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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for IRF6_IRF4_IRF5
Z-value: 2.48
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Transcription factors associated with IRF6_IRF4_IRF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000117595.6 | interferon regulatory factor 6 | |
| ENSG00000137265.10 | interferon regulatory factor 4 | |
| ENSG00000128604.14 | interferon regulatory factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF6 | hg19_v2_chr1_-_209979465_209979494 | -0.84 | 1.1e-07 | Click! |
| IRF5 | hg19_v2_chr7_+_128577972_128578047 | 0.72 | 5.0e-05 | Click! |
| IRF4 | hg19_v2_chr6_+_391739_391759 | 0.22 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 73.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 4.6 | 51.1 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 3.8 | 38.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.8 | 17.6 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 5.5 | 16.4 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 3.3 | 16.4 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 3.7 | 14.7 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.5 | 13.1 | GO:2000371 | phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 1.3 | 13.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.5 | 11.8 | GO:0030578 | PML body organization(GO:0030578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 129.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 67.3 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 44.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 13.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 11.9 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 1.7 | 11.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 9.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 7.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.4 | 6.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.6 | 5.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 89.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 53.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.6 | 42.8 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 33.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 31.8 | GO:0008270 | zinc ion binding(GO:0008270) |
| 4.1 | 16.4 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.2 | 16.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.7 | 13.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.5 | 11.8 | GO:0032183 | SUMO binding(GO:0032183) |
| 1.4 | 11.0 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 42.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 8.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.5 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.4 | 4.8 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 3.1 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 1.8 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 1.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 163.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.0 | 14.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.2 | 11.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 10.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 7.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 5.8 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 4.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 3.8 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 3.0 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 3.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |