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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for KLF16_SP2
Z-value: 1.75
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP2 | hg19_v2_chr17_+_45973516_45973618 | -0.28 | 1.7e-01 | Click! |
| KLF16 | hg19_v2_chr19_-_1863567_1863586 | -0.08 | 7.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.6 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.2 | 11.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 1.1 | 11.0 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 0.6 | 10.3 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.4 | 10.3 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 2.5 | 9.9 | GO:2000691 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.7 | 9.2 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.2 | 9.2 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 0.3 | 8.3 | GO:0014733 | regulation of skeletal muscle adaptation(GO:0014733) |
| 0.3 | 7.8 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 10.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 9.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 9.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 8.5 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 8.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 7.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 7.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 6.7 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.1 | 6.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 12.5 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.1 | 11.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.8 | 10.8 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.3 | 10.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.6 | 9.7 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 9.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 8.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 7.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 2.6 | 7.7 | GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 10.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 10.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.3 | 10.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 8.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 7.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 6.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.6 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 8.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 7.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 7.8 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.3 | 7.5 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.2 | 7.1 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 6.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 6.2 | REACTOME RNA POL III TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.2 | 6.0 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 5.9 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |