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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for KLF7

Z-value: 0.30

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208031943_2080319910.222.8e-01Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_161102367 0.95 ENST00000464113.1
DEDD
death effector domain containing
chr1_-_161102421 0.75 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr17_-_18218237 0.52 ENST00000542570.1
TOP3A
topoisomerase (DNA) III alpha
chr15_+_92937144 0.34 ENST00000539113.1
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr3_+_105085734 0.33 ENST00000306107.5
ALCAM
activated leukocyte cell adhesion molecule
chr8_+_17104539 0.30 ENST00000521829.1
ENST00000521005.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr15_+_92937058 0.30 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_+_43603552 0.29 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr17_+_18218587 0.26 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr1_-_157108266 0.24 ENST00000326786.4
ETV3
ets variant 3
chr19_+_39390587 0.23 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_+_39390320 0.22 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_-_19281203 0.19 ENST00000487415.2
B9D1
B9 protein domain 1
chr17_-_18218270 0.19 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr5_+_173315283 0.19 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr1_-_21948906 0.17 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr13_-_108867101 0.16 ENST00000356922.4
LIG4
ligase IV, DNA, ATP-dependent
chr9_+_130565487 0.15 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr6_-_109703600 0.14 ENST00000512821.1
CD164
CD164 molecule, sialomucin
chr9_+_130565147 0.13 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr12_-_49582593 0.12 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr2_-_74710078 0.11 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr14_+_29234870 0.11 ENST00000382535.3
FOXG1
forkhead box G1
chr6_-_109703634 0.11 ENST00000324953.5
ENST00000310786.4
ENST00000275080.7
ENST00000413644.2
CD164
CD164 molecule, sialomucin
chr8_+_72587535 0.10 ENST00000519840.1
ENST00000521131.1
RP11-1144P22.1
RP11-1144P22.1
chr5_+_141348721 0.10 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr6_-_109703663 0.10 ENST00000368961.5
CD164
CD164 molecule, sialomucin
chr16_+_31539197 0.10 ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr3_+_178866199 0.10 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr6_-_33239712 0.07 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr6_+_31865552 0.07 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr19_-_7694417 0.06 ENST00000358368.4
ENST00000534844.1
XAB2
XPA binding protein 2
chr17_-_4269768 0.05 ENST00000396981.2
UBE2G1
ubiquitin-conjugating enzyme E2G 1
chr8_-_17104356 0.05 ENST00000361272.4
ENST00000523917.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr17_+_38375574 0.03 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
WIPF2
WAS/WASL interacting protein family, member 2
chr16_+_81772633 0.03 ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
ENST00000565054.1
RP11-960L18.1
PLCG2
RP11-960L18.1
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr5_+_141348598 0.03 ENST00000394520.2
ENST00000347642.3
RNF14
ring finger protein 14
chr2_-_188430478 0.03 ENST00000421427.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr22_-_30987849 0.02 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chrX_-_92928557 0.02 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr3_+_186353756 0.01 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr2_+_97779233 0.01 ENST00000461153.2
ENST00000420699.2
ANKRD36
ankyrin repeat domain 36
chr22_-_30987837 0.01 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr6_-_33239612 0.01 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr19_-_39390350 0.01 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr1_-_6453399 0.00 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr16_+_31539183 0.00 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr6_+_33239787 0.00 ENST00000439602.2
ENST00000474973.1
RPS18
ribosomal protein S18

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.2 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
0.1 0.2 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.0 0.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.7 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.3 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.0 0.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 1.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0032807 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.0 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.7 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI