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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for IRF9
Z-value: 3.14
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Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 0.95 | 1.3e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 159.7 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 5.2 | 57.5 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 4.5 | 44.6 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 3.4 | 34.5 | GO:1901509 | positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509) |
| 9.5 | 28.4 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 1.4 | 25.5 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 24.2 | GO:0051607 | defense response to virus(GO:0051607) |
| 2.1 | 21.0 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 5.1 | 20.5 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 2.5 | 20.2 | GO:0030578 | PML body organization(GO:0030578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 178.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 65.1 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 63.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 34.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 20.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 2.9 | 20.2 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 2.3 | 16.4 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.2 | 14.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 12.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 11.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 101.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 57.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 2.1 | 56.0 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 38.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.3 | 37.6 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 6.9 | 34.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 7.1 | 28.4 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.0 | 23.5 | GO:0005525 | GTP binding(GO:0005525) |
| 1.0 | 22.8 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.5 | 16.4 | GO:0001968 | fibronectin binding(GO:0001968) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.4 | 19.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 18.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 16.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 14.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.8 | 11.7 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 10.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 10.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 4.7 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 3.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 259.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 34.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.9 | 25.5 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 21.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 20.3 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.4 | 20.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.1 | 15.8 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 3.2 | 12.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.6 | 12.5 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.3 | 10.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |