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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for KLF14_SP8
Z-value: 1.74
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Transcription factors associated with KLF14_SP8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP8 | hg19_v2_chr7_-_20826504_20826526 | -0.46 | 2.0e-02 | Click! |
| KLF14 | hg19_v2_chr7_-_130418888_130418888 | -0.40 | 4.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF14_SP8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.9 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 3.1 | 9.3 | GO:1902365 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.6 | 8.4 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.7 | 7.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 1.9 | 7.7 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 0.8 | 7.5 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.8 | 7.1 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.4 | 6.5 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
| 1.2 | 6.0 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.3 | 5.8 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.3 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.1 | 7.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.5 | 7.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 7.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 6.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.2 | 5.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 5.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.5 | 5.4 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.5 | 5.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.3 | 4.3 | GO:0000124 | SAGA complex(GO:0000124) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 16.7 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 13.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 10.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 9.7 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.6 | 9.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.4 | 8.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 6.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 6.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.5 | 6.5 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 11.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 8.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 6.5 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 6.1 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 6.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 5.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 5.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.0 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 8.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 7.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 7.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 7.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 5.5 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 5.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 5.2 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 4.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 4.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |