
2.9 17.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
2.8 8.4 GO:0098770 FBXO family protein binding(GO:0098770)
2.8 276.5 GO:0003727 single-stranded RNA binding(GO:0003727)
2.4 38.6 GO:0004908 interleukin-1 receptor activity(GO:0004908)
2.3 23.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.3 18.4 GO:0050816 phosphothreonine binding(GO:0050816)
2.2 15.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
2.1 6.4 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
2.1 27.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
1.9 7.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
1.8 5.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.8 8.9 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
1.6 6.3 GO:0004074 biliverdin reductase activity(GO:0004074)
1.6 34.4 GO:0051400 BH domain binding(GO:0051400)
1.5 12.3 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
1.5 4.6 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.4 4.3 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
1.4 10.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.4 26.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.4 4.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
1.3 36.9 GO:0070064 proline-rich region binding(GO:0070064)
1.3 5.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
1.3 60.8 GO:0051879 Hsp90 protein binding(GO:0051879)
1.3 3.8 GO:0008478 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
1.2 8.6 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
1.1 102.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.1 12.9 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
1.0 4.0 GO:0008281 sulfonylurea receptor activity(GO:0008281)
1.0 13.7 GO:0004985 opioid receptor activity(GO:0004985)
1.0 2.9 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.0 6.8 GO:0008174 mRNA methyltransferase activity(GO:0008174)
1.0 5.7 GO:0045569 TRAIL binding(GO:0045569)
0.9 26.4 GO:0005521 lamin binding(GO:0005521)
0.9 14.0 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.9 6.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.9 47.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.9 7.7 GO:1901612 cardiolipin binding(GO:1901612)
0.8 45.0 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.8 7.9 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.8 4.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.8 6.1 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.7 2.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 5.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 3.0 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.6 4.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.6 11.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.6 3.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.6 8.6 GO:0031996 thioesterase binding(GO:0031996)
0.6 8.6 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.6 3.9 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6 2.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.5 5.9 GO:0004969 histamine receptor activity(GO:0004969)
0.5 59.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5 32.7 GO:0001047 core promoter binding(GO:0001047)
0.5 220.6 GO:0003924 GTPase activity(GO:0003924)
0.5 2.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.5 6.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.5 2.9 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.5 14.0 GO:0005523 tropomyosin binding(GO:0005523)
0.5 2.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.5 5.5 GO:0042301 phosphate ion binding(GO:0042301)
0.5 18.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.4 0.4 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4 4.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 6.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.4 9.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.4 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 19.0 GO:0005109 frizzled binding(GO:0005109)
0.4 2.5 GO:0043515 kinetochore binding(GO:0043515)
0.4 33.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.4 2.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.4 11.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 9.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.4 8.5 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.4 71.9 GO:0004386 helicase activity(GO:0004386)
0.4 5.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.4 12.2 GO:0001968 fibronectin binding(GO:0001968)
0.4 2.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.4 4.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.4 3.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 7.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.3 2.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 2.0 GO:0005499 vitamin D binding(GO:0005499)
0.3 1.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 10.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 57.4 GO:0042393 histone binding(GO:0042393)
0.3 2.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 8.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.3 0.9 GO:0030984 kininogen binding(GO:0030984)
0.3 5.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.3 2.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 2.1 GO:0034618 arginine binding(GO:0034618)
0.3 5.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 5.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 6.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.5 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.3 4.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 286.5 GO:0008270 zinc ion binding(GO:0008270)
0.3 46.8 GO:0005319 lipid transporter activity(GO:0005319)
0.3 73.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 1.6 GO:0001515 opioid peptide activity(GO:0001515)
0.3 4.8 GO:0005549 odorant binding(GO:0005549)
0.2 5.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 1.1 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 1.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 2.4 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.2 0.7 GO:0048019 receptor antagonist activity(GO:0048019)
0.2 1.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 7.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 0.8 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 4.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 13.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 11.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.2 0.8 GO:0089720 caspase binding(GO:0089720)
0.2 12.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 6.0 GO:0051018 protein kinase A binding(GO:0051018)
0.2 40.2 GO:0005125 cytokine activity(GO:0005125)
0.2 2.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 1.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 5.5 GO:0042605 peptide antigen binding(GO:0042605)
0.2 7.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 1.0 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.2 1.0 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 2.2 GO:0034452 dynactin binding(GO:0034452)
0.2 1.0 GO:0001849 complement component C1q binding(GO:0001849)
0.2 5.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 0.7 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 2.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 1.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 7.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.5 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 3.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 17.6 GO:0005254 chloride channel activity(GO:0005254)
0.1 2.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.0 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 1.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 4.1 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0019534 toxin transporter activity(GO:0019534)
0.1 3.8 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 12.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 4.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.3 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.5 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.6 GO:0030492 hemoglobin binding(GO:0030492)
0.1 21.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 1.5 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.5 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.7 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 2.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 8.0 GO:0051117 ATPase binding(GO:0051117)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.1 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.7 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.5 GO:0030911 TPR domain binding(GO:0030911)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.0 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 3.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 2.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 3.6 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.1 2.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.8 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 3.6 GO:0043022 ribosome binding(GO:0043022)
0.1 0.8 GO:0004568 chitinase activity(GO:0004568)
0.1 2.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 3.1 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 1.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.3 GO:0031208 POZ domain binding(GO:0031208)
0.1 1.8 GO:0047555 cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.9 GO:0050681 androgen receptor binding(GO:0050681)
0.1 3.5 GO:0019843 rRNA binding(GO:0019843)
0.1 0.9 GO:0019864 IgG binding(GO:0019864)
0.1 1.8 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.9 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.1 2.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 11.1 GO:0003823 antigen binding(GO:0003823)
0.1 94.1 GO:0042802 identical protein binding(GO:0042802)
0.1 2.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 3.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.2 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.2 GO:0002039 p53 binding(GO:0002039)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 2.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.8 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 44.0 GO:0003723 RNA binding(GO:0003723)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 1.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 3.1 GO:0005261 cation channel activity(GO:0005261)
0.0 1.3 GO:0005539 glycosaminoglycan binding(GO:0005539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 25.2 PID IFNG PATHWAY IFN-gamma pathway
2.7 89.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.3 78.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
2.3 56.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
2.0 40.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
2.0 38.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.8 134.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
1.7 86.4 PID MYC PATHWAY C-MYC pathway
1.2 65.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
1.0 58.8 PID AURORA A PATHWAY Aurora A signaling
1.0 36.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.8 80.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 26.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.8 9.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.8 16.3 PID CD40 PATHWAY CD40/CD40L signaling
0.7 110.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.7 34.4 PID BCR 5PATHWAY BCR signaling pathway
0.7 31.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.7 26.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.6 10.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.6 20.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.6 36.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.6 34.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 29.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.4 16.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.4 69.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 28.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 20.6 NABA COLLAGENS Genes encoding collagen proteins
0.4 11.5 PID IL1 PATHWAY IL1-mediated signaling events
0.3 8.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 12.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 8.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 7.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.3 103.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.3 1.0 ST ADRENERGIC Adrenergic Pathway
0.2 7.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 5.8 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 6.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 2.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 1.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 9.3 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.2 2.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 13.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 6.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 29.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 8.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 3.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 2.9 PID CONE PATHWAY Visual signal transduction: Cones
0.1 3.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 1.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 24.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 2.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.4 PID CMYB PATHWAY C-MYB transcription factor network
0.1 1.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 12.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
14.7 1370.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
9.1 126.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
5.4 16.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
5.0 146.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
4.2 304.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
3.7 107.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
3.4 171.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
3.2 90.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
2.8 25.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
2.8 124.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
2.6 39.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
2.5 90.8 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
2.5 162.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
2.3 58.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
2.1 78.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.8 23.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.0 15.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.0 13.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.9 32.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.9 12.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.7 17.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.6 50.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 137.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 2.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.4 11.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.4 9.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 2.8 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.4 5.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 10.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 9.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 17.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 8.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.3 19.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 22.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 7.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 11.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.3 13.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 6.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 3.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 7.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 4.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 5.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 3.9 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.2 6.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 1.6 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.2 5.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 3.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 4.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 16.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 3.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.2 4.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 8.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 2.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 5.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.7 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 6.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 2.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 3.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 5.8 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.1 8.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 2.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.0 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 5.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.2 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.1 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 5.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.9 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 7.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 2.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides