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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for IRX6_IRX4

Z-value: 0.28

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.019.6e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_32655110 0.63 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_+_41361616 0.42 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr12_+_32655048 0.34 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_-_168865522 0.34 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr7_-_142232071 0.30 ENST00000390364.3
TRBV10-1
T cell receptor beta variable 10-1(gene/pseudogene)
chr1_+_63989004 0.29 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr15_+_66585555 0.29 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr15_+_66585879 0.28 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr6_+_116691001 0.24 ENST00000537543.1
DSE
dermatan sulfate epimerase
chr14_-_23623577 0.22 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr3_-_9994021 0.21 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr8_-_17555164 0.20 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr14_-_23624511 0.19 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr15_-_63448973 0.19 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr4_+_141264597 0.18 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr16_+_777118 0.16 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr8_+_84824920 0.15 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr21_-_48024986 0.15 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr2_+_133874577 0.14 ENST00000596384.1
AC011755.1
HCG2006742; Protein LOC100996685
chr4_-_104119528 0.14 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr19_-_22379753 0.14 ENST00000397121.2
ZNF676
zinc finger protein 676
chr2_-_183106641 0.13 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr13_-_41768654 0.11 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr17_-_47723943 0.11 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chrY_-_6742068 0.11 ENST00000215479.5
AMELY
amelogenin, Y-linked
chr1_-_89641680 0.11 ENST00000294671.2
GBP7
guanylate binding protein 7
chr1_+_220267429 0.10 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr1_-_152086556 0.09 ENST00000368804.1
TCHH
trichohyalin
chr15_+_41057818 0.09 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr19_+_50691437 0.09 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr6_-_52705641 0.08 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr16_+_776936 0.08 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr4_+_130017268 0.08 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr6_+_140175987 0.07 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr16_+_777246 0.07 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chrX_+_15767971 0.06 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr3_+_53528659 0.06 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr18_-_47376197 0.05 ENST00000592688.1
MYO5B
myosin VB
chr4_-_143481822 0.05 ENST00000510812.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr8_+_67976593 0.05 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr12_-_76462713 0.05 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr17_-_29641084 0.04 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr14_+_56127989 0.04 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr12_-_10282742 0.04 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr15_+_54901540 0.04 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr16_+_21689835 0.03 ENST00000286149.4
ENST00000388958.3
OTOA
otoancorin
chr4_-_153303658 0.03 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr20_+_11008408 0.03 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr12_-_10282836 0.03 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr4_-_177190364 0.03 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chrX_+_99899180 0.02 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_10282681 0.02 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr12_+_53848549 0.02 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr17_-_29641104 0.02 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr6_-_33679452 0.02 ENST00000374231.4
ENST00000607484.1
ENST00000374214.3
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr10_+_90660832 0.02 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr12_+_5541267 0.02 ENST00000423158.3
NTF3
neurotrophin 3
chr1_+_67673297 0.02 ENST00000425614.1
ENST00000395227.1
IL23R
interleukin 23 receptor
chr19_-_48059113 0.01 ENST00000391901.3
ENST00000314121.4
ENST00000448976.1
ZNF541
zinc finger protein 541
chr2_+_160590469 0.01 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr2_+_113829895 0.01 ENST00000393197.2
IL1F10
interleukin 1 family, member 10 (theta)
chrX_-_15333736 0.01 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr4_+_71457970 0.01 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chr18_+_616672 0.01 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr6_-_117747015 0.01 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr19_-_54974894 0.01 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr8_-_67976509 0.01 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr20_+_10199468 0.00 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr6_+_149887377 0.00 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr5_+_59783540 0.00 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_-_110284384 0.00 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.6 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:0051597 response to methylmercury(GO:0051597) negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.0 0.4 GO:0015695 organic cation transport(GO:0015695)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.4 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK