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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ISL1

Z-value: 0.62

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ISL1
ENSG00000016082.10 ISL LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_50678921-0.386.3e-02Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_186877806 3.49 ENST00000355634.5
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186877502 2.60 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr6_-_130031358 2.55 ENST00000368149.2
ARHGAP18
Rho GTPase activating protein 18
chr1_+_100111479 2.06 ENST00000263174.4
PALMD
palmdelphin
chr10_-_116444371 1.73 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr1_+_221054584 1.52 ENST00000549319.1
HLX
H2.0-like homeobox
chr1_+_82266053 1.37 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr9_+_2029019 1.35 ENST00000382194.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_-_117107680 1.31 ENST00000447671.2
ENST00000262820.3
KLHL13
kelch-like family member 13
chr11_+_7618413 1.23 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_117107542 1.09 ENST00000371878.1
KLHL13
kelch-like family member 13
chr6_+_132455118 1.03 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr7_+_13141097 0.94 ENST00000411542.1
AC011288.2
AC011288.2
chrX_+_10031499 0.88 ENST00000454666.1
WWC3
WWC family member 3
chr3_+_148508845 0.76 ENST00000491148.1
CPB1
carboxypeptidase B1 (tissue)
chrX_+_55478538 0.69 ENST00000342972.1
MAGEH1
melanoma antigen family H, 1
chr8_-_19540266 0.67 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chrX_-_117119243 0.67 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr8_-_19540086 0.66 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr21_+_17792672 0.66 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr6_+_144904334 0.66 ENST00000367526.4
UTRN
utrophin
chr6_-_111136513 0.65 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr14_-_77495007 0.60 ENST00000238647.3
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr18_-_52989217 0.60 ENST00000570287.2
TCF4
transcription factor 4
chr8_+_21911054 0.58 ENST00000519850.1
ENST00000381470.3
DMTN
dematin actin binding protein
chr16_+_20775358 0.56 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr17_-_21156578 0.56 ENST00000399011.2
ENST00000468196.1
C17orf103
chromosome 17 open reading frame 103
chrX_+_135251783 0.55 ENST00000394153.2
FHL1
four and a half LIM domains 1
chrX_+_135252050 0.55 ENST00000449474.1
ENST00000345434.3
FHL1
four and a half LIM domains 1
chr13_-_99667960 0.54 ENST00000448493.2
DOCK9
dedicator of cytokinesis 9
chr16_+_20775024 0.50 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr16_-_67517716 0.49 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr7_+_16793160 0.49 ENST00000262067.4
TSPAN13
tetraspanin 13
chr18_-_53177984 0.49 ENST00000543082.1
TCF4
transcription factor 4
chr13_+_78315466 0.49 ENST00000314070.5
ENST00000462234.1
SLAIN1
SLAIN motif family, member 1
chr2_-_89247338 0.48 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr6_+_90272027 0.48 ENST00000522441.1
ANKRD6
ankyrin repeat domain 6
chrX_+_135251835 0.47 ENST00000456445.1
FHL1
four and a half LIM domains 1
chr16_+_76587314 0.46 ENST00000563764.1
RP11-58C22.1
Uncharacterized protein
chr12_-_30887948 0.46 ENST00000433722.2
CAPRIN2
caprin family member 2
chr8_+_70404996 0.45 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr4_+_4861385 0.45 ENST00000382723.4
MSX1
msh homeobox 1
chr14_+_22458631 0.44 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr6_-_116575226 0.43 ENST00000420283.1
TSPYL4
TSPY-like 4
chr18_-_52989525 0.43 ENST00000457482.3
TCF4
transcription factor 4
chr2_+_28618532 0.43 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr6_-_111804905 0.42 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr9_+_136325089 0.42 ENST00000291722.7
ENST00000316948.4
ENST00000540581.1
CACFD1
calcium channel flower domain containing 1
chr9_-_113100088 0.41 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr17_+_66521936 0.40 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr19_-_42806842 0.39 ENST00000596265.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr19_-_17488143 0.38 ENST00000599426.1
ENST00000252590.4
PLVAP
plasmalemma vesicle associated protein
chr1_+_197170592 0.38 ENST00000535699.1
CRB1
crumbs homolog 1 (Drosophila)
chr1_-_114430169 0.36 ENST00000393316.3
BCL2L15
BCL2-like 15
chr12_-_50290839 0.36 ENST00000552863.1
FAIM2
Fas apoptotic inhibitory molecule 2
chr6_+_35996859 0.34 ENST00000472333.1
MAPK14
mitogen-activated protein kinase 14
chr1_-_154458520 0.34 ENST00000486773.1
SHE
Src homology 2 domain containing E
chr8_+_42873548 0.32 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr18_+_46065393 0.31 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr16_-_4665023 0.31 ENST00000591897.1
UBALD1
UBA-like domain containing 1
chr5_-_94417339 0.30 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr8_-_101571964 0.29 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr5_-_138210977 0.29 ENST00000274711.6
ENST00000521094.2
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr16_-_4664860 0.29 ENST00000587615.1
ENST00000587649.1
ENST00000590965.1
ENST00000591401.1
ENST00000283474.7
UBALD1
UBA-like domain containing 1
chr4_+_123300121 0.28 ENST00000446706.1
ENST00000296513.2
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chr5_+_102455853 0.28 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr13_+_78315295 0.28 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr20_-_25320367 0.27 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr3_-_185538849 0.27 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr7_-_5998714 0.27 ENST00000539903.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr3_-_149095652 0.27 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr8_-_101571933 0.25 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chr12_-_102591604 0.25 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr3_+_158787041 0.25 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr3_-_138312971 0.25 ENST00000485115.1
ENST00000484888.1
ENST00000468900.1
ENST00000542237.1
ENST00000481834.1
CEP70
centrosomal protein 70kDa
chr9_+_37667978 0.25 ENST00000539465.1
FRMPD1
FERM and PDZ domain containing 1
chr15_+_76352178 0.25 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr11_+_64018955 0.24 ENST00000279230.6
ENST00000540288.1
ENST00000325234.5
PLCB3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr2_-_68547061 0.24 ENST00000263655.3
CNRIP1
cannabinoid receptor interacting protein 1
chr9_+_134165063 0.24 ENST00000372264.3
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr6_+_168418553 0.24 ENST00000354419.2
ENST00000351261.3
KIF25
kinesin family member 25
chr17_-_15501932 0.24 ENST00000583965.1
CDRT1
CMT1A duplicated region transcript 1
chr10_-_95242044 0.24 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr10_-_95241951 0.24 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr18_+_46065483 0.22 ENST00000382998.4
CTIF
CBP80/20-dependent translation initiation factor
chr9_+_27109133 0.20 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr18_-_19283649 0.20 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr3_+_179322481 0.20 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr19_-_42759300 0.20 ENST00000222329.4
ERF
Ets2 repressor factor
chr1_-_234614849 0.20 ENST00000040877.1
TARBP1
TAR (HIV-1) RNA binding protein 1
chr4_+_159727272 0.19 ENST00000379346.3
FNIP2
folliculin interacting protein 2
chr8_+_110098850 0.19 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr2_-_220034712 0.18 ENST00000409370.2
ENST00000430764.1
ENST00000409878.3
SLC23A3
solute carrier family 23, member 3
chr5_+_140593509 0.18 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr5_+_134181755 0.18 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
C5orf24
chromosome 5 open reading frame 24
chrX_-_30327495 0.18 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr7_-_150675372 0.17 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr16_-_4524543 0.17 ENST00000573571.1
ENST00000404295.3
ENST00000574425.1
NMRAL1
NmrA-like family domain containing 1
chr5_+_140248518 0.17 ENST00000398640.2
PCDHA11
protocadherin alpha 11
chr1_+_217804661 0.17 ENST00000366933.4
SPATA17
spermatogenesis associated 17
chr17_+_35732955 0.17 ENST00000300618.4
C17orf78
chromosome 17 open reading frame 78
chr7_+_150811705 0.17 ENST00000335367.3
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chrY_-_6740649 0.17 ENST00000383036.1
ENST00000383037.4
AMELY
amelogenin, Y-linked
chr22_+_41075277 0.17 ENST00000381433.2
MCHR1
melanin-concentrating hormone receptor 1
chr17_+_35732916 0.17 ENST00000586700.1
C17orf78
chromosome 17 open reading frame 78
chr3_-_74570291 0.16 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr20_-_48732472 0.16 ENST00000340309.3
ENST00000415862.2
ENST00000371677.3
ENST00000420027.2
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr14_-_45252031 0.16 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr1_+_156024552 0.16 ENST00000368304.5
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr3_-_121740969 0.15 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1
immunoglobulin-like domain containing receptor 1
chr1_+_161736072 0.15 ENST00000367942.3
ATF6
activating transcription factor 6
chr15_+_48498480 0.15 ENST00000380993.3
ENST00000396577.3
SLC12A1
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr17_-_39471947 0.15 ENST00000334202.3
KRTAP17-1
keratin associated protein 17-1
chr6_+_36853607 0.14 ENST00000480824.2
ENST00000355190.3
ENST00000373685.1
C6orf89
chromosome 6 open reading frame 89
chr1_+_150980889 0.14 ENST00000450884.1
ENST00000271620.3
ENST00000271619.8
ENST00000368937.1
ENST00000431193.1
ENST00000368936.1
PRUNE
prune exopolyphosphatase
chr3_-_100712352 0.14 ENST00000471714.1
ENST00000284322.5
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_-_100598444 0.14 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr3_-_143567262 0.14 ENST00000474151.1
ENST00000316549.6
SLC9A9
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr1_+_196621156 0.14 ENST00000359637.2
CFH
complement factor H
chr8_-_133637624 0.13 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr13_+_108870714 0.13 ENST00000375898.3
ABHD13
abhydrolase domain containing 13
chr10_+_17270214 0.13 ENST00000544301.1
VIM
vimentin
chr16_-_52119019 0.13 ENST00000561513.1
ENST00000565742.1
LINC00919
long intergenic non-protein coding RNA 919
chr1_-_156217822 0.13 ENST00000368270.1
PAQR6
progestin and adipoQ receptor family member VI
chr1_+_156024525 0.12 ENST00000368305.4
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr1_+_171217622 0.12 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr17_-_7760457 0.12 ENST00000576384.1
LSMD1
LSM domain containing 1
chr19_+_13842559 0.12 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr21_-_34185944 0.12 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr1_-_156217875 0.12 ENST00000292291.5
PAQR6
progestin and adipoQ receptor family member VI
chr17_-_39341594 0.12 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr1_+_206972215 0.12 ENST00000340758.2
IL19
interleukin 19
chr22_+_30279144 0.12 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr17_-_57229155 0.11 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr8_+_26371763 0.11 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr10_-_17659357 0.11 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr11_-_59951889 0.11 ENST00000532169.1
ENST00000534596.1
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr6_-_117150198 0.11 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr3_-_107596910 0.11 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr3_+_130279178 0.11 ENST00000358511.6
ENST00000453409.2
COL6A6
collagen, type VI, alpha 6
chr2_-_227050079 0.11 ENST00000423838.1
AC068138.1
AC068138.1
chr12_-_28124903 0.11 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr3_+_57875711 0.10 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr10_-_17659234 0.10 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr3_-_146262637 0.10 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr19_+_3178736 0.10 ENST00000246115.3
S1PR4
sphingosine-1-phosphate receptor 4
chr12_-_6484715 0.10 ENST00000228916.2
SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
chr18_-_21977748 0.09 ENST00000399441.4
ENST00000319481.3
OSBPL1A
oxysterol binding protein-like 1A
chr8_+_53850991 0.09 ENST00000331251.3
NPBWR1
neuropeptides B/W receptor 1
chr9_-_86323118 0.09 ENST00000376395.4
UBQLN1
ubiquilin 1
chr15_+_65822756 0.09 ENST00000562901.1
ENST00000261875.5
ENST00000442729.2
ENST00000565299.1
ENST00000568793.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr3_+_142342228 0.09 ENST00000337777.3
PLS1
plastin 1
chr6_+_155537771 0.09 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr4_-_128887069 0.09 ENST00000541133.1
ENST00000296468.3
ENST00000513559.1
MFSD8
major facilitator superfamily domain containing 8
chr3_+_119501557 0.09 ENST00000337940.4
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr4_-_176923483 0.09 ENST00000280187.7
ENST00000512509.1
GPM6A
glycoprotein M6A
chrX_+_79675965 0.08 ENST00000308293.5
FAM46D
family with sequence similarity 46, member D
chr6_+_31707725 0.08 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr4_+_118955500 0.08 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_+_32710736 0.08 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr11_+_22688150 0.08 ENST00000454584.2
GAS2
growth arrest-specific 2
chr7_+_90338712 0.08 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr2_+_207804278 0.08 ENST00000272852.3
CPO
carboxypeptidase O
chr12_+_54402790 0.07 ENST00000040584.4
HOXC8
homeobox C8
chr21_-_47575481 0.07 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
FTCD
formimidoyltransferase cyclodeaminase
chr5_+_140772381 0.07 ENST00000398604.2
PCDHGA8
protocadherin gamma subfamily A, 8
chr1_+_192544857 0.07 ENST00000367459.3
ENST00000469578.2
RGS1
regulator of G-protein signaling 1
chr8_-_79717750 0.07 ENST00000263851.4
ENST00000379113.2
IL7
interleukin 7
chrX_-_100129320 0.07 ENST00000372966.3
NOX1
NADPH oxidase 1
chr20_+_42136308 0.06 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr3_+_38307293 0.06 ENST00000311856.4
SLC22A13
solute carrier family 22 (organic anion/urate transporter), member 13
chr1_-_79472365 0.06 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr10_+_114710211 0.06 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr3_+_57875738 0.06 ENST00000417128.1
ENST00000438794.1
SLMAP
sarcolemma associated protein
chr18_-_13915530 0.06 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr5_+_169659950 0.06 ENST00000593851.1
C5orf58
chromosome 5 open reading frame 58
chr16_-_23464459 0.06 ENST00000307149.5
COG7
component of oligomeric golgi complex 7
chr1_-_160254913 0.05 ENST00000440949.3
ENST00000368072.5
ENST00000608310.1
ENST00000556710.1
PEX19
DCAF8
DCAF8
peroxisomal biogenesis factor 19
DDB1 and CUL4 associated factor 8
DDB1- and CUL4-associated factor 8
chr17_+_1933404 0.05 ENST00000263083.6
ENST00000571418.1
DPH1
diphthamide biosynthesis 1
chr19_+_39687596 0.05 ENST00000339852.4
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr2_+_211421262 0.05 ENST00000233072.5
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr9_+_103947311 0.05 ENST00000395056.2
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr14_-_60337684 0.05 ENST00000267484.5
RTN1
reticulon 1
chr1_+_84873913 0.05 ENST00000370662.3
DNASE2B
deoxyribonuclease II beta
chr2_-_220034745 0.05 ENST00000455516.2
ENST00000396775.3
ENST00000295738.7
SLC23A3
solute carrier family 23, member 3
chr8_-_42234745 0.05 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr8_+_26247878 0.04 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr18_+_21529811 0.04 ENST00000588004.1
LAMA3
laminin, alpha 3
chr12_-_6484376 0.04 ENST00000360168.3
ENST00000358945.3
SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
chr14_-_92198403 0.04 ENST00000553329.1
ENST00000256343.3
CATSPERB
catsper channel auxiliary subunit beta
chr10_-_18940501 0.04 ENST00000377304.4
NSUN6
NOP2/Sun domain family, member 6
chr13_-_52027134 0.04 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr12_+_96883347 0.03 ENST00000524981.4
ENST00000298953.3
C12orf55
chromosome 12 open reading frame 55
chr1_-_119682812 0.03 ENST00000537870.1
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr16_+_47496023 0.03 ENST00000567200.1
PHKB
phosphorylase kinase, beta
chr3_-_33686743 0.03 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr8_+_119294456 0.03 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr4_-_72649763 0.03 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chr8_-_70016408 0.02 ENST00000518540.1
RP11-600K15.1
RP11-600K15.1
chr7_-_44580861 0.02 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 1.5 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 6.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.4 GO:0090427 activation of meiosis(GO:0090427)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.6 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.3 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.7 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.0 0.5 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.4 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0 1.6 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.2 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0 0.4 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 1.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 4.0 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0000050 urea cycle(GO:0000050)
0.0 0.1 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.5 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 2.9 GO:0000910 cytokinesis(GO:0000910)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:2000371 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 1.1 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 1.7 GO:0007286 spermatid development(GO:0007286)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.3 GO:0071986 Ragulator complex(GO:0071986)
0.0 2.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 5.2 GO:0030018 Z disc(GO:0030018)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.2 6.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 1.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.4 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.3 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.0 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.1 PID AURORA B PATHWAY Aurora B signaling
0.0 1.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB