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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ISX

Z-value: 0.51

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Transcription factors associated with ISX

Gene Symbol Gene ID Gene Info
ISX
ENSG00000175329.8 intestine specific homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISXhg19_v2_chr22_+_35462129_35462156-0.106.3e-01Click!

Activity profile of ISX motif

Sorted Z-values of ISX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_39394250 1.23 ENST00000254072.6
KRTAP9-8
keratin associated protein 9-8
chr14_+_22964877 0.69 ENST00000390494.1
TRAJ43
T cell receptor alpha joining 43
chr19_-_14945933 0.61 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr11_-_121986923 0.59 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr20_+_42544782 0.58 ENST00000423191.2
ENST00000372999.1
TOX2
TOX high mobility group box family member 2
chr17_-_18266765 0.53 ENST00000354098.3
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr6_-_111927062 0.47 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr4_-_186733363 0.47 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2
sorbin and SH3 domain containing 2
chr1_+_209602156 0.46 ENST00000429156.1
ENST00000366437.3
ENST00000603283.1
ENST00000431096.1
MIR205HG
MIR205 host gene (non-protein coding)
chr12_-_10022735 0.43 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr19_-_14785622 0.40 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr10_-_48416849 0.39 ENST00000249598.1
GDF2
growth differentiation factor 2
chr10_+_103986085 0.37 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr17_-_40829026 0.37 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chrX_+_77166172 0.35 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr17_+_42785976 0.34 ENST00000393547.2
ENST00000398338.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr19_-_14785674 0.34 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr6_-_111927449 0.33 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr17_-_18266797 0.33 ENST00000316694.3
ENST00000539052.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr2_-_183387430 0.33 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_-_183387064 0.32 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr19_+_12902289 0.32 ENST00000302754.4
JUNB
jun B proto-oncogene
chr4_+_108911036 0.32 ENST00000505878.1
HADH
hydroxyacyl-CoA dehydrogenase
chr1_-_36916066 0.31 ENST00000315643.9
OSCP1
organic solute carrier partner 1
chr14_-_94789663 0.30 ENST00000557225.1
ENST00000341584.3
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr8_+_7783859 0.29 ENST00000400120.3
ZNF705B
zinc finger protein 705B
chr3_-_105588231 0.28 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr8_-_7243080 0.28 ENST00000400156.4
ZNF705G
zinc finger protein 705G
chr14_+_70233810 0.27 ENST00000394366.2
ENST00000553548.1
ENST00000553369.1
ENST00000557154.1
ENST00000451983.2
ENST00000553635.1
SRSF5
serine/arginine-rich splicing factor 5
chr1_-_36915880 0.27 ENST00000445843.3
OSCP1
organic solute carrier partner 1
chr9_+_136501478 0.27 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr17_-_18266660 0.26 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr11_-_124981475 0.26 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr17_-_42277203 0.25 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr12_+_52695617 0.25 ENST00000293525.5
KRT86
keratin 86
chr4_-_138453606 0.24 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr11_-_63381925 0.23 ENST00000415826.1
PLA2G16
phospholipase A2, group XVI
chr17_+_40610862 0.23 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr3_-_105587879 0.22 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_+_95523621 0.22 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr4_-_141348789 0.22 ENST00000414773.1
CLGN
calmegin
chr3_-_15563229 0.22 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr4_+_144303093 0.22 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr6_+_130339710 0.22 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr3_+_97868170 0.21 ENST00000437310.1
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr10_-_99447024 0.20 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr1_-_143913143 0.20 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chrX_-_24690771 0.20 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_-_242089677 0.20 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr2_-_89247338 0.20 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr16_+_89160217 0.20 ENST00000317447.4
ENST00000537290.1
ACSF3
acyl-CoA synthetase family member 3
chr2_+_86947296 0.19 ENST00000283632.4
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr1_+_206138457 0.19 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr17_+_59489112 0.19 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr1_+_120839005 0.19 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr7_+_115862858 0.19 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr2_+_177015122 0.18 ENST00000468418.3
HOXD3
homeobox D3
chr5_+_140557371 0.17 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr4_-_141348999 0.17 ENST00000325617.5
CLGN
calmegin
chr14_+_32798547 0.17 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr6_+_34204642 0.16 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr4_-_122686261 0.16 ENST00000337677.5
TMEM155
transmembrane protein 155
chr2_+_242089833 0.16 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr1_-_161208013 0.16 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr1_-_68698197 0.15 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr22_-_29137771 0.15 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr17_-_7307358 0.15 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr7_-_36764004 0.15 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr6_+_36165133 0.15 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr9_-_132383055 0.14 ENST00000372478.4
C9orf50
chromosome 9 open reading frame 50
chr2_+_217524323 0.14 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr19_-_51071302 0.14 ENST00000389201.3
ENST00000600381.1
LRRC4B
leucine rich repeat containing 4B
chr12_-_10978957 0.14 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chrX_+_77154935 0.14 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr4_+_155702496 0.14 ENST00000510397.1
RBM46
RNA binding motif protein 46
chr6_-_32095968 0.14 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr6_+_3259148 0.13 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr14_-_81425828 0.13 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr2_-_96700664 0.13 ENST00000359548.4
ENST00000377137.3
ENST00000439254.1
ENST00000453542.1
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr9_+_104296122 0.13 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr4_-_138453559 0.12 ENST00000511115.1
PCDH18
protocadherin 18
chr6_+_53948328 0.12 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr15_-_55700457 0.12 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr20_+_9494987 0.12 ENST00000427562.2
ENST00000246070.2
LAMP5
lysosomal-associated membrane protein family, member 5
chr19_-_36001113 0.12 ENST00000434389.1
DMKN
dermokine
chr1_+_87595433 0.12 ENST00000469312.2
ENST00000490006.2
RP5-1052I5.1
long intergenic non-protein coding RNA 1140
chr8_+_38831683 0.12 ENST00000302495.4
HTRA4
HtrA serine peptidase 4
chrX_+_44703249 0.12 ENST00000339042.4
DUSP21
dual specificity phosphatase 21
chr17_+_42786051 0.12 ENST00000315005.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr19_+_4153598 0.11 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr12_-_22063787 0.11 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr7_+_50348268 0.11 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_-_190446759 0.11 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr6_+_148663729 0.11 ENST00000367467.3
SASH1
SAM and SH3 domain containing 1
chr10_-_105110831 0.11 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr4_-_174255536 0.11 ENST00000446922.2
HMGB2
high mobility group box 2
chr6_-_85474219 0.10 ENST00000369663.5
TBX18
T-box 18
chr2_+_90248739 0.10 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr1_-_153044083 0.10 ENST00000341611.2
SPRR2B
small proline-rich protein 2B
chr1_-_112281875 0.09 ENST00000527621.1
ENST00000534365.1
ENST00000357260.5
FAM212B
family with sequence similarity 212, member B
chr17_+_73452545 0.09 ENST00000314256.7
KIAA0195
KIAA0195
chr2_-_228244013 0.09 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr22_-_50523760 0.09 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_-_47137942 0.09 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr14_+_22670455 0.09 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr1_-_68698222 0.09 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr4_-_174255400 0.09 ENST00000506267.1
HMGB2
high mobility group box 2
chr4_-_177190364 0.09 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr17_-_43045439 0.09 ENST00000253407.3
C1QL1
complement component 1, q subcomponent-like 1
chr6_-_33860521 0.09 ENST00000525746.1
ENST00000531046.1
LINC01016
long intergenic non-protein coding RNA 1016
chr15_+_58430567 0.09 ENST00000536493.1
AQP9
aquaporin 9
chr15_-_55700522 0.08 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr1_+_44115814 0.08 ENST00000372396.3
KDM4A
lysine (K)-specific demethylase 4A
chr6_+_160542821 0.08 ENST00000366963.4
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr7_+_142985308 0.08 ENST00000310447.5
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr12_-_50790267 0.08 ENST00000327337.5
ENST00000543111.1
FAM186A
family with sequence similarity 186, member A
chr20_-_43133491 0.08 ENST00000411544.1
SERINC3
serine incorporator 3
chrX_+_130192318 0.08 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr2_+_172778952 0.08 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr15_+_58430368 0.08 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr15_-_75199213 0.07 ENST00000562698.1
FAM219B
family with sequence similarity 219, member B
chr5_+_159848807 0.07 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr2_-_89292422 0.07 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr19_-_40931891 0.07 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr9_+_131452239 0.07 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr17_-_40828969 0.07 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr12_-_10955226 0.07 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr10_-_56560939 0.07 ENST00000373955.1
PCDH15
protocadherin-related 15
chr2_-_183387283 0.07 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr13_+_40229764 0.07 ENST00000416691.1
ENST00000422759.2
ENST00000455146.3
COG6
component of oligomeric golgi complex 6
chr6_+_160542870 0.07 ENST00000324965.4
ENST00000457470.2
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr8_+_9413410 0.07 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr8_+_110552046 0.07 ENST00000529931.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr3_-_149095652 0.07 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr4_+_87515454 0.07 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr22_+_24322322 0.07 ENST00000215780.5
ENST00000402588.3
GSTT2
glutathione S-transferase theta 2
chr20_-_50418947 0.06 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr10_+_91461337 0.06 ENST00000260753.4
ENST00000416354.1
ENST00000394289.2
ENST00000371728.3
KIF20B
kinesin family member 20B
chr11_-_62521614 0.06 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chrX_+_43515467 0.06 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr11_-_63381823 0.06 ENST00000323646.5
PLA2G16
phospholipase A2, group XVI
chr3_-_151034734 0.06 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr22_+_21400229 0.06 ENST00000342608.4
ENST00000543388.1
ENST00000442047.1
AC002472.13
Leucine-rich repeat-containing protein LOC400891
chr14_+_22771851 0.06 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chr22_-_24316648 0.06 ENST00000403754.3
ENST00000430101.2
ENST00000398344.4
DDT
D-dopachrome tautomerase
chr10_-_99205607 0.06 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr14_+_104182105 0.06 ENST00000311141.2
ZFYVE21
zinc finger, FYVE domain containing 21
chr5_+_174151536 0.06 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chrX_+_8432871 0.06 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
VCX3B
variable charge, X-linked 3B
chr1_-_150849208 0.06 ENST00000358595.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr6_+_73076432 0.06 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr5_+_159848854 0.05 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
PTTG1
pituitary tumor-transforming 1
chr11_+_77532233 0.05 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr20_-_50418972 0.05 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr16_-_31105870 0.05 ENST00000394971.3
VKORC1
vitamin K epoxide reductase complex, subunit 1
chr14_+_104182061 0.05 ENST00000216602.6
ZFYVE21
zinc finger, FYVE domain containing 21
chr11_-_62414070 0.05 ENST00000540933.1
ENST00000346178.4
ENST00000356638.3
ENST00000534779.1
ENST00000525994.1
GANAB
glucosidase, alpha; neutral AB
chr6_-_119256311 0.05 ENST00000316316.6
MCM9
minichromosome maintenance complex component 9
chrX_-_21676442 0.05 ENST00000379499.2
KLHL34
kelch-like family member 34
chr1_+_62902308 0.05 ENST00000339950.4
USP1
ubiquitin specific peptidase 1
chr2_-_3521518 0.05 ENST00000382093.5
ADI1
acireductone dioxygenase 1
chr6_+_39760129 0.05 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_64345698 0.05 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr9_-_4666421 0.05 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr18_-_67624160 0.05 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr20_+_44441304 0.05 ENST00000352551.5
UBE2C
ubiquitin-conjugating enzyme E2C
chr6_-_30080876 0.05 ENST00000376734.3
TRIM31
tripartite motif containing 31
chr17_-_57229155 0.05 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr5_-_159846399 0.04 ENST00000297151.4
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr22_-_24303340 0.04 ENST00000404172.3
ENST00000290765.4
GSTT2B
glutathione S-transferase theta 2B (gene/pseudogene)
chr6_-_33385870 0.04 ENST00000488034.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr16_-_31106048 0.04 ENST00000300851.6
VKORC1
vitamin K epoxide reductase complex, subunit 1
chr16_+_3070313 0.04 ENST00000326577.4
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr16_+_1359511 0.04 ENST00000397514.3
ENST00000397515.2
ENST00000567383.1
ENST00000403747.2
ENST00000566587.1
UBE2I
ubiquitin-conjugating enzyme E2I
chr11_-_111741994 0.04 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr22_+_24309089 0.04 ENST00000215770.5
DDTL
D-dopachrome tautomerase-like
chr6_-_135271260 0.04 ENST00000265605.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr14_-_20801427 0.04 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr4_-_100242549 0.04 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chrX_-_8139308 0.04 ENST00000317103.4
VCX2
variable charge, X-linked 2
chr6_-_33385823 0.04 ENST00000494751.1
ENST00000374496.3
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr1_-_159915386 0.04 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr20_+_44441215 0.04 ENST00000356455.4
ENST00000405520.1
UBE2C
ubiquitin-conjugating enzyme E2C
chr16_-_31106211 0.04 ENST00000532364.1
ENST00000529564.1
ENST00000319788.7
ENST00000354895.4
ENST00000394975.2
RP11-196G11.1
VKORC1
Uncharacterized protein
vitamin K epoxide reductase complex, subunit 1
chr4_-_70080449 0.04 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr6_-_33385854 0.04 ENST00000488478.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chrX_-_153363188 0.04 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr19_+_1275917 0.04 ENST00000469144.1
C19orf24
chromosome 19 open reading frame 24
chr16_+_12059050 0.04 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_-_33385902 0.04 ENST00000374500.5
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr7_-_92107229 0.04 ENST00000603053.1
ERVW-1
endogenous retrovirus group W, member 1
chr12_-_120966943 0.04 ENST00000552443.1
ENST00000547736.1
ENST00000445328.2
ENST00000547943.1
ENST00000288532.6
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr6_-_135271219 0.03 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr11_+_77532155 0.03 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC
adipogenesis associated, Mth938 domain containing
chr16_+_89160269 0.03 ENST00000540697.1
ENST00000406948.3
ENST00000378345.4
ENST00000541755.2
ACSF3
acyl-CoA synthetase family member 3
chr4_-_66536057 0.03 ENST00000273854.3
EPHA5
EPH receptor A5
chr16_-_55866997 0.03 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr1_+_23345943 0.03 ENST00000400181.4
ENST00000542151.1
KDM1A
lysine (K)-specific demethylase 1A
chr6_-_33385655 0.03 ENST00000440279.3
ENST00000607266.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr16_-_58585513 0.03 ENST00000245138.4
ENST00000567285.1
CNOT1
CCR4-NOT transcription complex, subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ISX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1904482 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.1 0.3 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.2 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.3 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 0.3 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.2 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.0 0.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.0 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.1 GO:0090427 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0 0.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.4 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.0 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.1 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.3 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0044300 cerebellar mossy fiber(GO:0044300)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0070905 serine binding(GO:0070905)
0.1 0.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 0.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.3 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0047057 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.0 0.2 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.0 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.3 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
0.0 0.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR