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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for JUND

Z-value: 0.44

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Transcription factors associated with JUND

Gene Symbol Gene ID Gene Info
JUND
ENSG00000130522.4 JunD proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
JUNDhg19_v2_chr19_-_18392422_18392440-0.154.8e-01Click!

Activity profile of JUND motif

Sorted Z-values of JUND motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_89182178 2.32 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 2.29 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 2.02 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr7_+_55177416 1.46 ENST00000450046.1
ENST00000454757.2
EGFR
epidermal growth factor receptor
chr21_+_26934165 1.41 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr15_+_67420441 1.36 ENST00000558894.1
SMAD3
SMAD family member 3
chr1_-_153521597 1.15 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr1_-_153521714 1.04 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr3_+_11178779 0.98 ENST00000438284.2
HRH1
histamine receptor H1
chr17_-_28257080 0.75 ENST00000579954.1
ENST00000540801.1
ENST00000269033.3
ENST00000590153.1
ENST00000582084.1
SSH2
slingshot protein phosphatase 2
chrX_-_154563889 0.71 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr3_-_157251383 0.69 ENST00000487753.1
ENST00000489602.1
ENST00000461299.1
ENST00000479987.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_149539767 0.53 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr18_+_55888767 0.52 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr12_-_71182695 0.52 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr9_-_73029540 0.46 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr12_+_62654155 0.46 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr11_-_51412448 0.45 ENST00000319760.6
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr16_-_80603558 0.45 ENST00000567317.1
RP11-18F14.1
RP11-18F14.1
chr3_+_127770455 0.44 ENST00000464451.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr2_+_161993465 0.44 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr14_+_22977587 0.42 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr1_+_213224572 0.38 ENST00000543470.1
ENST00000366960.3
ENST00000366959.3
ENST00000543354.1
RPS6KC1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
chr12_+_54891495 0.38 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr4_-_122085469 0.37 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr1_-_6662919 0.37 ENST00000377658.4
ENST00000377663.3
KLHL21
kelch-like family member 21
chr18_-_74839891 0.32 ENST00000581878.1
MBP
myelin basic protein
chr19_-_35981358 0.31 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr2_+_161993412 0.31 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr18_+_9885961 0.29 ENST00000306084.6
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr11_-_5207612 0.28 ENST00000380367.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr3_-_37216055 0.28 ENST00000336686.4
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr9_-_95432536 0.26 ENST00000287996.3
IPPK
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr3_+_127771212 0.26 ENST00000243253.3
ENST00000481210.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr18_+_9885760 0.25 ENST00000536353.2
ENST00000584255.1
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr20_+_30946106 0.25 ENST00000375687.4
ENST00000542461.1
ASXL1
additional sex combs like 1 (Drosophila)
chr2_+_36923830 0.24 ENST00000379242.3
ENST00000389975.3
VIT
vitrin
chr18_-_5419797 0.24 ENST00000542146.1
ENST00000427684.2
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr1_-_153348067 0.23 ENST00000368737.3
S100A12
S100 calcium binding protein A12
chr3_+_30647994 0.22 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr6_+_159291090 0.22 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr1_-_153513170 0.22 ENST00000368717.2
S100A5
S100 calcium binding protein A5
chr10_-_81708854 0.22 ENST00000372292.3
SFTPD
surfactant protein D
chr3_-_11762202 0.21 ENST00000445411.1
ENST00000404339.1
ENST00000273038.3
VGLL4
vestigial like 4 (Drosophila)
chr12_+_62654119 0.21 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr17_+_28256874 0.20 ENST00000541045.1
ENST00000536908.2
EFCAB5
EF-hand calcium binding domain 5
chr19_-_54872556 0.20 ENST00000444687.1
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr17_-_39254391 0.20 ENST00000333822.4
KRTAP4-8
keratin associated protein 4-8
chr4_-_123542224 0.19 ENST00000264497.3
IL21
interleukin 21
chr2_+_201980827 0.19 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr6_+_159290917 0.19 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr2_-_152830479 0.18 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr11_-_5255696 0.18 ENST00000292901.3
ENST00000417377.1
HBD
hemoglobin, delta
chr16_+_31366536 0.18 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_+_46412345 0.18 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr4_-_123377880 0.18 ENST00000226730.4
IL2
interleukin 2
chr10_-_74114714 0.18 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr3_-_48632593 0.17 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr17_+_1936687 0.17 ENST00000570477.1
DPH1
diphthamide biosynthesis 1
chr6_-_43027105 0.17 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr1_+_85527987 0.17 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr3_-_87325728 0.17 ENST00000350375.2
POU1F1
POU class 1 homeobox 1
chr19_-_11545920 0.17 ENST00000356392.4
ENST00000591179.1
CCDC151
coiled-coil domain containing 151
chr17_-_7590745 0.16 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr2_-_231789941 0.16 ENST00000392040.1
ENST00000438398.1
GPR55
G protein-coupled receptor 55
chr2_+_68872954 0.16 ENST00000394342.2
PROKR1
prokineticin receptor 1
chr5_-_60140089 0.16 ENST00000507047.1
ENST00000438340.1
ENST00000425382.1
ENST00000508821.1
ELOVL7
ELOVL fatty acid elongase 7
chr10_+_18549645 0.15 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr16_-_72206034 0.15 ENST00000537465.1
ENST00000237353.10
PMFBP1
polyamine modulated factor 1 binding protein 1
chr15_-_51535208 0.14 ENST00000405913.3
ENST00000559878.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr15_+_59903975 0.14 ENST00000560585.1
ENST00000396065.1
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_-_60140009 0.14 ENST00000505959.1
ELOVL7
ELOVL fatty acid elongase 7
chr16_+_23847339 0.14 ENST00000303531.7
PRKCB
protein kinase C, beta
chr14_+_73525229 0.14 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr3_+_184032313 0.13 ENST00000392537.2
ENST00000444134.1
ENST00000450424.1
ENST00000421110.1
ENST00000382330.3
ENST00000426123.1
ENST00000350481.5
ENST00000455679.1
ENST00000440448.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr3_-_155011483 0.13 ENST00000489090.1
RP11-451G4.2
RP11-451G4.2
chr17_+_41052808 0.13 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr3_+_155860751 0.13 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr14_+_94492674 0.13 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr8_-_82359662 0.13 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr20_+_48429356 0.12 ENST00000361573.2
ENST00000541138.1
ENST00000539601.1
SLC9A8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr14_+_73525265 0.12 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr20_-_33460621 0.12 ENST00000427420.1
ENST00000336431.5
GGT7
gamma-glutamyltransferase 7
chr6_+_63921399 0.11 ENST00000356170.3
FKBP1C
FK506 binding protein 1C
chr3_-_49395705 0.11 ENST00000419349.1
GPX1
glutathione peroxidase 1
chr17_+_30771279 0.11 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_67266939 0.11 ENST00000304526.2
INSL5
insulin-like 5
chr10_+_49892904 0.10 ENST00000360890.2
WDFY4
WDFY family member 4
chr14_+_73525144 0.10 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr8_-_38008783 0.10 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr19_-_46285736 0.10 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr18_-_74207146 0.10 ENST00000443185.2
ZNF516
zinc finger protein 516
chr1_-_152297679 0.09 ENST00000368799.1
FLG
filaggrin
chr10_+_69865866 0.09 ENST00000354393.2
MYPN
myopalladin
chr19_+_35820064 0.09 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr17_-_33390667 0.09 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr2_+_169926047 0.09 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr10_-_27529486 0.09 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr10_-_30024716 0.08 ENST00000375398.2
ENST00000375400.3
SVIL
supervillin
chr20_+_48429233 0.08 ENST00000417961.1
SLC9A8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr18_+_9885934 0.08 ENST00000357775.5
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr13_+_109248500 0.08 ENST00000356711.2
MYO16
myosin XVI
chr1_+_160709029 0.08 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr14_-_24711470 0.08 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr10_-_61495760 0.08 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr3_+_184032283 0.08 ENST00000346169.2
ENST00000414031.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr5_+_145317356 0.08 ENST00000511217.1
SH3RF2
SH3 domain containing ring finger 2
chr5_+_126988732 0.07 ENST00000395322.3
CTXN3
cortexin 3
chr16_+_19467772 0.07 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr3_-_46608010 0.07 ENST00000395905.3
LRRC2
leucine rich repeat containing 2
chr3_+_191046810 0.07 ENST00000392455.3
ENST00000392456.3
CCDC50
coiled-coil domain containing 50
chr12_-_8218997 0.07 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr15_-_42565606 0.07 ENST00000307216.6
ENST00000448392.1
TMEM87A
transmembrane protein 87A
chr19_-_46285646 0.07 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr9_-_39239171 0.06 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr22_+_23101182 0.06 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr12_-_7818474 0.06 ENST00000229304.4
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chrX_+_22056165 0.06 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr18_+_32290218 0.06 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr10_-_31288398 0.06 ENST00000538351.2
ZNF438
zinc finger protein 438
chr3_-_150996239 0.06 ENST00000309170.3
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr10_-_50396425 0.06 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr3_-_52713729 0.05 ENST00000296302.7
ENST00000356770.4
ENST00000337303.4
ENST00000409057.1
ENST00000410007.1
ENST00000409114.3
ENST00000409767.1
ENST00000423351.1
PBRM1
polybromo 1
chr7_+_33765593 0.05 ENST00000311067.3
RP11-89N17.1
HCG1643653; Uncharacterized protein
chr3_+_130150307 0.05 ENST00000512836.1
COL6A5
collagen, type VI, alpha 5
chr3_+_98699880 0.05 ENST00000473756.1
LINC00973
long intergenic non-protein coding RNA 973
chr4_-_84035868 0.05 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chrY_+_15016725 0.04 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr2_+_113670548 0.04 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37
interleukin 37
chr15_-_59949667 0.04 ENST00000396061.1
GTF2A2
general transcription factor IIA, 2, 12kDa
chr2_-_152830441 0.04 ENST00000534999.1
ENST00000397327.2
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr11_-_82708435 0.04 ENST00000525117.1
ENST00000532548.1
RAB30
RAB30, member RAS oncogene family
chr16_-_20681177 0.04 ENST00000524149.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr8_-_19102999 0.04 ENST00000517949.1
RP11-1080G15.1
RP11-1080G15.1
chr1_+_160709055 0.04 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr2_+_102615416 0.03 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chrX_+_99839799 0.03 ENST00000373031.4
TNMD
tenomodulin
chr7_-_57207571 0.03 ENST00000331162.4
ZNF479
zinc finger protein 479
chr1_+_26605618 0.03 ENST00000270792.5
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr17_-_59668550 0.02 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr5_-_135701164 0.02 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr19_+_11546093 0.02 ENST00000591462.1
PRKCSH
protein kinase C substrate 80K-H
chr11_+_59856130 0.01 ENST00000278888.3
MS4A2
membrane-spanning 4-domains, subfamily A, member 2
chr16_+_29127282 0.01 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr5_+_145583107 0.01 ENST00000506502.1
RBM27
RNA binding motif protein 27
chrX_-_111923145 0.01 ENST00000371968.3
ENST00000536453.1
LHFPL1
lipoma HMGIC fusion partner-like 1
chr4_-_104119528 0.01 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr10_+_17686124 0.01 ENST00000377524.3
STAM
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr11_-_66104237 0.01 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr10_+_120116527 0.01 ENST00000445161.1
LINC00867
long intergenic non-protein coding RNA 867
chr16_+_28996364 0.01 ENST00000564277.1
LAT
linker for activation of T cells
chr19_+_13842559 0.01 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr15_+_38226827 0.00 ENST00000559502.1
ENST00000558148.1
ENST00000558158.1
TMCO5A
transmembrane and coiled-coil domains 5A
chr21_-_43786634 0.00 ENST00000291527.2
TFF1
trefoil factor 1
chr1_-_117753540 0.00 ENST00000328189.3
ENST00000369458.3
VTCN1
V-set domain containing T cell activation inhibitor 1
chr11_-_4719072 0.00 ENST00000396950.3
ENST00000532598.1
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chrX_-_154493791 0.00 ENST00000369454.3
RAB39B
RAB39B, member RAS oncogene family
chr4_-_100356291 0.00 ENST00000476959.1
ENST00000482593.1
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr8_-_141774467 0.00 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr5_-_96518907 0.00 ENST00000508447.1
ENST00000283109.3
RIOK2
RIO kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.4 1.5 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.3 1.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 0.7 GO:0039019 pronephric nephron development(GO:0039019)
0.2 0.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 1.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1 0.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.4 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.3 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.2 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 0.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.5 GO:0051414 response to cortisol(GO:0051414)
0.1 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1 0.3 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.2 GO:0051097 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.1 0.1 GO:0071373 cellular response to luteinizing hormone stimulus(GO:0071373)
0.0 0.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.0 0.7 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.6 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.3 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0009608 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.0 0.2 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.2 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.7 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.0 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.1 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.2 1.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 6.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.6 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.4 GO:0005827 polar microtubule(GO:0005827)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0097413 Lewy body(GO:0097413)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 1.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.3 1.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.0 GO:0004969 histamine receptor activity(GO:0004969)
0.1 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.2 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 0.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.1 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.5 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 1.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 1.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)