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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRF6_IRF4_IRF5

Z-value: 2.48

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 interferon regulatory factor 6
IRF4
ENSG00000137265.10 interferon regulatory factor 4
IRF5
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF6hg19_v2_chr1_-_209979465_209979494-0.841.1e-07Click!
IRF5hg19_v2_chr7_+_128577972_1285780470.725.0e-05Click!
IRF4hg19_v2_chr6_+_391739_3917590.223.0e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_113344755 32.17 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42792442 24.78 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344582 21.32 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_20370847 20.58 ENST00000423676.3
ENST00000324290.5
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr21_+_42798094 19.03 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344811 18.18 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_7005785 16.42 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr17_+_18380051 13.97 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr17_+_6659153 13.65 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr13_-_43566301 12.93 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr12_+_113376157 12.78 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_122283079 12.08 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283424 11.87 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr9_-_32526184 11.50 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_-_615942 11.30 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr6_-_82462425 11.18 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr11_-_57335280 10.34 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr17_+_25958174 9.77 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr9_-_100881466 8.67 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr3_+_122283064 8.58 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr19_+_10196981 7.64 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr21_+_42733870 7.29 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr1_-_8000872 7.09 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr3_-_122283100 6.89 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr2_+_7017796 6.69 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr16_-_67970990 5.83 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr10_+_91174314 5.61 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr8_+_23386557 5.15 ENST00000523930.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr11_-_615570 5.07 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr11_+_5710919 4.93 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr12_+_113376249 4.86 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr1_+_179262905 4.84 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr2_-_220252603 4.65 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr7_-_138794394 4.57 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr15_+_74287009 4.43 ENST00000395135.3
PML
promyelocytic leukemia
chr7_-_77045617 4.40 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr15_+_74287035 4.24 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr19_+_10196781 3.40 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr22_+_36044411 3.37 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr3_+_154797877 3.26 ENST00000462745.1
ENST00000493237.1
MME
membrane metallo-endopeptidase
chr17_-_4167142 3.15 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr15_+_74287118 3.09 ENST00000563500.1
PML
promyelocytic leukemia
chr11_+_19799327 3.04 ENST00000540292.1
NAV2
neuron navigator 2
chr3_-_146262352 3.01 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr16_-_74734672 3.01 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr2_-_231989808 3.00 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chrX_-_110655391 2.94 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr22_+_18632666 2.91 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr12_+_6881678 2.80 ENST00000441671.2
ENST00000203629.2
LAG3
lymphocyte-activation gene 3
chr7_+_151038850 2.74 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1
negative regulator of ubiquitin-like proteins 1
chr7_-_138794081 2.69 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr3_-_146262365 2.56 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr12_+_69004619 2.54 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr2_-_106810783 2.46 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr17_-_40264692 2.44 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr1_+_205197304 2.39 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr3_-_142166796 2.38 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chr3_-_146262488 2.35 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr19_+_56813305 2.33 ENST00000593151.1
AC006116.20
Uncharacterized protein
chr17_+_41363854 2.29 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr3_-_146262428 2.25 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr2_-_106810742 2.22 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chr11_-_104817919 2.18 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_+_62654119 2.12 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr1_+_948803 2.10 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr20_-_62203808 2.06 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr22_+_23487513 2.00 ENST00000263116.2
ENST00000341989.4
RAB36
RAB36, member RAS oncogene family
chr7_+_43798270 1.98 ENST00000265523.4
ENST00000402924.1
BLVRA
biliverdin reductase A
chr3_-_182880541 1.98 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr5_-_35938674 1.94 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chrX_-_8139308 1.89 ENST00000317103.4
VCX2
variable charge, X-linked 2
chr3_+_187086120 1.88 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr15_+_90544532 1.85 ENST00000268154.4
ZNF710
zinc finger protein 710
chr3_+_29322803 1.85 ENST00000396583.3
ENST00000383767.2
RBMS3
RNA binding motif, single stranded interacting protein 3
chr11_-_86383650 1.83 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr9_-_32526299 1.82 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_+_94577074 1.78 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr15_+_28624878 1.77 ENST00000450328.2
GOLGA8F
golgin A8 family, member F
chr2_-_37384175 1.74 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr8_+_13424352 1.72 ENST00000297324.4
C8orf48
chromosome 8 open reading frame 48
chr5_+_115298165 1.67 ENST00000357872.4
AQPEP
Aminopeptidase Q
chr10_+_24528108 1.66 ENST00000438429.1
KIAA1217
KIAA1217
chr5_-_95297678 1.60 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr17_-_56595196 1.60 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4
myotubularin related protein 4
chr5_-_95297534 1.58 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr3_-_146262637 1.57 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr17_+_78234625 1.57 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr12_+_75874580 1.56 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr2_-_55920952 1.54 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr12_+_75874984 1.51 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr14_+_105267250 1.41 ENST00000342537.7
ZBTB42
zinc finger and BTB domain containing 42
chr2_-_163175133 1.39 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr5_-_76788024 1.37 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WDR41
WD repeat domain 41
chr16_+_28962128 1.36 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr3_-_142166904 1.36 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr3_-_146262293 1.34 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr20_-_45061695 1.33 ENST00000445496.2
ELMO2
engulfment and cell motility 2
chrM_+_9207 1.32 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_+_64282447 1.32 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_78769549 1.29 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr4_-_39529180 1.28 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH
UDP-glucose 6-dehydrogenase
chr15_+_83478370 1.24 ENST00000286760.4
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr17_-_49198216 1.20 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr9_+_33629119 1.13 ENST00000331828.4
TRBV21OR9-2
T cell receptor beta variable 21/OR9-2 (pseudogene)
chr21_-_34914394 1.10 ENST00000361093.5
ENST00000381815.4
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr15_+_90895471 1.06 ENST00000354377.3
ENST00000379090.5
ZNF774
zinc finger protein 774
chr12_+_75874460 1.05 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr2_-_111435610 1.01 ENST00000447014.1
ENST00000420328.1
ENST00000535254.1
ENST00000409311.1
ENST00000302759.6
BUB1
BUB1 mitotic checkpoint serine/threonine kinase
chr10_+_121410882 0.99 ENST00000369085.3
BAG3
BCL2-associated athanogene 3
chr5_-_176057518 0.98 ENST00000393693.2
SNCB
synuclein, beta
chr2_+_187454749 0.95 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr1_-_153514241 0.95 ENST00000368718.1
ENST00000359215.1
S100A5
S100 calcium binding protein A5
chr3_-_179169330 0.94 ENST00000232564.3
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr7_-_98467543 0.93 ENST00000345589.4
TMEM130
transmembrane protein 130
chr17_+_78965624 0.92 ENST00000325167.5
CHMP6
charged multivesicular body protein 6
chr11_-_66056596 0.92 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_-_66056478 0.92 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr15_+_23810853 0.91 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr3_-_155572164 0.91 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr7_-_98467629 0.89 ENST00000339375.4
TMEM130
transmembrane protein 130
chr7_-_98467489 0.89 ENST00000416379.2
TMEM130
transmembrane protein 130
chr16_+_30751953 0.89 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr12_+_121131970 0.88 ENST00000535656.1
MLEC
malectin
chr4_+_57371509 0.88 ENST00000360096.2
ARL9
ADP-ribosylation factor-like 9
chrX_-_54824673 0.88 ENST00000218436.6
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr12_-_31477072 0.86 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr1_-_89357179 0.86 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr10_+_71561649 0.85 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chrX_-_139587225 0.84 ENST00000370536.2
SOX3
SRY (sex determining region Y)-box 3
chr9_+_102668915 0.84 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chrX_+_23801280 0.84 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr11_+_32851487 0.84 ENST00000257836.3
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_+_43738444 0.83 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr10_+_71561630 0.83 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr9_-_133814455 0.83 ENST00000448616.1
FIBCD1
fibrinogen C domain containing 1
chr19_-_48389651 0.82 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_-_112032284 0.81 ENST00000414219.1
ADORA3
adenosine A3 receptor
chr11_-_86383157 0.80 ENST00000393324.3
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr12_+_46123682 0.78 ENST00000422737.1
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr17_-_79885576 0.78 ENST00000574686.1
ENST00000357736.4
MAFG
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr16_+_89642120 0.78 ENST00000268720.5
ENST00000319518.8
CPNE7
copine VII
chr7_+_75028199 0.78 ENST00000437796.1
TRIM73
tripartite motif containing 73
chr6_-_88411911 0.78 ENST00000257787.5
AKIRIN2
akirin 2
chr10_+_71561704 0.76 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr2_-_47572105 0.74 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr2_-_75937994 0.73 ENST00000409857.3
ENST00000470503.1
ENST00000541687.1
ENST00000442309.1
GCFC2
GC-rich sequence DNA-binding factor 2
chr8_+_22102626 0.73 ENST00000519237.1
ENST00000397802.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr17_-_30185971 0.72 ENST00000378634.2
COPRS
coordinator of PRMT5, differentiation stimulator
chr10_+_123923205 0.71 ENST00000369004.3
ENST00000260733.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_142166846 0.71 ENST00000463916.1
ENST00000544157.1
XRN1
5'-3' exoribonuclease 1
chr1_-_154580616 0.70 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr2_-_75938115 0.69 ENST00000321027.3
GCFC2
GC-rich sequence DNA-binding factor 2
chr2_+_68961905 0.68 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr10_+_114710516 0.68 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr9_+_95820966 0.67 ENST00000375472.3
ENST00000465709.1
SUSD3
sushi domain containing 3
chr5_+_141346385 0.67 ENST00000513019.1
ENST00000356143.1
RNF14
ring finger protein 14
chr18_-_51884204 0.67 ENST00000577499.1
ENST00000584040.1
ENST00000581310.1
STARD6
StAR-related lipid transfer (START) domain containing 6
chr2_+_68961934 0.67 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr3_+_44771088 0.66 ENST00000396048.2
ZNF501
zinc finger protein 501
chr4_+_89378261 0.65 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr1_-_171621815 0.65 ENST00000037502.6
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr3_+_114012819 0.64 ENST00000383671.3
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr19_-_36705547 0.64 ENST00000304116.5
ZNF565
zinc finger protein 565
chr10_+_15139394 0.64 ENST00000441850.1
RPP38
ribonuclease P/MRP 38kDa subunit
chr2_-_74753332 0.64 ENST00000451518.1
ENST00000404568.3
DQX1
DEAQ box RNA-dependent ATPase 1
chr17_-_38083843 0.64 ENST00000304046.2
ENST00000579695.1
ORMDL3
ORM1-like 3 (S. cerevisiae)
chr2_-_74753305 0.63 ENST00000393951.2
DQX1
DEAQ box RNA-dependent ATPase 1
chr19_+_7600584 0.62 ENST00000600737.1
PNPLA6
patatin-like phospholipase domain containing 6
chrX_+_19373700 0.61 ENST00000379804.1
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr12_-_99548645 0.60 ENST00000549025.2
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr15_-_89764929 0.59 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr7_-_142176790 0.59 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)
chr10_+_91061712 0.58 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_168464875 0.57 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr2_-_180427304 0.57 ENST00000336917.5
ZNF385B
zinc finger protein 385B
chr15_+_69857515 0.56 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr12_+_54402790 0.54 ENST00000040584.4
HOXC8
homeobox C8
chr9_+_112542572 0.54 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr4_-_164534657 0.54 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr17_-_36981556 0.54 ENST00000536127.1
ENST00000225428.5
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chrX_-_48755030 0.53 ENST00000490755.2
ENST00000465150.2
ENST00000495490.2
TIMM17B
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr6_-_91296602 0.52 ENST00000369325.3
ENST00000369327.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr10_+_71562180 0.52 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr19_-_9649253 0.52 ENST00000593003.1
ZNF426
zinc finger protein 426
chr12_+_4758264 0.51 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr2_+_113299990 0.51 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr3_+_88199099 0.51 ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr3_+_45429998 0.49 ENST00000265537.3
ENST00000415258.1
ENST00000431023.1
ENST00000414984.1
LARS2
leucyl-tRNA synthetase 2, mitochondrial
chr6_+_139349817 0.49 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr3_-_113464906 0.49 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr4_-_88141755 0.49 ENST00000273963.5
KLHL8
kelch-like family member 8
chr19_-_9649303 0.48 ENST00000253115.2
ZNF426
zinc finger protein 426
chr2_+_124782857 0.48 ENST00000431078.1
CNTNAP5
contactin associated protein-like 5
chrX_-_119077695 0.47 ENST00000371410.3
NKAP
NFKB activating protein
chr12_+_53491220 0.47 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr13_+_51483814 0.47 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr12_-_12837423 0.46 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr6_-_48036363 0.46 ENST00000543600.1
ENST00000398738.2
ENST00000339488.4
PTCHD4
patched domain containing 4
chr19_+_52264449 0.46 ENST00000599326.1
ENST00000598953.1
FPR2
formyl peptide receptor 2
chr2_-_99797473 0.45 ENST00000409107.1
ENST00000289359.2
MITD1
MIT, microtubule interacting and transport, domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.4 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
4.6 51.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
3.8 38.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
3.7 14.7 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
3.3 16.4 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
3.3 9.8 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.8 17.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.7 5.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
1.5 11.8 GO:0030578 PML body organization(GO:0030578)
1.5 13.1 GO:2000371 phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
1.3 6.7 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
1.3 13.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.2 4.8 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
1.2 7.1 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.9 2.8 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.9 73.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.9 4.4 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.7 3.3 GO:0046449 creatinine metabolic process(GO:0046449) cellular response to UV-A(GO:0071492)
0.6 2.4 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.6 3.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.5 2.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 1.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.5 3.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.4 3.0 GO:0021564 vagus nerve development(GO:0021564)
0.4 8.7 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 1.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 2.6 GO:0072592 oxygen metabolic process(GO:0072592)
0.3 0.8 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.3 1.0 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.2 2.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2 1.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.2 8.2 GO:0010390 histone monoubiquitination(GO:0010390)
0.2 5.2 GO:0035456 response to interferon-beta(GO:0035456)
0.2 0.9 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.2 1.3 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.2 0.6 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.2 3.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.2 2.6 GO:0035455 response to interferon-alpha(GO:0035455)
0.2 4.7 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.2 1.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 0.7 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.2 0.8 GO:0016240 autophagosome docking(GO:0016240)
0.2 0.6 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.2 0.3 GO:0060948 cardiac vascular smooth muscle cell development(GO:0060948)
0.1 1.6 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.3 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 2.5 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 2.0 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.9 GO:0051182 coenzyme transport(GO:0051182)
0.1 1.1 GO:0003360 brainstem development(GO:0003360) 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.3 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 1.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.4 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 3.0 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 1.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 1.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 11.2 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.1 1.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.4 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 5.8 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 1.2 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 3.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 2.3 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 0.3 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.1 1.8 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.6 GO:0060982 coronary artery morphogenesis(GO:0060982)
0.1 1.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.0 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 2.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.2 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.6 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 4.9 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.8 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.6 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 1.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.8 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:1902725 cranial ganglion development(GO:0061550) trigeminal ganglion development(GO:0061551) regulation of branch elongation involved in ureteric bud branching(GO:0072095) negative regulation of satellite cell differentiation(GO:1902725)
0.0 3.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.5 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.4 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.2 GO:0072178 nephric duct morphogenesis(GO:0072178)
0.0 0.5 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 1.0 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 1.8 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.4 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.3 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.6 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.8 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.4 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 1.8 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 1.3 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 1.7 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 4.9 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 2.6 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 1.4 GO:0016925 protein sumoylation(GO:0016925)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 11.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.7 3.0 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.7 2.0 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.6 5.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.5 3.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.4 6.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 1.0 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.3 1.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.3 2.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 1.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 0.6 GO:0035339 SPOTS complex(GO:0035339)
0.2 0.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.3 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.1 3.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.6 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 7.3 GO:0005643 nuclear pore(GO:0005643)
0.1 0.8 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 44.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 9.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 13.5 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.5 GO:0015030 Cajal body(GO:0015030)
0.1 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 0.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 1.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 129.7 GO:0005739 mitochondrion(GO:0005739)
0.1 3.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.5 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 11.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 3.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.1 GO:0072562 blood microparticle(GO:0072562)
0.0 1.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.0 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.2 GO:0005903 brush border(GO:0005903)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 4.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 3.0 GO:0005875 microtubule associated complex(GO:0005875)
0.0 2.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 67.3 GO:0005829 cytosol(GO:0005829)
0.0 0.2 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 89.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
4.1 16.4 GO:0009041 uridylate kinase activity(GO:0009041)
2.0 9.8 GO:0048030 disaccharide binding(GO:0048030)
1.6 42.8 GO:0070403 NAD+ binding(GO:0070403)
1.4 11.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.7 13.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.6 4.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.6 2.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 11.8 GO:0032183 SUMO binding(GO:0032183)
0.5 2.0 GO:0004074 biliverdin reductase activity(GO:0004074)
0.5 1.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.4 2.6 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.4 1.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.4 1.3 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.4 0.4 GO:0033677 DNA/RNA helicase activity(GO:0033677)
0.3 2.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.3 0.9 GO:0005124 scavenger receptor binding(GO:0005124)
0.3 3.5 GO:0031386 protein tag(GO:0031386)
0.3 5.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.3 1.5 GO:0034046 poly(G) binding(GO:0034046)
0.3 3.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2 1.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.2 5.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 0.8 GO:0008061 chitin binding(GO:0008061)
0.2 4.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 5.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 6.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 16.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 4.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 1.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.2 0.6 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 0.9 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 53.8 GO:0008017 microtubule binding(GO:0008017)
0.1 1.0 GO:1903136 cuprous ion binding(GO:1903136)
0.1 0.7 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 6.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 1.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.8 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 2.2 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 1.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 33.0 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 8.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.8 GO:0005521 lamin binding(GO:0005521)
0.1 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.2 GO:0070984 SET domain binding(GO:0070984)
0.1 0.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.5 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.4 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.2 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.1 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661) Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.6 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 1.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 9.3 GO:0042393 histone binding(GO:0042393)
0.0 6.5 GO:0004386 helicase activity(GO:0004386)
0.0 2.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0030911 TPR domain binding(GO:0030911)
0.0 2.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.5 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 2.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 31.8 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.3 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 1.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 1.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.4 GO:0019956 chemokine binding(GO:0019956)
0.0 0.8 GO:0070405 ammonium ion binding(GO:0070405)
0.0 2.4 GO:0008201 heparin binding(GO:0008201)
0.0 2.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.6 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 9.6 PID MYC PATHWAY C-MYC pathway
0.2 42.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.8 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 3.1 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 2.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 8.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 163.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.0 14.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 11.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 3.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 3.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 10.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 1.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 5.8 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 2.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 1.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.9 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.0 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 7.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 2.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 1.7 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.0 2.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP