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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for LEF1
Z-value: 1.05
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Transcription factors associated with LEF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LEF1 | hg19_v2_chr4_-_109089573_109089585, hg19_v2_chr4_-_109090106_109090124 | -0.38 | 5.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_72441315 Show fit | 10.39 |
ENST00000305425.4
ENST00000313174.7 ENST00000354591.4 |
dachshund homolog 1 (Drosophila) |
|
| chr13_-_72440901 Show fit | 9.97 |
ENST00000359684.2
|
dachshund homolog 1 (Drosophila) |
|
| chr4_-_186877502 Show fit | 5.82 |
ENST00000431902.1
ENST00000284776.7 ENST00000415274.1 |
sorbin and SH3 domain containing 2 |
|
| chr1_+_100111580 Show fit | 5.48 |
ENST00000605497.1
|
palmdelphin |
|
| chr1_+_100111479 Show fit | 5.27 |
ENST00000263174.4
|
palmdelphin |
|
| chr13_+_32605437 Show fit | 4.27 |
ENST00000380250.3
|
furry homolog (Drosophila) |
|
| chr15_+_96869165 Show fit | 3.85 |
ENST00000421109.2
|
nuclear receptor subfamily 2, group F, member 2 |
|
| chr1_+_82266053 Show fit | 3.82 |
ENST00000370715.1
ENST00000370713.1 ENST00000319517.6 ENST00000370717.2 ENST00000394879.1 ENST00000271029.4 ENST00000335786.5 |
latrophilin 2 |
|
| chr3_-_18466026 Show fit | 3.56 |
ENST00000417717.2
|
SATB homeobox 1 |
|
| chr7_-_27219849 Show fit | 3.50 |
ENST00000396344.4
|
homeobox A10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of LEF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 20.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.3 | 10.7 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.0 | 9.0 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.2 | 8.4 | GO:0060065 | uterus development(GO:0060065) |
| 0.2 | 6.6 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 5.8 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.2 | 4.9 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.6 | 4.3 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 4.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 4.3 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 13.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 7.1 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 5.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 4.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 3.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 3.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 3.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 2.8 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 2.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 20.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 14.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.0 | 10.7 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 5.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 5.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 4.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 4.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.5 | 3.8 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 3.8 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 3.8 | GO:0051393 | alpha-actinin binding(GO:0051393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 7.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 4.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 4.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 3.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 3.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 7.1 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 6.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 3.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 2.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 2.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 2.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.9 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |