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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRF9

Z-value: 3.14

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.951.3e-13Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42798094 43.21 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr4_-_76944621 34.46 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr12_+_113344755 30.98 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_79086088 30.44 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr2_-_7005785 28.44 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr17_+_6659153 27.97 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr13_-_43566301 20.84 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr12_+_113344582 20.33 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_+_113344811 17.97 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_122283424 17.35 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 17.12 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr1_-_150738261 16.41 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr1_+_79115503 15.31 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr12_+_113376157 15.23 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr10_+_91092241 15.13 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42733870 14.26 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr6_-_82462425 13.19 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr14_+_24630465 13.12 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr3_+_122283064 13.06 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr9_+_5510492 12.91 ENST00000397745.2
PDCD1LG2
programmed cell death 1 ligand 2
chr9_+_5510558 12.60 ENST00000397747.3
PDCD1LG2
programmed cell death 1 ligand 2
chr9_-_32526184 11.78 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_+_122399444 11.25 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr17_-_40264692 10.94 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr3_-_122283100 10.09 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr22_+_18632666 9.88 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr6_-_32806506 9.05 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr10_+_91174314 8.99 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr11_-_615570 8.90 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr11_-_57335280 8.12 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr11_-_4414880 8.12 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr19_+_10196981 8.00 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr2_+_7017796 7.68 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr15_+_74287009 7.47 ENST00000395135.3
PML
promyelocytic leukemia
chr13_+_50070491 7.25 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr15_+_74287035 7.14 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr13_+_50070077 7.03 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr11_-_615942 6.92 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr3_-_142166796 6.59 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chr4_-_169239921 6.50 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr1_+_948803 6.16 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr2_-_106810783 5.83 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr2_-_152146385 5.80 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr12_+_113376249 5.80 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_-_121477039 5.64 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr15_+_74287118 5.62 ENST00000563500.1
PML
promyelocytic leukemia
chr2_-_106810742 5.58 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chr5_-_95297678 5.48 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr2_-_220252603 5.42 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr7_+_100728720 5.29 ENST00000306085.6
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr5_-_95297534 5.26 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr6_-_31324943 5.03 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr14_+_94577074 4.69 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr2_-_163175133 4.10 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr4_-_169401628 3.94 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr3_-_142166904 3.93 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr9_+_74764278 3.74 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr16_-_74734672 3.63 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr4_+_186990298 3.59 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr5_-_59481406 3.57 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_115439282 3.54 ENST00000369321.2
ENST00000345633.4
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr17_+_41363854 3.52 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr10_+_115439699 3.40 ENST00000369315.1
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr17_+_78234625 3.38 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr10_+_115439630 3.24 ENST00000369318.3
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr1_-_154580616 2.98 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr12_-_121476959 2.96 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr6_+_126240442 2.91 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr9_+_102668915 2.90 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr6_-_33282163 2.78 ENST00000434618.2
ENST00000456592.2
TAPBP
TAP binding protein (tapasin)
chr11_-_86383157 2.56 ENST00000393324.3
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr2_-_55920952 2.51 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr18_-_25616519 2.50 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr12_+_6881678 2.48 ENST00000441671.2
ENST00000203629.2
LAG3
lymphocyte-activation gene 3
chr3_+_187086120 2.45 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr17_-_4167142 2.41 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr11_-_86383650 2.37 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr3_-_121379739 2.36 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_121476750 2.29 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr7_+_134551583 2.24 ENST00000435928.1
CALD1
caldesmon 1
chr4_+_37892682 2.20 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr3_-_142166846 2.01 ENST00000463916.1
ENST00000544157.1
XRN1
5'-3' exoribonuclease 1
chr6_+_37400974 1.67 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr10_+_91061712 1.64 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr5_-_142783175 1.59 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_-_146262352 1.49 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr4_+_89378261 1.21 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr3_-_146262365 1.19 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr18_-_67624160 1.14 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr20_+_61436146 1.09 ENST00000290291.6
OGFR
opioid growth factor receptor
chr3_-_46037299 1.07 ENST00000296137.2
FYCO1
FYVE and coiled-coil domain containing 1
chr3_-_146262488 1.06 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr9_-_32526299 1.02 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_+_106546808 1.01 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr5_-_142783694 0.98 ENST00000394466.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_-_146262428 0.97 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr19_-_12807395 0.97 ENST00000587955.1
FBXW9
F-box and WD repeat domain containing 9
chr2_-_37384175 0.95 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr9_-_21995300 0.93 ENST00000498628.2
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr16_+_28962128 0.90 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr5_-_137911049 0.89 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr19_-_17516449 0.88 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr17_+_38296576 0.87 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr6_-_33282024 0.73 ENST00000475304.1
ENST00000489157.1
TAPBP
TAP binding protein (tapasin)
chr17_-_54991395 0.73 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr9_+_74764340 0.58 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr3_-_146262637 0.46 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr14_-_57277163 0.42 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr14_-_57277178 0.37 ENST00000339475.5
ENST00000554559.1
ENST00000555804.1
OTX2
orthodenticle homeobox 2
chr14_-_67981916 0.26 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr3_-_146262293 0.23 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr19_-_12807422 0.22 ENST00000380339.3
ENST00000544494.1
ENST00000393261.3
FBXW9
F-box and WD repeat domain containing 9
chr9_+_33265011 0.18 ENST00000419016.2
CHMP5
charged multivesicular body protein 5
chrX_-_48858630 0.11 ENST00000376425.3
ENST00000376444.3
GRIPAP1
GRIP1 associated protein 1
chr2_+_205410723 0.06 ENST00000358768.2
ENST00000351153.1
ENST00000349953.3
PARD3B
par-3 family cell polarity regulator beta
chrX_-_48858667 0.04 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 28.4 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
5.2 57.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
5.1 20.5 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
4.5 44.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
4.4 17.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
3.4 34.5 GO:1901509 positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509)
3.2 15.8 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
2.5 20.2 GO:0030578 PML body organization(GO:0030578)
2.5 12.5 GO:0071409 cellular response to cycloheximide(GO:0071409)
2.2 6.7 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
2.1 21.0 GO:0060700 regulation of ribonuclease activity(GO:0060700)
2.0 8.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
1.5 15.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.5 7.7 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
1.5 10.2 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.4 25.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
1.4 159.7 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
1.2 5.8 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.9 2.6 GO:0050823 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.9 4.3 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.8 2.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.8 2.5 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.8 5.3 GO:0034340 response to type I interferon(GO:0034340)
0.7 3.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.6 16.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 5.4 GO:2000373 phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.6 2.9 GO:0016240 autophagosome docking(GO:0016240)
0.5 4.9 GO:0072592 oxygen metabolic process(GO:0072592)
0.4 2.5 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.4 3.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.4 1.1 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.4 11.4 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.4 12.3 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 2.4 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.3 2.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 1.7 GO:0080009 mRNA methylation(GO:0080009)
0.2 1.0 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.2 2.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 2.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.0 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 10.7 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.9 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.8 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.9 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.1 3.6 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.1 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 13.2 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.1 24.2 GO:0051607 defense response to virus(GO:0051607)
0.1 10.9 GO:0009615 response to virus(GO:0009615)
0.0 0.9 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.2 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 2.2 GO:0031338 regulation of vesicle fusion(GO:0031338)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 20.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
2.3 16.4 GO:0036021 endolysosome lumen(GO:0036021)
1.3 9.3 GO:0042825 TAP complex(GO:0042825)
0.6 3.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.6 9.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 2.4 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.3 2.9 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 2.5 GO:0042788 polysomal ribosome(GO:0042788)
0.2 2.5 GO:0016342 catenin complex(GO:0016342)
0.2 14.1 GO:0005643 nuclear pore(GO:0005643)
0.2 10.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 3.6 GO:0036020 endolysosome membrane(GO:0036020)
0.1 2.2 GO:0030478 actin cap(GO:0030478)
0.1 5.0 GO:0098553 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 63.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 20.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 11.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 34.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 7.7 GO:0005811 lipid particle(GO:0005811)
0.1 12.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 178.7 GO:0005739 mitochondrion(GO:0005739)
0.1 1.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.2 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 5.4 GO:0072562 blood microparticle(GO:0072562)
0.0 6.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.9 GO:0005771 multivesicular body(GO:0005771)
0.0 65.1 GO:0005654 nucleoplasm(GO:0005654)
0.0 3.9 GO:0045121 membrane raft(GO:0045121)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 101.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
7.1 28.4 GO:0009041 uridylate kinase activity(GO:0009041)
6.9 34.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.1 56.0 GO:0070403 NAD+ binding(GO:0070403)
1.9 9.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
1.8 12.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
1.2 9.3 GO:0042296 ISG15 transferase activity(GO:0042296)
1.0 22.8 GO:0032183 SUMO binding(GO:0032183)
0.8 4.9 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.6 2.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.6 7.1 GO:0031386 protein tag(GO:0031386)
0.5 2.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 16.4 GO:0001968 fibronectin binding(GO:0001968)
0.4 11.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 2.5 GO:0034046 poly(G) binding(GO:0034046)
0.4 9.0 GO:0000339 RNA cap binding(GO:0000339)
0.3 37.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 10.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 5.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 1.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.2 5.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 3.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.2 2.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 4.7 GO:0005521 lamin binding(GO:0005521)
0.2 57.5 GO:0008017 microtubule binding(GO:0008017)
0.1 5.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 7.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 15.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 9.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.1 GO:0004985 opioid receptor activity(GO:0004985)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 13.1 GO:0042393 histone binding(GO:0042393)
0.1 0.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 2.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 7.2 GO:0001047 core promoter binding(GO:0001047)
0.0 23.5 GO:0005525 GTP binding(GO:0005525)
0.0 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 38.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 3.9 GO:0004386 helicase activity(GO:0004386)
0.0 2.4 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 11.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.4 34.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.4 19.9 PID MYC PATHWAY C-MYC pathway
0.3 10.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 14.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 18.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 10.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.7 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 16.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.8 259.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.1 15.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.9 25.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.6 12.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.5 34.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 20.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.3 3.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.3 4.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.3 10.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 20.3 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 6.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 21.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.0 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling