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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for KLF1

Z-value: 0.83

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Transcription factors associated with KLF1

Gene Symbol Gene ID Gene Info
KLF1
ENSG00000105610.4 Kruppel like factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF1hg19_v2_chr19_-_12997995_129980210.404.8e-02Click!

Activity profile of KLF1 motif

Sorted Z-values of KLF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_101963482 1.70 ENST00000419477.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr17_+_7210898 1.62 ENST00000572815.1
EIF5A
eukaryotic translation initiation factor 5A
chr22_-_39639021 1.54 ENST00000455790.1
PDGFB
platelet-derived growth factor beta polypeptide
chr5_-_115910630 1.27 ENST00000343348.6
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr5_-_131826457 1.23 ENST00000437654.1
ENST00000245414.4
IRF1
interferon regulatory factor 1
chr3_-_127542021 1.16 ENST00000434178.2
MGLL
monoglyceride lipase
chr9_+_35732312 1.12 ENST00000353704.2
CREB3
cAMP responsive element binding protein 3
chr15_+_90931450 1.07 ENST00000268182.5
ENST00000560738.1
ENST00000560418.1
IQGAP1
IQ motif containing GTPase activating protein 1
chrX_-_71526741 1.06 ENST00000454225.1
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr10_+_104155450 1.06 ENST00000471698.1
ENST00000189444.6
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr7_+_134430212 1.04 ENST00000436461.2
CALD1
caldesmon 1
chr5_-_115910091 0.96 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr16_-_31161380 0.95 ENST00000569305.1
ENST00000418068.2
ENST00000268281.4
PRSS36
protease, serine, 36
chr11_-_73471655 0.95 ENST00000400470.2
RAB6A
RAB6A, member RAS oncogene family
chr16_+_50776021 0.94 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr9_+_74764278 0.94 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr8_-_101962777 0.89 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr6_-_3227877 0.87 ENST00000259818.7
TUBB2B
tubulin, beta 2B class IIb
chr18_-_48723690 0.84 ENST00000406189.3
MEX3C
mex-3 RNA binding family member C
chr19_+_8117636 0.84 ENST00000253451.4
ENST00000315626.4
CCL25
chemokine (C-C motif) ligand 25
chr5_-_95297534 0.82 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr11_+_66384053 0.79 ENST00000310137.4
ENST00000393979.3
ENST00000409372.1
ENST00000443702.1
ENST00000409738.4
ENST00000514361.3
ENST00000503028.2
ENST00000412278.2
ENST00000500635.2
RBM14
RBM4
RBM14-RBM4
RNA binding motif protein 14
RNA binding motif protein 4
RBM14-RBM4 readthrough
chr6_-_43596899 0.78 ENST00000307126.5
ENST00000452781.1
GTPBP2
GTP binding protein 2
chr12_-_57504069 0.78 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr16_+_50775948 0.76 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD
cylindromatosis (turban tumor syndrome)
chr2_-_153573965 0.76 ENST00000448428.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr17_+_7210921 0.74 ENST00000573542.1
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_27816556 0.73 ENST00000536657.1
WASF2
WAS protein family, member 2
chr3_-_186080012 0.72 ENST00000544847.1
ENST00000265022.3
DGKG
diacylglycerol kinase, gamma 90kDa
chr9_-_38069208 0.70 ENST00000377707.3
ENST00000377700.4
SHB
Src homology 2 domain containing adaptor protein B
chr16_+_50775971 0.70 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD
cylindromatosis (turban tumor syndrome)
chr7_+_86274145 0.67 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3
glutamate receptor, metabotropic 3
chr10_+_120967072 0.67 ENST00000392870.2
GRK5
G protein-coupled receptor kinase 5
chr5_-_95297678 0.66 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr17_-_39507064 0.65 ENST00000007735.3
KRT33A
keratin 33A
chr1_+_183441500 0.64 ENST00000456731.2
SMG7
SMG7 nonsense mediated mRNA decay factor
chr8_+_123793633 0.64 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr22_-_36357671 0.63 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_160919112 0.63 ENST00000283243.7
ENST00000392771.1
PLA2R1
phospholipase A2 receptor 1, 180kDa
chr17_-_1619491 0.62 ENST00000570416.1
ENST00000575626.1
ENST00000610106.1
ENST00000608198.1
ENST00000609442.1
ENST00000334146.3
ENST00000576489.1
ENST00000608245.1
ENST00000609398.1
ENST00000608913.1
ENST00000574016.1
ENST00000571091.1
ENST00000573127.1
ENST00000609990.1
ENST00000576749.1
MIR22HG
MIR22 host gene (non-protein coding)
chr6_+_106546808 0.62 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr4_+_2845655 0.61 ENST00000511797.1
ENST00000513328.2
ENST00000508277.1
ENST00000503455.2
ADD1
adducin 1 (alpha)
chr1_-_159893507 0.60 ENST00000368096.1
TAGLN2
transgelin 2
chr17_-_1619535 0.59 ENST00000573075.1
ENST00000574306.1
MIR22HG
MIR22 host gene (non-protein coding)
chr12_+_100661156 0.58 ENST00000360820.2
SCYL2
SCY1-like 2 (S. cerevisiae)
chr15_+_100106126 0.58 ENST00000558812.1
ENST00000338042.6
MEF2A
myocyte enhancer factor 2A
chr8_+_120428546 0.57 ENST00000259526.3
NOV
nephroblastoma overexpressed
chr15_+_100106155 0.57 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr3_-_49449350 0.57 ENST00000454011.2
ENST00000445425.1
ENST00000422781.1
RHOA
ras homolog family member A
chr6_-_30654977 0.56 ENST00000399199.3
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr1_-_111743285 0.56 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr3_-_113464906 0.56 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr19_+_8117881 0.56 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chr17_-_7493390 0.55 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chr1_-_31712401 0.55 ENST00000373736.2
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr6_-_82462425 0.55 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr15_+_75074410 0.54 ENST00000439220.2
CSK
c-src tyrosine kinase
chr1_-_27816641 0.54 ENST00000430629.2
WASF2
WAS protein family, member 2
chr6_-_83903600 0.54 ENST00000506587.1
ENST00000507554.1
PGM3
phosphoglucomutase 3
chr22_+_38071615 0.53 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr3_-_88108212 0.52 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr17_-_42277203 0.52 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr4_-_103748696 0.51 ENST00000321805.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_+_23846210 0.51 ENST00000339180.4
ENST00000342473.4
ENST00000397227.3
ENST00000555731.1
CMTM5
CKLF-like MARVEL transmembrane domain containing 5
chr17_+_65374075 0.51 ENST00000581322.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr14_+_23845995 0.51 ENST00000359320.3
CMTM5
CKLF-like MARVEL transmembrane domain containing 5
chr1_-_167883327 0.51 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chrX_+_70503433 0.50 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr19_+_55795493 0.50 ENST00000309383.1
BRSK1
BR serine/threonine kinase 1
chr2_-_153573887 0.50 ENST00000493468.2
ENST00000545856.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr3_+_39093481 0.50 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WDR48
WD repeat domain 48
chr3_+_50273625 0.50 ENST00000536647.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr9_-_34048873 0.49 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
UBAP2
ubiquitin associated protein 2
chr12_-_49393092 0.49 ENST00000421952.2
DDN
dendrin
chr6_-_114664180 0.48 ENST00000312719.5
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr17_-_2614927 0.48 ENST00000435359.1
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr5_+_173315283 0.48 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr12_+_116997186 0.47 ENST00000306985.4
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr1_+_35225339 0.47 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr8_+_38614807 0.46 ENST00000330691.6
ENST00000348567.4
TACC1
transforming, acidic coiled-coil containing protein 1
chr1_-_243326612 0.46 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr14_+_42077552 0.45 ENST00000554120.1
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr6_-_83902933 0.44 ENST00000512866.1
ENST00000510258.1
ENST00000503094.1
ENST00000283977.4
ENST00000513973.1
ENST00000508748.1
PGM3
phosphoglucomutase 3
chr7_-_25164868 0.44 ENST00000409409.1
ENST00000409764.1
ENST00000413447.1
CYCS
cytochrome c, somatic
chr7_-_80548667 0.44 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_-_64648273 0.43 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chr19_-_18654293 0.43 ENST00000597547.1
ENST00000222308.4
ENST00000544835.3
ENST00000610101.1
ENST00000597960.3
ENST00000608443.1
FKBP8
FK506 binding protein 8, 38kDa
chr17_-_7141490 0.42 ENST00000574236.1
ENST00000572789.1
PHF23
PHD finger protein 23
chr4_-_10117949 0.41 ENST00000508079.1
WDR1
WD repeat domain 1
chr2_+_102314161 0.41 ENST00000425019.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_-_204183071 0.40 ENST00000308302.3
GOLT1A
golgi transport 1A
chr17_+_7210852 0.40 ENST00000576930.1
EIF5A
eukaryotic translation initiation factor 5A
chr11_-_62521614 0.40 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr8_-_145018080 0.40 ENST00000354589.3
PLEC
plectin
chr8_+_81398444 0.40 ENST00000455036.3
ENST00000426744.2
ZBTB10
zinc finger and BTB domain containing 10
chr20_+_35974532 0.39 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr11_+_67183141 0.39 ENST00000531040.1
ENST00000307823.3
ENST00000423745.2
CARNS1
carnosine synthase 1
chr6_-_138428613 0.39 ENST00000421351.3
PERP
PERP, TP53 apoptosis effector
chr6_-_131291572 0.39 ENST00000529208.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr13_+_24553933 0.38 ENST00000424834.2
ENST00000439928.2
SPATA13
RP11-309I15.1
spermatogenesis associated 13
RP11-309I15.1
chr13_+_88324870 0.38 ENST00000325089.6
SLITRK5
SLIT and NTRK-like family, member 5
chr19_+_8455200 0.38 ENST00000601897.1
ENST00000594216.1
RAB11B
RAB11B, member RAS oncogene family
chr19_+_41698927 0.38 ENST00000310054.4
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr11_+_1074870 0.37 ENST00000441003.2
ENST00000359061.5
MUC2
mucin 2, oligomeric mucus/gel-forming
chr12_+_7072354 0.37 ENST00000537269.1
U47924.27
U47924.27
chr10_+_31610064 0.37 ENST00000446923.2
ENST00000559476.1
ZEB1
zinc finger E-box binding homeobox 1
chr1_-_222885770 0.37 ENST00000355727.2
ENST00000340020.6
AIDA
axin interactor, dorsalization associated
chr16_-_4466622 0.37 ENST00000570645.1
ENST00000574025.1
ENST00000572898.1
ENST00000537233.2
ENST00000571059.1
ENST00000251166.4
CORO7
coronin 7
chr11_-_65625330 0.36 ENST00000531407.1
CFL1
cofilin 1 (non-muscle)
chr16_+_30675654 0.36 ENST00000287468.5
ENST00000395073.2
FBRS
fibrosin
chr1_-_159894319 0.36 ENST00000320307.4
TAGLN2
transgelin 2
chr3_-_197024965 0.36 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chr3_-_197024394 0.36 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1
discs, large homolog 1 (Drosophila)
chr1_-_167883353 0.35 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr16_+_89989687 0.35 ENST00000315491.7
ENST00000555576.1
ENST00000554336.1
ENST00000553967.1
TUBB3
Tubulin beta-3 chain
chr3_-_49449521 0.35 ENST00000431929.1
ENST00000418115.1
RHOA
ras homolog family member A
chrX_-_48768913 0.35 ENST00000376529.3
ENST00000247138.5
ENST00000413561.2
ENST00000452555.2
ENST00000445167.2
ENST00000376512.1
SLC35A2
solute carrier family 35 (UDP-galactose transporter), member A2
chr19_+_36119975 0.35 ENST00000589559.1
ENST00000360475.4
RBM42
RNA binding motif protein 42
chr6_-_39282329 0.35 ENST00000373231.4
KCNK17
potassium channel, subfamily K, member 17
chr9_-_37465396 0.34 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr6_+_83903061 0.34 ENST00000369724.4
ENST00000539997.1
RWDD2A
RWD domain containing 2A
chr10_+_98592009 0.34 ENST00000540664.1
ENST00000371103.3
LCOR
ligand dependent nuclear receptor corepressor
chr8_-_27115931 0.34 ENST00000523048.1
STMN4
stathmin-like 4
chr20_+_60878005 0.34 ENST00000253003.2
ADRM1
adhesion regulating molecule 1
chr2_-_153574480 0.34 ENST00000410080.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr17_-_27949911 0.34 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
CORO6
coronin 6
chr5_+_149546334 0.34 ENST00000231656.8
CDX1
caudal type homeobox 1
chr19_+_36120009 0.34 ENST00000589871.1
RBM42
RNA binding motif protein 42
chr11_+_67183557 0.33 ENST00000445895.2
CARNS1
carnosine synthase 1
chr12_-_54019755 0.33 ENST00000588078.1
ENST00000551480.2
ENST00000548118.2
ENST00000456903.4
ENST00000591834.1
ATF7
RP11-793H13.10
activating transcription factor 7
Uncharacterized protein
chr12_+_51632600 0.33 ENST00000549555.1
ENST00000439799.2
ENST00000425012.2
DAZAP2
DAZ associated protein 2
chr12_+_51632638 0.33 ENST00000549732.2
DAZAP2
DAZ associated protein 2
chr19_+_45681997 0.33 ENST00000433642.2
BLOC1S3
biogenesis of lysosomal organelles complex-1, subunit 3
chr15_-_89878025 0.33 ENST00000268124.5
ENST00000442287.2
POLG
polymerase (DNA directed), gamma
chr7_-_138794081 0.32 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr20_-_4804244 0.32 ENST00000379400.3
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr12_+_54332535 0.31 ENST00000243056.3
HOXC13
homeobox C13
chr1_+_29213678 0.31 ENST00000347529.3
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_+_35629702 0.31 ENST00000351325.4
FXYD1
FXYD domain containing ion transport regulator 1
chr6_-_39282221 0.31 ENST00000453413.2
KCNK17
potassium channel, subfamily K, member 17
chrX_-_23761317 0.31 ENST00000492081.1
ENST00000379303.5
ENST00000336430.7
ACOT9
acyl-CoA thioesterase 9
chr15_+_75074385 0.31 ENST00000220003.9
CSK
c-src tyrosine kinase
chr11_-_57089671 0.31 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr6_-_84140757 0.31 ENST00000541327.1
ENST00000369705.3
ENST00000543031.1
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_+_46850320 0.30 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr19_+_46850251 0.30 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr19_+_35630022 0.30 ENST00000589209.1
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_62313090 0.30 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr5_+_159895275 0.30 ENST00000517927.1
MIR146A
microRNA 146a
chr17_-_39526052 0.30 ENST00000251646.3
KRT33B
keratin 33B
chr11_-_75379612 0.29 ENST00000526740.1
MAP6
microtubule-associated protein 6
chr4_+_39699664 0.29 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
UBE2K
ubiquitin-conjugating enzyme E2K
chrX_+_23352133 0.29 ENST00000379361.4
PTCHD1
patched domain containing 1
chr12_-_54020107 0.29 ENST00000588232.1
ENST00000548446.2
ENST00000420353.2
ENST00000591397.1
ENST00000415113.1
ATF7
activating transcription factor 7
chr3_+_38206975 0.29 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr19_-_44008863 0.29 ENST00000601646.1
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr4_+_146403912 0.29 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1
SMAD family member 1
chr6_-_33548006 0.28 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr6_-_30709980 0.28 ENST00000416018.1
ENST00000445853.1
ENST00000413165.1
ENST00000418160.1
FLOT1
flotillin 1
chr17_+_30814707 0.28 ENST00000584792.1
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_-_23670752 0.28 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_+_6845384 0.28 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr11_+_64009072 0.28 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr2_+_220379052 0.28 ENST00000347842.3
ENST00000358078.4
ASIC4
acid-sensing (proton-gated) ion channel family member 4
chr17_-_7590745 0.27 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr16_+_67022633 0.27 ENST00000398354.1
ENST00000326686.5
CES4A
carboxylesterase 4A
chr5_+_71014990 0.27 ENST00000296777.4
CARTPT
CART prepropeptide
chr12_-_49365501 0.26 ENST00000403957.1
ENST00000301061.4
WNT10B
wingless-type MMTV integration site family, member 10B
chr17_+_46125707 0.26 ENST00000584137.1
ENST00000362042.3
ENST00000585291.1
ENST00000357480.5
NFE2L1
nuclear factor, erythroid 2-like 1
chr9_-_35732362 0.26 ENST00000314888.9
ENST00000540444.1
TLN1
talin 1
chr5_-_112257914 0.26 ENST00000513339.1
ENST00000545426.1
ENST00000504247.1
REEP5
receptor accessory protein 5
chr19_-_10047219 0.26 ENST00000264833.4
OLFM2
olfactomedin 2
chr6_+_106534192 0.26 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr6_-_33547975 0.26 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr2_+_85360499 0.26 ENST00000282111.3
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr12_-_56694142 0.26 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr4_+_2845547 0.26 ENST00000264758.7
ENST00000446856.1
ENST00000398125.1
ADD1
adducin 1 (alpha)
chr8_+_81397876 0.25 ENST00000430430.1
ZBTB10
zinc finger and BTB domain containing 10
chr12_-_93835665 0.25 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chrX_-_69479654 0.25 ENST00000374519.2
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr6_+_11094266 0.25 ENST00000416247.2
SMIM13
small integral membrane protein 13
chr15_-_101142401 0.25 ENST00000314742.8
LINS
lines homolog (Drosophila)
chr16_+_67022582 0.25 ENST00000541479.1
ENST00000338718.4
CES4A
carboxylesterase 4A
chr17_+_7210294 0.25 ENST00000336452.7
EIF5A
eukaryotic translation initiation factor 5A
chr5_+_71403061 0.25 ENST00000512974.1
ENST00000296755.7
MAP1B
microtubule-associated protein 1B
chr1_-_36851489 0.25 ENST00000373130.3
ENST00000373132.3
STK40
serine/threonine kinase 40
chr7_+_87257854 0.25 ENST00000394654.3
RUNDC3B
RUN domain containing 3B
chr16_+_67022476 0.24 ENST00000540947.2
CES4A
carboxylesterase 4A
chrX_+_133507389 0.24 ENST00000370800.4
PHF6
PHD finger protein 6
chr3_+_8775466 0.24 ENST00000343849.2
ENST00000397368.2
CAV3
caveolin 3
chr8_-_101963677 0.24 ENST00000395956.3
ENST00000395953.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr1_-_23670813 0.24 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr5_-_139283982 0.24 ENST00000340391.3
NRG2
neuregulin 2
chr1_-_36851475 0.23 ENST00000373129.3
STK40
serine/threonine kinase 40
chr5_-_83680603 0.23 ENST00000296591.5
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr10_+_96443378 0.23 ENST00000285979.6
CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
chr19_-_44285401 0.23 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_+_39687596 0.23 ENST00000339852.4
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr5_-_168006591 0.23 ENST00000239231.6
PANK3
pantothenate kinase 3
chr17_+_39845134 0.23 ENST00000591776.1
ENST00000469257.1
EIF1
eukaryotic translation initiation factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:1990108 protein linear deubiquitination(GO:1990108)
0.4 1.5 GO:0090678 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.4 3.0 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 1.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.3 1.1 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.2 1.5 GO:0071105 response to interleukin-11(GO:0071105)
0.2 1.4 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 0.9 GO:1990869 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.2 0.9 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 1.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.2 1.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.2 1.0 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.2 0.8 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 0.9 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 2.8 GO:0090168 Golgi reassembly(GO:0090168)
0.2 0.5 GO:0048627 myoblast development(GO:0048627)
0.2 0.5 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.2 0.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 0.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 0.9 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.2 0.2 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.2 1.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 1.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005) ERK5 cascade(GO:0070375)
0.2 0.6 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 2.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.9 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.4 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 0.1 GO:1903179 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.1 0.4 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.3 GO:2000308 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.1 0.9 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.1 0.8 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.1 0.6 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.4 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 0.4 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.4 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.3 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.1 0.7 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.3 GO:0051885 positive regulation of anagen(GO:0051885)
0.1 0.9 GO:1902669 positive regulation of axon guidance(GO:1902669)
0.1 0.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.6 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 1.1 GO:1900086 regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.1 0.6 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.1 0.8 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.2 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 0.2 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.7 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.7 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.7 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.1 0.6 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.5 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.1 0.2 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.1 0.2 GO:0060988 lipid tube assembly(GO:0060988)
0.1 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.3 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.3 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1 0.8 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.2 GO:1902868 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.2 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.5 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.6 GO:0002934 desmosome organization(GO:0002934)
0.0 1.2 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.4 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.3 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.0 0.6 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.8 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.3 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.4 GO:0045054 constitutive secretory pathway(GO:0045054)
0.0 0.4 GO:0015824 proline transport(GO:0015824)
0.0 0.2 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0072553 terminal button organization(GO:0072553)
0.0 0.2 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.5 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.2 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.4 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 1.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.7 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.7 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.3 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.9 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.3 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0002125 maternal aggressive behavior(GO:0002125)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.3 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.0 GO:1902463 establishment of Sertoli cell barrier(GO:0097368) protein localization to cell leading edge(GO:1902463)
0.0 0.1 GO:0090650 rRNA transport(GO:0051029) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 1.5 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.3 GO:0021756 striatum development(GO:0021756)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.2 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.4 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.0 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.0 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.1 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 0.2 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.5 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.3 3.0 GO:0005642 annulate lamellae(GO:0005642)
0.2 0.9 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.8 GO:0031415 NatA complex(GO:0031415)
0.1 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.3 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.1 0.4 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 1.3 GO:0031209 SCAR complex(GO:0031209)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 0.7 GO:0043219 lateral loop(GO:0043219)
0.1 1.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.2 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.1 0.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.5 GO:0042382 paraspeckles(GO:0042382)
0.0 0.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.2 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 1.8 GO:0097542 ciliary tip(GO:0097542)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 1.0 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.0 GO:0031417 NatC complex(GO:0031417)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.3 0.8 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.2 0.7 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.2 2.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 0.6 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
0.2 3.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 0.9 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 1.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.5 GO:0030395 lactose binding(GO:0030395)
0.1 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 1.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.5 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.2 GO:0015235 cobalamin transporter activity(GO:0015235)
0.1 0.2 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.1 0.7 GO:0097016 L27 domain binding(GO:0097016)
0.1 1.4 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 1.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.3 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.2 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 1.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 1.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 2.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0070878 primary miRNA binding(GO:0070878)
0.0 0.1 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.4 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 1.0 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0005220 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 3.2 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0097001 glycosphingolipid binding(GO:0043208) ceramide binding(GO:0097001)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.0 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 3.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 2.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 3.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 1.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.7 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 1.1 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 3.0 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 1.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline