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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for LEF1

Z-value: 1.05

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109089573_109089585,
hg19_v2_chr4_-_109090106_109090124		-0.385.8e-02Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_72441315 10.39 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr13_-_72440901 9.97 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr4_-_186877502 5.82 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr1_+_100111580 5.48 ENST00000605497.1
PALMD
palmdelphin
chr1_+_100111479 5.27 ENST00000263174.4
PALMD
palmdelphin
chr13_+_32605437 4.27 ENST00000380250.3
FRY
furry homolog (Drosophila)
chr15_+_96869165 3.85 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_+_82266053 3.82 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr3_-_18466026 3.56 ENST00000417717.2
SATB1
SATB homeobox 1
chr7_-_27219849 3.50 ENST00000396344.4
HOXA10
homeobox A10
chr3_-_66024213 3.26 ENST00000483466.1
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr1_+_78383813 3.14 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr1_+_61330931 2.88 ENST00000371191.1
NFIA
nuclear factor I/A
chr8_-_80993010 2.76 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr1_+_61548225 2.71 ENST00000371187.3
NFIA
nuclear factor I/A
chr7_-_27213893 2.70 ENST00000283921.4
HOXA10
homeobox A10
chr4_-_16900184 2.69 ENST00000515064.1
LDB2
LIM domain binding 2
chr4_-_16900410 2.69 ENST00000304523.5
LDB2
LIM domain binding 2
chr4_-_16900217 2.65 ENST00000441778.2
LDB2
LIM domain binding 2
chr4_-_16900242 2.64 ENST00000502640.1
ENST00000506732.1
LDB2
LIM domain binding 2
chr15_-_52944231 2.60 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr9_+_36036430 2.54 ENST00000377966.3
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr3_-_148804275 2.47 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr18_+_72922710 2.41 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr8_-_124553437 2.35 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr3_+_20081515 2.30 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr1_+_61548374 2.27 ENST00000485903.2
ENST00000371185.2
ENST00000371184.2
NFIA
nuclear factor I/A
chr8_-_93107443 2.08 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_84630053 2.05 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_176994408 2.02 ENST00000429017.1
ENST00000313173.4
ENST00000544999.1
HOXD8
homeobox D8
chr2_-_183387430 1.96 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_+_107244229 1.87 ENST00000456419.1
ENST00000402163.2
BBX
bobby sox homolog (Drosophila)
chr1_+_164528866 1.85 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr4_+_30721968 1.83 ENST00000361762.2
PCDH7
protocadherin 7
chr1_+_6845578 1.80 ENST00000467404.2
ENST00000439411.2
CAMTA1
calmodulin binding transcription activator 1
chr9_+_133971863 1.74 ENST00000372309.3
AIF1L
allograft inflammatory factor 1-like
chr9_+_133971909 1.69 ENST00000247291.3
ENST00000372302.1
ENST00000372300.1
ENST00000372298.1
AIF1L
allograft inflammatory factor 1-like
chr3_-_141747439 1.69 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr20_+_30598231 1.63 ENST00000300415.8
ENST00000262659.8
CCM2L
cerebral cavernous malformation 2-like
chr1_+_6845497 1.61 ENST00000473578.1
ENST00000557126.1
CAMTA1
calmodulin binding transcription activator 1
chr3_-_169381183 1.61 ENST00000494292.1
MECOM
MDS1 and EVI1 complex locus
chr8_-_17579726 1.61 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr5_-_88179302 1.61 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr7_+_116312411 1.55 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
MET
met proto-oncogene
chr2_-_165424973 1.54 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr1_-_211752073 1.53 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr3_+_152017924 1.52 ENST00000465907.2
ENST00000492948.1
ENST00000485509.1
ENST00000464596.1
MBNL1
muscleblind-like splicing regulator 1
chr3_-_149375783 1.50 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr10_+_54074033 1.47 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr11_-_94965667 1.42 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr13_+_39612485 1.39 ENST00000379599.2
NHLRC3
NHL repeat containing 3
chr2_-_157189180 1.38 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr13_-_67802549 1.37 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr6_+_143929307 1.34 ENST00000427704.2
ENST00000305766.6
PHACTR2
phosphatase and actin regulator 2
chr8_+_29952914 1.33 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr13_+_39612442 1.32 ENST00000470258.1
ENST00000379600.3
NHLRC3
NHL repeat containing 3
chrX_+_80457442 1.31 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_+_79258547 1.30 ENST00000457153.2
SYT1
synaptotagmin I
chr2_-_183387064 1.30 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_-_93107696 1.30 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_-_141747459 1.29 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr18_-_52989217 1.28 ENST00000570287.2
TCF4
transcription factor 4
chrX_+_86772787 1.24 ENST00000373114.4
KLHL4
kelch-like family member 4
chr5_-_90679145 1.19 ENST00000265138.3
ARRDC3
arrestin domain containing 3
chr10_-_116444371 1.18 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr20_+_11898507 1.15 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chrX_-_80457385 1.14 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr18_-_53089723 1.14 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr15_+_57511609 1.13 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr2_+_181845843 1.13 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr8_-_93107827 1.12 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_-_88178964 1.10 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C
myocyte enhancer factor 2C
chrX_-_119694538 1.10 ENST00000371322.5
CUL4B
cullin 4B
chr1_+_84630367 1.08 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_16793160 1.08 ENST00000262067.4
TSPAN13
tetraspanin 13
chr13_-_45150392 1.07 ENST00000501704.2
TSC22D1
TSC22 domain family, member 1
chr21_+_17791648 1.06 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478
long intergenic non-protein coding RNA 478
chr5_+_95066823 1.06 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr8_+_29953163 1.06 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chrX_-_32173579 1.06 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr11_-_66445219 1.06 ENST00000525754.1
ENST00000531969.1
ENST00000524637.1
ENST00000531036.2
ENST00000310046.4
RBM4B
RNA binding motif protein 4B
chr5_-_88179017 1.05 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C
chr11_-_119234876 1.05 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr3_-_141747950 1.02 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_+_96873921 1.01 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr7_-_27224842 1.00 ENST00000517402.1
HOXA11
homeobox A11
chr17_-_46690839 0.98 ENST00000498634.2
HOXB8
homeobox B8
chr7_-_27224795 0.97 ENST00000006015.3
HOXA11
homeobox A11
chr1_+_93913713 0.97 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr1_+_185703513 0.96 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr12_-_6772303 0.95 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
ING4
inhibitor of growth family, member 4
chr11_-_47207390 0.95 ENST00000539589.1
ENST00000528462.1
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr14_-_21270995 0.94 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr16_-_15736881 0.94 ENST00000540441.2
KIAA0430
KIAA0430
chr11_+_92085262 0.93 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr21_+_17791838 0.92 ENST00000453910.1
LINC00478
long intergenic non-protein coding RNA 478
chr1_+_87797351 0.91 ENST00000370542.1
LMO4
LIM domain only 4
chr3_-_65583561 0.90 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr19_+_1249869 0.90 ENST00000591446.2
MIDN
midnolin
chr6_-_159466042 0.90 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr2_+_198669365 0.88 ENST00000428675.1
PLCL1
phospholipase C-like 1
chr3_+_141105235 0.88 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr11_-_130184555 0.87 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chrX_-_10588595 0.86 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_179184955 0.86 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr20_-_23066953 0.86 ENST00000246006.4
CD93
CD93 molecule
chr3_-_112320749 0.85 ENST00000610103.1
RP11-572C15.6
RP11-572C15.6
chr4_+_170581213 0.85 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chrX_+_86772707 0.84 ENST00000373119.4
KLHL4
kelch-like family member 4
chrX_-_10588459 0.84 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr15_-_65067773 0.83 ENST00000300069.4
RBPMS2
RNA binding protein with multiple splicing 2
chr6_-_112575838 0.83 ENST00000455073.1
LAMA4
laminin, alpha 4
chr12_+_9067123 0.83 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_-_63557759 0.83 ENST00000307078.5
AXIN2
axin 2
chr7_+_115850547 0.82 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr11_+_5410607 0.81 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr9_+_82186682 0.78 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_16085244 0.75 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr3_+_183353356 0.75 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr7_+_80275621 0.74 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr15_-_101792137 0.72 ENST00000254190.3
CHSY1
chondroitin sulfate synthase 1
chr17_-_46623441 0.72 ENST00000330070.4
HOXB2
homeobox B2
chr1_+_66999268 0.71 ENST00000371039.1
ENST00000424320.1
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr1_+_66797687 0.71 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_-_112575912 0.71 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr4_+_113152978 0.71 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chrX_-_50557014 0.70 ENST00000376020.2
SHROOM4
shroom family member 4
chr12_-_6233828 0.70 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr2_+_66666432 0.69 ENST00000495021.2
MEIS1
Meis homeobox 1
chr10_+_18948311 0.69 ENST00000377275.3
ARL5B
ADP-ribosylation factor-like 5B
chrX_+_135229600 0.69 ENST00000370690.3
FHL1
four and a half LIM domains 1
chr14_-_23624511 0.68 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr18_-_53069419 0.68 ENST00000570177.2
TCF4
transcription factor 4
chr9_+_82186872 0.68 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr11_+_92085707 0.67 ENST00000525166.1
FAT3
FAT atypical cadherin 3
chr7_+_107224364 0.67 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr21_+_17443434 0.66 ENST00000400178.2
LINC00478
long intergenic non-protein coding RNA 478
chr5_+_161274940 0.66 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_-_211341411 0.66 ENST00000233714.4
ENST00000443314.1
ENST00000441020.3
ENST00000450366.2
ENST00000431941.2
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)
chr16_-_30122717 0.66 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr17_-_27503770 0.65 ENST00000533112.1
MYO18A
myosin XVIIIA
chr11_-_130184470 0.64 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chr14_+_75230011 0.64 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr8_-_16859690 0.64 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr5_+_175288631 0.64 ENST00000509837.1
CPLX2
complexin 2
chr7_+_7811992 0.64 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr14_+_21236586 0.63 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr5_-_138210977 0.63 ENST00000274711.6
ENST00000521094.2
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr19_-_3029011 0.63 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chrX_+_135229559 0.63 ENST00000394155.2
FHL1
four and a half LIM domains 1
chr21_+_17443521 0.63 ENST00000456342.1
LINC00478
long intergenic non-protein coding RNA 478
chr9_-_97356075 0.62 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr20_+_10199468 0.62 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr15_-_82338460 0.62 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr11_-_104769141 0.62 ENST00000508062.1
ENST00000422698.2
CASP12
caspase 12 (gene/pseudogene)
chr9_+_33629119 0.62 ENST00000331828.4
TRBV21OR9-2
T cell receptor beta variable 21/OR9-2 (pseudogene)
chrX_-_10645773 0.61 ENST00000453318.2
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_234667504 0.61 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr14_+_89290965 0.61 ENST00000345383.5
ENST00000536576.1
ENST00000346301.4
ENST00000338104.6
ENST00000354441.6
ENST00000380656.2
ENST00000556651.1
ENST00000554686.1
TTC8
tetratricopeptide repeat domain 8
chr7_-_19813192 0.60 ENST00000422233.1
ENST00000433641.1
TMEM196
transmembrane protein 196
chr16_+_53242350 0.60 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr4_+_113152881 0.59 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr2_-_183387283 0.59 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr14_-_35182994 0.59 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr22_-_32860427 0.59 ENST00000534972.1
ENST00000397450.1
ENST00000397452.1
BPIFC
BPI fold containing family C
chrX_-_63425561 0.58 ENST00000374869.3
ENST00000330258.3
AMER1
APC membrane recruitment protein 1
chr1_-_94079648 0.58 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr13_+_76210448 0.58 ENST00000377499.5
LMO7
LIM domain 7
chr8_+_39770803 0.58 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chrX_-_19817869 0.58 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chrX_+_54835493 0.57 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr9_+_504674 0.57 ENST00000382297.2
KANK1
KN motif and ankyrin repeat domains 1
chr7_-_148581360 0.56 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_+_231664390 0.55 ENST00000366639.4
ENST00000413309.2
TSNAX
translin-associated factor X
chr12_-_104359475 0.55 ENST00000553183.1
C12orf73
chromosome 12 open reading frame 73
chr15_+_52043758 0.55 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr14_+_54863739 0.55 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr19_+_1248547 0.55 ENST00000586757.1
ENST00000300952.2
MIDN
midnolin
chr14_+_54863682 0.55 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3
cyclin-dependent kinase inhibitor 3
chr9_+_125703282 0.55 ENST00000373647.4
ENST00000402311.1
RABGAP1
RAB GTPase activating protein 1
chr1_+_155036204 0.54 ENST00000368409.3
ENST00000359751.4
ENST00000427683.2
ENST00000556931.1
ENST00000505139.1
EFNA4
EFNA3
EFNA3
ephrin-A4
ephrin-A3
Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, highly similar to Ephrin-A3
chr4_+_78078304 0.54 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chr17_+_75447326 0.53 ENST00000591088.1
SEPT9
septin 9
chr14_+_54976603 0.53 ENST00000557317.1
CGRRF1
cell growth regulator with ring finger domain 1
chr5_-_137514333 0.53 ENST00000411594.2
ENST00000430331.1
BRD8
bromodomain containing 8
chr4_+_78079450 0.52 ENST00000395640.1
ENST00000512918.1
CCNG2
cyclin G2
chr14_+_54863667 0.52 ENST00000335183.6
CDKN3
cyclin-dependent kinase inhibitor 3
chr18_+_6729698 0.51 ENST00000383472.4
ARHGAP28
Rho GTPase activating protein 28
chr7_-_140178775 0.51 ENST00000474576.1
ENST00000473444.1
ENST00000471104.1
MKRN1
makorin ring finger protein 1
chr14_+_85996507 0.51 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_-_85887503 0.51 ENST00000509172.1
ENST00000322366.6
ENST00000295888.4
ENST00000502713.1
WDFY3
WD repeat and FYVE domain containing 3
chr1_+_196621002 0.51 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr6_-_112575758 0.51 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr5_-_148930960 0.50 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chr18_-_52989525 0.50 ENST00000457482.3
TCF4
transcription factor 4
chr7_-_148581251 0.50 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr5_+_138677515 0.50 ENST00000265192.4
ENST00000511706.1
PAIP2
poly(A) binding protein interacting protein 2
chr22_-_23484246 0.50 ENST00000216036.4
RTDR1
rhabdoid tumor deletion region gene 1
chr14_-_81425828 0.50 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr11_-_124806297 0.50 ENST00000298251.4
HEPACAM
hepatic and glial cell adhesion molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 20.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.2 4.9 GO:0009956 radial pattern formation(GO:0009956)
0.9 3.8 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.6 4.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.6 2.3 GO:0035948 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.5 1.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.5 1.5 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.5 2.4 GO:0060023 soft palate development(GO:0060023)
0.5 1.4 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.4 3.1 GO:0097338 response to clozapine(GO:0097338)
0.4 1.3 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.4 1.3 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.4 1.2 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.4 1.1 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.3 10.7 GO:0010669 epithelial structure maintenance(GO:0010669)
0.3 1.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.3 1.6 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3 2.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.3 0.9 GO:0021569 rhombomere 3 development(GO:0021569)
0.3 2.5 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.3 1.9 GO:2000332 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.3 0.8 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.2 8.4 GO:0060065 uterus development(GO:0060065)
0.2 6.6 GO:0072189 ureter development(GO:0072189)
0.2 1.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 0.4 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 1.5 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.2 0.6 GO:1903028 positive regulation of opsonization(GO:1903028)
0.2 2.4 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 2.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 3.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.6 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.2 1.0 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 0.4 GO:0002572 pro-T cell differentiation(GO:0002572)
0.2 0.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 5.8 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 3.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 0.5 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 2.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 0.5 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.2 0.2 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.2 0.5 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.2 0.6 GO:0046351 sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.2 0.2 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.2 0.8 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.1 0.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.6 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.6 GO:0036269 positive regulation of chronic inflammatory response(GO:0002678) swimming behavior(GO:0036269)
0.1 1.9 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.4 GO:0021938 positive regulation of hh target transcription factor activity(GO:0007228) ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.8 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 2.4 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.1 0.4 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.3 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 0.6 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.1 0.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 1.2 GO:0042659 regulation of cell fate specification(GO:0042659)
0.1 1.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.7 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 0.2 GO:1902811 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 4.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.3 GO:0072560 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.3 GO:0034091 regulation of maintenance of sister chromatid cohesion(GO:0034091) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182) negative regulation of sister chromatid cohesion(GO:0045875)
0.1 0.7 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.5 GO:1905247 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 0.6 GO:0050893 sensory processing(GO:0050893)
0.1 2.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 1.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 1.8 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.4 GO:0070980 biphenyl catabolic process(GO:0070980)
0.1 0.9 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.8 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 1.2 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 0.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.5 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.5 GO:0051013 microtubule severing(GO:0051013)
0.1 0.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.5 GO:0035973 aggrephagy(GO:0035973)
0.1 0.5 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 1.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 1.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 2.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.4 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.5 GO:0031936 DNA replication-dependent nucleosome assembly(GO:0006335) negative regulation of chromatin silencing(GO:0031936) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.5 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 1.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.5 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.6 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.2 GO:1903786 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 1.2 GO:0007625 grooming behavior(GO:0007625)
0.0 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0 0.6 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.3 GO:0007144 female meiosis I(GO:0007144)
0.0 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 2.5 GO:0006301 postreplication repair(GO:0006301)
0.0 2.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 9.0 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.6 GO:0097264 self proteolysis(GO:0097264)
0.0 0.2 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 1.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 1.3 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.8 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.4 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.2 GO:2000741 asymmetric neuroblast division(GO:0055059) positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.2 GO:0070162 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.3 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.3 GO:0009629 response to gravity(GO:0009629)
0.0 0.4 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.0 GO:1901671 regulation of superoxide dismutase activity(GO:1901668) positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.0 0.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.2 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.6 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 2.9 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 4.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.5 GO:0051923 sulfation(GO:0051923)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.4 GO:0035329 hippo signaling(GO:0035329)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 1.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.9 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.7 GO:0008542 visual learning(GO:0008542)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.3 1.3 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 2.1 GO:0000125 PCAF complex(GO:0000125)
0.2 0.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 3.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 4.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.6 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.1 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.4 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.5 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 42.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.1 GO:0045120 pronucleus(GO:0045120)
0.1 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.1 3.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 1.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 13.7 GO:0030018 Z disc(GO:0030018)
0.1 0.8 GO:0034464 BBSome(GO:0034464)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.1 2.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.2 GO:0044753 amphisome(GO:0044753)
0.0 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.2 GO:0031105 septin complex(GO:0031105)
0.0 0.4 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.5 GO:0030315 T-tubule(GO:0030315)
0.0 7.1 GO:0043197 dendritic spine(GO:0043197)
0.0 0.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.0 5.6 GO:0000922 spindle pole(GO:0000922)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.4 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.8 GO:0042641 actomyosin(GO:0042641)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.9 GO:0097542 ciliary tip(GO:0097542)
0.0 1.0 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.8 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 2.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0051233 spindle midzone(GO:0051233)
0.0 1.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.9 GO:0000123 histone acetyltransferase complex(GO:0000123)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 20.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.0 10.7 GO:0030274 LIM domain binding(GO:0030274)
0.5 3.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 1.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.4 1.5 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.3 1.9 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.3 2.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 3.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 3.8 GO:0003680 AT DNA binding(GO:0003680)
0.2 5.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.6 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.2 0.7 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2 3.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 0.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 0.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.6 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 2.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 0.6 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.9 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 5.4 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.5 GO:0004461 lactose synthase activity(GO:0004461)
0.1 1.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.8 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.9 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.1 3.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.8 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.5 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 1.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.4 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 1.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.2 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.6 GO:0005113 patched binding(GO:0005113)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.7 GO:0043295 glutathione binding(GO:0043295)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 14.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 2.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.8 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 4.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.5 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.9 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.6 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 4.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.0 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.6 GO:0043531 ADP binding(GO:0043531)
0.0 0.0 GO:0005497 androgen binding(GO:0005497)
0.0 0.4 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0070905 serine binding(GO:0070905)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 12.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 3.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 4.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.8 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.5 PID EPHA FWDPATHWAY EPHA forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 7.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 7.1 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.1 1.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 6.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 3.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.9 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.1 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins