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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRF3

Z-value: 2.88

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50168962_50169062-0.471.8e-02Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_91087651 25.46 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91092241 23.68 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42792442 22.40 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_32821924 19.46 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_40264692 18.59 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr3_+_122399444 16.79 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr6_-_32821599 16.03 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_-_49701686 15.20 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr3_-_122283424 14.36 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr12_+_113376157 14.28 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_122283079 14.06 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr19_+_18284477 12.76 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr3_+_122283064 12.60 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr11_-_4414880 11.95 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr6_-_32806506 11.92 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr7_-_92777606 11.27 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr22_-_36556821 10.34 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr4_-_169239921 10.28 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr12_+_113416191 10.23 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr6_+_26440700 10.16 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr17_+_6659153 10.00 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr2_-_163175133 9.76 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr2_+_127413677 9.53 ENST00000356887.7
GYPC
glycophorin C (Gerbich blood group)
chr2_+_127413704 9.48 ENST00000409836.3
GYPC
glycophorin C (Gerbich blood group)
chr2_+_127413481 9.25 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr22_+_36044411 8.79 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr16_-_67970990 8.69 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr1_+_79115503 8.61 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr19_+_10196781 8.13 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr22_+_18632666 7.70 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr3_-_122283100 7.40 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr11_-_57335280 7.39 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr7_+_100728720 7.31 ENST00000306085.6
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr1_-_89664595 7.29 ENST00000355754.6
GBP4
guanylate binding protein 4
chr3_-_123339418 7.28 ENST00000583087.1
MYLK
myosin light chain kinase
chr3_-_123339343 7.24 ENST00000578202.1
MYLK
myosin light chain kinase
chr9_-_32526184 7.00 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_113376249 6.88 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr22_+_36649056 6.75 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr2_-_231084820 6.60 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr19_+_10196981 6.56 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr20_-_47894569 6.56 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr6_+_26402465 6.08 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_-_36355513 5.99 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chr7_-_92747269 5.84 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr11_-_615570 5.77 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr19_-_47735918 5.75 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr2_-_220252603 5.46 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr2_-_231084617 5.26 ENST00000409815.2
SP110
SP110 nuclear body protein
chr7_-_138794394 4.87 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr10_+_115439282 4.66 ENST00000369321.2
ENST00000345633.4
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr17_+_25958174 4.65 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr10_+_115439630 4.57 ENST00000369318.3
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr11_+_93861993 4.57 ENST00000227638.3
ENST00000436171.2
PANX1
pannexin 1
chr10_+_115439699 4.54 ENST00000369315.1
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr4_+_100495864 4.39 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr11_-_615942 4.36 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr1_+_948803 4.18 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr14_+_24605361 4.12 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr10_+_91061712 4.11 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr14_-_24615805 4.10 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_-_24615523 4.08 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_+_24605389 4.04 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr2_-_231989808 4.02 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr7_-_138794081 3.98 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr2_-_231084659 3.98 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr4_-_169401628 3.75 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr22_-_36635684 3.58 ENST00000358502.5
APOL2
apolipoprotein L, 2
chr17_-_63052929 3.47 ENST00000439174.2
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr20_+_388679 3.45 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_322821 3.39 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr6_+_26365443 3.26 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr19_+_50431959 3.20 ENST00000595125.1
ATF5
activating transcription factor 5
chr17_+_36861735 3.18 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_+_201981527 3.13 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr12_+_6561190 3.02 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr5_-_96143796 2.82 ENST00000296754.3
ERAP1
endoplasmic reticulum aminopeptidase 1
chr1_-_154580616 2.78 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr5_-_77656175 2.74 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
CTD-2037K23.2
chr20_+_388935 2.72 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr5_-_96143602 2.64 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr20_+_61436146 2.48 ENST00000290291.6
OGFR
opioid growth factor receptor
chr12_+_113416265 2.46 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr10_+_48355024 2.44 ENST00000395702.2
ENST00000442001.1
ENST00000433077.1
ENST00000436850.1
ENST00000494156.1
ENST00000586537.1
ZNF488
zinc finger protein 488
chr1_-_161015752 2.44 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chr15_-_88799948 2.34 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr22_+_39436862 2.32 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr6_+_26402517 2.31 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr11_+_124735282 2.27 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr15_-_62352570 2.14 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr9_+_74764278 2.13 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr15_-_55611306 2.08 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr6_-_30181133 2.04 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr9_-_32526299 2.02 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_+_49977466 2.02 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr12_+_4758264 1.98 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr20_+_388791 1.96 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr6_+_31540056 1.94 ENST00000418386.2
LTA
lymphotoxin alpha
chr9_-_95640218 1.92 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr6_-_30181156 1.87 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr12_-_99288536 1.84 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_190044480 1.76 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr20_-_33872518 1.63 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr10_-_102046098 1.57 ENST00000441611.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr3_-_160283348 1.51 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr10_-_22292675 1.50 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr3_+_187086120 1.47 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr14_+_73525144 1.47 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr21_-_43346790 1.46 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr3_+_42190714 1.41 ENST00000449246.1
TRAK1
trafficking protein, kinesin binding 1
chr1_+_110577229 1.39 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr20_-_33872548 1.39 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr10_-_102046417 1.38 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr16_-_75681522 1.34 ENST00000568378.1
ENST00000568682.1
ENST00000570215.1
ENST00000319410.5
ENST00000302445.3
KARS
lysyl-tRNA synthetase
chr14_+_73525229 1.27 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr20_-_43589109 1.26 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr6_+_28193037 1.25 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
ZSCAN9
zinc finger and SCAN domain containing 9
chr1_-_146644122 1.24 ENST00000254101.3
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr19_+_50432400 1.23 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
ATF5
activating transcription factor 5
chr2_-_73869508 1.23 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr9_+_77112244 1.21 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr6_-_711395 1.21 ENST00000606285.1
RP11-532F6.3
RP11-532F6.3
chrX_+_146993449 1.18 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr1_-_177939348 1.15 ENST00000464631.2
SEC16B
SEC16 homolog B (S. cerevisiae)
chr5_+_140071178 1.15 ENST00000508522.1
ENST00000448069.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr6_+_134758827 1.13 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr20_+_44509857 1.08 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chr2_-_119605253 1.05 ENST00000295206.6
EN1
engrailed homeobox 1
chr1_-_11042094 0.98 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chr20_-_47894936 0.95 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr5_-_135701164 0.94 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr2_+_99771418 0.88 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
LIPT1
MRPL30
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr19_+_50887585 0.88 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr6_-_110964453 0.87 ENST00000413605.2
CDK19
cyclin-dependent kinase 19
chr6_-_36355486 0.84 ENST00000538992.1
ETV7
ets variant 7
chr8_+_145438870 0.83 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr2_+_113672770 0.80 ENST00000311328.2
IL37
interleukin 37
chr4_-_156875003 0.80 ENST00000433477.3
CTSO
cathepsin O
chr3_+_63897605 0.79 ENST00000487717.1
ATXN7
ataxin 7
chr1_+_236557569 0.78 ENST00000334232.4
EDARADD
EDAR-associated death domain
chr12_-_127256858 0.75 ENST00000542248.1
ENST00000540684.1
LINC00944
long intergenic non-protein coding RNA 944
chr16_+_66968343 0.75 ENST00000417689.1
ENST00000561697.1
ENST00000317091.4
ENST00000566182.1
CES2
carboxylesterase 2
chr1_+_151129103 0.73 ENST00000368910.3
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr10_-_120355149 0.73 ENST00000239032.2
PRLHR
prolactin releasing hormone receptor
chr1_+_145292806 0.66 ENST00000448873.2
NBPF10
neuroblastoma breakpoint family, member 10
chr8_-_7274385 0.64 ENST00000318157.2
DEFB4B
defensin, beta 4B
chr9_+_74764340 0.60 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr12_+_97300995 0.60 ENST00000266742.4
ENST00000429527.2
ENST00000554226.1
ENST00000557478.1
ENST00000557092.1
ENST00000411739.2
ENST00000553609.1
NEDD1
neural precursor cell expressed, developmentally down-regulated 1
chr7_+_142829162 0.58 ENST00000291009.3
PIP
prolactin-induced protein
chr14_-_91976794 0.58 ENST00000555462.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr8_+_7752151 0.58 ENST00000302247.2
DEFB4A
defensin, beta 4A
chrX_+_146993534 0.52 ENST00000334557.6
ENST00000439526.2
ENST00000370475.4
FMR1
fragile X mental retardation 1
chrX_+_52920336 0.48 ENST00000452154.2
FAM156B
family with sequence similarity 156, member B
chr12_-_4758159 0.46 ENST00000545990.2
AKAP3
A kinase (PRKA) anchor protein 3
chr6_-_27840099 0.43 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr5_+_140749803 0.42 ENST00000576222.1
PCDHGB3
protocadherin gamma subfamily B, 3
chr9_-_100954910 0.39 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr5_-_180288248 0.39 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62
ZFP62 zinc finger protein
chr19_+_49977818 0.36 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr10_-_135187193 0.36 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chrX_-_48937531 0.36 ENST00000473974.1
ENST00000475880.1
ENST00000396681.4
ENST00000553851.1
ENST00000471338.1
ENST00000476728.1
ENST00000376368.2
ENST00000485908.1
ENST00000376372.3
ENST00000376358.3
WDR45
AF196779.12
WD repeat domain 45
WD repeat domain phosphoinositide-interacting protein 4
chr3_-_172241250 0.31 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr11_+_66008698 0.29 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr1_+_25598989 0.27 ENST00000454452.2
RHD
Rh blood group, D antigen
chr11_-_796197 0.25 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr17_+_21730180 0.24 ENST00000584398.1
UBBP4
ubiquitin B pseudogene 4
chr14_+_35452104 0.23 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr1_+_151129135 0.23 ENST00000602841.1
SCNM1
sodium channel modifier 1
chr12_-_133613794 0.23 ENST00000443154.3
RP11-386I8.6
RP11-386I8.6
chr1_-_151148492 0.18 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chrX_+_119384607 0.15 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chr19_-_17516449 0.15 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr4_+_124320665 0.12 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr9_-_140082983 0.12 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr9_+_140083099 0.12 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr16_+_75681650 0.11 ENST00000300086.4
TERF2IP
telomeric repeat binding factor 2, interacting protein
chr9_-_135282195 0.09 ENST00000334270.2
TTF1
transcription termination factor, RNA polymerase I
chr1_-_161014731 0.09 ENST00000368020.1
USF1
upstream transcription factor 1
chr8_+_22446763 0.07 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 28.9 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
6.4 25.6 GO:0046967 cytosol to ER transport(GO:0046967)
4.7 18.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
4.5 44.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
4.1 53.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
3.0 3.0 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
3.0 12.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
2.1 21.2 GO:0060700 regulation of ribonuclease activity(GO:0060700)
2.0 22.4 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
2.0 10.1 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
1.7 13.8 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.6 14.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.6 12.7 GO:0018377 protein myristoylation(GO:0018377)
1.5 4.6 GO:0002519 natural killer cell tolerance induction(GO:0002519) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.1 4.6 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
1.1 11.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.1 12.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
1.0 8.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.9 2.8 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.8 4.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.8 2.4 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.8 2.3 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.8 3.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.7 4.4 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.7 2.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.6 1.9 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.6 1.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.6 2.3 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.5 2.7 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.5 11.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.4 51.6 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.4 1.3 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.4 2.5 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.4 28.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4 2.3 GO:0070383 DNA cytosine deamination(GO:0070383)
0.4 1.1 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.4 1.9 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.4 1.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.4 12.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 3.5 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.3 2.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.3 4.4 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.3 1.0 GO:0061743 motor learning(GO:0061743)
0.2 9.4 GO:0035456 response to interferon-beta(GO:0035456)
0.2 1.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 2.9 GO:0060155 platelet dense granule organization(GO:0060155)
0.2 3.9 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 14.4 GO:0034340 response to type I interferon(GO:0034340)
0.2 3.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 2.5 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 0.9 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 1.4 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 6.1 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 9.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 0.9 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 2.4 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.1 0.9 GO:0009249 protein lipoylation(GO:0009249)
0.1 2.0 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 20.8 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.1 1.1 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.5 GO:0019054 modulation by virus of host process(GO:0019054)
0.1 2.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 2.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.1 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 1.2 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 12.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.6 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 1.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.7 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0000042 protein targeting to Golgi(GO:0000042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 25.6 GO:0042825 TAP complex(GO:0042825)
3.1 28.1 GO:1990111 spermatoproteasome complex(GO:1990111)
2.7 16.3 GO:0008537 proteasome activator complex(GO:0008537)
1.6 8.1 GO:0071797 LUBAC complex(GO:0071797)
0.8 2.3 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.6 1.8 GO:0005588 collagen type V trimer(GO:0005588)
0.6 1.7 GO:0019034 viral replication complex(GO:0019034)
0.6 2.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 4.6 GO:0032059 bleb(GO:0032059)
0.2 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 28.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 12.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 14.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 4.5 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 2.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 2.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 2.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 3.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 9.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 23.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 10.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.9 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.4 GO:1904115 axon cytoplasm(GO:1904115)
0.0 90.0 GO:0005739 mitochondrion(GO:0005739)
0.0 3.9 GO:0043202 lysosomal lumen(GO:0043202)
0.0 5.5 GO:0072562 blood microparticle(GO:0072562)
0.0 1.8 GO:0015030 Cajal body(GO:0015030)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 8.1 GO:0005769 early endosome(GO:0005769)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 25.4 GO:0005615 extracellular space(GO:0005615)
0.0 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 6.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 9.6 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 25.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
3.1 33.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
2.0 16.3 GO:0061133 endopeptidase activator activity(GO:0061133)
1.7 44.7 GO:0070403 NAD+ binding(GO:0070403)
1.5 14.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.4 5.5 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.9 4.6 GO:0048030 disaccharide binding(GO:0048030)
0.9 4.6 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.9 28.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 7.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.7 16.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.6 3.5 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.6 3.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.5 2.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 14.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.4 49.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.4 1.1 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.4 1.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 4.2 GO:0031386 protein tag(GO:0031386)
0.3 4.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3 5.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 3.6 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.2 0.9 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.2 0.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 1.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 2.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 2.5 GO:0004985 opioid receptor activity(GO:0004985)
0.2 1.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.7 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 14.7 GO:0005319 lipid transporter activity(GO:0005319)
0.1 31.7 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 2.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 7.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.9 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 35.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.3 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 5.7 GO:0051117 ATPase binding(GO:0051117)
0.0 1.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 2.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 4.5 GO:0005254 chloride channel activity(GO:0005254)
0.0 2.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0019864 IgG binding(GO:0019864)
0.0 24.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.4 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 12.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 16.4 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.4 GO:0015631 tubulin binding(GO:0015631)
0.0 26.3 GO:0042802 identical protein binding(GO:0042802)
0.0 1.3 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 2.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 13.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 14.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 3.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 16.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 4.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 7.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 20.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 10.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.3 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 141.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.3 18.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.9 25.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6 44.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.4 13.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 25.2 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.3 4.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 4.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 2.3 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 14.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 5.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 4.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 2.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 31.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 7.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 3.5 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 2.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 0.9 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 12.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes